Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJZ1_LEIMU

TriTrypDb:

LmxM.04.0070

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJZ1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.479
CLV_PCSK_KEX2_1	17	19	PF00082	0.451
DEG_Nend_UBRbox_2	1	3	PF02207	0.330
DOC_CYCLIN_RxL_1	58	67	PF00134	0.365
DOC_MAPK_gen_1	186	194	PF00069	0.355
DOC_MAPK_MEF2A_6	186	194	PF00069	0.355
DOC_WW_Pin1_4	236	241	PF00397	0.495
LIG_14-3-3_CanoR_1	17	25	PF00244	0.451
LIG_14-3-3_CanoR_1	232	237	PF00244	0.402
LIG_14-3-3_CanoR_1	77	81	PF00244	0.454
LIG_APCC_ABBA_1	139	144	PF00400	0.418
LIG_FHA_1	193	199	PF00498	0.349
LIG_FHA_1	233	239	PF00498	0.462
LIG_FHA_1	57	63	PF00498	0.439
LIG_FHA_2	18	24	PF00498	0.469
LIG_LIR_Apic_2	195	199	PF02991	0.336
LIG_LIR_Gen_1	197	205	PF02991	0.498
LIG_LIR_Gen_1	22	33	PF02991	0.381
LIG_LIR_Gen_1	99	109	PF02991	0.474
LIG_LIR_Nem_3	185	191	PF02991	0.435
LIG_LIR_Nem_3	197	203	PF02991	0.293
LIG_LIR_Nem_3	219	225	PF02991	0.420
LIG_LIR_Nem_3	22	28	PF02991	0.384
LIG_LIR_Nem_3	228	234	PF02991	0.309
LIG_LIR_Nem_3	89	95	PF02991	0.500
LIG_LIR_Nem_3	99	104	PF02991	0.368
LIG_Pex14_1	15	19	PF04695	0.389
LIG_Pex14_1	196	200	PF04695	0.371
LIG_Pex14_2	139	143	PF04695	0.497
LIG_SH2_CRK	101	105	PF00017	0.339
LIG_SH2_CRK	222	226	PF00017	0.403
LIG_SH2_CRK	92	96	PF00017	0.449
LIG_SH2_NCK_1	101	105	PF00017	0.193
LIG_SH2_STAP1	101	105	PF00017	0.430
LIG_SH2_STAP1	234	238	PF00017	0.459
LIG_SH2_STAP1	80	84	PF00017	0.504
LIG_SH2_STAT3	47	50	PF00017	0.494
LIG_SH2_STAT3	9	12	PF00017	0.448
LIG_SH2_STAT5	19	22	PF00017	0.467
LIG_SH2_STAT5	200	203	PF00017	0.404
LIG_SH2_STAT5	205	208	PF00017	0.366
LIG_SH2_STAT5	234	237	PF00017	0.376
LIG_SH3_1	112	118	PF00018	0.368
LIG_SH3_3	112	118	PF00018	0.486
LIG_SH3_3	235	241	PF00018	0.498
LIG_TRAF2_1	20	23	PF00917	0.426
LIG_TYR_ITIM	198	203	PF00017	0.365
LIG_TYR_ITIM	220	225	PF00017	0.381
LIG_TYR_ITSM	97	104	PF00017	0.476
MOD_CK2_1	17	23	PF00069	0.431
MOD_GlcNHglycan	100	104	PF01048	0.462
MOD_GSK3_1	232	239	PF00069	0.469
MOD_GSK3_1	52	59	PF00069	0.371
MOD_NEK2_1	203	208	PF00069	0.391
MOD_NEK2_1	56	61	PF00069	0.502
MOD_PKA_1	17	23	PF00069	0.472
MOD_PKA_2	17	23	PF00069	0.427
MOD_PKA_2	76	82	PF00069	0.371
MOD_Plk_1	130	136	PF00069	0.429
MOD_Plk_1	218	224	PF00069	0.473
MOD_Plk_1	99	105	PF00069	0.419
MOD_Plk_2-3	148	154	PF00069	0.333
MOD_Plk_4	27	33	PF00069	0.441
MOD_Plk_4	67	73	PF00069	0.180
MOD_ProDKin_1	236	242	PF00069	0.507
MOD_SUMO_rev_2	75	85	PF00179	0.519
TRG_ENDOCYTIC_2	101	104	PF00928	0.344
TRG_ENDOCYTIC_2	188	191	PF00928	0.334
TRG_ENDOCYTIC_2	200	203	PF00928	0.290
TRG_ENDOCYTIC_2	222	225	PF00928	0.374
TRG_ENDOCYTIC_2	25	28	PF00928	0.394
TRG_ENDOCYTIC_2	92	95	PF00928	0.455
TRG_ER_diArg_1	17	19	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY0	Leptomonas seymouri	67%	99%
A0A0S4IH71	Bodo saltans	40%	92%
A0A0S4IJP7	Bodo saltans	28%	100%
A0A0S4J8X8	Bodo saltans	40%	100%
A0A1X0NMV1	Trypanosomatidae	49%	100%
A0A3S5H574	Leishmania donovani	89%	100%
A0A422NN81	Trypanosoma rangeli	44%	100%
A4H3S8	Leishmania braziliensis	85%	100%
A4HS03	Leishmania infantum	88%	100%
C9ZY01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
P0DPD7	Homo sapiens	30%	96%
Q95Z88	Leishmania major	91%	100%
V5BI94	Trypanosoma cruzi	48%	100%