GRAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRAM domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK06_LEIMU

TriTrypDb:

LmxM.04.0240

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.634
CLV_NRD_NRD_1	59	61	PF00675	0.549
CLV_PCSK_KEX2_1	59	61	PF00082	0.444
CLV_PCSK_SKI1_1	50	54	PF00082	0.682
DEG_Nend_UBRbox_3	1	3	PF02207	0.706
DEG_SPOP_SBC_1	155	159	PF00917	0.384
DOC_ANK_TNKS_1	185	192	PF00023	0.399
DOC_MAPK_gen_1	108	115	PF00069	0.230
DOC_MAPK_JIP1_4	229	235	PF00069	0.507
DOC_PP2B_LxvP_1	223	226	PF13499	0.456
DOC_USP7_MATH_1	89	93	PF00917	0.567
DOC_USP7_UBL2_3	50	54	PF12436	0.617
DOC_WW_Pin1_4	34	39	PF00397	0.490
LIG_14-3-3_CanoR_1	130	138	PF00244	0.517
LIG_14-3-3_CanoR_1	59	69	PF00244	0.663
LIG_eIF4E_1	12	18	PF01652	0.511
LIG_FHA_1	156	162	PF00498	0.471
LIG_FHA_1	163	169	PF00498	0.497
LIG_FHA_1	280	286	PF00498	0.590
LIG_FHA_2	264	270	PF00498	0.537
LIG_FHA_2	35	41	PF00498	0.476
LIG_FHA_2	91	97	PF00498	0.688
LIG_LIR_Apic_2	21	25	PF02991	0.440
LIG_LIR_Gen_1	147	155	PF02991	0.400
LIG_LIR_Gen_1	240	251	PF02991	0.467
LIG_LIR_Gen_1	269	278	PF02991	0.387
LIG_LIR_Nem_3	147	153	PF02991	0.418
LIG_LIR_Nem_3	269	275	PF02991	0.387
LIG_Pex14_2	111	115	PF04695	0.364
LIG_SH2_CRK	148	152	PF00017	0.219
LIG_SH2_CRK	22	26	PF00017	0.525
LIG_SH2_SRC	274	277	PF00017	0.384
LIG_SH2_STAT5	14	17	PF00017	0.477
LIG_SH2_STAT5	150	153	PF00017	0.371
LIG_SH2_STAT5	22	25	PF00017	0.551
LIG_SH2_STAT5	236	239	PF00017	0.454
LIG_SH2_STAT5	274	277	PF00017	0.384
LIG_SH3_1	22	28	PF00018	0.496
LIG_SH3_3	175	181	PF00018	0.599
LIG_SH3_3	22	28	PF00018	0.460
LIG_TRFH_1	220	224	PF08558	0.551
LIG_TYR_ITIM	146	151	PF00017	0.219
LIG_UBA3_1	69	74	PF00899	0.715
MOD_CK1_1	250	256	PF00069	0.580
MOD_CK1_1	64	70	PF00069	0.659
MOD_CK1_1	72	78	PF00069	0.641
MOD_CK1_1	92	98	PF00069	0.480
MOD_CK2_1	34	40	PF00069	0.489
MOD_CK2_1	90	96	PF00069	0.613
MOD_GlcNHglycan	131	134	PF01048	0.362
MOD_GlcNHglycan	140	143	PF01048	0.295
MOD_GlcNHglycan	255	258	PF01048	0.680
MOD_GlcNHglycan	64	67	PF01048	0.609
MOD_GlcNHglycan	74	77	PF01048	0.589
MOD_GSK3_1	157	164	PF00069	0.549
MOD_GSK3_1	200	207	PF00069	0.463
MOD_GSK3_1	224	231	PF00069	0.568
MOD_GSK3_1	60	67	PF00069	0.637
MOD_GSK3_1	90	97	PF00069	0.584
MOD_NEK2_1	138	143	PF00069	0.300
MOD_NEK2_1	154	159	PF00069	0.394
MOD_NEK2_1	20	25	PF00069	0.521
MOD_NEK2_1	62	67	PF00069	0.581
MOD_NEK2_1	69	74	PF00069	0.674
MOD_PIKK_1	234	240	PF00454	0.406
MOD_PIKK_1	75	81	PF00454	0.652
MOD_PIKK_1	94	100	PF00454	0.616
MOD_PKA_2	129	135	PF00069	0.501
MOD_PKA_2	228	234	PF00069	0.483
MOD_PKA_2	253	259	PF00069	0.713
MOD_PKA_2	279	285	PF00069	0.538
MOD_Plk_4	204	210	PF00069	0.479
MOD_Plk_4	247	253	PF00069	0.475
MOD_ProDKin_1	34	40	PF00069	0.489
TRG_ENDOCYTIC_2	12	15	PF00928	0.499
TRG_ENDOCYTIC_2	148	151	PF00928	0.425
TRG_ENDOCYTIC_2	243	246	PF00928	0.370
TRG_ENDOCYTIC_2	272	275	PF00928	0.380
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAZ3	Leptomonas seymouri	49%	85%
A0A0S4IUM5	Bodo saltans	34%	98%
A0A1X0NMU9	Trypanosomatidae	42%	100%
A0A3R7NSA7	Trypanosoma rangeli	44%	97%
A0A3S5H589	Leishmania donovani	90%	100%
A4H3U4	Leishmania braziliensis	56%	100%
A4HS19	Leishmania infantum	90%	100%
C9ZY11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
Q9XZY4	Leishmania major	88%	100%
V5D9R6	Trypanosoma cruzi	42%	96%