C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJY7_LEIMU

TriTrypDb:

LmxM.04.0040

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.639
CLV_PCSK_SKI1_1	320	324	PF00082	0.513
CLV_PCSK_SKI1_1	392	396	PF00082	0.527
CLV_PCSK_SKI1_1	417	421	PF00082	0.653
CLV_PCSK_SKI1_1	57	61	PF00082	0.482
DEG_SCF_FBW7_1	427	434	PF00400	0.529
DEG_SPOP_SBC_1	120	124	PF00917	0.806
DEG_SPOP_SBC_1	172	176	PF00917	0.627
DOC_CKS1_1	428	433	PF01111	0.620
DOC_MAPK_gen_1	126	135	PF00069	0.772
DOC_MAPK_gen_1	178	186	PF00069	0.553
DOC_MAPK_gen_1	308	318	PF00069	0.580
DOC_MAPK_gen_1	362	372	PF00069	0.642
DOC_MAPK_MEF2A_6	263	271	PF00069	0.525
DOC_MAPK_MEF2A_6	401	410	PF00069	0.340
DOC_USP7_MATH_1	120	124	PF00917	0.806
DOC_USP7_MATH_1	179	183	PF00917	0.573
DOC_USP7_MATH_1	240	244	PF00917	0.637
DOC_USP7_MATH_1	397	401	PF00917	0.595
DOC_USP7_MATH_1	68	72	PF00917	0.669
DOC_USP7_UBL2_3	341	345	PF12436	0.538
DOC_USP7_UBL2_3	401	405	PF12436	0.551
DOC_WW_Pin1_4	109	114	PF00397	0.793
DOC_WW_Pin1_4	419	424	PF00397	0.588
DOC_WW_Pin1_4	427	432	PF00397	0.541
DOC_WW_Pin1_4	57	62	PF00397	0.762
DOC_WW_Pin1_4	84	89	PF00397	0.794
LIG_14-3-3_CanoR_1	178	187	PF00244	0.550
LIG_14-3-3_CanoR_1	214	220	PF00244	0.556
LIG_14-3-3_CanoR_1	362	372	PF00244	0.471
LIG_14-3-3_CanoR_1	417	422	PF00244	0.604
LIG_Actin_WH2_2	347	364	PF00022	0.551
LIG_APCC_ABBAyCdc20_2	126	132	PF00400	0.492
LIG_FHA_1	110	116	PF00498	0.698
LIG_FHA_1	160	166	PF00498	0.566
LIG_FHA_1	275	281	PF00498	0.511
LIG_FHA_1	321	327	PF00498	0.588
LIG_FHA_1	329	335	PF00498	0.617
LIG_FHA_1	414	420	PF00498	0.659
LIG_FHA_2	335	341	PF00498	0.621
LIG_LIR_Nem_3	28	34	PF02991	0.596
LIG_LIR_Nem_3	349	354	PF02991	0.585
LIG_NRBOX	424	430	PF00104	0.599
LIG_PTB_Apo_2	223	230	PF02174	0.534
LIG_PTB_Phospho_1	223	229	PF10480	0.538
LIG_SH2_GRB2like	168	171	PF00017	0.614
LIG_SH2_SRC	14	17	PF00017	0.698
LIG_SH2_STAP1	168	172	PF00017	0.613
LIG_SH2_STAP1	229	233	PF00017	0.525
LIG_SH2_STAP1	247	251	PF00017	0.463
LIG_SH2_STAP1	27	31	PF00017	0.660
LIG_SH2_STAT3	209	212	PF00017	0.516
LIG_SH2_STAT3	228	231	PF00017	0.523
LIG_SH2_STAT5	14	17	PF00017	0.698
LIG_SH2_STAT5	209	212	PF00017	0.516
LIG_SH2_STAT5	265	268	PF00017	0.523
LIG_SH2_STAT5	290	293	PF00017	0.556
LIG_SH2_STAT5	363	366	PF00017	0.523
LIG_SH2_STAT5	63	66	PF00017	0.726
LIG_SH3_3	17	23	PF00018	0.597
LIG_SH3_3	5	11	PF00018	0.715
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.520
LIG_SUMO_SIM_anti_2	330	337	PF11976	0.656
LIG_SUMO_SIM_par_1	265	270	PF11976	0.616
LIG_SUMO_SIM_par_1	424	430	PF11976	0.577
LIG_TRAF2_1	337	340	PF00917	0.703
LIG_UBA3_1	425	432	PF00899	0.713
MOD_CDK_SPK_2	419	424	PF00069	0.655
MOD_CDK_SPK_2	427	432	PF00069	0.573
MOD_CDK_SPK_2	84	89	PF00069	0.794
MOD_CDK_SPxxK_3	84	91	PF00069	0.798
MOD_CK1_1	105	111	PF00069	0.691
MOD_CK1_1	114	120	PF00069	0.706
MOD_CK1_1	174	180	PF00069	0.725
MOD_CK1_1	344	350	PF00069	0.572
MOD_CK1_1	357	363	PF00069	0.480
MOD_CK1_1	413	419	PF00069	0.632
MOD_CK1_1	97	103	PF00069	0.678
MOD_CK2_1	105	111	PF00069	0.691
MOD_CK2_1	334	340	PF00069	0.605
MOD_CK2_1	343	349	PF00069	0.524
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.482
MOD_GlcNHglycan	107	110	PF01048	0.692
MOD_GlcNHglycan	118	121	PF01048	0.714
MOD_GlcNHglycan	17	20	PF01048	0.608
MOD_GlcNHglycan	234	237	PF01048	0.569
MOD_GlcNHglycan	242	245	PF01048	0.580
MOD_GlcNHglycan	346	349	PF01048	0.726
MOD_GlcNHglycan	365	368	PF01048	0.391
MOD_GlcNHglycan	410	413	PF01048	0.554
MOD_GlcNHglycan	70	73	PF01048	0.649
MOD_GlcNHglycan	82	85	PF01048	0.696
MOD_GlcNHglycan	94	97	PF01048	0.697
MOD_GSK3_1	105	112	PF00069	0.772
MOD_GSK3_1	116	123	PF00069	0.764
MOD_GSK3_1	159	166	PF00069	0.566
MOD_GSK3_1	330	337	PF00069	0.549
MOD_GSK3_1	339	346	PF00069	0.638
MOD_GSK3_1	408	415	PF00069	0.587
MOD_GSK3_1	427	434	PF00069	0.576
MOD_GSK3_1	80	87	PF00069	0.731
MOD_N-GLC_1	272	277	PF02516	0.494
MOD_NEK2_1	116	121	PF00069	0.812
MOD_NEK2_1	163	168	PF00069	0.586
MOD_NEK2_1	173	178	PF00069	0.638
MOD_NEK2_1	203	208	PF00069	0.588
MOD_NEK2_1	272	277	PF00069	0.500
MOD_NEK2_1	55	60	PF00069	0.754
MOD_NEK2_1	92	97	PF00069	0.707
MOD_NEK2_2	26	31	PF00069	0.604
MOD_PIKK_1	100	106	PF00454	0.695
MOD_PIKK_1	227	233	PF00454	0.523
MOD_PIKK_1	395	401	PF00454	0.488
MOD_PKA_2	213	219	PF00069	0.551
MOD_Plk_1	267	273	PF00069	0.592
MOD_Plk_1	357	363	PF00069	0.552
MOD_Plk_4	111	117	PF00069	0.799
MOD_Plk_4	26	32	PF00069	0.623
MOD_Plk_4	267	273	PF00069	0.614
MOD_Plk_4	330	336	PF00069	0.654
MOD_Plk_4	368	374	PF00069	0.531
MOD_Plk_4	4	10	PF00069	0.656
MOD_ProDKin_1	109	115	PF00069	0.794
MOD_ProDKin_1	419	425	PF00069	0.587
MOD_ProDKin_1	427	433	PF00069	0.546
MOD_ProDKin_1	57	63	PF00069	0.765
MOD_ProDKin_1	84	90	PF00069	0.795
TRG_DiLeu_BaEn_1	111	116	PF01217	0.720
TRG_DiLeu_BaEn_1	262	267	PF01217	0.645
TRG_ENDOCYTIC_2	27	30	PF00928	0.658
TRG_ENDOCYTIC_2	351	354	PF00928	0.589
TRG_ENDOCYTIC_2	63	66	PF00928	0.639
TRG_NES_CRM1_1	268	281	PF08389	0.515
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X9	Leptomonas seymouri	63%	94%
A0A451EJV0	Leishmania donovani	94%	99%
A4H3S4	Leishmania braziliensis	84%	100%
A4HRZ9	Leishmania infantum	94%	99%
Q95Z91	Leishmania major	93%	100%