Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK05_LEIMU

TriTrypDb:

LmxM.04.0230

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AK05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.457
CLV_NRD_NRD_1	104	106	PF00675	0.538
CLV_NRD_NRD_1	249	251	PF00675	0.544
CLV_NRD_NRD_1	74	76	PF00675	0.419
CLV_PCSK_KEX2_1	104	106	PF00082	0.538
CLV_PCSK_KEX2_1	248	250	PF00082	0.548
CLV_PCSK_KEX2_1	74	76	PF00082	0.388
CLV_PCSK_SKI1_1	76	80	PF00082	0.415
DEG_Nend_UBRbox_2	1	3	PF02207	0.389
DEG_SIAH_1	164	172	PF03145	0.711
DEG_SPOP_SBC_1	109	113	PF00917	0.657
DEG_SPOP_SBC_1	123	127	PF00917	0.707
DOC_CKS1_1	171	176	PF01111	0.625
DOC_CYCLIN_yClb3_PxF_3	164	170	PF00134	0.674
DOC_CYCLIN_yClb5_NLxxxL_5	43	51	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.600
DOC_MAPK_gen_1	248	256	PF00069	0.733
DOC_PP1_RVXF_1	251	257	PF00149	0.726
DOC_PP2B_LxvP_1	162	165	PF13499	0.603
DOC_PP2B_PxIxI_1	33	39	PF00149	0.484
DOC_WW_Pin1_4	103	108	PF00397	0.649
DOC_WW_Pin1_4	110	115	PF00397	0.666
DOC_WW_Pin1_4	119	124	PF00397	0.634
DOC_WW_Pin1_4	132	137	PF00397	0.672
DOC_WW_Pin1_4	170	175	PF00397	0.628
DOC_WW_Pin1_4	192	197	PF00397	0.717
DOC_WW_Pin1_4	217	222	PF00397	0.747
DOC_WW_Pin1_4	235	240	PF00397	0.646
DOC_WW_Pin1_4	30	35	PF00397	0.509
LIG_14-3-3_CanoR_1	148	153	PF00244	0.719
LIG_14-3-3_CanoR_1	228	236	PF00244	0.736
LIG_FHA_1	110	116	PF00498	0.635
LIG_FHA_1	124	130	PF00498	0.706
LIG_FHA_1	31	37	PF00498	0.463
LIG_FHA_2	12	18	PF00498	0.499
LIG_FHA_2	239	245	PF00498	0.731
LIG_LIR_Nem_3	3	9	PF02991	0.356
LIG_LIR_Nem_3	81	87	PF02991	0.614
LIG_PDZ_Class_2	254	259	PF00595	0.723
LIG_Pex14_1	85	89	PF04695	0.538
LIG_Pex14_2	48	52	PF04695	0.412
LIG_PTB_Apo_2	179	186	PF02174	0.713
LIG_PTB_Phospho_1	179	185	PF10480	0.712
LIG_SH2_STAP1	197	201	PF00017	0.613
LIG_SH2_STAT5	177	180	PF00017	0.662
LIG_SH2_STAT5	185	188	PF00017	0.716
LIG_SH2_STAT5	197	200	PF00017	0.644
LIG_SH3_1	240	246	PF00018	0.646
LIG_SH3_2	243	248	PF14604	0.751
LIG_SH3_3	155	161	PF00018	0.713
LIG_SH3_3	162	168	PF00018	0.691
LIG_SH3_3	213	219	PF00018	0.705
LIG_SH3_3	230	236	PF00018	0.686
LIG_SH3_3	240	246	PF00018	0.712
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.484
LIG_WRC_WIRS_1	68	73	PF05994	0.510
MOD_CDK_SPK_2	235	240	PF00069	0.649
MOD_CK1_1	103	109	PF00069	0.778
MOD_CK1_1	113	119	PF00069	0.702
MOD_CK1_1	192	198	PF00069	0.723
MOD_CK1_1	22	28	PF00069	0.401
MOD_CK1_1	238	244	PF00069	0.708
MOD_CK1_1	252	258	PF00069	0.652
MOD_CK1_1	30	36	PF00069	0.488
MOD_CK2_1	11	17	PF00069	0.432
MOD_CK2_1	238	244	PF00069	0.734
MOD_GlcNHglycan	107	110	PF01048	0.471
MOD_GlcNHglycan	191	194	PF01048	0.489
MOD_GlcNHglycan	230	233	PF01048	0.449
MOD_GSK3_1	105	112	PF00069	0.739
MOD_GSK3_1	119	126	PF00069	0.669
MOD_GSK3_1	148	155	PF00069	0.707
MOD_GSK3_1	224	231	PF00069	0.720
MOD_GSK3_1	235	242	PF00069	0.696
MOD_N-GLC_1	38	43	PF02516	0.632
MOD_N-GLC_1	94	99	PF02516	0.401
MOD_NEK2_1	19	24	PF00069	0.360
MOD_NEK2_2	206	211	PF00069	0.696
MOD_PIKK_1	130	136	PF00454	0.698
MOD_PIKK_1	152	158	PF00454	0.703
MOD_PK_1	142	148	PF00069	0.713
MOD_PKA_1	249	255	PF00069	0.733
MOD_PKA_2	152	158	PF00069	0.719
MOD_PKA_2	227	233	PF00069	0.724
MOD_PKA_2	249	255	PF00069	0.733
MOD_Plk_1	94	100	PF00069	0.557
MOD_Plk_4	206	212	PF00069	0.698
MOD_Plk_4	252	258	PF00069	0.723
MOD_Plk_4	94	100	PF00069	0.557
MOD_ProDKin_1	103	109	PF00069	0.652
MOD_ProDKin_1	110	116	PF00069	0.668
MOD_ProDKin_1	119	125	PF00069	0.636
MOD_ProDKin_1	132	138	PF00069	0.672
MOD_ProDKin_1	170	176	PF00069	0.626
MOD_ProDKin_1	192	198	PF00069	0.718
MOD_ProDKin_1	217	223	PF00069	0.746
MOD_ProDKin_1	235	241	PF00069	0.646
MOD_ProDKin_1	30	36	PF00069	0.508
MOD_SUMO_for_1	78	81	PF00179	0.614
TRG_ENDOCYTIC_2	84	87	PF00928	0.609
TRG_ER_diArg_1	247	250	PF00400	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H588	Leishmania donovani	85%	100%
A4H444	Leishmania braziliensis	54%	100%
A4HS18	Leishmania infantum	85%	100%
Q9U191	Leishmania major	82%	99%