Putative cAMP-specific phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-specific phosphodiesterase, putative

Species:

Leishmania mexicana

UniProt:

E9AJY5_LEIMU

TriTrypDb:

LmxM.04.0030

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AJY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY5

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	12
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.398
CLV_C14_Caspase3-7	378	382	PF00656	0.461
CLV_C14_Caspase3-7	592	596	PF00656	0.415
CLV_NRD_NRD_1	129	131	PF00675	0.479
CLV_NRD_NRD_1	424	426	PF00675	0.512
CLV_NRD_NRD_1	541	543	PF00675	0.505
CLV_PCSK_KEX2_1	467	469	PF00082	0.706
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.605
CLV_PCSK_SKI1_1	130	134	PF00082	0.393
CLV_PCSK_SKI1_1	248	252	PF00082	0.330
CLV_PCSK_SKI1_1	355	359	PF00082	0.471
CLV_PCSK_SKI1_1	415	419	PF00082	0.471
CLV_PCSK_SKI1_1	519	523	PF00082	0.413
CLV_PCSK_SKI1_1	56	60	PF00082	0.468
CLV_PCSK_SKI1_1	99	103	PF00082	0.304
DEG_APCC_DBOX_1	330	338	PF00400	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.442
DEG_SPOP_SBC_1	37	41	PF00917	0.656
DOC_AGCK_PIF_1	109	114	PF00069	0.321
DOC_CKS1_1	232	237	PF01111	0.297
DOC_CYCLIN_RxL_1	124	134	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.530
DOC_MAPK_gen_1	97	104	PF00069	0.368
DOC_MAPK_MEF2A_6	327	334	PF00069	0.297
DOC_MAPK_MEF2A_6	97	104	PF00069	0.400
DOC_MAPK_NFAT4_5	97	105	PF00069	0.442
DOC_PP1_RVXF_1	122	129	PF00149	0.316
DOC_PP1_RVXF_1	370	376	PF00149	0.422
DOC_PP4_FxxP_1	159	162	PF00568	0.415
DOC_PP4_FxxP_1	232	235	PF00568	0.297
DOC_USP7_MATH_1	188	192	PF00917	0.321
DOC_USP7_MATH_1	201	205	PF00917	0.273
DOC_USP7_MATH_1	259	263	PF00917	0.379
DOC_USP7_MATH_1	295	299	PF00917	0.432
DOC_USP7_MATH_1	300	304	PF00917	0.396
DOC_USP7_MATH_1	435	439	PF00917	0.640
DOC_USP7_MATH_1	495	499	PF00917	0.617
DOC_USP7_MATH_1	514	518	PF00917	0.384
DOC_USP7_MATH_1	579	583	PF00917	0.633
DOC_USP7_MATH_2	235	241	PF00917	0.238
DOC_WW_Pin1_4	231	236	PF00397	0.409
DOC_WW_Pin1_4	433	438	PF00397	0.535
DOC_WW_Pin1_4	46	51	PF00397	0.482
DOC_WW_Pin1_4	487	492	PF00397	0.705
DOC_WW_Pin1_4	625	630	PF00397	0.715
DOC_WW_Pin1_4	643	648	PF00397	0.636
LIG_14-3-3_CanoR_1	130	138	PF00244	0.393
LIG_14-3-3_CanoR_1	278	285	PF00244	0.388
LIG_14-3-3_CanoR_1	331	335	PF00244	0.439
LIG_14-3-3_CanoR_1	494	504	PF00244	0.530
LIG_14-3-3_CanoR_1	99	105	PF00244	0.320
LIG_Actin_WH2_2	400	416	PF00022	0.465
LIG_Actin_WH2_2	55	73	PF00022	0.353
LIG_BRCT_BRCA1_1	155	159	PF00533	0.415
LIG_BRCT_BRCA1_1	297	301	PF00533	0.414
LIG_Clathr_ClatBox_1	195	199	PF01394	0.415
LIG_Clathr_ClatBox_1	599	603	PF01394	0.466
LIG_FHA_1	219	225	PF00498	0.297
LIG_FHA_1	359	365	PF00498	0.314
LIG_FHA_1	402	408	PF00498	0.543
LIG_FHA_1	47	53	PF00498	0.470
LIG_FHA_1	568	574	PF00498	0.464
LIG_FHA_2	232	238	PF00498	0.285
LIG_FHA_2	278	284	PF00498	0.398
LIG_LIR_Apic_2	156	162	PF02991	0.415
LIG_LIR_Gen_1	113	122	PF02991	0.284
LIG_LIR_Gen_1	123	133	PF02991	0.406
LIG_LIR_Gen_1	176	185	PF02991	0.194
LIG_LIR_Gen_1	249	260	PF02991	0.369
LIG_LIR_Gen_1	347	357	PF02991	0.308
LIG_LIR_Gen_1	499	508	PF02991	0.411
LIG_LIR_Gen_1	57	67	PF02991	0.345
LIG_LIR_Gen_1	594	605	PF02991	0.463
LIG_LIR_Gen_1	98	109	PF02991	0.329
LIG_LIR_Nem_3	107	112	PF02991	0.295
LIG_LIR_Nem_3	113	118	PF02991	0.333
LIG_LIR_Nem_3	123	128	PF02991	0.294
LIG_LIR_Nem_3	176	180	PF02991	0.194
LIG_LIR_Nem_3	204	209	PF02991	0.377
LIG_LIR_Nem_3	249	255	PF02991	0.343
LIG_LIR_Nem_3	347	352	PF02991	0.314
LIG_LIR_Nem_3	498	504	PF02991	0.430
LIG_LIR_Nem_3	57	62	PF02991	0.412
LIG_LIR_Nem_3	594	600	PF02991	0.461
LIG_LIR_Nem_3	98	104	PF02991	0.349
LIG_MLH1_MIPbox_1	155	159	PF16413	0.415
LIG_PTB_Apo_2	108	115	PF02174	0.301
LIG_REV1ctd_RIR_1	156	161	PF16727	0.415
LIG_SH2_CRK	252	256	PF00017	0.390
LIG_SH2_GRB2like	142	145	PF00017	0.286
LIG_SH2_GRB2like	349	352	PF00017	0.392
LIG_SH2_PTP2	349	352	PF00017	0.415
LIG_SH2_SRC	349	352	PF00017	0.357
LIG_SH2_STAP1	252	256	PF00017	0.415
LIG_SH2_STAP1	593	597	PF00017	0.233
LIG_SH2_STAT5	349	352	PF00017	0.294
LIG_SH2_STAT5	501	504	PF00017	0.347
LIG_SH2_STAT5	536	539	PF00017	0.351
LIG_SH2_STAT5	593	596	PF00017	0.448
LIG_SH2_STAT5	605	608	PF00017	0.432
LIG_SH2_STAT5	72	75	PF00017	0.387
LIG_SH3_3	182	188	PF00018	0.415
LIG_SH3_3	329	335	PF00018	0.284
LIG_SH3_3	350	356	PF00018	0.373
LIG_SH3_3	627	633	PF00018	0.783
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.213
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.415
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.343
LIG_SUMO_SIM_anti_2	404	411	PF11976	0.499
LIG_SUMO_SIM_par_1	179	184	PF11976	0.349
LIG_SUMO_SIM_par_1	194	199	PF11976	0.405
LIG_SUMO_SIM_par_1	216	222	PF11976	0.425
LIG_TRAF2_1	169	172	PF00917	0.365
LIG_TRFH_1	480	484	PF08558	0.454
LIG_WRC_WIRS_1	501	506	PF05994	0.384
MOD_CDC14_SPxK_1	436	439	PF00782	0.652
MOD_CDC14_SPxK_1	646	649	PF00782	0.668
MOD_CDK_SPK_2	51	56	PF00069	0.441
MOD_CDK_SPxK_1	433	439	PF00069	0.580
MOD_CDK_SPxK_1	643	649	PF00069	0.679
MOD_CDK_SPxxK_3	487	494	PF00069	0.693
MOD_CK1_1	11	17	PF00069	0.673
MOD_CK1_1	113	119	PF00069	0.328
MOD_CK1_1	240	246	PF00069	0.425
MOD_CK1_1	262	268	PF00069	0.398
MOD_CK1_1	382	388	PF00069	0.366
MOD_CK1_1	40	46	PF00069	0.594
MOD_CK1_1	405	411	PF00069	0.468
MOD_CK1_1	452	458	PF00069	0.607
MOD_CK1_1	607	613	PF00069	0.459
MOD_CK1_1	656	662	PF00069	0.732
MOD_CK2_1	166	172	PF00069	0.287
MOD_CK2_1	231	237	PF00069	0.285
MOD_CK2_1	405	411	PF00069	0.399
MOD_CK2_1	51	57	PF00069	0.511
MOD_CK2_1	559	565	PF00069	0.423
MOD_CK2_1	566	572	PF00069	0.436
MOD_CK2_1	89	95	PF00069	0.408
MOD_GlcNHglycan	2	5	PF01048	0.650
MOD_GlcNHglycan	242	245	PF01048	0.335
MOD_GlcNHglycan	267	270	PF01048	0.408
MOD_GlcNHglycan	274	278	PF01048	0.370
MOD_GlcNHglycan	459	462	PF01048	0.762
MOD_GlcNHglycan	463	466	PF01048	0.724
MOD_GlcNHglycan	485	488	PF01048	0.647
MOD_GlcNHglycan	516	519	PF01048	0.521
MOD_GlcNHglycan	609	612	PF01048	0.544
MOD_GSK3_1	100	107	PF00069	0.301
MOD_GSK3_1	110	117	PF00069	0.309
MOD_GSK3_1	273	280	PF00069	0.418
MOD_GSK3_1	36	43	PF00069	0.595
MOD_GSK3_1	379	386	PF00069	0.410
MOD_GSK3_1	401	408	PF00069	0.473
MOD_GSK3_1	415	422	PF00069	0.451
MOD_GSK3_1	433	440	PF00069	0.508
MOD_GSK3_1	449	456	PF00069	0.587
MOD_GSK3_1	457	464	PF00069	0.657
MOD_GSK3_1	483	490	PF00069	0.609
MOD_GSK3_1	8	15	PF00069	0.708
MOD_N-GLC_1	110	115	PF02516	0.283
MOD_N-GLC_1	143	148	PF02516	0.365
MOD_N-GLC_1	433	438	PF02516	0.494
MOD_NEK2_1	100	105	PF00069	0.376
MOD_NEK2_1	114	119	PF00069	0.316
MOD_NEK2_1	138	143	PF00069	0.481
MOD_NEK2_1	218	223	PF00069	0.378
MOD_NEK2_1	230	235	PF00069	0.253
MOD_NEK2_1	379	384	PF00069	0.511
MOD_NEK2_1	38	43	PF00069	0.645
MOD_NEK2_1	403	408	PF00069	0.525
MOD_NEK2_1	453	458	PF00069	0.651
MOD_NEK2_1	559	564	PF00069	0.544
MOD_NEK2_1	8	13	PF00069	0.697
MOD_NEK2_1	81	86	PF00069	0.429
MOD_NEK2_2	110	115	PF00069	0.416
MOD_NEK2_2	201	206	PF00069	0.415
MOD_NEK2_2	66	71	PF00069	0.481
MOD_PIKK_1	300	306	PF00454	0.398
MOD_PIKK_1	437	443	PF00454	0.619
MOD_PKA_1	425	431	PF00069	0.489
MOD_PKA_2	262	268	PF00069	0.331
MOD_PKA_2	277	283	PF00069	0.325
MOD_PKA_2	330	336	PF00069	0.428
MOD_PKA_2	607	613	PF00069	0.290
MOD_PKA_2	8	14	PF00069	0.764
MOD_Plk_1	110	116	PF00069	0.295
MOD_Plk_1	138	144	PF00069	0.401
MOD_Plk_1	395	401	PF00069	0.510
MOD_Plk_2-3	237	243	PF00069	0.238
MOD_Plk_4	104	110	PF00069	0.187
MOD_Plk_4	153	159	PF00069	0.367
MOD_Plk_4	201	207	PF00069	0.385
MOD_Plk_4	213	219	PF00069	0.342
MOD_Plk_4	262	268	PF00069	0.388
MOD_Plk_4	40	46	PF00069	0.583
MOD_Plk_4	405	411	PF00069	0.484
MOD_Plk_4	593	599	PF00069	0.354
MOD_Plk_4	614	620	PF00069	0.451
MOD_Plk_4	89	95	PF00069	0.543
MOD_ProDKin_1	231	237	PF00069	0.409
MOD_ProDKin_1	433	439	PF00069	0.543
MOD_ProDKin_1	46	52	PF00069	0.473
MOD_ProDKin_1	487	493	PF00069	0.702
MOD_ProDKin_1	625	631	PF00069	0.717
MOD_ProDKin_1	643	649	PF00069	0.641
MOD_SUMO_for_1	466	469	PF00179	0.544
MOD_SUMO_rev_2	421	428	PF00179	0.460
TRG_DiLeu_BaEn_1	213	218	PF01217	0.415
TRG_DiLeu_BaEn_1	556	561	PF01217	0.408
TRG_ENDOCYTIC_2	252	255	PF00928	0.390
TRG_ENDOCYTIC_2	349	352	PF00928	0.314
TRG_ENDOCYTIC_2	501	504	PF00928	0.363
TRG_ER_diArg_1	260	263	PF00400	0.286
TRG_ER_diArg_1	662	665	PF00400	0.731
TRG_NES_CRM1_1	171	184	PF08389	0.415
TRG_NES_CRM1_1	520	533	PF08389	0.280
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J8	Leptomonas seymouri	66%	90%
A0A0S4J2W3	Bodo saltans	27%	96%
A0A1X0NMW5	Trypanosomatidae	38%	100%
A0A3R7NEI4	Trypanosoma rangeli	35%	100%
A0A3S5H571	Leishmania donovani	96%	92%
A4HRZ8	Leishmania infantum	96%	92%
C9ZXZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AI20	Leishmania braziliensis	84%	100%
Q95Z92	Leishmania major	94%	100%
V5BDS9	Trypanosoma cruzi	37%	100%