Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK12_LEIMU

TriTrypDb:

LmxM.04.0300

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.665
CLV_NRD_NRD_1	117	119	PF00675	0.560
CLV_NRD_NRD_1	154	156	PF00675	0.494
CLV_NRD_NRD_1	167	169	PF00675	0.449
CLV_NRD_NRD_1	242	244	PF00675	0.554
CLV_NRD_NRD_1	246	248	PF00675	0.583
CLV_PCSK_FUR_1	121	125	PF00082	0.549
CLV_PCSK_KEX2_1	117	119	PF00082	0.560
CLV_PCSK_KEX2_1	123	125	PF00082	0.572
CLV_PCSK_KEX2_1	135	137	PF00082	0.590
CLV_PCSK_KEX2_1	154	156	PF00082	0.494
CLV_PCSK_KEX2_1	169	171	PF00082	0.453
CLV_PCSK_KEX2_1	246	248	PF00082	0.561
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.565
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.602
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.453
CLV_PCSK_SKI1_1	136	140	PF00082	0.648
DOC_CKS1_1	226	231	PF01111	0.657
DOC_CYCLIN_yClb3_PxF_3	110	118	PF00134	0.487
DOC_USP7_UBL2_3	135	139	PF12436	0.580
DOC_WW_Pin1_4	175	180	PF00397	0.518
DOC_WW_Pin1_4	225	230	PF00397	0.666
LIG_14-3-3_CanoR_1	12	22	PF00244	0.574
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	177	181	PF00533	0.369
LIG_eIF4E_1	86	92	PF01652	0.561
LIG_FHA_1	219	225	PF00498	0.658
LIG_FHA_1	68	74	PF00498	0.669
LIG_FHA_2	144	150	PF00498	0.466
LIG_FHA_2	226	232	PF00498	0.542
LIG_GBD_Chelix_1	91	99	PF00786	0.560
LIG_LIR_Gen_1	134	144	PF02991	0.511
LIG_LIR_Gen_1	146	156	PF02991	0.498
LIG_LIR_Gen_1	16	26	PF02991	0.732
LIG_LIR_Gen_1	83	93	PF02991	0.570
LIG_LIR_Nem_3	134	140	PF02991	0.494
LIG_LIR_Nem_3	146	151	PF02991	0.477
LIG_LIR_Nem_3	16	22	PF02991	0.585
LIG_LIR_Nem_3	50	56	PF02991	0.566
LIG_LIR_Nem_3	83	89	PF02991	0.501
LIG_LIR_Nem_3	94	99	PF02991	0.438
LIG_SH2_CRK	137	141	PF00017	0.493
LIG_SH2_CRK	96	100	PF00017	0.480
LIG_SH2_SRC	207	210	PF00017	0.638
LIG_SH2_STAP1	148	152	PF00017	0.487
LIG_SH2_STAP1	56	60	PF00017	0.554
LIG_SH2_STAT3	11	14	PF00017	0.680
LIG_SH2_STAT5	195	198	PF00017	0.638
LIG_SH2_STAT5	227	230	PF00017	0.541
LIG_SH2_STAT5	241	244	PF00017	0.493
LIG_SH2_STAT5	60	63	PF00017	0.543
LIG_SH3_3	107	113	PF00018	0.476
LIG_SH3_3	25	31	PF00018	0.709
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.454
LIG_TYR_ITAM	83	99	PF00017	0.567
LIG_TYR_ITIM	84	89	PF00017	0.497
MOD_CK2_1	225	231	PF00069	0.525
MOD_CK2_1	95	101	PF00069	0.340
MOD_GlcNHglycan	3	6	PF01048	0.669
MOD_NEK2_1	1	6	PF00069	0.604
MOD_NEK2_1	182	187	PF00069	0.610
MOD_NEK2_1	95	100	PF00069	0.354
MOD_PKA_2	218	224	PF00069	0.714
MOD_Plk_1	182	188	PF00069	0.539
MOD_Plk_4	143	149	PF00069	0.463
MOD_Plk_4	56	62	PF00069	0.567
MOD_ProDKin_1	175	181	PF00069	0.517
MOD_ProDKin_1	225	231	PF00069	0.663
TRG_DiLeu_BaEn_1	87	92	PF01217	0.554
TRG_ENDOCYTIC_2	137	140	PF00928	0.494
TRG_ENDOCYTIC_2	148	151	PF00928	0.476
TRG_ENDOCYTIC_2	156	159	PF00928	0.420
TRG_ENDOCYTIC_2	86	89	PF00928	0.501
TRG_ENDOCYTIC_2	96	99	PF00928	0.480
TRG_ER_diArg_1	117	119	PF00400	0.560
TRG_ER_diArg_1	153	155	PF00400	0.504
TRG_ER_diArg_1	245	247	PF00400	0.585
TRG_NLS_MonoExtC_3	242	247	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B4	Leptomonas seymouri	78%	84%
A0A0S4J2A8	Bodo saltans	46%	76%
A0A1X0NL02	Trypanosomatidae	61%	92%
A0A3S5H594	Leishmania donovani	96%	80%
A4H3V0	Leishmania braziliensis	90%	100%
A4HS25	Leishmania infantum	96%	97%
C9ZY18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	90%
Q9BLQ5	Leishmania major	94%	100%
V5ATQ3	Trypanosoma cruzi	63%	93%