Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania mexicana

UniProt:

E9AK00_LEIMU

TriTrypDb:

LmxM.04.0180

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.322
CLV_PCSK_KEX2_1	112	114	PF00082	0.534
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.534
CLV_PCSK_SKI1_1	145	149	PF00082	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DEG_SCF_FBW7_1	308	313	PF00400	0.395
DOC_ANK_TNKS_1	24	31	PF00023	0.353
DOC_CKS1_1	307	312	PF01111	0.394
DOC_CKS1_1	329	334	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.244
DOC_PP1_RVXF_1	143	149	PF00149	0.306
DOC_PP2B_LxvP_1	479	482	PF13499	0.244
DOC_USP7_MATH_1	147	151	PF00917	0.296
DOC_USP7_MATH_1	168	172	PF00917	0.340
DOC_USP7_MATH_1	211	215	PF00917	0.408
DOC_WW_Pin1_4	306	311	PF00397	0.400
DOC_WW_Pin1_4	312	317	PF00397	0.355
DOC_WW_Pin1_4	328	333	PF00397	0.305
DOC_WW_Pin1_4	388	393	PF00397	0.396
DOC_WW_Pin1_4	7	12	PF00397	0.591
DOC_WW_Pin1_4	72	77	PF00397	0.334
LIG_BRCT_BRCA1_1	170	174	PF00533	0.341
LIG_CSL_BTD_1	479	482	PF09270	0.244
LIG_FHA_1	220	226	PF00498	0.314
LIG_FHA_1	367	373	PF00498	0.363
LIG_FHA_1	46	52	PF00498	0.395
LIG_FHA_1	82	88	PF00498	0.411
LIG_FHA_2	123	129	PF00498	0.312
LIG_FHA_2	402	408	PF00498	0.329
LIG_GBD_Chelix_1	317	325	PF00786	0.588
LIG_LIR_Apic_2	242	248	PF02991	0.331
LIG_LIR_Nem_3	345	350	PF02991	0.368
LIG_LIR_Nem_3	459	465	PF02991	0.381
LIG_PTB_Apo_2	414	421	PF02174	0.387
LIG_PTB_Phospho_1	414	420	PF10480	0.388
LIG_SH2_CRK	245	249	PF00017	0.327
LIG_SH2_CRK	347	351	PF00017	0.366
LIG_SH2_CRK	462	466	PF00017	0.373
LIG_SH2_STAP1	239	243	PF00017	0.353
LIG_SH2_STAP1	380	384	PF00017	0.390
LIG_SH2_STAP1	477	481	PF00017	0.345
LIG_SH2_STAT5	15	18	PF00017	0.408
LIG_SH2_STAT5	188	191	PF00017	0.361
LIG_SH2_STAT5	239	242	PF00017	0.407
LIG_SH2_STAT5	245	248	PF00017	0.384
LIG_SH2_STAT5	307	310	PF00017	0.403
LIG_SH2_STAT5	342	345	PF00017	0.355
LIG_SH2_STAT5	415	418	PF00017	0.399
LIG_SH2_STAT5	421	424	PF00017	0.364
LIG_SH2_STAT5	434	437	PF00017	0.303
LIG_SH2_STAT5	456	459	PF00017	0.378
LIG_SH2_STAT5	86	89	PF00017	0.373
LIG_SH3_2	329	334	PF14604	0.397
LIG_SH3_3	326	332	PF00018	0.390
LIG_SH3_3	38	44	PF00018	0.332
LIG_SH3_3	61	67	PF00018	0.366
LIG_SH3_3	84	90	PF00018	0.402
LIG_SUMO_SIM_par_1	483	489	PF11976	0.244
LIG_TRFH_1	306	310	PF08558	0.394
LIG_TRFH_1	86	90	PF08558	0.337
MOD_CDK_SPxK_1	328	334	PF00069	0.394
MOD_CK1_1	135	141	PF00069	0.418
MOD_CK1_1	158	164	PF00069	0.313
MOD_CK1_1	177	183	PF00069	0.326
MOD_CK1_1	237	243	PF00069	0.406
MOD_CK1_1	259	265	PF00069	0.410
MOD_CK1_1	291	297	PF00069	0.363
MOD_CK1_1	312	318	PF00069	0.305
MOD_CK1_1	388	394	PF00069	0.399
MOD_CK1_1	489	495	PF00069	0.520
MOD_CK1_1	65	71	PF00069	0.377
MOD_CK2_1	104	110	PF00069	0.345
MOD_CK2_1	122	128	PF00069	0.308
MOD_Cter_Amidation	110	113	PF01082	0.548
MOD_GlcNHglycan	106	109	PF01048	0.509
MOD_GlcNHglycan	176	179	PF01048	0.531
MOD_GlcNHglycan	191	194	PF01048	0.530
MOD_GlcNHglycan	198	201	PF01048	0.520
MOD_GlcNHglycan	204	207	PF01048	0.512
MOD_GlcNHglycan	209	212	PF01048	0.496
MOD_GlcNHglycan	213	216	PF01048	0.536
MOD_GlcNHglycan	36	39	PF01048	0.546
MOD_GlcNHglycan	382	385	PF01048	0.546
MOD_GSK3_1	135	142	PF00069	0.411
MOD_GSK3_1	147	154	PF00069	0.380
MOD_GSK3_1	196	203	PF00069	0.307
MOD_GSK3_1	207	214	PF00069	0.364
MOD_GSK3_1	259	266	PF00069	0.413
MOD_GSK3_1	306	313	PF00069	0.392
MOD_GSK3_1	380	387	PF00069	0.375
MOD_GSK3_1	443	450	PF00069	0.394
MOD_N-GLC_2	403	405	PF02516	0.586
MOD_N-GLC_2	92	94	PF02516	0.522
MOD_N-GLC_2	95	97	PF02516	0.522
MOD_NEK2_1	148	153	PF00069	0.340
MOD_NEK2_1	174	179	PF00069	0.342
MOD_NEK2_1	186	191	PF00069	0.339
MOD_NEK2_1	443	448	PF00069	0.407
MOD_NEK2_1	457	462	PF00069	0.322
MOD_NEK2_1	486	491	PF00069	0.345
MOD_NEK2_1	78	83	PF00069	0.416
MOD_OFUCOSY	260	267	PF10250	0.602
MOD_OFUCOSY	63	69	PF10250	0.545
MOD_PIKK_1	132	138	PF00454	0.413
MOD_PIKK_1	139	145	PF00454	0.351
MOD_PIKK_1	297	303	PF00454	0.347
MOD_PIKK_1	391	397	PF00454	0.416
MOD_Plk_1	237	243	PF00069	0.308
MOD_Plk_1	367	373	PF00069	0.330
MOD_Plk_4	28	34	PF00069	0.393
MOD_Plk_4	475	481	PF00069	0.357
MOD_ProDKin_1	306	312	PF00069	0.396
MOD_ProDKin_1	328	334	PF00069	0.394
MOD_ProDKin_1	388	394	PF00069	0.404
MOD_ProDKin_1	7	13	PF00069	0.587
MOD_ProDKin_1	72	78	PF00069	0.333
TRG_ENDOCYTIC_2	121	124	PF00928	0.369
TRG_ENDOCYTIC_2	274	277	PF00928	0.353
TRG_ENDOCYTIC_2	347	350	PF00928	0.371
TRG_ENDOCYTIC_2	462	465	PF00928	0.369
TRG_NLS_MonoExtC_3	362	368	PF00514	0.291
TRG_NLS_MonoExtN_4	360	367	PF00514	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H584	Leishmania donovani	90%	98%
A0A451EJW6	Leishmania donovani	69%	70%
A4H3U2	Leishmania braziliensis	67%	95%
A4H3Y2	Leishmania braziliensis	30%	100%
A4HS13	Leishmania infantum	90%	98%
A4HS14	Leishmania infantum	69%	70%
E9AK01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	70%
Q03185	Giardia intestinalis	29%	74%
Q9XZX8	Leishmania major	90%	100%
Q9XZX9	Leishmania major	69%	70%