LeishMANIAdb
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RNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RNA helicase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AK18_LEIMU
TriTrypDb:
LmxM.04.0370
Length:
190

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AK18
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 27 31 PF00656 0.623
CLV_NRD_NRD_1 106 108 PF00675 0.623
CLV_NRD_NRD_1 180 182 PF00675 0.554
CLV_NRD_NRD_1 20 22 PF00675 0.552
CLV_NRD_NRD_1 91 93 PF00675 0.424
CLV_PCSK_KEX2_1 105 107 PF00082 0.559
CLV_PCSK_KEX2_1 11 13 PF00082 0.521
CLV_PCSK_KEX2_1 180 182 PF00082 0.579
CLV_PCSK_KEX2_1 91 93 PF00082 0.424
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.484
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.564
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.579
CLV_PCSK_SKI1_1 11 15 PF00082 0.465
CLV_PCSK_SKI1_1 172 176 PF00082 0.569
CLV_PCSK_SKI1_1 22 26 PF00082 0.486
CLV_PCSK_SKI1_1 91 95 PF00082 0.483
DOC_MAPK_gen_1 11 20 PF00069 0.473
DOC_PP2B_LxvP_1 3 6 PF13499 0.530
DOC_USP7_MATH_1 158 162 PF00917 0.586
DOC_USP7_UBL2_3 7 11 PF12436 0.501
DOC_WW_Pin1_4 123 128 PF00397 0.678
LIG_BRCT_BRCA1_1 63 67 PF00533 0.492
LIG_FHA_2 14 20 PF00498 0.614
LIG_FHA_2 92 98 PF00498 0.540
LIG_MAD2 163 171 PF02301 0.578
LIG_Pex14_2 174 178 PF04695 0.579
LIG_REV1ctd_RIR_1 172 181 PF16727 0.573
LIG_SH2_STAP1 37 41 PF00017 0.460
LIG_WRC_WIRS_1 80 85 PF05994 0.459
MOD_CDK_SPK_2 123 128 PF00069 0.693
MOD_CK2_1 13 19 PF00069 0.606
MOD_CK2_1 163 169 PF00069 0.546
MOD_CK2_1 91 97 PF00069 0.524
MOD_GlcNHglycan 101 104 PF01048 0.444
MOD_GlcNHglycan 160 163 PF01048 0.698
MOD_GSK3_1 150 157 PF00069 0.563
MOD_GSK3_1 22 29 PF00069 0.651
MOD_NEK2_1 35 40 PF00069 0.503
MOD_NEK2_1 50 55 PF00069 0.556
MOD_PKA_1 91 97 PF00069 0.549
MOD_PKA_2 91 97 PF00069 0.495
MOD_PKB_1 152 160 PF00069 0.671
MOD_ProDKin_1 123 129 PF00069 0.680
TRG_ER_diArg_1 90 92 PF00400 0.447
TRG_NLS_MonoCore_2 178 183 PF00514 0.584
TRG_NLS_MonoExtC_3 178 184 PF00514 0.582
TRG_NLS_MonoExtN_4 177 183 PF00514 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC96 Leptomonas seymouri 82% 99%
A0A0S4J1V1 Bodo saltans 54% 98%
A0A1X0NLC2 Trypanosomatidae 55% 100%
A0A3R7MRB1 Trypanosoma rangeli 58% 88%
A0A3S7WNN7 Leishmania donovani 92% 100%
A4HS31 Leishmania infantum 91% 100%
C9ZY23 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q9XZX5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS