Putative mitochondrial exoribonuclease DSS-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial exoribonuclease DSS-1, putative

Species:

Leishmania mexicana

UniProt:

E9AK15_LEIMU

TriTrypDb:

LmxM.04.0330

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

E9AK15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK15

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	6
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	6
GO:0008859	exoribonuclease II activity	7	6
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.524
CLV_C14_Caspase3-7	392	396	PF00656	0.429
CLV_C14_Caspase3-7	407	411	PF00656	0.465
CLV_C14_Caspase3-7	482	486	PF00656	0.510
CLV_C14_Caspase3-7	540	544	PF00656	0.472
CLV_C14_Caspase3-7	839	843	PF00656	0.651
CLV_NRD_NRD_1	241	243	PF00675	0.491
CLV_NRD_NRD_1	297	299	PF00675	0.344
CLV_NRD_NRD_1	30	32	PF00675	0.670
CLV_NRD_NRD_1	359	361	PF00675	0.251
CLV_NRD_NRD_1	558	560	PF00675	0.344
CLV_NRD_NRD_1	591	593	PF00675	0.244
CLV_NRD_NRD_1	610	612	PF00675	0.473
CLV_NRD_NRD_1	712	714	PF00675	0.627
CLV_NRD_NRD_1	749	751	PF00675	0.766
CLV_PCSK_FUR_1	239	243	PF00082	0.481
CLV_PCSK_KEX2_1	241	243	PF00082	0.491
CLV_PCSK_KEX2_1	297	299	PF00082	0.344
CLV_PCSK_KEX2_1	30	32	PF00082	0.670
CLV_PCSK_KEX2_1	359	361	PF00082	0.244
CLV_PCSK_KEX2_1	558	560	PF00082	0.344
CLV_PCSK_KEX2_1	591	593	PF00082	0.244
CLV_PCSK_KEX2_1	610	612	PF00082	0.473
CLV_PCSK_KEX2_1	712	714	PF00082	0.617
CLV_PCSK_KEX2_1	749	751	PF00082	0.682
CLV_PCSK_SKI1_1	185	189	PF00082	0.426
CLV_PCSK_SKI1_1	297	301	PF00082	0.244
CLV_PCSK_SKI1_1	359	363	PF00082	0.256
CLV_PCSK_SKI1_1	4	8	PF00082	0.581
CLV_PCSK_SKI1_1	537	541	PF00082	0.222
CLV_PCSK_SKI1_1	628	632	PF00082	0.451
DEG_APCC_DBOX_1	184	192	PF00400	0.476
DEG_Kelch_Keap1_1	339	344	PF01344	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.616
DEG_SCF_FBW7_1	42	48	PF00400	0.500
DEG_SPOP_SBC_1	104	108	PF00917	0.528
DEG_SPOP_SBC_1	621	625	PF00917	0.728
DEG_SPOP_SBC_1	740	744	PF00917	0.625
DOC_ANK_TNKS_1	240	247	PF00023	0.522
DOC_CKS1_1	17	22	PF01111	0.654
DOC_CKS1_1	42	47	PF01111	0.499
DOC_CKS1_1	452	457	PF01111	0.470
DOC_CKS1_1	764	769	PF01111	0.549
DOC_CYCLIN_RxL_1	182	189	PF00134	0.466
DOC_CYCLIN_yClb5_NLxxxL_5	409	416	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	734	740	PF00134	0.551
DOC_MAPK_gen_1	2	11	PF00069	0.563
DOC_MAPK_gen_1	327	336	PF00069	0.455
DOC_MAPK_gen_1	591	598	PF00069	0.444
DOC_MAPK_gen_1	701	707	PF00069	0.483
DOC_MAPK_JIP1_4	750	756	PF00069	0.643
DOC_PP2B_LxvP_1	734	737	PF13499	0.591
DOC_PP2B_LxvP_1	738	741	PF13499	0.579
DOC_PP2B_PxIxI_1	463	469	PF00149	0.444
DOC_PP4_FxxP_1	311	314	PF00568	0.453
DOC_PP4_FxxP_1	459	462	PF00568	0.544
DOC_SPAK_OSR1_1	667	671	PF12202	0.419
DOC_USP7_MATH_1	248	252	PF00917	0.462
DOC_USP7_MATH_1	286	290	PF00917	0.510
DOC_USP7_MATH_1	45	49	PF00917	0.817
DOC_USP7_MATH_1	519	523	PF00917	0.538
DOC_USP7_MATH_1	552	556	PF00917	0.521
DOC_USP7_MATH_1	622	626	PF00917	0.545
DOC_USP7_MATH_1	643	647	PF00917	0.457
DOC_USP7_MATH_1	724	728	PF00917	0.556
DOC_USP7_MATH_1	739	743	PF00917	0.605
DOC_USP7_MATH_1	99	103	PF00917	0.440
DOC_WW_Pin1_4	16	21	PF00397	0.722
DOC_WW_Pin1_4	383	388	PF00397	0.515
DOC_WW_Pin1_4	41	46	PF00397	0.748
DOC_WW_Pin1_4	451	456	PF00397	0.470
DOC_WW_Pin1_4	585	590	PF00397	0.518
DOC_WW_Pin1_4	763	768	PF00397	0.659
DOC_WW_Pin1_4	97	102	PF00397	0.537
LIG_14-3-3_CanoR_1	121	131	PF00244	0.452
LIG_14-3-3_CanoR_1	297	306	PF00244	0.446
LIG_14-3-3_CanoR_1	327	333	PF00244	0.469
LIG_14-3-3_CanoR_1	359	364	PF00244	0.444
LIG_14-3-3_CanoR_1	4	10	PF00244	0.571
LIG_14-3-3_CanoR_1	518	526	PF00244	0.527
LIG_14-3-3_CanoR_1	537	543	PF00244	0.551
LIG_14-3-3_CanoR_1	558	564	PF00244	0.457
LIG_14-3-3_CanoR_1	628	633	PF00244	0.669
LIG_14-3-3_CanoR_1	657	661	PF00244	0.512
LIG_14-3-3_CanoR_1	722	730	PF00244	0.604
LIG_14-3-3_CanoR_1	749	755	PF00244	0.703
LIG_Actin_WH2_1	80	97	PF00022	0.445
LIG_Actin_WH2_2	81	97	PF00022	0.495
LIG_BIR_III_4	259	263	PF00653	0.444
LIG_BRCT_BRCA1_1	544	548	PF00533	0.557
LIG_BRCT_BRCA1_1	664	668	PF00533	0.486
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.416
LIG_EVH1_2	455	459	PF00568	0.508
LIG_FHA_1	106	112	PF00498	0.629
LIG_FHA_1	12	18	PF00498	0.663
LIG_FHA_1	124	130	PF00498	0.390
LIG_FHA_1	218	224	PF00498	0.447
LIG_FHA_1	252	258	PF00498	0.444
LIG_FHA_1	300	306	PF00498	0.460
LIG_FHA_1	329	335	PF00498	0.444
LIG_FHA_1	340	346	PF00498	0.444
LIG_FHA_1	452	458	PF00498	0.555
LIG_FHA_1	469	475	PF00498	0.409
LIG_FHA_1	515	521	PF00498	0.455
LIG_FHA_1	562	568	PF00498	0.466
LIG_FHA_1	585	591	PF00498	0.444
LIG_FHA_1	709	715	PF00498	0.448
LIG_FHA_1	807	813	PF00498	0.425
LIG_FHA_2	134	140	PF00498	0.529
LIG_FHA_2	157	163	PF00498	0.465
LIG_FHA_2	184	190	PF00498	0.451
LIG_FHA_2	251	257	PF00498	0.465
LIG_FHA_2	320	326	PF00498	0.464
LIG_FHA_2	403	409	PF00498	0.466
LIG_FHA_2	529	535	PF00498	0.508
LIG_FHA_2	538	544	PF00498	0.359
LIG_FHA_2	651	657	PF00498	0.438
LIG_FHA_2	70	76	PF00498	0.516
LIG_LIR_Apic_2	124	130	PF02991	0.409
LIG_LIR_Apic_2	458	462	PF02991	0.548
LIG_LIR_Gen_1	233	243	PF02991	0.423
LIG_LIR_Gen_1	331	338	PF02991	0.544
LIG_LIR_Gen_1	362	371	PF02991	0.444
LIG_LIR_Gen_1	70	77	PF02991	0.544
LIG_LIR_Gen_1	703	708	PF02991	0.492
LIG_LIR_Gen_1	766	777	PF02991	0.495
LIG_LIR_Gen_1	826	837	PF02991	0.519
LIG_LIR_Nem_3	233	238	PF02991	0.385
LIG_LIR_Nem_3	282	287	PF02991	0.506
LIG_LIR_Nem_3	307	313	PF02991	0.447
LIG_LIR_Nem_3	331	335	PF02991	0.549
LIG_LIR_Nem_3	362	366	PF02991	0.444
LIG_LIR_Nem_3	410	416	PF02991	0.545
LIG_LIR_Nem_3	665	671	PF02991	0.330
LIG_LIR_Nem_3	70	76	PF02991	0.550
LIG_LIR_Nem_3	703	707	PF02991	0.473
LIG_LIR_Nem_3	766	772	PF02991	0.470
LIG_LIR_Nem_3	826	832	PF02991	0.520
LIG_NRBOX	83	89	PF00104	0.356
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.462
LIG_PDZ_Class_2	838	843	PF00595	0.651
LIG_Pex14_1	669	673	PF04695	0.387
LIG_Pex14_1	78	82	PF04695	0.338
LIG_Pex14_2	332	336	PF04695	0.444
LIG_SH2_CRK	363	367	PF00017	0.510
LIG_SH2_CRK	91	95	PF00017	0.515
LIG_SH2_NCK_1	363	367	PF00017	0.428
LIG_SH2_NCK_1	530	534	PF00017	0.486
LIG_SH2_NCK_1	96	100	PF00017	0.480
LIG_SH2_PTP2	193	196	PF00017	0.422
LIG_SH2_SRC	193	196	PF00017	0.422
LIG_SH2_SRC	73	76	PF00017	0.421
LIG_SH2_SRC	96	99	PF00017	0.571
LIG_SH2_STAP1	348	352	PF00017	0.486
LIG_SH2_STAP1	593	597	PF00017	0.428
LIG_SH2_STAP1	720	724	PF00017	0.527
LIG_SH2_STAP1	829	833	PF00017	0.604
LIG_SH2_STAT3	211	214	PF00017	0.517
LIG_SH2_STAT5	193	196	PF00017	0.397
LIG_SH2_STAT5	273	276	PF00017	0.461
LIG_SH2_STAT5	277	280	PF00017	0.452
LIG_SH2_STAT5	284	287	PF00017	0.454
LIG_SH2_STAT5	304	307	PF00017	0.477
LIG_SH2_STAT5	414	417	PF00017	0.544
LIG_SH2_STAT5	530	533	PF00017	0.486
LIG_SH2_STAT5	583	586	PF00017	0.534
LIG_SH2_STAT5	673	676	PF00017	0.404
LIG_SH2_STAT5	704	707	PF00017	0.515
LIG_SH2_STAT5	73	76	PF00017	0.363
LIG_SH2_STAT5	771	774	PF00017	0.412
LIG_SH2_STAT5	776	779	PF00017	0.413
LIG_SH3_1	95	101	PF00018	0.521
LIG_SH3_3	127	133	PF00018	0.421
LIG_SH3_3	14	20	PF00018	0.716
LIG_SH3_3	166	172	PF00018	0.421
LIG_SH3_3	280	286	PF00018	0.444
LIG_SH3_3	39	45	PF00018	0.495
LIG_SH3_3	449	455	PF00018	0.504
LIG_SH3_3	629	635	PF00018	0.569
LIG_SH3_3	712	718	PF00018	0.575
LIG_SH3_3	745	751	PF00018	0.755
LIG_SH3_3	772	778	PF00018	0.472
LIG_SH3_3	95	101	PF00018	0.597
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.456
LIG_SUMO_SIM_par_1	471	478	PF11976	0.445
LIG_TRAF2_1	375	378	PF00917	0.462
LIG_TRAF2_1	653	656	PF00917	0.421
LIG_TYR_ITIM	361	366	PF00017	0.283
MOD_CDC14_SPxK_1	588	591	PF00782	0.283
MOD_CDK_SPxK_1	41	47	PF00069	0.734
MOD_CDK_SPxK_1	585	591	PF00069	0.283
MOD_CDK_SPxxK_3	585	592	PF00069	0.283
MOD_CK1_1	100	106	PF00069	0.630
MOD_CK1_1	251	257	PF00069	0.283
MOD_CK1_1	279	285	PF00069	0.283
MOD_CK1_1	35	41	PF00069	0.739
MOD_CK1_1	48	54	PF00069	0.794
MOD_CK1_1	561	567	PF00069	0.318
MOD_CK1_1	620	626	PF00069	0.611
MOD_CK1_1	742	748	PF00069	0.678
MOD_CK2_1	133	139	PF00069	0.497
MOD_CK2_1	156	162	PF00069	0.466
MOD_CK2_1	183	189	PF00069	0.454
MOD_CK2_1	250	256	PF00069	0.283
MOD_CK2_1	286	292	PF00069	0.323
MOD_CK2_1	319	325	PF00069	0.307
MOD_CK2_1	338	344	PF00069	0.445
MOD_CK2_1	528	534	PF00069	0.352
MOD_CK2_1	650	656	PF00069	0.373
MOD_CK2_1	723	729	PF00069	0.603
MOD_GlcNHglycan	113	116	PF01048	0.483
MOD_GlcNHglycan	250	253	PF01048	0.283
MOD_GlcNHglycan	395	398	PF01048	0.405
MOD_GlcNHglycan	619	622	PF01048	0.658
MOD_GlcNHglycan	624	627	PF01048	0.663
MOD_GlcNHglycan	680	683	PF01048	0.562
MOD_GlcNHglycan	69	72	PF01048	0.519
MOD_GlcNHglycan	726	729	PF01048	0.603
MOD_GSK3_1	248	255	PF00069	0.283
MOD_GSK3_1	32	39	PF00069	0.790
MOD_GSK3_1	41	48	PF00069	0.780
MOD_GSK3_1	468	475	PF00069	0.336
MOD_GSK3_1	49	56	PF00069	0.638
MOD_GSK3_1	514	521	PF00069	0.294
MOD_GSK3_1	538	545	PF00069	0.354
MOD_GSK3_1	577	584	PF00069	0.286
MOD_GSK3_1	616	623	PF00069	0.669
MOD_GSK3_1	691	698	PF00069	0.458
MOD_GSK3_1	724	731	PF00069	0.662
MOD_GSK3_1	739	746	PF00069	0.523
MOD_GSK3_1	763	770	PF00069	0.629
MOD_GSK3_1	99	106	PF00069	0.500
MOD_N-GLC_1	198	203	PF02516	0.285
MOD_N-GLC_1	346	351	PF02516	0.312
MOD_N-GLC_1	49	54	PF02516	0.549
MOD_N-GLC_1	578	583	PF02516	0.187
MOD_NEK2_1	111	116	PF00069	0.522
MOD_NEK2_1	122	127	PF00069	0.414
MOD_NEK2_1	156	161	PF00069	0.464
MOD_NEK2_1	299	304	PF00069	0.316
MOD_NEK2_1	5	10	PF00069	0.468
MOD_NEK2_1	514	519	PF00069	0.424
MOD_NEK2_1	542	547	PF00069	0.385
MOD_NEK2_1	553	558	PF00069	0.321
MOD_NEK2_1	578	583	PF00069	0.424
MOD_NEK2_1	650	655	PF00069	0.336
MOD_NEK2_1	69	74	PF00069	0.457
MOD_NEK2_1	723	728	PF00069	0.551
MOD_NEK2_1	782	787	PF00069	0.541
MOD_PIKK_1	116	122	PF00454	0.534
MOD_PIKK_1	480	486	PF00454	0.467
MOD_PIKK_1	728	734	PF00454	0.584
MOD_PIKK_1	806	812	PF00454	0.362
MOD_PIKK_1	836	842	PF00454	0.617
MOD_PK_1	346	352	PF00069	0.299
MOD_PKA_1	297	303	PF00069	0.424
MOD_PKA_1	359	365	PF00069	0.283
MOD_PKA_1	558	564	PF00069	0.424
MOD_PKA_2	11	17	PF00069	0.612
MOD_PKA_2	297	303	PF00069	0.387
MOD_PKA_2	359	365	PF00069	0.283
MOD_PKA_2	514	520	PF00069	0.293
MOD_PKA_2	558	564	PF00069	0.424
MOD_PKA_2	617	623	PF00069	0.510
MOD_PKA_2	656	662	PF00069	0.515
MOD_PKA_2	678	684	PF00069	0.500
MOD_PKA_2	801	807	PF00069	0.247
MOD_PKB_1	2	10	PF00069	0.536
MOD_Plk_1	198	204	PF00069	0.460
MOD_Plk_1	279	285	PF00069	0.283
MOD_Plk_1	287	293	PF00069	0.283
MOD_Plk_1	346	352	PF00069	0.294
MOD_Plk_1	457	463	PF00069	0.400
MOD_Plk_1	542	548	PF00069	0.426
MOD_Plk_1	578	584	PF00069	0.424
MOD_Plk_1	662	668	PF00069	0.437
MOD_Plk_1	728	734	PF00069	0.584
MOD_Plk_1	767	773	PF00069	0.564
MOD_Plk_2-3	319	325	PF00069	0.318
MOD_Plk_4	279	285	PF00069	0.299
MOD_Plk_4	300	306	PF00069	0.283
MOD_Plk_4	469	475	PF00069	0.172
MOD_Plk_4	578	584	PF00069	0.424
MOD_Plk_4	656	662	PF00069	0.438
MOD_Plk_4	69	75	PF00069	0.438
MOD_Plk_4	700	706	PF00069	0.466
MOD_Plk_4	83	89	PF00069	0.375
MOD_ProDKin_1	16	22	PF00069	0.724
MOD_ProDKin_1	383	389	PF00069	0.384
MOD_ProDKin_1	41	47	PF00069	0.750
MOD_ProDKin_1	451	457	PF00069	0.320
MOD_ProDKin_1	585	591	PF00069	0.387
MOD_ProDKin_1	763	769	PF00069	0.655
MOD_ProDKin_1	97	103	PF00069	0.539
MOD_SUMO_for_1	371	374	PF00179	0.259
MOD_SUMO_rev_2	463	471	PF00179	0.320
TRG_AP2beta_CARGO_1	410	420	PF09066	0.320
TRG_DiLeu_BaEn_1	118	123	PF01217	0.462
TRG_DiLeu_BaEn_1	656	661	PF01217	0.437
TRG_DiLeu_BaEn_1	729	734	PF01217	0.561
TRG_DiLeu_BaEn_2	306	312	PF01217	0.283
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.345
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.374
TRG_DiLeu_LyEn_5	118	123	PF01217	0.462
TRG_ENDOCYTIC_2	273	276	PF00928	0.309
TRG_ENDOCYTIC_2	284	287	PF00928	0.301
TRG_ENDOCYTIC_2	363	366	PF00928	0.283
TRG_ENDOCYTIC_2	568	571	PF00928	0.374
TRG_ENDOCYTIC_2	593	596	PF00928	0.283
TRG_ENDOCYTIC_2	704	707	PF00928	0.437
TRG_ENDOCYTIC_2	720	723	PF00928	0.409
TRG_ENDOCYTIC_2	73	76	PF00928	0.504
TRG_ENDOCYTIC_2	829	832	PF00928	0.604
TRG_ENDOCYTIC_2	91	94	PF00928	0.409
TRG_ER_diArg_1	1	4	PF00400	0.720
TRG_ER_diArg_1	297	299	PF00400	0.424
TRG_ER_diArg_1	358	360	PF00400	0.283
TRG_ER_diArg_1	420	423	PF00400	0.290
TRG_ER_diArg_1	424	427	PF00400	0.290
TRG_ER_diArg_1	557	559	PF00400	0.424
TRG_ER_diArg_1	590	592	PF00400	0.283
TRG_ER_diArg_1	712	714	PF00400	0.586
TRG_ER_diArg_1	748	750	PF00400	0.768
TRG_ER_diArg_1	9	12	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	518	523	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	672	676	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA76	Leptomonas seymouri	69%	100%
A0A0S4J212	Bodo saltans	43%	100%
A0A1X0NLV5	Trypanosomatidae	53%	100%
A0A3S5H597	Leishmania donovani	92%	99%
A0A422NN62	Trypanosoma rangeli	52%	100%
A4H3V2	Leishmania braziliensis	82%	98%
A4HS28	Leishmania infantum	92%	99%
C9ZY19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q86MA2	Trypanosoma brucei brucei	51%	100%
Q9XZX1	Leishmania major	91%	100%
V5B958	Trypanosoma cruzi	53%	100%