Calcium-transporting ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

organelle-type calcium ATPase

Species:

Leishmania mexicana

UniProt:

E9AJY3_LEIMU

TriTrypDb:

LmxM.04.0010

Length:

1013

Annotations

LeishMANIAdb annotations

Homologous to animal ER-localized Ca2+ ATPases. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9AJY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY3

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005388	P-type calcium transporter activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015085	calcium ion transmembrane transporter activity	6	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	493	497	PF00656	0.408
CLV_C14_Caspase3-7	596	600	PF00656	0.484
CLV_NRD_NRD_1	25	27	PF00675	0.228
CLV_NRD_NRD_1	317	319	PF00675	0.270
CLV_NRD_NRD_1	483	485	PF00675	0.306
CLV_NRD_NRD_1	594	596	PF00675	0.277
CLV_NRD_NRD_1	627	629	PF00675	0.282
CLV_NRD_NRD_1	655	657	PF00675	0.282
CLV_NRD_NRD_1	811	813	PF00675	0.296
CLV_PCSK_KEX2_1	25	27	PF00082	0.307

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y1	Leptomonas seymouri	76%	100%
A0A0N1HWG6	Leptomonas seymouri	30%	91%
A0A0N1HZI4	Leptomonas seymouri	21%	81%
A0A0N1I8I8	Leptomonas seymouri	28%	83%
A0A0N1PFH3	Leptomonas seymouri	31%	83%
A0A0S4INU6	Bodo saltans	21%	83%
A0A0S4J1M1	Bodo saltans	30%	93%
A0A0S4J5A1	Bodo saltans	31%	95%
A0A0S4J6U4	Bodo saltans	27%	93%
A0A0S4JA92	Bodo saltans	28%	100%

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