Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJZ8_LEIMU

TriTrypDb:

LmxM.04.0127

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.742
CLV_NRD_NRD_1	133	135	PF00675	0.536
CLV_NRD_NRD_1	219	221	PF00675	0.473
CLV_NRD_NRD_1	372	374	PF00675	0.427
CLV_NRD_NRD_1	381	383	PF00675	0.518
CLV_PCSK_FUR_1	101	105	PF00082	0.630
CLV_PCSK_FUR_1	130	134	PF00082	0.505
CLV_PCSK_KEX2_1	103	105	PF00082	0.742
CLV_PCSK_KEX2_1	132	134	PF00082	0.648
CLV_PCSK_KEX2_1	219	221	PF00082	0.473
CLV_PCSK_KEX2_1	372	374	PF00082	0.427
CLV_PCSK_KEX2_1	381	383	PF00082	0.518
CLV_PCSK_SKI1_1	178	182	PF00082	0.606
CLV_PCSK_SKI1_1	219	223	PF00082	0.669
DEG_APCC_DBOX_1	218	226	PF00400	0.528
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DEG_SCF_FBW7_1	138	145	PF00400	0.620
DOC_MAPK_gen_1	130	140	PF00069	0.527
DOC_MAPK_gen_1	266	275	PF00069	0.627
DOC_MAPK_gen_1	356	366	PF00069	0.474
DOC_MAPK_gen_1	372	378	PF00069	0.330
DOC_USP7_MATH_1	108	112	PF00917	0.634
DOC_USP7_MATH_1	128	132	PF00917	0.577
DOC_USP7_MATH_1	229	233	PF00917	0.524
DOC_USP7_MATH_1	262	266	PF00917	0.508
DOC_USP7_MATH_1	297	301	PF00917	0.486
DOC_USP7_MATH_1	328	332	PF00917	0.529
DOC_WW_Pin1_4	138	143	PF00397	0.745
DOC_WW_Pin1_4	153	158	PF00397	0.578
DOC_WW_Pin1_4	209	214	PF00397	0.575
LIG_14-3-3_CanoR_1	132	137	PF00244	0.518
LIG_14-3-3_CanoR_1	305	309	PF00244	0.621
LIG_14-3-3_CanoR_1	45	51	PF00244	0.612
LIG_14-3-3_CanoR_1	90	98	PF00244	0.528
LIG_Actin_WH2_2	165	180	PF00022	0.608
LIG_Actin_WH2_2	341	358	PF00022	0.466
LIG_eIF4E_1	67	73	PF01652	0.567
LIG_FHA_1	183	189	PF00498	0.648
LIG_FHA_1	228	234	PF00498	0.566
LIG_FHA_1	340	346	PF00498	0.417
LIG_FHA_1	350	356	PF00498	0.416
LIG_FHA_2	139	145	PF00498	0.675
LIG_FHA_2	4	10	PF00498	0.642
LIG_FHA_2	52	58	PF00498	0.541
LIG_GBD_Chelix_1	233	241	PF00786	0.445
LIG_LIR_Gen_1	62	73	PF02991	0.687
LIG_LIR_Nem_3	319	324	PF02991	0.626
LIG_LIR_Nem_3	365	369	PF02991	0.399
LIG_LIR_Nem_3	62	68	PF02991	0.587
LIG_PCNA_yPIPBox_3	274	283	PF02747	0.373
LIG_SH2_CRK	280	284	PF00017	0.418
LIG_SH2_STAT5	167	170	PF00017	0.703
LIG_SH2_STAT5	369	372	PF00017	0.374
LIG_SH2_STAT5	379	382	PF00017	0.518
LIG_SH2_STAT5	67	70	PF00017	0.592
LIG_SH2_STAT5	88	91	PF00017	0.512
LIG_SH3_3	281	287	PF00018	0.444
LIG_SH3_3	306	312	PF00018	0.614
LIG_TRAF2_1	161	164	PF00917	0.811
MOD_CK1_1	111	117	PF00069	0.806
MOD_CK1_1	121	127	PF00069	0.684
MOD_CK1_1	156	162	PF00069	0.667
MOD_CK1_1	339	345	PF00069	0.439
MOD_CK1_1	60	66	PF00069	0.392
MOD_CK1_1	93	99	PF00069	0.565
MOD_CK2_1	138	144	PF00069	0.642
MOD_CK2_1	204	210	PF00069	0.595
MOD_CK2_1	3	9	PF00069	0.646
MOD_CK2_1	323	329	PF00069	0.473
MOD_CK2_1	78	84	PF00069	0.640
MOD_GlcNHglycan	113	116	PF01048	0.765
MOD_GlcNHglycan	178	181	PF01048	0.728
MOD_GlcNHglycan	198	201	PF01048	0.679
MOD_GlcNHglycan	312	315	PF01048	0.550
MOD_GSK3_1	107	114	PF00069	0.764
MOD_GSK3_1	128	135	PF00069	0.696
MOD_GSK3_1	138	145	PF00069	0.560
MOD_GSK3_1	167	174	PF00069	0.553
MOD_GSK3_1	182	189	PF00069	0.660
MOD_GSK3_1	86	93	PF00069	0.644
MOD_N-GLC_1	329	334	PF02516	0.563
MOD_NEK2_1	184	189	PF00069	0.656
MOD_NEK2_1	322	327	PF00069	0.620
MOD_NEK2_1	37	42	PF00069	0.578
MOD_NEK2_2	3	8	PF00069	0.513
MOD_PIKK_1	37	43	PF00454	0.548
MOD_PIKK_1	44	50	PF00454	0.638
MOD_PIKK_1	60	66	PF00454	0.530
MOD_PKA_1	132	138	PF00069	0.508
MOD_PKA_2	1	7	PF00069	0.679
MOD_PKA_2	102	108	PF00069	0.621
MOD_PKA_2	121	127	PF00069	0.556
MOD_PKA_2	132	138	PF00069	0.566
MOD_PKA_2	227	233	PF00069	0.642
MOD_PKA_2	254	260	PF00069	0.574
MOD_PKA_2	297	303	PF00069	0.576
MOD_PKA_2	304	310	PF00069	0.664
MOD_PKA_2	44	50	PF00069	0.611
MOD_PKA_2	51	57	PF00069	0.656
MOD_PKA_2	89	95	PF00069	0.621
MOD_PKB_1	11	19	PF00069	0.509
MOD_PKB_1	130	138	PF00069	0.507
MOD_Plk_1	60	66	PF00069	0.613
MOD_Plk_2-3	204	210	PF00069	0.620
MOD_Plk_2-3	57	63	PF00069	0.387
MOD_Plk_4	211	217	PF00069	0.374
MOD_Plk_4	229	235	PF00069	0.528
MOD_Plk_4	237	243	PF00069	0.441
MOD_Plk_4	341	347	PF00069	0.471
MOD_ProDKin_1	138	144	PF00069	0.747
MOD_ProDKin_1	153	159	PF00069	0.577
MOD_ProDKin_1	209	215	PF00069	0.566
MOD_SUMO_rev_2	174	180	PF00179	0.480
TRG_DiLeu_BaEn_4	163	169	PF01217	0.566
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.523
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.421
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.525
TRG_ENDOCYTIC_2	280	283	PF00928	0.415
TRG_ER_diArg_1	101	104	PF00400	0.755
TRG_ER_diArg_1	130	133	PF00400	0.584
TRG_ER_diArg_1	219	221	PF00400	0.464
TRG_ER_diArg_1	372	374	PF00400	0.422
TRG_ER_diArg_1	381	384	PF00400	0.514
TRG_ER_diArg_1	95	98	PF00400	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL6	Leptomonas seymouri	36%	94%
A0A3S5H580	Leishmania donovani	84%	89%
A4H3T5	Leishmania braziliensis	64%	100%
A4HS10	Leishmania infantum	84%	89%
E9ACP7	Leishmania major	83%	100%
V5BDS0	Trypanosoma cruzi	24%	91%