Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJZ4_LEIMU

TriTrypDb:

LmxM.04.0100

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AJZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.291
CLV_C14_Caspase3-7	279	283	PF00656	0.493
CLV_C14_Caspase3-7	518	522	PF00656	0.780
CLV_NRD_NRD_1	12	14	PF00675	0.478
CLV_NRD_NRD_1	20	22	PF00675	0.318
CLV_NRD_NRD_1	50	52	PF00675	0.694
CLV_NRD_NRD_1	547	549	PF00675	0.561
CLV_NRD_NRD_1	570	572	PF00675	0.587
CLV_NRD_NRD_1	582	584	PF00675	0.548
CLV_PCSK_FUR_1	568	572	PF00082	0.549
CLV_PCSK_KEX2_1	102	104	PF00082	0.531
CLV_PCSK_KEX2_1	11	13	PF00082	0.490
CLV_PCSK_KEX2_1	19	21	PF00082	0.433
CLV_PCSK_KEX2_1	312	314	PF00082	0.647
CLV_PCSK_KEX2_1	49	51	PF00082	0.692
CLV_PCSK_KEX2_1	549	551	PF00082	0.534
CLV_PCSK_KEX2_1	570	572	PF00082	0.592
CLV_PCSK_KEX2_1	582	584	PF00082	0.562
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.531
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.647
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.536
CLV_PCSK_SKI1_1	124	128	PF00082	0.501
CLV_PCSK_SKI1_1	20	24	PF00082	0.325
CLV_PCSK_SKI1_1	396	400	PF00082	0.685
DEG_Nend_UBRbox_2	1	3	PF02207	0.706
DEG_SPOP_SBC_1	515	519	PF00917	0.743
DOC_CYCLIN_RxL_1	393	403	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.557
DOC_MAPK_gen_1	19	25	PF00069	0.524
DOC_MAPK_MEF2A_6	122	129	PF00069	0.316
DOC_MAPK_NFAT4_5	122	130	PF00069	0.315
DOC_PP1_RVXF_1	345	351	PF00149	0.239
DOC_PP2B_LxvP_1	54	57	PF13499	0.416
DOC_USP7_MATH_1	140	144	PF00917	0.462
DOC_USP7_MATH_1	245	249	PF00917	0.452
DOC_USP7_MATH_1	263	267	PF00917	0.400
DOC_USP7_MATH_1	299	303	PF00917	0.435
DOC_USP7_MATH_1	404	408	PF00917	0.441
DOC_USP7_MATH_1	489	493	PF00917	0.788
DOC_USP7_MATH_1	520	524	PF00917	0.786
DOC_USP7_MATH_2	536	542	PF00917	0.783
DOC_WW_Pin1_4	422	427	PF00397	0.577
DOC_WW_Pin1_4	504	509	PF00397	0.697
DOC_WW_Pin1_4	542	547	PF00397	0.786
DOC_WW_Pin1_4	67	72	PF00397	0.545
DOC_WW_Pin1_4	95	100	PF00397	0.427
LIG_14-3-3_CanoR_1	213	221	PF00244	0.450
LIG_14-3-3_CanoR_1	276	285	PF00244	0.488
LIG_14-3-3_CanoR_1	371	377	PF00244	0.564
LIG_14-3-3_CanoR_1	431	436	PF00244	0.605
LIG_Actin_WH2_2	260	278	PF00022	0.413
LIG_CSL_BTD_1	498	501	PF09270	0.708
LIG_FHA_1	29	35	PF00498	0.425
LIG_FHA_1	319	325	PF00498	0.426
LIG_FHA_1	390	396	PF00498	0.311
LIG_FHA_2	401	407	PF00498	0.375
LIG_FHA_2	423	429	PF00498	0.607
LIG_FHA_2	516	522	PF00498	0.776
LIG_FHA_2	58	64	PF00498	0.412
LIG_LIR_Gen_1	171	182	PF02991	0.370
LIG_LIR_Gen_1	402	413	PF02991	0.354
LIG_LIR_Nem_3	171	177	PF02991	0.328
LIG_LIR_Nem_3	309	314	PF02991	0.372
LIG_LIR_Nem_3	402	408	PF02991	0.354
LIG_LIR_Nem_3	418	422	PF02991	0.401
LIG_MYND_1	71	75	PF01753	0.555
LIG_NRBOX	333	339	PF00104	0.526
LIG_SH2_STAP1	174	178	PF00017	0.365
LIG_SH2_STAT3	468	471	PF00017	0.732
LIG_SH2_STAT5	190	193	PF00017	0.357
LIG_SH2_STAT5	419	422	PF00017	0.332
LIG_SH2_STAT5	424	427	PF00017	0.570
LIG_SH2_STAT5	468	471	PF00017	0.664
LIG_SH2_STAT5	47	50	PF00017	0.473
LIG_SH3_3	380	386	PF00018	0.266
LIG_SH3_3	464	470	PF00018	0.696
LIG_SH3_3	502	508	PF00018	0.681
LIG_SH3_3	530	536	PF00018	0.768
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.463
LIG_TRAF2_1	436	439	PF00917	0.598
LIG_WW_3	342	346	PF00397	0.298
MOD_CDK_SPK_2	504	509	PF00069	0.727
MOD_CDK_SPK_2	67	72	PF00069	0.440
MOD_CDK_SPxK_1	542	548	PF00069	0.788
MOD_CDK_SPxxK_3	542	549	PF00069	0.789
MOD_CDK_SPxxK_3	95	102	PF00069	0.418
MOD_CK1_1	149	155	PF00069	0.483
MOD_CK1_1	278	284	PF00069	0.460
MOD_CK1_1	307	313	PF00069	0.470
MOD_CK1_1	523	529	PF00069	0.753
MOD_CK1_1	541	547	PF00069	0.742
MOD_CK1_1	7	13	PF00069	0.722
MOD_CK2_1	221	227	PF00069	0.366
MOD_CK2_1	400	406	PF00069	0.455
MOD_GlcNHglycan	148	151	PF01048	0.702
MOD_GlcNHglycan	156	160	PF01048	0.560
MOD_GlcNHglycan	171	174	PF01048	0.609
MOD_GlcNHglycan	223	226	PF01048	0.588
MOD_GlcNHglycan	485	488	PF01048	0.453
MOD_GlcNHglycan	540	543	PF01048	0.596
MOD_GSK3_1	128	135	PF00069	0.448
MOD_GSK3_1	212	219	PF00069	0.457
MOD_GSK3_1	274	281	PF00069	0.444
MOD_GSK3_1	400	407	PF00069	0.443
MOD_GSK3_1	422	429	PF00069	0.624
MOD_GSK3_1	500	507	PF00069	0.695
MOD_GSK3_1	516	523	PF00069	0.727
MOD_GSK3_1	525	532	PF00069	0.679
MOD_GSK3_1	537	544	PF00069	0.752
MOD_GSK3_1	566	573	PF00069	0.748
MOD_GSK3_1	574	581	PF00069	0.750
MOD_NEK2_1	169	174	PF00069	0.373
MOD_NEK2_1	211	216	PF00069	0.398
MOD_NEK2_1	221	226	PF00069	0.350
MOD_NEK2_1	232	237	PF00069	0.383
MOD_NEK2_1	275	280	PF00069	0.440
MOD_NEK2_1	359	364	PF00069	0.323
MOD_NEK2_1	400	405	PF00069	0.368
MOD_NEK2_1	408	413	PF00069	0.331
MOD_NEK2_1	460	465	PF00069	0.665
MOD_NEK2_1	483	488	PF00069	0.654
MOD_NEK2_2	426	431	PF00069	0.592
MOD_NEK2_2	574	579	PF00069	0.743
MOD_OFUCOSY	356	363	PF10250	0.377
MOD_PIKK_1	149	155	PF00454	0.450
MOD_PIKK_1	232	238	PF00454	0.467
MOD_PIKK_1	304	310	PF00454	0.441
MOD_PKA_1	548	554	PF00069	0.618
MOD_PKA_1	570	576	PF00069	0.744
MOD_PKA_2	212	218	PF00069	0.448
MOD_PKA_2	275	281	PF00069	0.479
MOD_PKA_2	569	575	PF00069	0.747
MOD_PKA_2	578	584	PF00069	0.761
MOD_PKB_1	568	576	PF00069	0.771
MOD_Plk_1	117	123	PF00069	0.417
MOD_Plk_1	489	495	PF00069	0.718
MOD_Plk_4	245	251	PF00069	0.495
MOD_Plk_4	372	378	PF00069	0.510
MOD_Plk_4	460	466	PF00069	0.593
MOD_Plk_4	500	506	PF00069	0.716
MOD_ProDKin_1	422	428	PF00069	0.580
MOD_ProDKin_1	504	510	PF00069	0.699
MOD_ProDKin_1	542	548	PF00069	0.788
MOD_ProDKin_1	67	73	PF00069	0.544
MOD_ProDKin_1	95	101	PF00069	0.421
TRG_DiLeu_BaEn_1	227	232	PF01217	0.420
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.383
TRG_ENDOCYTIC_2	174	177	PF00928	0.365
TRG_ER_diArg_1	11	13	PF00400	0.565
TRG_ER_diArg_1	121	124	PF00400	0.319
TRG_ER_diArg_1	18	21	PF00400	0.638
TRG_ER_diArg_1	340	343	PF00400	0.509
TRG_ER_diArg_1	344	347	PF00400	0.435
TRG_ER_diArg_1	48	51	PF00400	0.489
TRG_ER_diArg_1	550	553	PF00400	0.740
TRG_ER_diArg_1	568	571	PF00400	0.778
TRG_NLS_MonoExtC_3	547	552	PF00514	0.740
TRG_NLS_MonoExtN_4	546	553	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X8	Leptomonas seymouri	46%	94%
A0A451EJV6	Leishmania donovani	90%	100%
A4H3T1	Leishmania braziliensis	77%	99%
A4HS06	Leishmania infantum	90%	100%
Q9N858	Leishmania major	91%	99%
V5B969	Trypanosoma cruzi	30%	100%