Mitochondrial ribosomal protein L47

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial 39-S ribosomal protein L47 (MRP-L47), putative

Species:

Leishmania mexicana

UniProt:

E9AK09_LEIMU

TriTrypDb:

LmxM.04.0270

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	11
GO:0005761	mitochondrial ribosome	7	11
GO:0005840	ribosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0044391	ribosomal subunit	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0099568	cytoplasmic region	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AK09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK09

PDB structure(s): 7aih_R , 7am2_R , 7ane_R

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.333
CLV_C14_Caspase3-7	337	341	PF00656	0.432
CLV_C14_Caspase3-7	351	355	PF00656	0.395
CLV_NRD_NRD_1	147	149	PF00675	0.446
CLV_NRD_NRD_1	199	201	PF00675	0.581
CLV_NRD_NRD_1	40	42	PF00675	0.420
CLV_NRD_NRD_1	6	8	PF00675	0.551
CLV_PCSK_KEX2_1	147	149	PF00082	0.446
CLV_PCSK_KEX2_1	185	187	PF00082	0.516
CLV_PCSK_KEX2_1	199	201	PF00082	0.423
CLV_PCSK_KEX2_1	25	27	PF00082	0.179
CLV_PCSK_KEX2_1	40	42	PF00082	0.297
CLV_PCSK_KEX2_1	465	467	PF00082	0.580
CLV_PCSK_KEX2_1	6	8	PF00082	0.551
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.556
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.313
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.580
CLV_PCSK_PC7_1	2	8	PF00082	0.600
CLV_PCSK_SKI1_1	111	115	PF00082	0.406
CLV_PCSK_SKI1_1	116	120	PF00082	0.243
CLV_PCSK_SKI1_1	142	146	PF00082	0.526
CLV_PCSK_SKI1_1	155	159	PF00082	0.411
CLV_PCSK_SKI1_1	288	292	PF00082	0.514
CLV_PCSK_SKI1_1	431	435	PF00082	0.391
CLV_PCSK_SKI1_1	466	470	PF00082	0.579
CLV_PCSK_SKI1_1	58	62	PF00082	0.297
CLV_PCSK_SKI1_1	96	100	PF00082	0.342
DEG_APCC_DBOX_1	276	284	PF00400	0.590
DEG_APCC_DBOX_1	40	48	PF00400	0.411
DEG_APCC_DBOX_1	57	65	PF00400	0.208
DEG_Nend_UBRbox_1	1	4	PF02207	0.684
DEG_SIAH_1	370	378	PF03145	0.440
DEG_SPOP_SBC_1	209	213	PF00917	0.623
DOC_CYCLIN_RxL_1	152	162	PF00134	0.428
DOC_MAPK_MEF2A_6	168	175	PF00069	0.393
DOC_MAPK_RevD_3	171	186	PF00069	0.433
DOC_PP2B_LxvP_1	264	267	PF13499	0.568
DOC_SPAK_OSR1_1	160	164	PF12202	0.549
DOC_USP7_MATH_1	209	213	PF00917	0.675
DOC_USP7_MATH_1	242	246	PF00917	0.728
DOC_USP7_MATH_1	248	252	PF00917	0.522
DOC_USP7_MATH_1	349	353	PF00917	0.383
DOC_USP7_MATH_1	35	39	PF00917	0.299
DOC_USP7_MATH_1	79	83	PF00917	0.297
DOC_USP7_UBL2_3	95	99	PF12436	0.333
DOC_WW_Pin1_4	275	280	PF00397	0.556
DOC_WW_Pin1_4	440	445	PF00397	0.543
LIG_14-3-3_CanoR_1	2	10	PF00244	0.647
LIG_14-3-3_CanoR_1	263	267	PF00244	0.357
LIG_14-3-3_CanoR_1	333	337	PF00244	0.499
LIG_14-3-3_CanoR_1	40	45	PF00244	0.315
LIG_14-3-3_CanoR_1	466	475	PF00244	0.533
LIG_14-3-3_CanoR_1	58	68	PF00244	0.410
LIG_Actin_WH2_2	71	87	PF00022	0.313
LIG_APCC_ABBA_1	110	115	PF00400	0.433
LIG_DLG_GKlike_1	40	47	PF00625	0.313
LIG_FHA_1	136	142	PF00498	0.434
LIG_FHA_1	172	178	PF00498	0.586
LIG_FHA_1	467	473	PF00498	0.576
LIG_FHA_2	223	229	PF00498	0.523
LIG_FHA_2	238	244	PF00498	0.588
LIG_FHA_2	310	316	PF00498	0.513
LIG_FHA_2	349	355	PF00498	0.472
LIG_FHA_2	61	67	PF00498	0.433
LIG_LIR_Apic_2	203	209	PF02991	0.560
LIG_LIR_Apic_2	439	444	PF02991	0.415
LIG_LIR_Nem_3	189	195	PF02991	0.417
LIG_NRBOX	153	159	PF00104	0.504
LIG_PAM2_1	395	407	PF00658	0.264
LIG_PDZ_Class_1	475	480	PF00595	0.432
LIG_Pex14_1	402	406	PF04695	0.368
LIG_SH2_CRK	122	126	PF00017	0.461
LIG_SH2_CRK	422	426	PF00017	0.377
LIG_SH2_GRB2like	422	425	PF00017	0.382
LIG_SH2_NCK_1	372	376	PF00017	0.430
LIG_SH2_SRC	379	382	PF00017	0.463
LIG_SH2_STAP1	222	226	PF00017	0.585
LIG_SH2_STAP1	422	426	PF00017	0.391
LIG_SH2_STAT5	300	303	PF00017	0.472
LIG_SH2_STAT5	344	347	PF00017	0.454
LIG_SH2_STAT5	409	412	PF00017	0.393
LIG_SH2_STAT5	428	431	PF00017	0.292
LIG_SH2_STAT5	68	71	PF00017	0.316
LIG_SH3_1	122	128	PF00018	0.467
LIG_SH3_1	270	276	PF00018	0.545
LIG_SH3_3	122	128	PF00018	0.467
LIG_SH3_3	24	30	PF00018	0.297
LIG_SH3_3	263	269	PF00018	0.483
LIG_SH3_3	270	276	PF00018	0.480
LIG_SH3_3	314	320	PF00018	0.457
LIG_SH3_3	394	400	PF00018	0.406
LIG_SUMO_SIM_par_1	169	174	PF11976	0.431
LIG_SUMO_SIM_par_1	357	364	PF11976	0.470
LIG_SUMO_SIM_par_1	442	448	PF11976	0.422
LIG_TRAF2_1	241	244	PF00917	0.477
LIG_TRAF2_1	360	363	PF00917	0.528
LIG_TRAF2_1	378	381	PF00917	0.296
LIG_TRAF2_1	388	391	PF00917	0.403
LIG_UBA3_1	60	65	PF00899	0.369
LIG_WW_3	274	278	PF00397	0.612
MOD_CK1_1	289	295	PF00069	0.521
MOD_CK2_1	222	228	PF00069	0.527
MOD_CK2_1	237	243	PF00069	0.581
MOD_CK2_1	357	363	PF00069	0.546
MOD_CK2_1	436	442	PF00069	0.414
MOD_CK2_1	60	66	PF00069	0.297
MOD_GlcNHglycan	217	220	PF01048	0.552
MOD_GlcNHglycan	234	237	PF01048	0.521
MOD_GlcNHglycan	240	243	PF01048	0.708
MOD_GlcNHglycan	3	6	PF01048	0.634
MOD_GSK3_1	238	245	PF00069	0.681
MOD_GSK3_1	344	351	PF00069	0.444
MOD_GSK3_1	436	443	PF00069	0.501
MOD_N-GLC_1	302	307	PF02516	0.413
MOD_N-GLC_1	420	425	PF02516	0.379
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	143	148	PF00069	0.543
MOD_NEK2_1	348	353	PF00069	0.418
MOD_NEK2_1	60	65	PF00069	0.297
MOD_NEK2_2	137	142	PF00069	0.485
MOD_NEK2_2	35	40	PF00069	0.309
MOD_PIKK_1	180	186	PF00454	0.555
MOD_PKA_1	40	46	PF00069	0.420
MOD_PKA_2	1	7	PF00069	0.682
MOD_PKA_2	262	268	PF00069	0.355
MOD_PKA_2	309	315	PF00069	0.510
MOD_PKA_2	332	338	PF00069	0.523
MOD_PKA_2	40	46	PF00069	0.420
MOD_Plk_1	222	228	PF00069	0.563
MOD_Plk_1	389	395	PF00069	0.414
MOD_Plk_1	87	93	PF00069	0.389
MOD_Plk_2-3	217	223	PF00069	0.554
MOD_Plk_4	217	223	PF00069	0.538
MOD_Plk_4	389	395	PF00069	0.414
MOD_Plk_4	50	56	PF00069	0.433
MOD_ProDKin_1	275	281	PF00069	0.553
MOD_ProDKin_1	440	446	PF00069	0.548
TRG_ENDOCYTIC_2	14	17	PF00928	0.311
TRG_ENDOCYTIC_2	372	375	PF00928	0.416
TRG_ENDOCYTIC_2	422	425	PF00928	0.382
TRG_ER_diArg_1	147	149	PF00400	0.446
TRG_ER_diArg_1	39	41	PF00400	0.418
TRG_NES_CRM1_1	152	165	PF08389	0.494
TRG_NES_CRM1_1	340	354	PF08389	0.532
TRG_NLS_MonoCore_2	461	466	PF00514	0.564
TRG_NLS_MonoExtC_3	461	466	PF00514	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA99	Leptomonas seymouri	78%	98%
A0A0S4IZC9	Bodo saltans	53%	99%
A0A1X0NLD2	Trypanosomatidae	61%	98%
A0A3S5H591	Leishmania donovani	95%	100%
A0A422NNG2	Trypanosoma rangeli	63%	97%
A4H3U7	Leishmania braziliensis	90%	100%
A4HS22	Leishmania infantum	95%	100%
C9ZY15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
Q9XZY7	Leishmania major	95%	100%
V5B964	Trypanosoma cruzi	62%	98%