Putative pteridine transporter (Truncated)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated), putative

Species:

Leishmania mexicana

UniProt:

E9AJY4_LEIMU

TriTrypDb:

LmxM.04.0020

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 69
NetGPI	no	yes: 0, no: 69

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	70
GO:0110165	cellular anatomical entity	1	70
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AJY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.320
CLV_NRD_NRD_1	206	208	PF00675	0.325
CLV_PCSK_KEX2_1	100	102	PF00082	0.252
CLV_PCSK_KEX2_1	206	208	PF00082	0.310
CLV_PCSK_KEX2_1	42	44	PF00082	0.302
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.211
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.269
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.302
CLV_PCSK_SKI1_1	25	29	PF00082	0.352
CLV_PCSK_SKI1_1	496	500	PF00082	0.489
CLV_PCSK_SKI1_1	97	101	PF00082	0.211
DEG_Nend_UBRbox_1	1	4	PF02207	0.443
DEG_SCF_TRCP1_1	133	138	PF00400	0.205
DEG_SPOP_SBC_1	467	471	PF00917	0.465
DEG_SPOP_SBC_1	483	487	PF00917	0.251
DOC_ANK_TNKS_1	12	19	PF00023	0.485
DOC_CKS1_1	504	509	PF01111	0.438
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.448
DOC_MAPK_gen_1	169	176	PF00069	0.558
DOC_MAPK_gen_1	42	48	PF00069	0.509
DOC_MAPK_gen_1	541	550	PF00069	0.709
DOC_MAPK_MEF2A_6	136	143	PF00069	0.341
DOC_MAPK_MEF2A_6	407	414	PF00069	0.361
DOC_PP2B_LxvP_1	306	309	PF13499	0.448
DOC_PP2B_PxIxI_1	136	142	PF00149	0.288
DOC_PP4_FxxP_1	504	507	PF00568	0.262
DOC_USP7_MATH_1	185	189	PF00917	0.509
DOC_USP7_MATH_1	218	222	PF00917	0.498
DOC_USP7_MATH_1	241	245	PF00917	0.412
DOC_USP7_MATH_1	467	471	PF00917	0.447
DOC_USP7_MATH_1	483	487	PF00917	0.283
DOC_USP7_MATH_1	519	523	PF00917	0.385
DOC_USP7_UBL2_3	204	208	PF12436	0.414
DOC_WW_Pin1_4	214	219	PF00397	0.558
DOC_WW_Pin1_4	484	489	PF00397	0.354
DOC_WW_Pin1_4	503	508	PF00397	0.441
DOC_WW_Pin1_4	531	536	PF00397	0.582
LIG_14-3-3_CanoR_1	207	212	PF00244	0.416
LIG_14-3-3_CanoR_1	259	264	PF00244	0.506
LIG_14-3-3_CanoR_1	384	388	PF00244	0.496
LIG_BRCT_BRCA1_1	18	22	PF00533	0.486
LIG_BRCT_BRCA1_1	31	35	PF00533	0.400
LIG_BRCT_BRCA1_1	350	354	PF00533	0.331
LIG_BRCT_BRCA1_1	452	456	PF00533	0.516
LIG_EVH1_2	488	492	PF00568	0.365
LIG_FHA_1	136	142	PF00498	0.348
LIG_FHA_1	26	32	PF00498	0.584
LIG_FHA_1	269	275	PF00498	0.366
LIG_FHA_1	284	290	PF00498	0.261
LIG_FHA_1	388	394	PF00498	0.340
LIG_FHA_1	5	11	PF00498	0.416
LIG_FHA_1	504	510	PF00498	0.423
LIG_LIR_Gen_1	111	122	PF02991	0.502
LIG_LIR_Gen_1	171	181	PF02991	0.623
LIG_LIR_Gen_1	285	294	PF02991	0.300
LIG_LIR_Gen_1	32	40	PF02991	0.522
LIG_LIR_Gen_1	353	362	PF02991	0.337
LIG_LIR_Gen_1	398	405	PF02991	0.346
LIG_LIR_Gen_1	453	462	PF02991	0.521
LIG_LIR_Gen_1	491	500	PF02991	0.276
LIG_LIR_Gen_1	8	17	PF02991	0.518
LIG_LIR_Gen_1	92	103	PF02991	0.525
LIG_LIR_Nem_3	111	117	PF02991	0.298
LIG_LIR_Nem_3	171	176	PF02991	0.605
LIG_LIR_Nem_3	285	290	PF02991	0.295
LIG_LIR_Nem_3	32	38	PF02991	0.494
LIG_LIR_Nem_3	325	329	PF02991	0.383
LIG_LIR_Nem_3	353	358	PF02991	0.309
LIG_LIR_Nem_3	398	403	PF02991	0.343
LIG_LIR_Nem_3	406	411	PF02991	0.294
LIG_LIR_Nem_3	453	459	PF02991	0.482
LIG_LIR_Nem_3	491	495	PF02991	0.271
LIG_LIR_Nem_3	8	14	PF02991	0.456
LIG_LIR_Nem_3	92	98	PF02991	0.532
LIG_NRBOX	494	500	PF00104	0.226
LIG_PDZ_Class_2	545	550	PF00595	0.557
LIG_Pex14_2	150	154	PF04695	0.337
LIG_Pex14_2	155	159	PF04695	0.286
LIG_Pex14_2	317	321	PF04695	0.368
LIG_Pex14_2	350	354	PF04695	0.316
LIG_Pex14_2	374	378	PF04695	0.379
LIG_Pex14_2	78	82	PF04695	0.382
LIG_REV1ctd_RIR_1	173	182	PF16727	0.384
LIG_SH2_CRK	11	15	PF00017	0.519
LIG_SH2_CRK	266	270	PF00017	0.359
LIG_SH2_CRK	287	291	PF00017	0.315
LIG_SH2_CRK	355	359	PF00017	0.309
LIG_SH2_CRK	45	49	PF00017	0.384
LIG_SH2_CRK	60	64	PF00017	0.331
LIG_SH2_CRK	95	99	PF00017	0.520
LIG_SH2_NCK_1	355	359	PF00017	0.312
LIG_SH2_PTP2	326	329	PF00017	0.355
LIG_SH2_PTP2	411	414	PF00017	0.402
LIG_SH2_STAP1	40	44	PF00017	0.511
LIG_SH2_STAP1	428	432	PF00017	0.458
LIG_SH2_STAP1	95	99	PF00017	0.495
LIG_SH2_STAT5	173	176	PF00017	0.478
LIG_SH2_STAT5	326	329	PF00017	0.352
LIG_SH2_STAT5	372	375	PF00017	0.313
LIG_SH2_STAT5	40	43	PF00017	0.504
LIG_SH2_STAT5	411	414	PF00017	0.311
LIG_SH2_STAT5	420	423	PF00017	0.305
LIG_SH3_3	342	348	PF00018	0.286
LIG_SH3_3	513	519	PF00018	0.408
LIG_SH3_3	61	67	PF00018	0.325
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.328
LIG_SUMO_SIM_par_1	273	278	PF11976	0.306
LIG_SUMO_SIM_par_1	401	406	PF11976	0.355
LIG_TYR_ITIM	289	294	PF00017	0.381
LIG_TYR_ITIM	324	329	PF00017	0.341
LIG_TYR_ITIM	58	63	PF00017	0.393
LIG_TYR_ITSM	351	358	PF00017	0.428
LIG_UBA3_1	174	178	PF00899	0.523
LIG_UBA3_1	442	449	PF00899	0.226
LIG_Vh1_VBS_1	275	293	PF01044	0.468
LIG_WRC_WIRS_1	459	464	PF05994	0.230
MOD_CK1_1	330	336	PF00069	0.387
MOD_CK1_1	339	345	PF00069	0.413
MOD_CK1_1	379	385	PF00069	0.358
MOD_CK1_1	468	474	PF00069	0.365
MOD_CK1_1	534	540	PF00069	0.585
MOD_CK2_1	218	224	PF00069	0.312
MOD_GlcNHglycan	124	127	PF01048	0.419
MOD_GlcNHglycan	133	136	PF01048	0.391
MOD_GlcNHglycan	14	17	PF01048	0.326
MOD_GlcNHglycan	143	146	PF01048	0.379
MOD_GlcNHglycan	329	332	PF01048	0.440
MOD_GlcNHglycan	68	71	PF01048	0.357
MOD_GSK3_1	12	19	PF00069	0.428
MOD_GSK3_1	131	138	PF00069	0.389
MOD_GSK3_1	198	205	PF00069	0.414
MOD_GSK3_1	214	221	PF00069	0.321
MOD_GSK3_1	25	32	PF00069	0.360
MOD_GSK3_1	255	262	PF00069	0.482
MOD_GSK3_1	350	357	PF00069	0.386
MOD_GSK3_1	379	386	PF00069	0.370
MOD_GSK3_1	465	472	PF00069	0.387
MOD_GSK3_1	526	533	PF00069	0.339
MOD_N-GLC_1	259	264	PF02516	0.520
MOD_NEK2_1	131	136	PF00069	0.360
MOD_NEK2_1	20	25	PF00069	0.392
MOD_NEK2_1	240	245	PF00069	0.513
MOD_NEK2_1	283	288	PF00069	0.304
MOD_NEK2_1	350	355	PF00069	0.370
MOD_NEK2_1	38	43	PF00069	0.290
MOD_NEK2_1	387	392	PF00069	0.378
MOD_NEK2_1	441	446	PF00069	0.310
MOD_NEK2_1	46	51	PF00069	0.348
MOD_NEK2_1	465	470	PF00069	0.360
MOD_NEK2_1	477	482	PF00069	0.358
MOD_NEK2_2	451	456	PF00069	0.226
MOD_PIKK_1	348	354	PF00454	0.226
MOD_PK_1	259	265	PF00069	0.226
MOD_PKA_1	206	212	PF00069	0.190
MOD_PKA_2	12	18	PF00069	0.403
MOD_PKA_2	135	141	PF00069	0.229
MOD_PKA_2	206	212	PF00069	0.407
MOD_PKA_2	383	389	PF00069	0.356
MOD_Plk_1	241	247	PF00069	0.303
MOD_Plk_1	259	265	PF00069	0.448
MOD_Plk_1	339	345	PF00069	0.403
MOD_Plk_1	451	457	PF00069	0.303
MOD_Plk_4	275	281	PF00069	0.329
MOD_Plk_4	308	314	PF00069	0.434
MOD_Plk_4	322	328	PF00069	0.385
MOD_Plk_4	350	356	PF00069	0.446
MOD_Plk_4	383	389	PF00069	0.353
MOD_Plk_4	395	401	PF00069	0.334
MOD_Plk_4	451	457	PF00069	0.390
MOD_Plk_4	477	483	PF00069	0.368
MOD_ProDKin_1	214	220	PF00069	0.430
MOD_ProDKin_1	484	490	PF00069	0.424
MOD_ProDKin_1	503	509	PF00069	0.441
MOD_ProDKin_1	531	537	PF00069	0.461
MOD_SUMO_for_1	177	180	PF00179	0.425
TRG_DiLeu_BaEn_1	162	167	PF01217	0.458
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.336
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.282
TRG_ENDOCYTIC_2	11	14	PF00928	0.329
TRG_ENDOCYTIC_2	173	176	PF00928	0.250
TRG_ENDOCYTIC_2	266	269	PF00928	0.360
TRG_ENDOCYTIC_2	287	290	PF00928	0.366
TRG_ENDOCYTIC_2	291	294	PF00928	0.365
TRG_ENDOCYTIC_2	326	329	PF00928	0.364
TRG_ENDOCYTIC_2	355	358	PF00928	0.364
TRG_ENDOCYTIC_2	411	414	PF00928	0.485
TRG_ENDOCYTIC_2	45	48	PF00928	0.355
TRG_ENDOCYTIC_2	60	63	PF00928	0.348
TRG_ENDOCYTIC_2	95	98	PF00928	0.344
TRG_ER_diArg_1	541	544	PF00400	0.479
TRG_NLS_MonoExtN_4	204	210	PF00514	0.188
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	78%
A0A0N1HY49	Leptomonas seymouri	46%	82%
A0A0N1HZ06	Leptomonas seymouri	38%	100%
A0A0N1IHL1	Leptomonas seymouri	41%	77%
A0A0N1PB77	Leptomonas seymouri	40%	85%
A0A0N1PBZ2	Leptomonas seymouri	45%	82%
A0A0N1PCC1	Leptomonas seymouri	44%	82%
A0A0S4INN8	Bodo saltans	31%	85%
A0A381MBI0	Leishmania infantum	93%	83%
A0A3Q8I8X7	Leishmania donovani	93%	83%
A0A3Q8IAZ0	Leishmania donovani	45%	79%
A0A3Q8IH50	Leishmania donovani	48%	76%
A0A3Q8IVN0	Leishmania donovani	39%	88%
A0A3R7M4J1	Trypanosoma rangeli	40%	86%
A0A3S5H5P4	Leishmania donovani	46%	81%
A0A3S5H5V2	Leishmania donovani	45%	84%
A0A3S5H6F6	Leishmania donovani	44%	79%
A0A3S5H763	Leishmania donovani	49%	82%
A0A3S7WR10	Leishmania donovani	42%	74%
A0A3S7WR14	Leishmania donovani	47%	80%
A0A3S7WR24	Leishmania donovani	45%	78%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	85%	100%
A4H617	Leishmania braziliensis	46%	100%
A4H618	Leishmania braziliensis	46%	100%
A4H619	Leishmania braziliensis	47%	100%
A4H620	Leishmania braziliensis	51%	100%
A4H6C3	Leishmania braziliensis	83%	100%
A4HNH7	Leishmania braziliensis	40%	100%
A4HSS2	Leishmania infantum	46%	81%
A4HUE4	Leishmania infantum	42%	74%
A4HUE5	Leishmania infantum	46%	80%
A4HUE6	Leishmania infantum	47%	80%
A4HUE7	Leishmania infantum	45%	79%
A4HUE8	Leishmania infantum	45%	78%
A4HUF4	Leishmania infantum	44%	79%
A4HUF5	Leishmania infantum	48%	84%
A4HYA9	Leishmania infantum	49%	82%
A4IC33	Leishmania infantum	39%	87%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	84%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	84%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	87%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	87%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	87%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	86%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AG72	Leishmania infantum	45%	84%
E9AI40	Leishmania braziliensis	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	81%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	84%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	74%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	84%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	77%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	83%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	82%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	87%
Q4QDC4	Leishmania major	48%	100%
Q4QH81	Leishmania major	93%	100%
Q4QHH7	Leishmania major	46%	100%
Q4QHH8	Leishmania major	44%	100%
Q4QHH9	Leishmania major	44%	100%
Q4QHI0	Leishmania major	44%	100%
Q4QHI1	Leishmania major	46%	100%
Q4QHI2	Leishmania major	45%	100%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	39%	100%