Putative exosome complex exonuclease RRP40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome complex exonuclease RRP40, putative

Species:

Leishmania mexicana

UniProt:

E9AJZ6_LEIMU

TriTrypDb:

LmxM.04.0120

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AJZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ6

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071043	CUT metabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.424
CLV_C14_Caspase3-7	292	296	PF00656	0.421
CLV_NRD_NRD_1	114	116	PF00675	0.417
CLV_NRD_NRD_1	227	229	PF00675	0.331
CLV_NRD_NRD_1	244	246	PF00675	0.338
CLV_NRD_NRD_1	271	273	PF00675	0.352
CLV_NRD_NRD_1	301	303	PF00675	0.404
CLV_NRD_NRD_1	99	101	PF00675	0.526
CLV_PCSK_KEX2_1	227	229	PF00082	0.358
CLV_PCSK_KEX2_1	246	248	PF00082	0.358
CLV_PCSK_KEX2_1	271	273	PF00082	0.352
CLV_PCSK_KEX2_1	301	303	PF00082	0.404
CLV_PCSK_KEX2_1	99	101	PF00082	0.526
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.312
CLV_PCSK_SKI1_1	12	16	PF00082	0.495
CLV_PCSK_SKI1_1	227	231	PF00082	0.289
DEG_APCC_DBOX_1	226	234	PF00400	0.532
DEG_SCF_FBW7_1	229	235	PF00400	0.492
DEG_SCF_FBW7_1	52	57	PF00400	0.414
DEG_SPOP_SBC_1	4	8	PF00917	0.633
DOC_CKS1_1	229	234	PF01111	0.533
DOC_CKS1_1	51	56	PF01111	0.403
DOC_CKS1_1	93	98	PF01111	0.608
DOC_CYCLIN_RxL_1	224	231	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.546
DOC_MAPK_gen_1	271	279	PF00069	0.546
DOC_MAPK_HePTP_8	269	281	PF00069	0.479
DOC_MAPK_MEF2A_6	104	112	PF00069	0.398
DOC_MAPK_MEF2A_6	272	281	PF00069	0.479
DOC_PP2B_LxvP_1	219	222	PF13499	0.546
DOC_USP7_MATH_1	232	236	PF00917	0.552
DOC_USP7_MATH_1	305	309	PF00917	0.463
DOC_USP7_MATH_1	54	58	PF00917	0.555
DOC_WW_Pin1_4	228	233	PF00397	0.567
DOC_WW_Pin1_4	50	55	PF00397	0.549
DOC_WW_Pin1_4	92	97	PF00397	0.570
DOC_WW_Pin1_4	99	104	PF00397	0.522
LIG_14-3-3_CanoR_1	115	123	PF00244	0.463
LIG_14-3-3_CanoR_1	12	20	PF00244	0.409
LIG_14-3-3_CanoR_1	301	305	PF00244	0.400
LIG_14-3-3_CanoR_1	90	94	PF00244	0.436
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	177	181	PF00533	0.608
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.424
LIG_FHA_1	182	188	PF00498	0.518
LIG_FHA_1	301	307	PF00498	0.388
LIG_FHA_1	4	10	PF00498	0.508
LIG_FHA_2	181	187	PF00498	0.595
LIG_FHA_2	190	196	PF00498	0.404
LIG_FHA_2	202	208	PF00498	0.399
LIG_FHA_2	248	254	PF00498	0.538
LIG_FHA_2	316	322	PF00498	0.389
LIG_GBD_Chelix_1	38	46	PF00786	0.266
LIG_LIR_Apic_2	71	76	PF02991	0.443
LIG_LIR_Gen_1	154	164	PF02991	0.395
LIG_LIR_Nem_3	154	160	PF02991	0.362
LIG_LIR_Nem_3	207	213	PF02991	0.386
LIG_NRBOX	264	270	PF00104	0.465
LIG_SH2_CRK	123	127	PF00017	0.456
LIG_SH2_CRK	157	161	PF00017	0.361
LIG_SH2_CRK	73	77	PF00017	0.355
LIG_SH2_CRK	91	95	PF00017	0.564
LIG_SH2_NCK_1	91	95	PF00017	0.538
LIG_SH2_PTP2	159	162	PF00017	0.500
LIG_SH2_SRC	168	171	PF00017	0.577
LIG_SH2_STAT3	264	267	PF00017	0.550
LIG_SH2_STAT5	101	104	PF00017	0.431
LIG_SH2_STAT5	123	126	PF00017	0.356
LIG_SH2_STAT5	157	160	PF00017	0.429
LIG_SH2_STAT5	168	171	PF00017	0.646
LIG_SH2_STAT5	225	228	PF00017	0.550
LIG_SH2_STAT5	264	267	PF00017	0.550
LIG_SH2_STAT5	329	332	PF00017	0.431
LIG_SH2_STAT5	73	76	PF00017	0.492
LIG_SH2_STAT5	91	94	PF00017	0.324
LIG_SH3_3	142	148	PF00018	0.535
LIG_SH3_3	193	199	PF00018	0.505
LIG_SH3_3	206	212	PF00018	0.341
LIG_SH3_3	21	27	PF00018	0.346
LIG_SH3_3	325	331	PF00018	0.441
LIG_SH3_3	90	96	PF00018	0.512
LIG_SUMO_SIM_par_1	302	308	PF11976	0.499
LIG_SxIP_EBH_1	2	12	PF03271	0.443
LIG_TYR_ITIM	155	160	PF00017	0.353
MOD_CDC14_SPxK_1	236	239	PF00782	0.538
MOD_CDK_SPK_2	99	104	PF00069	0.560
MOD_CDK_SPxK_1	233	239	PF00069	0.538
MOD_CDK_SPxxK_3	92	99	PF00069	0.609
MOD_CK1_1	175	181	PF00069	0.662
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	308	314	PF00069	0.484
MOD_CK2_1	180	186	PF00069	0.630
MOD_CK2_1	189	195	PF00069	0.403
MOD_CK2_1	201	207	PF00069	0.418
MOD_CK2_1	247	253	PF00069	0.495
MOD_CK2_1	315	321	PF00069	0.420
MOD_Cter_Amidation	269	272	PF01082	0.346
MOD_GlcNHglycan	128	131	PF01048	0.482
MOD_GlcNHglycan	177	180	PF01048	0.593
MOD_GlcNHglycan	204	207	PF01048	0.504
MOD_GlcNHglycan	240	243	PF01048	0.362
MOD_GlcNHglycan	56	59	PF01048	0.462
MOD_GSK3_1	228	235	PF00069	0.515
MOD_GSK3_1	300	307	PF00069	0.521
MOD_GSK3_1	4	11	PF00069	0.633
MOD_GSK3_1	50	57	PF00069	0.685
MOD_GSK3_1	59	66	PF00069	0.585
MOD_GSK3_1	95	102	PF00069	0.502
MOD_PIKK_1	115	121	PF00454	0.525
MOD_PIKK_1	31	37	PF00454	0.561
MOD_PIKK_1	59	65	PF00454	0.699
MOD_PKA_1	115	121	PF00069	0.444
MOD_PKA_2	300	306	PF00069	0.400
MOD_PKA_2	78	84	PF00069	0.511
MOD_PKA_2	89	95	PF00069	0.366
MOD_PKB_1	245	253	PF00069	0.512
MOD_Plk_4	260	266	PF00069	0.489
MOD_ProDKin_1	228	234	PF00069	0.567
MOD_ProDKin_1	50	56	PF00069	0.554
MOD_ProDKin_1	92	98	PF00069	0.573
MOD_ProDKin_1	99	105	PF00069	0.521
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.573
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.543
TRG_ENDOCYTIC_2	123	126	PF00928	0.473
TRG_ENDOCYTIC_2	157	160	PF00928	0.337
TRG_ER_diArg_1	147	150	PF00400	0.392
TRG_ER_diArg_1	226	228	PF00400	0.558
TRG_ER_diArg_1	271	273	PF00400	0.547
TRG_ER_diArg_1	99	101	PF00400	0.515
TRG_NES_CRM1_1	16	29	PF08389	0.356
TRG_NLS_Bipartite_1	227	249	PF00514	0.433
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B7	Leptomonas seymouri	69%	100%
A0A0S4IMH2	Bodo saltans	40%	100%
A0A1X0NL22	Trypanosomatidae	50%	100%
A0A3S5H578	Leishmania donovani	95%	100%
A0A422NN72	Trypanosoma rangeli	49%	100%
A4H3T3	Leishmania braziliensis	87%	100%
A4HS08	Leishmania infantum	94%	100%
C9ZY06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q9N857	Leishmania major	95%	100%
V5BI90	Trypanosoma cruzi	48%	100%