LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9AJZ9_LEIMU
TriTrypDb:
LmxM.04.0130
Length:
613

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 7
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AJZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 448 452 PF00656 0.441
CLV_NRD_NRD_1 6 8 PF00675 0.642
CLV_PCSK_KEX2_1 6 8 PF00082 0.642
CLV_PCSK_PC7_1 2 8 PF00082 0.658
CLV_PCSK_SKI1_1 123 127 PF00082 0.429
DEG_Nend_UBRbox_1 1 4 PF02207 0.474
DEG_SPOP_SBC_1 546 550 PF00917 0.412
DOC_CKS1_1 83 88 PF01111 0.438
DOC_CYCLIN_yCln2_LP_2 83 89 PF00134 0.437
DOC_MAPK_FxFP_2 371 374 PF00069 0.400
DOC_PP2B_LxvP_1 28 31 PF13499 0.431
DOC_PP2B_LxvP_1 67 70 PF13499 0.448
DOC_PP4_FxxP_1 371 374 PF00568 0.400
DOC_PP4_FxxP_1 81 84 PF00568 0.446
DOC_USP7_MATH_1 199 203 PF00917 0.467
DOC_USP7_MATH_1 215 219 PF00917 0.328
DOC_USP7_MATH_1 243 247 PF00917 0.553
DOC_USP7_MATH_1 34 38 PF00917 0.458
DOC_USP7_MATH_1 364 368 PF00917 0.427
DOC_USP7_MATH_1 408 412 PF00917 0.466
DOC_USP7_MATH_1 421 425 PF00917 0.326
DOC_USP7_MATH_1 46 50 PF00917 0.443
DOC_USP7_MATH_1 474 478 PF00917 0.497
DOC_USP7_MATH_1 558 562 PF00917 0.413
DOC_USP7_MATH_1 564 568 PF00917 0.403
DOC_WW_Pin1_4 26 31 PF00397 0.428
DOC_WW_Pin1_4 490 495 PF00397 0.423
DOC_WW_Pin1_4 75 80 PF00397 0.468
DOC_WW_Pin1_4 82 87 PF00397 0.446
LIG_14-3-3_CanoR_1 169 178 PF00244 0.658
LIG_14-3-3_CanoR_1 205 215 PF00244 0.457
LIG_14-3-3_CanoR_1 528 536 PF00244 0.486
LIG_14-3-3_CanoR_1 575 581 PF00244 0.449
LIG_BRCT_BRCA1_1 325 329 PF00533 0.445
LIG_BRCT_BRCA1_1 380 384 PF00533 0.349
LIG_BRCT_BRCA1_1 77 81 PF00533 0.451
LIG_Clathr_ClatBox_1 270 274 PF01394 0.329
LIG_FHA_1 120 126 PF00498 0.687
LIG_FHA_1 134 140 PF00498 0.662
LIG_FHA_1 148 154 PF00498 0.608
LIG_FHA_1 182 188 PF00498 0.273
LIG_FHA_1 208 214 PF00498 0.387
LIG_FHA_1 230 236 PF00498 0.462
LIG_FHA_1 247 253 PF00498 0.408
LIG_FHA_1 265 271 PF00498 0.407
LIG_FHA_1 495 501 PF00498 0.433
LIG_FHA_1 552 558 PF00498 0.391
LIG_FHA_1 595 601 PF00498 0.474
LIG_FHA_2 124 130 PF00498 0.763
LIG_FHA_2 349 355 PF00498 0.387
LIG_FHA_2 373 379 PF00498 0.438
LIG_FHA_2 446 452 PF00498 0.476
LIG_FHA_2 511 517 PF00498 0.376
LIG_FHA_2 54 60 PF00498 0.457
LIG_LIR_Apic_2 78 84 PF02991 0.445
LIG_LIR_Gen_1 221 227 PF02991 0.284
LIG_LIR_Gen_1 393 402 PF02991 0.498
LIG_LIR_Nem_3 221 225 PF02991 0.445
LIG_LIR_Nem_3 356 361 PF02991 0.381
LIG_LIR_Nem_3 393 399 PF02991 0.512
LIG_PCNA_yPIPBox_3 96 107 PF02747 0.252
LIG_PDZ_Class_2 608 613 PF00595 0.672
LIG_SH2_CRK 491 495 PF00017 0.457
LIG_SH2_CRK 5 9 PF00017 0.439
LIG_SH2_NCK_1 47 51 PF00017 0.452
LIG_SH2_NCK_1 491 495 PF00017 0.409
LIG_SH2_STAP1 361 365 PF00017 0.328
LIG_SH2_STAP1 47 51 PF00017 0.452
LIG_SH2_STAT5 19 22 PF00017 0.443
LIG_SH2_STAT5 358 361 PF00017 0.430
LIG_SH3_1 5 11 PF00018 0.432
LIG_SH3_3 21 27 PF00018 0.419
LIG_SH3_3 237 243 PF00018 0.480
LIG_SH3_3 28 34 PF00018 0.436
LIG_SH3_3 496 502 PF00018 0.428
LIG_SH3_3 5 11 PF00018 0.432
LIG_SH3_3 60 66 PF00018 0.459
LIG_SH3_3 89 95 PF00018 0.430
LIG_SUMO_SIM_anti_2 251 256 PF11976 0.436
LIG_SUMO_SIM_par_1 136 145 PF11976 0.664
LIG_SUMO_SIM_par_1 231 236 PF11976 0.449
LIG_SUMO_SIM_par_1 251 256 PF11976 0.430
LIG_SUMO_SIM_par_1 319 324 PF11976 0.420
MOD_CK1_1 128 134 PF00069 0.702
MOD_CK1_1 142 148 PF00069 0.655
MOD_CK1_1 156 162 PF00069 0.630
MOD_CK1_1 172 178 PF00069 0.684
MOD_CK1_1 181 187 PF00069 0.286
MOD_CK1_1 190 196 PF00069 0.401
MOD_CK1_1 246 252 PF00069 0.537
MOD_CK1_1 346 352 PF00069 0.387
MOD_CK1_1 353 359 PF00069 0.389
MOD_CK1_1 372 378 PF00069 0.381
MOD_CK1_1 389 395 PF00069 0.372
MOD_CK1_1 411 417 PF00069 0.359
MOD_CK1_1 456 462 PF00069 0.497
MOD_CK1_1 569 575 PF00069 0.492
MOD_CK1_1 82 88 PF00069 0.439
MOD_CK2_1 360 366 PF00069 0.426
MOD_CK2_1 372 378 PF00069 0.430
MOD_CK2_1 411 417 PF00069 0.323
MOD_CK2_1 474 480 PF00069 0.501
MOD_CK2_1 53 59 PF00069 0.457
MOD_GlcNHglycan 144 147 PF01048 0.468
MOD_GlcNHglycan 158 161 PF01048 0.419
MOD_GlcNHglycan 174 177 PF01048 0.511
MOD_GlcNHglycan 189 192 PF01048 0.438
MOD_GlcNHglycan 194 197 PF01048 0.514
MOD_GlcNHglycan 20 23 PF01048 0.640
MOD_GlcNHglycan 221 225 PF01048 0.635
MOD_GlcNHglycan 255 258 PF01048 0.668
MOD_GlcNHglycan 311 314 PF01048 0.572
MOD_GlcNHglycan 345 348 PF01048 0.720
MOD_GlcNHglycan 354 358 PF01048 0.543
MOD_GlcNHglycan 362 365 PF01048 0.580
MOD_GlcNHglycan 366 369 PF01048 0.600
MOD_GlcNHglycan 388 391 PF01048 0.640
MOD_GlcNHglycan 423 426 PF01048 0.533
MOD_GlcNHglycan 456 459 PF01048 0.762
MOD_GlcNHglycan 476 479 PF01048 0.665
MOD_GlcNHglycan 48 51 PF01048 0.653
MOD_GlcNHglycan 566 569 PF01048 0.695
MOD_GSK3_1 115 122 PF00069 0.700
MOD_GSK3_1 123 130 PF00069 0.631
MOD_GSK3_1 161 168 PF00069 0.633
MOD_GSK3_1 172 179 PF00069 0.667
MOD_GSK3_1 181 188 PF00069 0.334
MOD_GSK3_1 288 295 PF00069 0.448
MOD_GSK3_1 342 349 PF00069 0.407
MOD_GSK3_1 360 367 PF00069 0.487
MOD_GSK3_1 386 393 PF00069 0.435
MOD_GSK3_1 408 415 PF00069 0.449
MOD_GSK3_1 434 441 PF00069 0.430
MOD_GSK3_1 445 452 PF00069 0.386
MOD_GSK3_1 476 483 PF00069 0.525
MOD_GSK3_1 490 497 PF00069 0.384
MOD_GSK3_1 523 530 PF00069 0.475
MOD_GSK3_1 544 551 PF00069 0.463
MOD_GSK3_1 566 573 PF00069 0.440
MOD_GSK3_1 75 82 PF00069 0.465
MOD_N-GLC_1 229 234 PF02516 0.652
MOD_N-GLC_2 527 529 PF02516 0.672
MOD_NEK2_1 127 132 PF00069 0.651
MOD_NEK2_1 139 144 PF00069 0.609
MOD_NEK2_1 153 158 PF00069 0.592
MOD_NEK2_1 178 183 PF00069 0.600
MOD_NEK2_1 18 23 PF00069 0.444
MOD_NEK2_1 220 225 PF00069 0.431
MOD_NEK2_1 273 278 PF00069 0.473
MOD_NEK2_1 309 314 PF00069 0.308
MOD_NEK2_1 329 334 PF00069 0.349
MOD_NEK2_1 343 348 PF00069 0.433
MOD_NEK2_1 386 391 PF00069 0.433
MOD_NEK2_1 416 421 PF00069 0.348
MOD_NEK2_1 495 500 PF00069 0.447
MOD_NEK2_2 215 220 PF00069 0.382
MOD_PIKK_1 153 159 PF00454 0.659
MOD_PIKK_1 185 191 PF00454 0.413
MOD_PIKK_1 285 291 PF00454 0.425
MOD_PIKK_1 449 455 PF00454 0.457
MOD_PKA_2 165 171 PF00069 0.678
MOD_PKA_2 176 182 PF00069 0.627
MOD_PKA_2 329 335 PF00069 0.339
MOD_PKA_2 527 533 PF00069 0.478
MOD_PKB_1 169 177 PF00069 0.586
MOD_Plk_1 123 129 PF00069 0.703
MOD_Plk_1 220 226 PF00069 0.372
MOD_Plk_1 229 235 PF00069 0.460
MOD_Plk_1 273 279 PF00069 0.366
MOD_Plk_1 323 329 PF00069 0.410
MOD_Plk_1 353 359 PF00069 0.442
MOD_Plk_1 510 516 PF00069 0.327
MOD_Plk_4 133 139 PF00069 0.613
MOD_Plk_4 215 221 PF00069 0.458
MOD_Plk_4 229 235 PF00069 0.401
MOD_Plk_4 248 254 PF00069 0.457
MOD_Plk_4 279 285 PF00069 0.498
MOD_Plk_4 324 330 PF00069 0.377
MOD_Plk_4 392 398 PF00069 0.401
MOD_Plk_4 445 451 PF00069 0.503
MOD_Plk_4 495 501 PF00069 0.435
MOD_Plk_4 69 75 PF00069 0.476
MOD_ProDKin_1 26 32 PF00069 0.430
MOD_ProDKin_1 490 496 PF00069 0.424
MOD_ProDKin_1 75 81 PF00069 0.470
MOD_ProDKin_1 82 88 PF00069 0.449
TRG_ER_diArg_1 5 7 PF00400 0.454
TRG_NES_CRM1_1 217 228 PF08389 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P251 Leptomonas seymouri 24% 100%
A0A381M9M8 Leishmania infantum 87% 100%
A0A3S5H581 Leishmania donovani 86% 100%
A0A3S5H583 Leishmania donovani 86% 100%
A0A451EJW1 Leishmania donovani 86% 100%
A0A451EJW4 Leishmania donovani 86% 100%
A0A451EJW6 Leishmania donovani 23% 86%
A4H3T8 Leishmania braziliensis 68% 100%
A4H3T9 Leishmania braziliensis 68% 100%
A4H3U0 Leishmania braziliensis 66% 100%
A4H3U1 Leishmania braziliensis 66% 100%
A4HS14 Leishmania infantum 23% 86%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 86%
Q9N852 Leishmania major 85% 100%
Q9N853 Leishmania major 86% 100%
Q9N856 Leishmania major 85% 100%
Q9XZX9 Leishmania major 23% 86%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS