LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9AK04_LEIMU
TriTrypDb:
LmxM.04.0220
Length:
354

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 5
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9AK04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK04

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.414
CLV_C14_Caspase3-7 336 340 PF00656 0.701
CLV_NRD_NRD_1 317 319 PF00675 0.462
CLV_PCSK_KEX2_1 317 319 PF00082 0.441
CLV_PCSK_PC7_1 313 319 PF00082 0.454
DEG_SPOP_SBC_1 257 261 PF00917 0.343
DOC_CKS1_1 117 122 PF01111 0.393
DOC_CKS1_1 181 186 PF01111 0.350
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.430
DOC_PP4_FxxP_1 182 185 PF00568 0.438
DOC_PP4_FxxP_1 37 40 PF00568 0.405
DOC_USP7_MATH_1 144 148 PF00917 0.460
DOC_USP7_MATH_1 257 261 PF00917 0.436
DOC_USP7_MATH_1 5 9 PF00917 0.236
DOC_USP7_MATH_1 75 79 PF00917 0.371
DOC_WW_Pin1_4 116 121 PF00397 0.390
DOC_WW_Pin1_4 180 185 PF00397 0.346
LIG_14-3-3_CanoR_1 134 141 PF00244 0.483
LIG_14-3-3_CanoR_1 162 168 PF00244 0.447
LIG_14-3-3_CanoR_1 217 223 PF00244 0.438
LIG_14-3-3_CanoR_1 251 255 PF00244 0.393
LIG_14-3-3_CanoR_1 317 325 PF00244 0.656
LIG_BRCT_BRCA1_1 272 276 PF00533 0.289
LIG_BRCT_BRCA1_1 77 81 PF00533 0.387
LIG_deltaCOP1_diTrp_1 114 121 PF00928 0.427
LIG_deltaCOP1_diTrp_1 265 272 PF00928 0.249
LIG_FHA_1 10 16 PF00498 0.294
LIG_FHA_1 154 160 PF00498 0.489
LIG_FHA_1 20 26 PF00498 0.503
LIG_FHA_1 205 211 PF00498 0.439
LIG_FHA_1 275 281 PF00498 0.243
LIG_FHA_1 63 69 PF00498 0.413
LIG_FHA_2 219 225 PF00498 0.409
LIG_FHA_2 234 240 PF00498 0.402
LIG_FHA_2 43 49 PF00498 0.365
LIG_LIR_Apic_2 114 120 PF02991 0.362
LIG_LIR_Apic_2 34 40 PF02991 0.411
LIG_LIR_Gen_1 265 276 PF02991 0.255
LIG_LIR_Gen_1 282 288 PF02991 0.245
LIG_LIR_Gen_1 82 93 PF02991 0.419
LIG_LIR_Nem_3 102 108 PF02991 0.419
LIG_LIR_Nem_3 239 243 PF02991 0.381
LIG_LIR_Nem_3 265 271 PF02991 0.281
LIG_LIR_Nem_3 282 286 PF02991 0.250
LIG_LIR_Nem_3 78 84 PF02991 0.415
LIG_Pex14_1 117 121 PF04695 0.433
LIG_Pex14_1 211 215 PF04695 0.464
LIG_Pex14_1 267 271 PF04695 0.337
LIG_Pex14_2 176 180 PF04695 0.434
LIG_Pex14_2 272 276 PF04695 0.325
LIG_SH2_CRK 28 32 PF00017 0.438
LIG_SH2_CRK 85 89 PF00017 0.449
LIG_SH2_NCK_1 254 258 PF00017 0.437
LIG_SH2_SRC 38 41 PF00017 0.372
LIG_SH2_STAP1 169 173 PF00017 0.434
LIG_SH2_STAT3 161 164 PF00017 0.418
LIG_SH2_STAT3 169 172 PF00017 0.508
LIG_SH2_STAT3 319 322 PF00017 0.673
LIG_SH2_STAT5 319 322 PF00017 0.673
LIG_SH2_STAT5 38 41 PF00017 0.365
LIG_SH2_STAT5 59 62 PF00017 0.424
LIG_SH3_3 138 144 PF00018 0.418
LIG_SH3_3 178 184 PF00018 0.430
LIG_Sin3_3 64 71 PF02671 0.417
LIG_SUMO_SIM_anti_2 12 18 PF11976 0.443
LIG_SUMO_SIM_anti_2 282 288 PF11976 0.379
LIG_WRC_WIRS_1 280 285 PF05994 0.289
LIG_WW_1 184 187 PF00397 0.433
MOD_CK1_1 321 327 PF00069 0.676
MOD_CK1_1 330 336 PF00069 0.699
MOD_CK1_1 341 347 PF00069 0.727
MOD_CK2_1 341 347 PF00069 0.674
MOD_CK2_1 42 48 PF00069 0.363
MOD_GlcNHglycan 135 138 PF01048 0.590
MOD_GlcNHglycan 146 149 PF01048 0.676
MOD_GlcNHglycan 329 333 PF01048 0.541
MOD_GlcNHglycan 7 10 PF01048 0.377
MOD_GSK3_1 270 277 PF00069 0.321
MOD_GSK3_1 40 47 PF00069 0.339
MOD_GSK3_1 5 12 PF00069 0.215
MOD_GSK3_1 75 82 PF00069 0.452
MOD_N-GLC_1 257 262 PF02516 0.601
MOD_N-GLC_1 327 332 PF02516 0.442
MOD_N-GLC_2 129 131 PF02516 0.599
MOD_NEK2_1 204 209 PF00069 0.430
MOD_NEK2_1 256 261 PF00069 0.546
MOD_PIKK_1 119 125 PF00454 0.453
MOD_PIKK_1 243 249 PF00454 0.506
MOD_PIKK_1 258 264 PF00454 0.416
MOD_PIKK_1 318 324 PF00454 0.679
MOD_PKA_2 133 139 PF00069 0.487
MOD_PKA_2 250 256 PF00069 0.433
MOD_Plk_1 233 239 PF00069 0.400
MOD_Plk_1 62 68 PF00069 0.491
MOD_Plk_4 80 86 PF00069 0.474
MOD_Plk_4 9 15 PF00069 0.321
MOD_ProDKin_1 116 122 PF00069 0.391
MOD_ProDKin_1 180 186 PF00069 0.345
MOD_SUMO_rev_2 147 156 PF00179 0.419
MOD_SUMO_rev_2 234 243 PF00179 0.362
TRG_DiLeu_BaEn_3 153 159 PF01217 0.349
TRG_ENDOCYTIC_2 28 31 PF00928 0.468
TRG_ENDOCYTIC_2 84 87 PF00928 0.446
TRG_ER_diArg_1 317 319 PF00400 0.645

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY91 Leptomonas seymouri 45% 100%
A0A0N1PG18 Leptomonas seymouri 36% 79%
A0A3S5H587 Leishmania donovani 90% 100%
A0A3S5H6P8 Leishmania donovani 36% 84%
A4H3U3 Leishmania braziliensis 78% 100%
A4H7B4 Leishmania braziliensis 33% 100%
A4HS17 Leishmania infantum 90% 100%
A4HVQ9 Leishmania infantum 36% 84%
E9APF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 85%
Q4QG23 Leishmania major 34% 100%
Q9XZY2 Leishmania major 89% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS