Cilia- and flagella-associated protein 45

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJY9_LEIMU

TriTrypDb:

LmxM.04.0050

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.687
CLV_NRD_NRD_1	228	230	PF00675	0.522
CLV_NRD_NRD_1	257	259	PF00675	0.594
CLV_NRD_NRD_1	306	308	PF00675	0.582
CLV_NRD_NRD_1	395	397	PF00675	0.391
CLV_NRD_NRD_1	457	459	PF00675	0.543
CLV_NRD_NRD_1	500	502	PF00675	0.635
CLV_PCSK_KEX2_1	226	228	PF00082	0.540
CLV_PCSK_KEX2_1	257	259	PF00082	0.594
CLV_PCSK_KEX2_1	306	308	PF00082	0.582
CLV_PCSK_KEX2_1	395	397	PF00082	0.391
CLV_PCSK_KEX2_1	445	447	PF00082	0.569
CLV_PCSK_KEX2_1	457	459	PF00082	0.454
CLV_PCSK_KEX2_1	500	502	PF00082	0.635
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.540
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.635
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.539
CLV_PCSK_SKI1_1	376	380	PF00082	0.602
CLV_Separin_Metazoa	198	202	PF03568	0.348
CLV_Separin_Metazoa	418	422	PF03568	0.400
DEG_APCC_DBOX_1	420	428	PF00400	0.491
DEG_Kelch_Keap1_1	95	100	PF01344	0.543
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DOC_CKS1_1	180	185	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.515
DOC_MAPK_gen_1	157	167	PF00069	0.624
DOC_MAPK_gen_1	421	429	PF00069	0.578
DOC_MAPK_MEF2A_6	436	443	PF00069	0.393
DOC_MAPK_NFAT4_5	436	444	PF00069	0.393
DOC_PP2B_LxvP_1	247	250	PF13499	0.428
DOC_PP4_FxxP_1	207	210	PF00568	0.368
DOC_USP7_MATH_1	210	214	PF00917	0.515
DOC_USP7_MATH_1	477	481	PF00917	0.499
DOC_USP7_MATH_1	518	522	PF00917	0.625
DOC_USP7_MATH_1	89	93	PF00917	0.667
DOC_USP7_UBL2_3	131	135	PF12436	0.664
DOC_USP7_UBL2_3	141	145	PF12436	0.581
DOC_USP7_UBL2_3	160	164	PF12436	0.575
DOC_USP7_UBL2_3	204	208	PF12436	0.372
DOC_USP7_UBL2_3	236	240	PF12436	0.591
DOC_WW_Pin1_4	14	19	PF00397	0.692
DOC_WW_Pin1_4	179	184	PF00397	0.549
DOC_WW_Pin1_4	263	268	PF00397	0.529
DOC_WW_Pin1_4	319	324	PF00397	0.604
DOC_WW_Pin1_4	339	344	PF00397	0.695
LIG_14-3-3_CanoR_1	220	225	PF00244	0.526
LIG_14-3-3_CanoR_1	306	311	PF00244	0.638
LIG_14-3-3_CanoR_1	345	349	PF00244	0.780
LIG_14-3-3_CanoR_1	376	385	PF00244	0.530
LIG_14-3-3_CanoR_1	500	507	PF00244	0.606
LIG_APCC_ABBAyCdc20_2	410	416	PF00400	0.490
LIG_Clathr_ClatBox_1	412	416	PF01394	0.536
LIG_FHA_1	160	166	PF00498	0.433
LIG_FHA_1	486	492	PF00498	0.444
LIG_FHA_2	310	316	PF00498	0.480
LIG_FHA_2	377	383	PF00498	0.531
LIG_IBAR_NPY_1	484	486	PF08397	0.626
LIG_LIR_Gen_1	483	494	PF02991	0.603
LIG_LIR_Nem_3	218	224	PF02991	0.538
LIG_LIR_Nem_3	483	489	PF02991	0.596
LIG_SH2_CRK	486	490	PF00017	0.570
LIG_SH2_STAP1	368	372	PF00017	0.527
LIG_SH2_STAP1	486	490	PF00017	0.570
LIG_SH2_STAT3	202	205	PF00017	0.383
LIG_SH2_STAT5	328	331	PF00017	0.569
LIG_SH3_2	153	158	PF14604	0.665
LIG_SH3_3	147	153	PF00018	0.666
LIG_SH3_3	171	177	PF00018	0.600
LIG_SH3_3	250	256	PF00018	0.590
LIG_SH3_3	264	270	PF00018	0.531
LIG_SH3_3	277	283	PF00018	0.511
LIG_SH3_3	32	38	PF00018	0.631
LIG_SH3_3	355	361	PF00018	0.674
LIG_SH3_3	479	485	PF00018	0.503
LIG_SH3_4	160	167	PF00018	0.554
LIG_SH3_4	236	243	PF00018	0.486
LIG_SUMO_SIM_par_1	248	254	PF11976	0.469
LIG_SUMO_SIM_par_1	381	388	PF11976	0.547
LIG_TRAF2_1	262	265	PF00917	0.711
LIG_TRAF2_1	83	86	PF00917	0.692
LIG_WW_3	322	326	PF00397	0.609
MOD_CDC14_SPxK_1	322	325	PF00782	0.612
MOD_CDC14_SPxK_1	342	345	PF00782	0.546
MOD_CDK_SPK_2	179	184	PF00069	0.549
MOD_CDK_SPxK_1	263	269	PF00069	0.530
MOD_CDK_SPxK_1	319	325	PF00069	0.608
MOD_CDK_SPxK_1	339	345	PF00069	0.699
MOD_CK1_1	333	339	PF00069	0.670
MOD_CK1_1	347	353	PF00069	0.569
MOD_CK1_1	39	45	PF00069	0.654
MOD_CK1_1	480	486	PF00069	0.480
MOD_CK1_1	495	501	PF00069	0.655
MOD_CK1_1	505	511	PF00069	0.589
MOD_CK2_1	23	29	PF00069	0.573
MOD_CK2_1	3	9	PF00069	0.637
MOD_CK2_1	368	374	PF00069	0.539
MOD_CK2_1	376	382	PF00069	0.498
MOD_CK2_1	39	45	PF00069	0.679
MOD_CK2_1	469	475	PF00069	0.508
MOD_CK2_1	505	511	PF00069	0.569
MOD_CK2_1	518	524	PF00069	0.673
MOD_CK2_1	80	86	PF00069	0.701
MOD_GlcNHglycan	115	119	PF01048	0.516
MOD_GlcNHglycan	253	256	PF01048	0.604
MOD_GlcNHglycan	338	341	PF01048	0.605
MOD_GlcNHglycan	350	353	PF01048	0.648
MOD_GlcNHglycan	362	365	PF01048	0.611
MOD_GlcNHglycan	368	371	PF01048	0.487
MOD_GlcNHglycan	494	497	PF01048	0.604
MOD_GlcNHglycan	513	516	PF01048	0.525
MOD_GlcNHglycan	97	100	PF01048	0.580
MOD_GSK3_1	190	197	PF00069	0.365
MOD_GSK3_1	309	316	PF00069	0.659
MOD_GSK3_1	344	351	PF00069	0.714
MOD_GSK3_1	36	43	PF00069	0.656
MOD_GSK3_1	368	375	PF00069	0.534
MOD_GSK3_1	492	499	PF00069	0.743
MOD_GSK3_1	501	508	PF00069	0.668
MOD_GSK3_1	513	520	PF00069	0.566
MOD_GSK3_1	67	74	PF00069	0.708
MOD_LATS_1	444	450	PF00433	0.392
MOD_N-GLC_1	120	125	PF02516	0.535
MOD_N-GLC_1	14	19	PF02516	0.668
MOD_N-GLC_1	348	353	PF02516	0.665
MOD_N-GLC_1	446	451	PF02516	0.391
MOD_NEK2_1	348	353	PF00069	0.733
MOD_NEK2_1	469	474	PF00069	0.374
MOD_NEK2_2	330	335	PF00069	0.617
MOD_PIKK_1	108	114	PF00454	0.546
MOD_PIKK_1	376	382	PF00454	0.478
MOD_PIKK_1	396	402	PF00454	0.547
MOD_PIKK_1	505	511	PF00454	0.672
MOD_PIKK_1	513	519	PF00454	0.627
MOD_PK_1	190	196	PF00069	0.365
MOD_PKA_1	134	140	PF00069	0.660
MOD_PKA_1	159	165	PF00069	0.450
MOD_PKA_1	306	312	PF00069	0.606
MOD_PKA_1	500	506	PF00069	0.629
MOD_PKA_2	306	312	PF00069	0.609
MOD_PKA_2	344	350	PF00069	0.834
MOD_PKA_2	354	360	PF00069	0.645
MOD_PKA_2	499	505	PF00069	0.623
MOD_Plk_1	190	196	PF00069	0.384
MOD_Plk_1	23	29	PF00069	0.540
MOD_Plk_1	469	475	PF00069	0.375
MOD_Plk_1	58	64	PF00069	0.537
MOD_Plk_2-3	24	30	PF00069	0.677
MOD_Plk_2-3	41	47	PF00069	0.524
MOD_Plk_2-3	80	86	PF00069	0.614
MOD_Plk_4	368	374	PF00069	0.485
MOD_Plk_4	485	491	PF00069	0.574
MOD_Plk_4	89	95	PF00069	0.543
MOD_ProDKin_1	14	20	PF00069	0.694
MOD_ProDKin_1	179	185	PF00069	0.544
MOD_ProDKin_1	263	269	PF00069	0.530
MOD_ProDKin_1	319	325	PF00069	0.608
MOD_ProDKin_1	339	345	PF00069	0.699
TRG_DiLeu_BaEn_1	408	413	PF01217	0.539
TRG_ENDOCYTIC_2	239	242	PF00928	0.358
TRG_ENDOCYTIC_2	486	489	PF00928	0.618
TRG_ER_diArg_1	227	229	PF00400	0.375
TRG_ER_diArg_1	395	397	PF00400	0.391
TRG_NES_CRM1_1	418	430	PF08389	0.491
TRG_NLS_MonoCore_2	156	161	PF00514	0.683
TRG_NLS_MonoExtC_3	156	161	PF00514	0.635
TRG_NLS_MonoExtN_4	131	137	PF00514	0.661
TRG_NLS_MonoExtN_4	156	162	PF00514	0.676
TRG_NLS_MonoExtN_4	256	261	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H573	Leishmania donovani	83%	99%
A4H3S6	Leishmania braziliensis	54%	100%
A4HS01	Leishmania infantum	83%	99%
Q95Z90	Leishmania major	78%	98%