Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJZ5_LEIMU

TriTrypDb:

LmxM.04.0110

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.675
CLV_C14_Caspase3-7	58	62	PF00656	0.625
CLV_NRD_NRD_1	125	127	PF00675	0.643
CLV_NRD_NRD_1	215	217	PF00675	0.643
CLV_NRD_NRD_1	337	339	PF00675	0.621
CLV_NRD_NRD_1	79	81	PF00675	0.474
CLV_PCSK_KEX2_1	125	127	PF00082	0.643
CLV_PCSK_KEX2_1	215	217	PF00082	0.674
CLV_PCSK_KEX2_1	311	313	PF00082	0.536
CLV_PCSK_KEX2_1	337	339	PF00082	0.577
CLV_PCSK_KEX2_1	79	81	PF00082	0.530
CLV_PCSK_KEX2_1	87	89	PF00082	0.583
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.536
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.649
CLV_PCSK_PC7_1	211	217	PF00082	0.647
CLV_PCSK_SKI1_1	117	121	PF00082	0.528
CLV_PCSK_SKI1_1	125	129	PF00082	0.440
CLV_PCSK_SKI1_1	138	142	PF00082	0.504
CLV_PCSK_SKI1_1	215	219	PF00082	0.669
CLV_PCSK_SKI1_1	273	277	PF00082	0.822
CLV_PCSK_SKI1_1	325	329	PF00082	0.696
CLV_PCSK_SKI1_1	80	84	PF00082	0.572
DEG_APCC_DBOX_1	124	132	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_CKS1_1	219	224	PF01111	0.716
DOC_CKS1_1	265	270	PF01111	0.746
DOC_CKS1_1	281	286	PF01111	0.537
DOC_MAPK_RevD_3	202	216	PF00069	0.689
DOC_USP7_MATH_1	279	283	PF00917	0.678
DOC_USP7_MATH_1	301	305	PF00917	0.726
DOC_USP7_MATH_1	86	90	PF00917	0.353
DOC_WW_Pin1_4	14	19	PF00397	0.452
DOC_WW_Pin1_4	186	191	PF00397	0.726
DOC_WW_Pin1_4	195	200	PF00397	0.766
DOC_WW_Pin1_4	218	223	PF00397	0.672
DOC_WW_Pin1_4	264	269	PF00397	0.731
DOC_WW_Pin1_4	280	285	PF00397	0.775
DOC_WW_Pin1_4	297	302	PF00397	0.802
DOC_WW_Pin1_4	316	321	PF00397	0.665
LIG_14-3-3_CanoR_1	11	19	PF00244	0.745
LIG_14-3-3_CanoR_1	273	281	PF00244	0.811
LIG_BIR_III_2	15	19	PF00653	0.450
LIG_eIF4E_1	207	213	PF01652	0.684
LIG_FHA_1	195	201	PF00498	0.638
LIG_FHA_1	225	231	PF00498	0.569
LIG_FHA_1	276	282	PF00498	0.652
LIG_FHA_1	72	78	PF00498	0.459
LIG_FHA_1	91	97	PF00498	0.349
LIG_FHA_2	10	16	PF00498	0.674
LIG_FHA_2	131	137	PF00498	0.533
LIG_FHA_2	166	172	PF00498	0.476
LIG_Integrin_RGD_1	258	260	PF01839	0.725
LIG_LIR_Gen_1	146	157	PF02991	0.515
LIG_LIR_Nem_3	146	152	PF02991	0.514
LIG_NRBOX	127	133	PF00104	0.567
LIG_SH2_CRK	214	218	PF00017	0.672
LIG_SH2_SRC	207	210	PF00017	0.634
LIG_SH2_SRC	59	62	PF00017	0.623
LIG_SH2_STAP1	59	63	PF00017	0.521
LIG_SH3_1	216	222	PF00018	0.657
LIG_SH3_2	206	211	PF14604	0.768
LIG_SH3_3	203	209	PF00018	0.652
LIG_SH3_3	216	222	PF00018	0.654
LIG_SH3_3	262	268	PF00018	0.834
LIG_SH3_3	278	284	PF00018	0.584
LIG_SH3_3	314	320	PF00018	0.660
LIG_SH3_3	43	49	PF00018	0.532
LIG_Sin3_3	53	60	PF02671	0.629
LIG_SUMO_SIM_par_1	17	23	PF11976	0.530
LIG_SUMO_SIM_par_1	42	48	PF11976	0.531
LIG_TRAF2_1	119	122	PF00917	0.473
LIG_TRAF2_1	133	136	PF00917	0.472
LIG_TRAF2_1	168	171	PF00917	0.619
LIG_TRAF2_1	20	23	PF00917	0.686
LIG_TRAF2_1	99	102	PF00917	0.559
LIG_TYR_ITIM	212	217	PF00017	0.693
LIG_UBA3_1	326	334	PF00899	0.629
MOD_CDK_SPxK_1	297	303	PF00069	0.723
MOD_CDK_SPxxK_3	266	273	PF00069	0.741
MOD_CDK_SPxxK_3	316	323	PF00069	0.749
MOD_CK1_1	112	118	PF00069	0.654
MOD_CK1_1	14	20	PF00069	0.563
MOD_CK1_1	269	275	PF00069	0.839
MOD_CK1_1	304	310	PF00069	0.553
MOD_CK1_1	47	53	PF00069	0.393
MOD_CK2_1	130	136	PF00069	0.534
MOD_CK2_1	165	171	PF00069	0.556
MOD_CK2_1	241	247	PF00069	0.662
MOD_CK2_1	26	32	PF00069	0.482
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.711
MOD_GlcNHglycan	181	184	PF01048	0.621
MOD_GlcNHglycan	307	310	PF01048	0.788
MOD_GlcNHglycan	343	346	PF01048	0.502
MOD_GlcNHglycan	48	52	PF01048	0.463
MOD_GSK3_1	109	116	PF00069	0.609
MOD_GSK3_1	269	276	PF00069	0.712
MOD_GSK3_1	297	304	PF00069	0.744
MOD_GSK3_1	339	346	PF00069	0.627
MOD_GSK3_1	86	93	PF00069	0.402
MOD_N-GLC_1	289	294	PF02516	0.749
MOD_N-GLC_1	305	310	PF02516	0.830
MOD_NEK2_1	2	7	PF00069	0.618
MOD_NEK2_1	66	71	PF00069	0.634
MOD_PIKK_1	131	137	PF00454	0.649
MOD_PK_1	241	247	PF00069	0.616
MOD_PKA_2	113	119	PF00069	0.607
MOD_PKA_2	302	308	PF00069	0.736
MOD_Plk_1	143	149	PF00069	0.630
MOD_Plk_1	289	295	PF00069	0.747
MOD_Plk_4	226	232	PF00069	0.611
MOD_Plk_4	59	65	PF00069	0.545
MOD_ProDKin_1	14	20	PF00069	0.444
MOD_ProDKin_1	186	192	PF00069	0.735
MOD_ProDKin_1	195	201	PF00069	0.765
MOD_ProDKin_1	218	224	PF00069	0.666
MOD_ProDKin_1	264	270	PF00069	0.727
MOD_ProDKin_1	280	286	PF00069	0.773
MOD_ProDKin_1	297	303	PF00069	0.803
MOD_ProDKin_1	316	322	PF00069	0.655
MOD_SUMO_for_1	310	313	PF00179	0.536
MOD_SUMO_rev_2	331	336	PF00179	0.606
TRG_DiLeu_BaEn_1	123	128	PF01217	0.562
TRG_DiLeu_BaEn_4	136	142	PF01217	0.521
TRG_DiLeu_BaEn_4	331	337	PF01217	0.610
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.683
TRG_DiLeu_LyEn_5	123	128	PF01217	0.562
TRG_ENDOCYTIC_2	214	217	PF00928	0.674
TRG_ER_diArg_1	125	127	PF00400	0.643
TRG_ER_diArg_1	214	216	PF00400	0.678
TRG_ER_diArg_1	255	258	PF00400	0.730
TRG_ER_diArg_1	322	325	PF00400	0.682
TRG_ER_diArg_1	336	338	PF00400	0.567
TRG_ER_diArg_1	52	55	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB32	Leptomonas seymouri	48%	96%
A0A3S5H577	Leishmania donovani	88%	100%
A4H3T2	Leishmania braziliensis	70%	100%
A4HS07	Leishmania infantum	88%	100%
Q9GRM8	Leishmania major	88%	100%