ADH_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alcohol dehydrogenase GroES-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK11_LEIMU

TriTrypDb:

LmxM.04.0290

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK11

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	5	1
GO:0003960	NADPH:quinone reductase activity	5	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	2
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.484
CLV_NRD_NRD_1	231	233	PF00675	0.366
CLV_NRD_NRD_1	300	302	PF00675	0.344
CLV_NRD_NRD_1	352	354	PF00675	0.397
CLV_NRD_NRD_1	367	369	PF00675	0.525
CLV_NRD_NRD_1	433	435	PF00675	0.615
CLV_PCSK_KEX2_1	231	233	PF00082	0.366
CLV_PCSK_KEX2_1	300	302	PF00082	0.419
CLV_PCSK_KEX2_1	367	369	PF00082	0.509
CLV_PCSK_KEX2_1	433	435	PF00082	0.595
CLV_PCSK_SKI1_1	189	193	PF00082	0.313
CLV_PCSK_SKI1_1	214	218	PF00082	0.338
CLV_PCSK_SKI1_1	231	235	PF00082	0.344
CLV_PCSK_SKI1_1	241	245	PF00082	0.330
CLV_PCSK_SKI1_1	291	295	PF00082	0.316
CLV_PCSK_SKI1_1	354	358	PF00082	0.316
CLV_PCSK_SKI1_1	428	432	PF00082	0.570
DEG_APCC_DBOX_1	230	238	PF00400	0.383
DEG_Nend_UBRbox_1	1	4	PF02207	0.570
DOC_CKS1_1	405	410	PF01111	0.526
DOC_CYCLIN_RxL_1	226	236	PF00134	0.392
DOC_CYCLIN_RxL_1	238	247	PF00134	0.338
DOC_MAPK_gen_1	189	199	PF00069	0.329
DOC_MAPK_gen_1	300	310	PF00069	0.389
DOC_MAPK_MEF2A_6	44	53	PF00069	0.284
DOC_PP1_RVXF_1	426	433	PF00149	0.567
DOC_PP2B_LxvP_1	54	57	PF13499	0.265
DOC_PP4_FxxP_1	293	296	PF00568	0.304
DOC_PP4_FxxP_1	432	435	PF00568	0.616
DOC_USP7_MATH_1	115	119	PF00917	0.193
DOC_USP7_MATH_1	174	178	PF00917	0.346
DOC_USP7_MATH_1	349	353	PF00917	0.406
DOC_USP7_MATH_1	419	423	PF00917	0.602
DOC_WW_Pin1_4	404	409	PF00397	0.539
LIG_14-3-3_CanoR_1	231	240	PF00244	0.343
LIG_14-3-3_CanoR_1	367	376	PF00244	0.530
LIG_Actin_WH2_2	88	106	PF00022	0.344
LIG_ActinCP_TwfCPI_2	432	439	PF01115	0.595
LIG_CaM_IQ_9	179	194	PF13499	0.295
LIG_FHA_1	119	125	PF00498	0.297
LIG_FHA_1	194	200	PF00498	0.347
LIG_FHA_2	123	129	PF00498	0.330
LIG_FHA_2	405	411	PF00498	0.652
LIG_LIR_Apic_2	343	349	PF02991	0.408
LIG_LIR_Apic_2	36	41	PF02991	0.369
LIG_LIR_Apic_2	365	369	PF02991	0.511
LIG_LIR_Apic_2	402	408	PF02991	0.526
LIG_LIR_Apic_2	429	435	PF02991	0.610
LIG_LIR_Gen_1	157	168	PF02991	0.315
LIG_LIR_Gen_1	407	417	PF02991	0.521
LIG_LIR_Nem_3	157	163	PF02991	0.308
LIG_LIR_Nem_3	407	412	PF02991	0.562
LIG_NRBOX	254	260	PF00104	0.321
LIG_OCRL_FandH_1	408	420	PF00620	0.586
LIG_Pex14_2	294	298	PF04695	0.315
LIG_Pex14_2	342	346	PF04695	0.373
LIG_REV1ctd_RIR_1	208	218	PF16727	0.392
LIG_REV1ctd_RIR_1	429	434	PF16727	0.590
LIG_SH2_CRK	38	42	PF00017	0.428
LIG_SH2_STAP1	251	255	PF00017	0.303
LIG_SH2_STAT5	143	146	PF00017	0.284
LIG_SH2_STAT5	185	188	PF00017	0.307
LIG_SH2_STAT5	406	409	PF00017	0.566
LIG_SH3_3	234	240	PF00018	0.338
LIG_SH3_3	432	438	PF00018	0.576
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.346
MOD_CK1_1	118	124	PF00069	0.440
MOD_CK1_1	393	399	PF00069	0.517
MOD_CK2_1	122	128	PF00069	0.373
MOD_CK2_1	392	398	PF00069	0.396
MOD_GlcNHglycan	337	340	PF01048	0.572
MOD_GlcNHglycan	392	395	PF01048	0.503
MOD_GlcNHglycan	45	48	PF01048	0.353
MOD_GSK3_1	118	125	PF00069	0.295
MOD_GSK3_1	12	19	PF00069	0.442
MOD_GSK3_1	145	152	PF00069	0.268
MOD_GSK3_1	169	176	PF00069	0.295
MOD_GSK3_1	264	271	PF00069	0.320
MOD_GSK3_1	314	321	PF00069	0.362
MOD_GSK3_1	390	397	PF00069	0.508
MOD_N-GLC_1	244	249	PF02516	0.300
MOD_N-GLC_1	269	274	PF02516	0.476
MOD_NEK2_1	1	6	PF00069	0.542
MOD_NEK2_1	149	154	PF00069	0.274
MOD_NEK2_1	193	198	PF00069	0.336
MOD_NEK2_1	244	249	PF00069	0.303
MOD_NEK2_1	276	281	PF00069	0.510
MOD_NEK2_1	318	323	PF00069	0.391
MOD_NEK2_1	340	345	PF00069	0.393
MOD_NEK2_1	390	395	PF00069	0.499
MOD_NEK2_1	42	47	PF00069	0.416
MOD_NEK2_2	145	150	PF00069	0.283
MOD_PIKK_1	318	324	PF00454	0.377
MOD_PKA_1	300	306	PF00069	0.340
MOD_PKA_2	1	7	PF00069	0.542
MOD_PKA_2	300	306	PF00069	0.390
MOD_PKA_2	43	49	PF00069	0.424
MOD_Plk_4	145	151	PF00069	0.267
MOD_Plk_4	294	300	PF00069	0.402
MOD_Plk_4	412	418	PF00069	0.603
MOD_ProDKin_1	404	410	PF00069	0.538
MOD_SUMO_rev_2	414	422	PF00179	0.518
TRG_DiLeu_BaEn_1	203	208	PF01217	0.386
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.345
TRG_ENDOCYTIC_2	406	409	PF00928	0.558
TRG_ER_diArg_1	230	232	PF00400	0.349
TRG_ER_diArg_1	299	301	PF00400	0.348
TRG_ER_diArg_1	307	310	PF00400	0.360
TRG_ER_diArg_1	366	368	PF00400	0.519
TRG_ER_diArg_1	432	434	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X4	Leptomonas seymouri	91%	100%
A0A0S4ILA6	Bodo saltans	27%	100%
A0A0S4J2L6	Bodo saltans	72%	100%
A0A1X0NL46	Trypanosomatidae	82%	98%
A0A3R7KI38	Trypanosoma rangeli	81%	100%
A0A3S5H593	Leishmania donovani	98%	100%
A0A3S5H5I3	Leishmania donovani	30%	100%
A4H3U9	Leishmania braziliensis	95%	100%
A4H498	Leishmania braziliensis	28%	100%
A4HS24	Leishmania infantum	97%	100%
A4HSH5	Leishmania infantum	30%	100%
C9ZY17	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AKF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q10488	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q28GQ2	Xenopus tropicalis	29%	100%
Q4QJF0	Leishmania major	30%	100%
Q54YT4	Dictyostelium discoideum	33%	100%
Q6BLV6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6CBE4	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6CIR6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q8LCU7	Arabidopsis thaliana	31%	100%
Q8NJJ9	Kluyveromyces marxianus	24%	100%
Q8WZM3	Candida tropicalis	24%	100%
Q8WZM4	Candida tropicalis	25%	100%
Q9V6U9	Drosophila melanogaster	28%	100%
Q9XZY9	Leishmania major	98%	100%
V5D9R3	Trypanosoma cruzi	83%	99%