LeishMANIAdb
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Putative beta-fructofuranosidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative beta-fructofuranosidase
Gene product:
beta-fructofuranosidase, putative
Species:
Leishmania mexicana
UniProt:
E9AK13_LEIMU
TriTrypDb:
LmxM.04.0310
Length:
636

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 7
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AK13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK13

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 19
GO:0008152 metabolic process 1 19
GO:0044238 primary metabolic process 2 19
GO:0071704 organic substance metabolic process 2 19
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 19
GO:0004564 beta-fructofuranosidase activity 5 10
GO:0016787 hydrolase activity 2 19
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.626
CLV_NRD_NRD_1 312 314 PF00675 0.489
CLV_PCSK_KEX2_1 145 147 PF00082 0.357
CLV_PCSK_KEX2_1 2 4 PF00082 0.628
CLV_PCSK_KEX2_1 312 314 PF00082 0.416
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.339
CLV_PCSK_SKI1_1 289 293 PF00082 0.457
CLV_PCSK_SKI1_1 350 354 PF00082 0.395
CLV_PCSK_SKI1_1 620 624 PF00082 0.669
DEG_APCC_DBOX_1 516 524 PF00400 0.473
DEG_COP1_1 413 423 PF00400 0.374
DEG_Nend_UBRbox_1 1 4 PF02207 0.414
DOC_MAPK_gen_1 2 10 PF00069 0.611
DOC_MAPK_gen_1 361 371 PF00069 0.460
DOC_MAPK_gen_1 83 93 PF00069 0.432
DOC_MAPK_HePTP_8 590 602 PF00069 0.371
DOC_MAPK_MEF2A_6 153 160 PF00069 0.282
DOC_MAPK_MEF2A_6 2 10 PF00069 0.634
DOC_MAPK_MEF2A_6 593 602 PF00069 0.371
DOC_MAPK_NFAT4_5 3 11 PF00069 0.606
DOC_PP1_RVXF_1 495 501 PF00149 0.461
DOC_PP4_FxxP_1 174 177 PF00568 0.311
DOC_PP4_FxxP_1 239 242 PF00568 0.456
DOC_PP4_FxxP_1 305 308 PF00568 0.478
DOC_USP7_MATH_1 287 291 PF00917 0.441
DOC_USP7_MATH_1 450 454 PF00917 0.400
DOC_USP7_MATH_1 467 471 PF00917 0.423
DOC_USP7_MATH_1 472 476 PF00917 0.469
DOC_USP7_UBL2_3 497 501 PF12436 0.497
DOC_USP7_UBL2_3 97 101 PF12436 0.384
DOC_WW_Pin1_4 376 381 PF00397 0.563
DOC_WW_Pin1_4 544 549 PF00397 0.475
DOC_WW_Pin1_4 612 617 PF00397 0.660
DOC_WW_Pin1_4 86 91 PF00397 0.468
LIG_14-3-3_CanoR_1 289 294 PF00244 0.373
LIG_14-3-3_CanoR_1 312 316 PF00244 0.249
LIG_14-3-3_CanoR_1 399 403 PF00244 0.404
LIG_Actin_WH2_2 240 258 PF00022 0.330
LIG_APCC_ABBA_1 553 558 PF00400 0.327
LIG_APCC_ABBA_1 562 567 PF00400 0.327
LIG_BRCT_BRCA1_1 289 293 PF00533 0.409
LIG_BRCT_BRCA1_1 485 489 PF00533 0.504
LIG_deltaCOP1_diTrp_1 96 102 PF00928 0.461
LIG_FHA_1 352 358 PF00498 0.394
LIG_FHA_1 379 385 PF00498 0.515
LIG_FHA_1 452 458 PF00498 0.456
LIG_FHA_1 493 499 PF00498 0.403
LIG_FHA_1 50 56 PF00498 0.423
LIG_FHA_1 532 538 PF00498 0.396
LIG_FHA_1 572 578 PF00498 0.352
LIG_FHA_1 583 589 PF00498 0.352
LIG_FHA_1 597 603 PF00498 0.381
LIG_FHA_1 621 627 PF00498 0.648
LIG_FHA_2 120 126 PF00498 0.420
LIG_FHA_2 244 250 PF00498 0.445
LIG_FHA_2 290 296 PF00498 0.347
LIG_FHA_2 302 308 PF00498 0.374
LIG_FHA_2 317 323 PF00498 0.458
LIG_FHA_2 377 383 PF00498 0.510
LIG_FHA_2 399 405 PF00498 0.437
LIG_FHA_2 486 492 PF00498 0.333
LIG_FHA_2 513 519 PF00498 0.464
LIG_FHA_2 626 632 PF00498 0.585
LIG_FHA_2 75 81 PF00498 0.311
LIG_FHA_2 83 89 PF00498 0.311
LIG_LIR_Apic_2 172 177 PF02991 0.327
LIG_LIR_Apic_2 178 184 PF02991 0.275
LIG_LIR_Apic_2 236 242 PF02991 0.432
LIG_LIR_Apic_2 304 308 PF02991 0.478
LIG_LIR_Apic_2 608 614 PF02991 0.572
LIG_LIR_Gen_1 252 261 PF02991 0.375
LIG_LIR_Gen_1 278 287 PF02991 0.478
LIG_LIR_Gen_1 288 299 PF02991 0.490
LIG_LIR_Gen_1 391 400 PF02991 0.475
LIG_LIR_Gen_1 434 444 PF02991 0.311
LIG_LIR_Gen_1 625 634 PF02991 0.599
LIG_LIR_Nem_3 100 105 PF02991 0.416
LIG_LIR_Nem_3 243 247 PF02991 0.350
LIG_LIR_Nem_3 252 257 PF02991 0.387
LIG_LIR_Nem_3 265 269 PF02991 0.287
LIG_LIR_Nem_3 278 284 PF02991 0.331
LIG_LIR_Nem_3 288 294 PF02991 0.317
LIG_LIR_Nem_3 295 299 PF02991 0.295
LIG_LIR_Nem_3 304 309 PF02991 0.413
LIG_LIR_Nem_3 391 396 PF02991 0.537
LIG_LIR_Nem_3 434 439 PF02991 0.360
LIG_LIR_Nem_3 458 463 PF02991 0.424
LIG_LIR_Nem_3 625 630 PF02991 0.583
LIG_LIR_Nem_3 70 76 PF02991 0.326
LIG_LYPXL_yS_3 460 463 PF13949 0.404
LIG_NRBOX 625 631 PF00104 0.625
LIG_PCNA_yPIPBox_3 337 351 PF02747 0.404
LIG_PDZ_Class_2 631 636 PF00595 0.583
LIG_Pex14_1 190 194 PF04695 0.322
LIG_PTB_Apo_2 108 115 PF02174 0.347
LIG_PTB_Apo_2 621 628 PF02174 0.610
LIG_PTB_Phospho_1 108 114 PF10480 0.347
LIG_PTB_Phospho_1 621 627 PF10480 0.612
LIG_REV1ctd_RIR_1 242 252 PF16727 0.347
LIG_SH2_CRK 306 310 PF00017 0.347
LIG_SH2_CRK 436 440 PF00017 0.439
LIG_SH2_GRB2like 436 439 PF00017 0.200
LIG_SH2_NCK_1 27 31 PF00017 0.510
LIG_SH2_NCK_1 436 440 PF00017 0.439
LIG_SH2_PTP2 281 284 PF00017 0.476
LIG_SH2_SRC 27 30 PF00017 0.514
LIG_SH2_SRC 306 309 PF00017 0.355
LIG_SH2_STAP1 591 595 PF00017 0.470
LIG_SH2_STAT5 121 124 PF00017 0.300
LIG_SH2_STAT5 229 232 PF00017 0.473
LIG_SH2_STAT5 254 257 PF00017 0.327
LIG_SH2_STAT5 266 269 PF00017 0.310
LIG_SH2_STAT5 281 284 PF00017 0.269
LIG_SH2_STAT5 414 417 PF00017 0.290
LIG_SH2_STAT5 436 439 PF00017 0.327
LIG_SH2_STAT5 487 490 PF00017 0.426
LIG_SH2_STAT5 522 525 PF00017 0.473
LIG_SH2_STAT5 578 581 PF00017 0.327
LIG_SH2_STAT5 605 608 PF00017 0.527
LIG_SH2_STAT5 627 630 PF00017 0.374
LIG_SH2_STAT5 81 84 PF00017 0.311
LIG_SH3_1 501 507 PF00018 0.200
LIG_SH3_2 184 189 PF14604 0.456
LIG_SH3_2 43 48 PF14604 0.324
LIG_SH3_3 181 187 PF00018 0.463
LIG_SH3_3 23 29 PF00018 0.448
LIG_SH3_3 281 287 PF00018 0.475
LIG_SH3_3 40 46 PF00018 0.261
LIG_SH3_3 438 444 PF00018 0.333
LIG_SH3_3 501 507 PF00018 0.366
LIG_SH3_3 513 519 PF00018 0.338
LIG_SH3_3 60 66 PF00018 0.176
LIG_SH3_3 84 90 PF00018 0.468
LIG_SUMO_SIM_par_1 115 122 PF11976 0.441
LIG_SUMO_SIM_par_1 598 603 PF11976 0.498
LIG_TYR_ITIM 25 30 PF00017 0.538
LIG_TYR_ITSM 302 309 PF00017 0.420
LIG_TYR_ITSM 389 396 PF00017 0.569
MOD_CK1_1 217 223 PF00069 0.482
MOD_CK1_1 434 440 PF00069 0.397
MOD_CK1_1 625 631 PF00069 0.507
MOD_CK2_1 119 125 PF00069 0.420
MOD_CK2_1 243 249 PF00069 0.370
MOD_CK2_1 316 322 PF00069 0.478
MOD_CK2_1 376 382 PF00069 0.460
MOD_CK2_1 485 491 PF00069 0.383
MOD_CK2_1 512 518 PF00069 0.514
MOD_CK2_1 557 563 PF00069 0.439
MOD_CK2_1 82 88 PF00069 0.458
MOD_Cter_Amidation 143 146 PF01082 0.339
MOD_DYRK1A_RPxSP_1 86 90 PF00069 0.458
MOD_GlcNHglycan 105 108 PF01048 0.324
MOD_GlcNHglycan 153 156 PF01048 0.396
MOD_GlcNHglycan 219 222 PF01048 0.411
MOD_GlcNHglycan 333 336 PF01048 0.330
MOD_GlcNHglycan 408 411 PF01048 0.326
MOD_GlcNHglycan 448 451 PF01048 0.513
MOD_GlcNHglycan 469 472 PF01048 0.455
MOD_GlcNHglycan 474 477 PF01048 0.438
MOD_GlcNHglycan 512 515 PF01048 0.364
MOD_GlcNHglycan 527 530 PF01048 0.279
MOD_GSK3_1 147 154 PF00069 0.293
MOD_GSK3_1 210 217 PF00069 0.403
MOD_GSK3_1 220 227 PF00069 0.405
MOD_GSK3_1 255 262 PF00069 0.330
MOD_GSK3_1 285 292 PF00069 0.447
MOD_GSK3_1 374 381 PF00069 0.549
MOD_GSK3_1 406 413 PF00069 0.457
MOD_GSK3_1 446 453 PF00069 0.440
MOD_GSK3_1 527 534 PF00069 0.396
MOD_GSK3_1 625 632 PF00069 0.376
MOD_GSK3_1 82 89 PF00069 0.455
MOD_N-GLC_1 112 117 PF02516 0.461
MOD_N-GLC_1 274 279 PF02516 0.345
MOD_N-GLC_1 388 393 PF02516 0.540
MOD_N-GLC_1 437 442 PF02516 0.507
MOD_N-GLC_1 472 477 PF02516 0.389
MOD_N-GLC_1 478 483 PF02516 0.356
MOD_N-GLC_1 620 625 PF02516 0.667
MOD_N-GLC_2 494 496 PF02516 0.347
MOD_NEK2_1 119 124 PF00069 0.325
MOD_NEK2_1 151 156 PF00069 0.282
MOD_NEK2_1 224 229 PF00069 0.329
MOD_NEK2_1 255 260 PF00069 0.330
MOD_NEK2_1 274 279 PF00069 0.330
MOD_NEK2_1 339 344 PF00069 0.496
MOD_NEK2_1 466 471 PF00069 0.454
MOD_NEK2_1 483 488 PF00069 0.319
MOD_NEK2_1 492 497 PF00069 0.425
MOD_NEK2_1 622 627 PF00069 0.633
MOD_NEK2_1 629 634 PF00069 0.537
MOD_NEK2_2 301 306 PF00069 0.478
MOD_PIKK_1 351 357 PF00454 0.520
MOD_PIKK_1 431 437 PF00454 0.468
MOD_PKA_2 311 317 PF00069 0.452
MOD_PKA_2 398 404 PF00069 0.404
MOD_PKB_1 525 533 PF00069 0.200
MOD_Plk_1 388 394 PF00069 0.555
MOD_Plk_1 431 437 PF00069 0.475
MOD_Plk_1 478 484 PF00069 0.222
MOD_Plk_1 557 563 PF00069 0.327
MOD_Plk_2-3 243 249 PF00069 0.387
MOD_Plk_2-3 485 491 PF00069 0.405
MOD_Plk_2-3 603 609 PF00069 0.425
MOD_Plk_4 105 111 PF00069 0.470
MOD_Plk_4 147 153 PF00069 0.284
MOD_Plk_4 224 230 PF00069 0.399
MOD_Plk_4 301 307 PF00069 0.467
MOD_Plk_4 388 394 PF00069 0.594
MOD_Plk_4 485 491 PF00069 0.470
MOD_Plk_4 557 563 PF00069 0.338
MOD_Plk_4 606 612 PF00069 0.412
MOD_Plk_4 622 628 PF00069 0.673
MOD_Plk_4 629 635 PF00069 0.558
MOD_ProDKin_1 376 382 PF00069 0.567
MOD_ProDKin_1 544 550 PF00069 0.475
MOD_ProDKin_1 612 618 PF00069 0.663
MOD_ProDKin_1 86 92 PF00069 0.468
MOD_SUMO_for_1 565 568 PF00179 0.395
MOD_SUMO_rev_2 346 352 PF00179 0.448
MOD_SUMO_rev_2 366 374 PF00179 0.346
TRG_DiLeu_BaEn_2 551 557 PF01217 0.395
TRG_DiLeu_BaLyEn_6 516 521 PF01217 0.475
TRG_ENDOCYTIC_2 254 257 PF00928 0.373
TRG_ENDOCYTIC_2 27 30 PF00928 0.514
TRG_ENDOCYTIC_2 281 284 PF00928 0.458
TRG_ENDOCYTIC_2 296 299 PF00928 0.369
TRG_ENDOCYTIC_2 306 309 PF00928 0.273
TRG_ENDOCYTIC_2 393 396 PF00928 0.387
TRG_ENDOCYTIC_2 436 439 PF00928 0.327
TRG_ENDOCYTIC_2 460 463 PF00928 0.447
TRG_ENDOCYTIC_2 627 630 PF00928 0.645
TRG_ER_diArg_1 1 3 PF00400 0.641
TRG_NES_CRM1_1 366 378 PF08389 0.301
TRG_NES_CRM1_1 568 580 PF08389 0.395
TRG_Pf-PMV_PEXEL_1 361 366 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT6 Leptomonas seymouri 76% 99%
A0A0S4J9J2 Bodo saltans 32% 100%
A0A1X0NFY9 Trypanosomatidae 41% 100%
A0A1X0NTL0 Trypanosomatidae 41% 100%
A0A1X0NTM3 Trypanosomatidae 40% 100%
A0A1X0NY19 Trypanosomatidae 41% 100%
A0A1X0NYR4 Trypanosomatidae 38% 100%
A0A1X0P322 Trypanosomatidae 38% 100%
A0A1X0P5Y7 Trypanosomatidae 41% 99%
A0A3Q8IB13 Leishmania donovani 26% 100%
A0A3Q8IFU7 Leishmania donovani 27% 100%
A0A3S5H595 Leishmania donovani 92% 99%
A0A3S5H596 Leishmania donovani 91% 100%
A0A3S5H7I4 Leishmania donovani 24% 100%
A0A3S7WXQ4 Leishmania donovani 27% 100%
A0A3S7WXS2 Leishmania donovani 27% 100%
A2R0E0 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 24% 100%
A2YZ01 Oryza sativa subsp. indica 28% 100%
A4H3V1 Leishmania braziliensis 84% 100%
A4HCV9 Leishmania braziliensis 25% 100%
A4HCW0 Leishmania braziliensis 27% 100%
A4HG14 Leishmania braziliensis 26% 100%
A4HS26 Leishmania infantum 91% 99%
A4HS27 Leishmania infantum 89% 100%
A4I0D9 Leishmania infantum 26% 100%
A4I0E0 Leishmania infantum 27% 100%
A4I336 Leishmania infantum 24% 100%
A4IAW1 Leishmania infantum 64% 91%
B6DXP5 Leymus chinensis 27% 100%
B6DZC8 Triticum aestivum 28% 100%
B6DZD0 Triticum urartu 29% 100%
B6DZD1 Aegilops speltoides 29% 100%
B6DZD2 Aegilops tauschii 28% 100%
D2IGW7 Bromus pictus 30% 100%
E1ABX2 Aspergillus ficuum 24% 100%
E8NHF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E8NHF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ACV4 Leishmania major 24% 100%
E9AZE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
O24509 Phaseolus vulgaris 30% 98%
P05656 Bacillus subtilis (strain 168) 24% 94%
P26792 Daucus carota 30% 100%
P29000 Solanum lycopersicum 29% 100%
P29001 Vigna radiata var. radiata 31% 98%
P49174 Zea mays 29% 100%
P49175 Zea mays 30% 95%
P80065 Daucus carota 28% 96%
P92916 Allium cepa 27% 100%
P93761 Capsicum annuum 28% 99%
Q01IS7 Oryza sativa subsp. indica 29% 100%
Q01IS8 Oryza sativa subsp. indica 29% 100%
Q0J360 Oryza sativa subsp. japonica 28% 100%
Q0JDC5 Oryza sativa subsp. japonica 29% 100%
Q0JDC6 Oryza sativa subsp. japonica 29% 100%
Q1PEF8 Arabidopsis thaliana 29% 100%
Q2UXF7 Triticum aestivum 29% 100%
Q39693 Daucus carota 30% 100%
Q43089 Pisum sativum 29% 100%
Q43857 Vicia faba 31% 99%
Q43866 Arabidopsis thaliana 30% 100%
Q4QB75 Leishmania major 29% 100%
Q4QB76 Leishmania major 25% 100%
Q56UD0 Oryza sativa subsp. japonica 29% 100%
Q56UD1 Oryza sativa subsp. japonica 25% 100%
Q5FC15 Asparagus officinalis 30% 100%
Q5JJV0 Oryza sativa subsp. japonica 29% 100%
Q67XZ3 Arabidopsis thaliana 30% 100%
Q70AT7 Hordeum vulgare 28% 100%
Q70XE6 Beta vulgaris 28% 100%
Q76HP6 Aspergillus niger 24% 100%
Q84LA1 Triticum aestivum 28% 100%
Q84PN8 Triticum aestivum 28% 100%
Q8W413 Arabidopsis thaliana 29% 100%
Q8W4S6 Arabidopsis thaliana 27% 100%
Q9LIB9 Arabidopsis thaliana 27% 100%
Q9XTP3 Leishmania major 91% 100%
Q9XZX0 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS