MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AJY1_LEIMU

TriTrypDb:

LmxM.03.0970

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJY1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.339
CLV_C14_Caspase3-7	15	19	PF00656	0.373
CLV_PCSK_FUR_1	184	188	PF00082	0.275
CLV_PCSK_KEX2_1	186	188	PF00082	0.275
CLV_PCSK_KEX2_1	209	211	PF00082	0.256
CLV_PCSK_KEX2_1	300	302	PF00082	0.415
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.275
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.256
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.390
CLV_PCSK_SKI1_1	146	150	PF00082	0.503
DOC_MAPK_gen_1	24	30	PF00069	0.431
DOC_MAPK_MEF2A_6	158	165	PF00069	0.240
DOC_MAPK_NFAT4_5	158	166	PF00069	0.235
DOC_USP7_MATH_1	242	246	PF00917	0.308
DOC_USP7_UBL2_3	142	146	PF12436	0.413
DOC_USP7_UBL2_3	229	233	PF12436	0.296
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.402
LIG_deltaCOP1_diTrp_1	50	56	PF00928	0.357
LIG_EH1_1	163	171	PF00400	0.446
LIG_FHA_1	305	311	PF00498	0.469
LIG_FHA_1	75	81	PF00498	0.380
LIG_FHA_2	45	51	PF00498	0.470
LIG_GBD_Chelix_1	155	163	PF00786	0.239
LIG_LIR_Gen_1	270	280	PF02991	0.262
LIG_LIR_Nem_3	234	239	PF02991	0.338
LIG_LIR_Nem_3	285	291	PF02991	0.411
LIG_LYPXL_yS_3	288	291	PF13949	0.431
LIG_Pex14_1	52	56	PF04695	0.380
LIG_Pex14_2	67	71	PF04695	0.462
LIG_REV1ctd_RIR_1	107	118	PF16727	0.273
LIG_SH2_CRK	81	85	PF00017	0.351
LIG_SH2_GRB2like	218	221	PF00017	0.268
LIG_SH2_NCK_1	34	38	PF00017	0.461
LIG_SH2_SRC	218	221	PF00017	0.256
LIG_SH2_STAP1	34	38	PF00017	0.403
LIG_SH2_STAT5	120	123	PF00017	0.268
LIG_SH2_STAT5	182	185	PF00017	0.284
LIG_SH2_STAT5	218	221	PF00017	0.270
LIG_SH2_STAT5	29	32	PF00017	0.387
LIG_SH3_3	300	306	PF00018	0.390
LIG_TYR_ITIM	286	291	PF00017	0.319
MOD_CK1_1	101	107	PF00069	0.421
MOD_CK1_1	60	66	PF00069	0.504
MOD_CK1_1	74	80	PF00069	0.320
MOD_CK2_1	264	270	PF00069	0.366
MOD_CK2_1	44	50	PF00069	0.563
MOD_Cter_Amidation	111	114	PF01082	0.268
MOD_Cter_Amidation	184	187	PF01082	0.275
MOD_GlcNHglycan	100	103	PF01048	0.248
MOD_GlcNHglycan	224	227	PF01048	0.298
MOD_GlcNHglycan	307	310	PF01048	0.383
MOD_GlcNHglycan	61	65	PF01048	0.488
MOD_GlcNHglycan	91	94	PF01048	0.254
MOD_GSK3_1	121	128	PF00069	0.253
MOD_GSK3_1	44	51	PF00069	0.547
MOD_NEK2_1	293	298	PF00069	0.392
MOD_NEK2_1	71	76	PF00069	0.282
MOD_Plk_2-3	44	50	PF00069	0.496
MOD_Plk_4	196	202	PF00069	0.266
MOD_Plk_4	264	270	PF00069	0.391
MOD_Plk_4	48	54	PF00069	0.388
MOD_SUMO_for_1	141	144	PF00179	0.283
MOD_SUMO_rev_2	139	148	PF00179	0.426
MOD_SUMO_rev_2	267	273	PF00179	0.387
MOD_SUMO_rev_2	3	9	PF00179	0.616
TRG_ENDOCYTIC_2	216	219	PF00928	0.233
TRG_ENDOCYTIC_2	288	291	PF00928	0.431
TRG_NES_CRM1_1	154	167	PF08389	0.237
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVW7	Leptomonas seymouri	80%	100%
A0A0S4IT41	Bodo saltans	54%	100%
A0A0S4KIY0	Bodo saltans	33%	91%
A0A1X0P8X9	Trypanosomatidae	58%	100%
A0A3S7XBA2	Leishmania donovani	24%	100%
A0A451EJU5	Leishmania donovani	94%	100%
A4H3Q9	Leishmania braziliensis	84%	100%
A4HPP6	Leishmania braziliensis	22%	100%
A4HRY3	Leishmania infantum	94%	100%
A4ID18	Leishmania infantum	24%	100%
C9ZKJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
E9ACP2	Leishmania major	94%	100%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q6V8	Leishmania major	30%	91%
V5DTY1	Trypanosoma cruzi	61%	100%