Phytanoyl-CoA dioxygenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytanoyl-CoA dioxygenase (PhyH), putative

Species:

Leishmania mexicana

UniProt:

E9AK19_LEIMU

TriTrypDb:

LmxM.04.0380

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK19

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0051213	dioxygenase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.431
CLV_NRD_NRD_1	2	4	PF00675	0.647
CLV_NRD_NRD_1	267	269	PF00675	0.369
CLV_PCSK_KEX2_1	19	21	PF00082	0.431
CLV_PCSK_KEX2_1	2	4	PF00082	0.659
CLV_PCSK_KEX2_1	267	269	PF00082	0.310
CLV_PCSK_SKI1_1	2	6	PF00082	0.670
CLV_PCSK_SKI1_1	277	281	PF00082	0.458
CLV_PCSK_SKI1_1	80	84	PF00082	0.346
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DEG_SCF_FBW7_1	256	263	PF00400	0.310
DOC_CDC14_PxL_1	140	148	PF14671	0.400
DOC_CYCLIN_RxL_1	274	282	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	225	228	PF00134	0.369
DOC_MAPK_DCC_7	58	66	PF00069	0.440
DOC_MAPK_DCC_7	80	90	PF00069	0.458
DOC_MAPK_gen_1	19	28	PF00069	0.489
DOC_MAPK_gen_1	267	274	PF00069	0.310
DOC_MAPK_MEF2A_6	58	66	PF00069	0.440
DOC_PP2B_LxvP_1	225	228	PF13499	0.404
DOC_PP2B_LxvP_1	83	86	PF13499	0.458
DOC_PP4_FxxP_1	60	63	PF00568	0.374
DOC_USP7_MATH_1	15	19	PF00917	0.658
DOC_WW_Pin1_4	187	192	PF00397	0.369
DOC_WW_Pin1_4	256	261	PF00397	0.310
LIG_14-3-3_CanoR_1	13	21	PF00244	0.560
LIG_14-3-3_CanoR_1	185	191	PF00244	0.372
LIG_BRCT_BRCA1_1	324	328	PF00533	0.535
LIG_Clathr_ClatBox_1	341	345	PF01394	0.624
LIG_EVH1_1	226	230	PF00568	0.440
LIG_FHA_1	143	149	PF00498	0.326
LIG_FHA_1	187	193	PF00498	0.310
LIG_FHA_1	257	263	PF00498	0.314
LIG_FHA_1	301	307	PF00498	0.486
LIG_FHA_1	336	342	PF00498	0.472
LIG_FHA_2	232	238	PF00498	0.373
LIG_FHA_2	241	247	PF00498	0.314
LIG_FHA_2	48	54	PF00498	0.448
LIG_HCF-1_HBM_1	109	112	PF13415	0.458
LIG_LIR_Nem_3	18	24	PF02991	0.498
LIG_LIR_Nem_3	325	331	PF02991	0.518
LIG_LIR_Nem_3	55	60	PF02991	0.405
LIG_MYND_1	211	215	PF01753	0.326
LIG_MYND_1	81	85	PF01753	0.384
LIG_Pex14_1	179	183	PF04695	0.310
LIG_Pex14_2	329	333	PF04695	0.460
LIG_SH2_CRK	48	52	PF00017	0.405
LIG_SH2_CRK	70	74	PF00017	0.400
LIG_SH2_CRK	75	79	PF00017	0.400
LIG_SH2_NCK_1	163	167	PF00017	0.310
LIG_SH2_SRC	163	166	PF00017	0.310
LIG_SH2_STAP1	112	116	PF00017	0.310
LIG_SH2_STAP1	163	167	PF00017	0.310
LIG_SH2_STAT5	126	129	PF00017	0.354
LIG_SH2_STAT5	142	145	PF00017	0.242
LIG_SH2_STAT5	183	186	PF00017	0.442
LIG_SH2_STAT5	24	27	PF00017	0.492
LIG_SH3_1	172	178	PF00018	0.310
LIG_SH3_3	138	144	PF00018	0.400
LIG_SH3_3	172	178	PF00018	0.310
LIG_SH3_3	224	230	PF00018	0.326
LIG_SH3_3	307	313	PF00018	0.444
LIG_SH3_3	321	327	PF00018	0.362
LIG_SH3_3	329	335	PF00018	0.357
LIG_SH3_3	79	85	PF00018	0.387
LIG_SUMO_SIM_par_1	196	203	PF11976	0.310
LIG_SUMO_SIM_par_1	258	265	PF11976	0.241
LIG_SUMO_SIM_par_1	338	345	PF11976	0.612
LIG_TYR_ITIM	161	166	PF00017	0.315
LIG_TYR_ITIM	73	78	PF00017	0.346
LIG_UBA3_1	197	206	PF00899	0.329
LIG_UBA3_1	341	347	PF00899	0.599
MOD_CK2_1	231	237	PF00069	0.349
MOD_GlcNHglycan	324	327	PF01048	0.490
MOD_GSK3_1	144	151	PF00069	0.310
MOD_GSK3_1	256	263	PF00069	0.310
MOD_GSK3_1	275	282	PF00069	0.310
MOD_N-GLC_1	284	289	PF02516	0.310
MOD_NEK2_1	111	116	PF00069	0.310
MOD_NEK2_1	279	284	PF00069	0.326
MOD_NEK2_1	47	52	PF00069	0.431
MOD_PIKK_1	148	154	PF00454	0.310
MOD_PIKK_1	231	237	PF00454	0.440
MOD_PKA_2	322	328	PF00069	0.522
MOD_PKB_1	317	325	PF00069	0.487
MOD_Plk_1	284	290	PF00069	0.310
MOD_Plk_4	193	199	PF00069	0.310
MOD_Plk_4	20	26	PF00069	0.512
MOD_Plk_4	240	246	PF00069	0.310
MOD_Plk_4	275	281	PF00069	0.310
MOD_ProDKin_1	187	193	PF00069	0.369
MOD_ProDKin_1	256	262	PF00069	0.310
MOD_SUMO_for_1	106	109	PF00179	0.310
MOD_SUMO_rev_2	339	348	PF00179	0.505
TRG_DiLeu_BaEn_2	55	61	PF01217	0.402
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.447
TRG_ENDOCYTIC_2	163	166	PF00928	0.315
TRG_ENDOCYTIC_2	48	51	PF00928	0.410
TRG_ENDOCYTIC_2	57	60	PF00928	0.394
TRG_ENDOCYTIC_2	70	73	PF00928	0.263
TRG_ENDOCYTIC_2	75	78	PF00928	0.185
TRG_ER_diArg_1	1	3	PF00400	0.634
TRG_ER_diArg_1	19	21	PF00400	0.417
TRG_ER_diArg_1	266	268	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T2	Leptomonas seymouri	88%	99%
A0A0S4IYZ7	Bodo saltans	70%	100%
A0A1X0NL63	Trypanosomatidae	76%	94%
A0A3S5H5A0	Leishmania donovani	98%	100%
A0A3S5IRI3	Trypanosoma rangeli	80%	95%
A4H3V6	Leishmania braziliensis	94%	100%
A4HS32	Leishmania infantum	98%	100%
C9ZY24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	96%
Q9XZX7	Leishmania major	97%	100%
V5B953	Trypanosoma cruzi	78%	94%