TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK08_LEIMU

TriTrypDb:

LmxM.04.0260

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.658
CLV_NRD_NRD_1	199	201	PF00675	0.359
CLV_NRD_NRD_1	221	223	PF00675	0.507
CLV_NRD_NRD_1	250	252	PF00675	0.478
CLV_NRD_NRD_1	99	101	PF00675	0.595
CLV_PCSK_KEX2_1	199	201	PF00082	0.355
CLV_PCSK_KEX2_1	221	223	PF00082	0.507
CLV_PCSK_KEX2_1	99	101	PF00082	0.617
CLV_PCSK_SKI1_1	161	165	PF00082	0.446
CLV_PCSK_SKI1_1	173	177	PF00082	0.422
CLV_PCSK_SKI1_1	195	199	PF00082	0.391
DOC_CKS1_1	182	187	PF01111	0.638
DOC_MAPK_gen_1	199	207	PF00069	0.451
DOC_MAPK_gen_1	257	266	PF00069	0.524
DOC_MAPK_gen_1	51	57	PF00069	0.425
DOC_MAPK_MEF2A_6	257	266	PF00069	0.524
DOC_MAPK_NFAT4_5	259	267	PF00069	0.529
DOC_PP2B_LxvP_1	3	6	PF13499	0.465
DOC_USP7_MATH_1	118	122	PF00917	0.674
DOC_USP7_MATH_1	12	16	PF00917	0.533
DOC_USP7_MATH_1	228	232	PF00917	0.515
DOC_USP7_MATH_1	6	10	PF00917	0.682
DOC_WW_Pin1_4	10	15	PF00397	0.646
DOC_WW_Pin1_4	116	121	PF00397	0.608
DOC_WW_Pin1_4	181	186	PF00397	0.636
DOC_WW_Pin1_4	188	193	PF00397	0.493
DOC_WW_Pin1_4	67	72	PF00397	0.564
LIG_14-3-3_CanoR_1	44	49	PF00244	0.479
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BIR_III_1	1	5	PF00653	0.589
LIG_BIR_III_3	1	5	PF00653	0.589
LIG_FHA_1	162	168	PF00498	0.400
LIG_FHA_2	110	116	PF00498	0.711
LIG_LIR_Nem_3	47	53	PF02991	0.457
LIG_PCNA_PIPBox_1	132	141	PF02747	0.517
LIG_PCNA_yPIPBox_3	130	139	PF02747	0.472
LIG_PCNA_yPIPBox_3	87	101	PF02747	0.654
LIG_SH2_CRK	50	54	PF00017	0.452
LIG_SH2_PTP2	204	207	PF00017	0.534
LIG_SH2_SRC	60	63	PF00017	0.519
LIG_SH2_STAP1	139	143	PF00017	0.529
LIG_SH2_STAT3	22	25	PF00017	0.546
LIG_SH2_STAT5	204	207	PF00017	0.502
LIG_SH2_STAT5	22	25	PF00017	0.510
LIG_SH2_STAT5	54	57	PF00017	0.392
LIG_SH2_STAT5	60	63	PF00017	0.406
MOD_CDK_SPxK_1	181	187	PF00069	0.394
MOD_CDK_SPxxK_3	188	195	PF00069	0.525
MOD_CK1_1	116	122	PF00069	0.630
MOD_CK1_1	8	14	PF00069	0.652
MOD_CK2_1	109	115	PF00069	0.753
MOD_CK2_1	118	124	PF00069	0.672
MOD_Cter_Amidation	249	252	PF01082	0.550
MOD_GlcNHglycan	115	119	PF01048	0.686
MOD_GlcNHglycan	230	233	PF01048	0.656
MOD_GlcNHglycan	67	70	PF01048	0.561
MOD_GlcNHglycan	8	11	PF01048	0.755
MOD_GlcNHglycan	87	90	PF01048	0.354
MOD_GSK3_1	109	116	PF00069	0.709
MOD_GSK3_1	6	13	PF00069	0.613
MOD_GSK3_1	79	86	PF00069	0.544
MOD_NEK2_1	138	143	PF00069	0.438
MOD_PIKK_1	133	139	PF00454	0.550
MOD_PKA_2	113	119	PF00069	0.717
MOD_PKA_2	186	192	PF00069	0.551
MOD_Plk_1	133	139	PF00069	0.487
MOD_ProDKin_1	10	16	PF00069	0.636
MOD_ProDKin_1	116	122	PF00069	0.602
MOD_ProDKin_1	181	187	PF00069	0.629
MOD_ProDKin_1	188	194	PF00069	0.485
MOD_ProDKin_1	67	73	PF00069	0.561
MOD_SUMO_rev_2	254	262	PF00179	0.545
MOD_SUMO_rev_2	47	53	PF00179	0.438
TRG_DiLeu_BaEn_1	124	129	PF01217	0.454
TRG_DiLeu_BaEn_4	124	130	PF01217	0.550
TRG_DiLeu_BaEn_4	133	139	PF01217	0.358
TRG_ENDOCYTIC_2	204	207	PF00928	0.534
TRG_ENDOCYTIC_2	50	53	PF00928	0.451
TRG_ENDOCYTIC_2	54	57	PF00928	0.456
TRG_ER_diArg_1	198	200	PF00400	0.380
TRG_ER_diArg_1	220	222	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG7	Leptomonas seymouri	53%	86%
A0A0S4J1V3	Bodo saltans	31%	100%
A0A1X0NLP6	Trypanosomatidae	33%	100%
A0A3R7L3M0	Trypanosoma rangeli	30%	100%
A0A3S5H590	Leishmania donovani	91%	100%
A4H3U6	Leishmania braziliensis	73%	100%
A4HS21	Leishmania infantum	91%	100%
C9ZY14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q9XZY6	Leishmania major	91%	100%