Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania mexicana

UniProt:

E9AK03_LEIMU

TriTrypDb:

LmxM.04.0210

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AK03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.526
CLV_NRD_NRD_1	325	327	PF00675	0.712
CLV_NRD_NRD_1	48	50	PF00675	0.387
CLV_PCSK_KEX2_1	48	50	PF00082	0.387
CLV_PCSK_KEX2_1	71	73	PF00082	0.467
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_CKS1_1	135	140	PF01111	0.392
DOC_MAPK_FxFP_2	52	55	PF00069	0.575
DOC_MAPK_gen_1	114	121	PF00069	0.389
DOC_MAPK_gen_1	71	79	PF00069	0.521
DOC_PP4_FxxP_1	52	55	PF00568	0.575
DOC_USP7_MATH_1	102	106	PF00917	0.355
DOC_USP7_MATH_1	18	22	PF00917	0.580
DOC_USP7_MATH_1	193	197	PF00917	0.482
DOC_USP7_MATH_1	207	211	PF00917	0.563
DOC_USP7_MATH_1	221	225	PF00917	0.417
DOC_USP7_MATH_1	235	239	PF00917	0.460
DOC_USP7_MATH_1	246	250	PF00917	0.562
DOC_USP7_MATH_1	288	292	PF00917	0.409
DOC_USP7_MATH_1	328	332	PF00917	0.492
DOC_USP7_MATH_1	343	347	PF00917	0.216
DOC_USP7_MATH_1	64	68	PF00917	0.622
DOC_WW_Pin1_4	131	136	PF00397	0.407
DOC_WW_Pin1_4	191	196	PF00397	0.432
DOC_WW_Pin1_4	200	205	PF00397	0.611
DOC_WW_Pin1_4	214	219	PF00397	0.485
DOC_WW_Pin1_4	228	233	PF00397	0.442
DOC_WW_Pin1_4	242	247	PF00397	0.393
DOC_WW_Pin1_4	254	259	PF00397	0.271
DOC_WW_Pin1_4	32	37	PF00397	0.577
DOC_WW_Pin1_4	333	338	PF00397	0.482
LIG_14-3-3_CanoR_1	307	315	PF00244	0.364
LIG_14-3-3_CanoR_1	48	53	PF00244	0.583
LIG_14-3-3_CanoR_1	66	74	PF00244	0.534
LIG_14-3-3_CanoR_1	9	15	PF00244	0.596
LIG_BRCT_BRCA1_1	23	27	PF00533	0.591
LIG_BRCT_BRCA1_1	50	54	PF00533	0.581
LIG_EVH1_1	98	102	PF00568	0.297
LIG_FHA_1	1	7	PF00498	0.581
LIG_FHA_1	149	155	PF00498	0.394
LIG_FHA_1	164	170	PF00498	0.263
LIG_FHA_1	268	274	PF00498	0.376
LIG_FHA_1	334	340	PF00498	0.285
LIG_FHA_1	48	54	PF00498	0.583
LIG_FHA_1	85	91	PF00498	0.276
LIG_FHA_2	135	141	PF00498	0.388
LIG_LIR_Apic_2	50	55	PF02991	0.577
LIG_LIR_Gen_1	318	328	PF02991	0.407
LIG_LIR_Nem_3	318	324	PF02991	0.476
LIG_LIR_Nem_3	96	101	PF02991	0.373
LIG_LYPXL_yS_3	175	178	PF13949	0.391
LIG_LYPXL_yS_3	98	101	PF13949	0.414
LIG_PDZ_Class_2	350	355	PF00595	0.210
LIG_SH2_CRK	321	325	PF00017	0.387
LIG_SH2_NCK_1	321	325	PF00017	0.387
LIG_SH2_STAP1	129	133	PF00017	0.331
LIG_SH2_STAP1	269	273	PF00017	0.378
LIG_SH2_STAP1	315	319	PF00017	0.386
LIG_SH2_STAT5	181	184	PF00017	0.427
LIG_SH2_STAT5	269	272	PF00017	0.359
LIG_SH2_STAT5	321	324	PF00017	0.382
LIG_SH2_STAT5	39	42	PF00017	0.602
LIG_SH3_1	143	149	PF00018	0.336
LIG_SH3_3	132	138	PF00018	0.423
LIG_SH3_3	143	149	PF00018	0.306
LIG_SH3_3	166	172	PF00018	0.332
LIG_SH3_3	28	34	PF00018	0.577
LIG_SH3_3	322	328	PF00018	0.299
LIG_SH3_3	96	102	PF00018	0.304
LIG_SUMO_SIM_par_1	117	123	PF11976	0.385
LIG_SUMO_SIM_par_1	278	283	PF11976	0.277
LIG_SUMO_SIM_par_1	82	87	PF11976	0.295
LIG_SxIP_EBH_1	317	327	PF03271	0.398
LIG_TYR_ITIM	173	178	PF00017	0.397
LIG_TYR_ITIM	319	324	PF00017	0.392
LIG_UBA3_1	118	126	PF00899	0.379
MOD_CK1_1	120	126	PF00069	0.368
MOD_CK1_1	134	140	PF00069	0.342
MOD_CK1_1	196	202	PF00069	0.520
MOD_CK1_1	203	209	PF00069	0.579
MOD_CK1_1	21	27	PF00069	0.588
MOD_CK1_1	210	216	PF00069	0.535
MOD_CK1_1	217	223	PF00069	0.486
MOD_CK1_1	224	230	PF00069	0.477
MOD_CK1_1	231	237	PF00069	0.479
MOD_CK1_1	238	244	PF00069	0.520
MOD_CK1_1	245	251	PF00069	0.446
MOD_CK1_1	267	273	PF00069	0.270
MOD_CK1_1	310	316	PF00069	0.416
MOD_CK1_1	91	97	PF00069	0.388
MOD_CK2_1	10	16	PF00069	0.595
MOD_CK2_1	134	140	PF00069	0.386
MOD_CK2_1	306	312	PF00069	0.372
MOD_GlcNHglycan	10	13	PF01048	0.396
MOD_GlcNHglycan	248	251	PF01048	0.679
MOD_GlcNHglycan	275	278	PF01048	0.619
MOD_GlcNHglycan	282	285	PF01048	0.546
MOD_GlcNHglycan	312	315	PF01048	0.559
MOD_GlcNHglycan	330	333	PF01048	0.728
MOD_GlcNHglycan	90	93	PF01048	0.628
MOD_GSK3_1	127	134	PF00069	0.384
MOD_GSK3_1	184	191	PF00069	0.489
MOD_GSK3_1	193	200	PF00069	0.454
MOD_GSK3_1	203	210	PF00069	0.457
MOD_GSK3_1	212	219	PF00069	0.586
MOD_GSK3_1	221	228	PF00069	0.453
MOD_GSK3_1	231	238	PF00069	0.472
MOD_GSK3_1	240	247	PF00069	0.542
MOD_GSK3_1	250	257	PF00069	0.364
MOD_GSK3_1	306	313	PF00069	0.274
MOD_GSK3_1	315	322	PF00069	0.330
MOD_GSK3_1	343	350	PF00069	0.348
MOD_GSK3_1	84	91	PF00069	0.286
MOD_N-GLC_2	306	308	PF02516	0.577
MOD_NEK2_1	280	285	PF00069	0.346
MOD_NEK2_1	317	322	PF00069	0.410
MOD_NEK2_1	65	70	PF00069	0.562
MOD_NEK2_1	88	93	PF00069	0.530
MOD_NEK2_2	10	15	PF00069	0.595
MOD_OFUCOSY	255	260	PF10250	0.566
MOD_OFUCOSY	286	292	PF10250	0.687
MOD_PIKK_1	264	270	PF00454	0.274
MOD_PKA_1	48	54	PF00069	0.583
MOD_PKA_2	306	312	PF00069	0.329
MOD_PKA_2	47	53	PF00069	0.584
MOD_PKA_2	65	71	PF00069	0.542
MOD_PKA_2	8	14	PF00069	0.594
MOD_Plk_1	103	109	PF00069	0.339
MOD_Plk_4	177	183	PF00069	0.414
MOD_Plk_4	349	355	PF00069	0.342
MOD_Plk_4	48	54	PF00069	0.583
MOD_ProDKin_1	131	137	PF00069	0.411
MOD_ProDKin_1	191	197	PF00069	0.435
MOD_ProDKin_1	200	206	PF00069	0.611
MOD_ProDKin_1	214	220	PF00069	0.484
MOD_ProDKin_1	228	234	PF00069	0.441
MOD_ProDKin_1	242	248	PF00069	0.391
MOD_ProDKin_1	254	260	PF00069	0.264
MOD_ProDKin_1	32	38	PF00069	0.581
MOD_ProDKin_1	333	339	PF00069	0.481
TRG_ENDOCYTIC_2	175	178	PF00928	0.391
TRG_ENDOCYTIC_2	321	324	PF00928	0.382
TRG_ENDOCYTIC_2	98	101	PF00928	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ5	Leptomonas seymouri	32%	100%
A0A3S5H586	Leishmania donovani	72%	100%
A4HS16	Leishmania infantum	74%	100%
Q9XZY1	Leishmania major	74%	100%