Multicopper oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Multicopper oxidase

Gene product:

multicopper oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9AJX9_LEIMU

TriTrypDb:

LmxM.03.0950

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AJX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005507	copper ion binding	6	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.459
CLV_C14_Caspase3-7	224	228	PF00656	0.377
CLV_C14_Caspase3-7	269	273	PF00656	0.269
CLV_NRD_NRD_1	167	169	PF00675	0.621
CLV_NRD_NRD_1	232	234	PF00675	0.642
CLV_NRD_NRD_1	249	251	PF00675	0.541
CLV_NRD_NRD_1	287	289	PF00675	0.574
CLV_NRD_NRD_1	554	556	PF00675	0.432
CLV_PCSK_FUR_1	191	195	PF00082	0.605
CLV_PCSK_KEX2_1	141	143	PF00082	0.654
CLV_PCSK_KEX2_1	193	195	PF00082	0.640
CLV_PCSK_KEX2_1	232	234	PF00082	0.642
CLV_PCSK_KEX2_1	249	251	PF00082	0.527
CLV_PCSK_KEX2_1	287	289	PF00082	0.574
CLV_PCSK_KEX2_1	554	556	PF00082	0.432
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.464
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.640
CLV_PCSK_SKI1_1	250	254	PF00082	0.484
CLV_PCSK_SKI1_1	441	445	PF00082	0.513
CLV_PCSK_SKI1_1	62	66	PF00082	0.521
DEG_APCC_DBOX_1	13	21	PF00400	0.386
DEG_APCC_DBOX_1	248	256	PF00400	0.381
DOC_CKS1_1	57	62	PF01111	0.177
DOC_CYCLIN_RxL_1	247	257	PF00134	0.330
DOC_MAPK_gen_1	191	200	PF00069	0.418
DOC_MAPK_gen_1	249	255	PF00069	0.376
DOC_MAPK_gen_1	282	292	PF00069	0.452
DOC_MAPK_HePTP_8	190	202	PF00069	0.406
DOC_MAPK_MEF2A_6	193	202	PF00069	0.380
DOC_PP1_RVXF_1	199	205	PF00149	0.326
DOC_PP1_RVXF_1	286	293	PF00149	0.472
DOC_PP1_RVXF_1	312	319	PF00149	0.343
DOC_PP4_FxxP_1	366	369	PF00568	0.282
DOC_USP7_MATH_1	147	151	PF00917	0.439
DOC_USP7_MATH_1	154	158	PF00917	0.439
DOC_USP7_MATH_1	205	209	PF00917	0.310
DOC_USP7_MATH_1	496	500	PF00917	0.494
DOC_USP7_UBL2_3	278	282	PF12436	0.336
DOC_WW_Pin1_4	114	119	PF00397	0.475
DOC_WW_Pin1_4	297	302	PF00397	0.452
DOC_WW_Pin1_4	468	473	PF00397	0.385
DOC_WW_Pin1_4	541	546	PF00397	0.715
DOC_WW_Pin1_4	56	61	PF00397	0.230
LIG_14-3-3_CanoR_1	232	236	PF00244	0.365
LIG_14-3-3_CanoR_1	249	253	PF00244	0.270
LIG_Actin_WH2_2	219	234	PF00022	0.346
LIG_BRCT_BRCA1_1	421	425	PF00533	0.330
LIG_BRCT_BRCA1_1	502	506	PF00533	0.352
LIG_Clathr_ClatBox_1	158	162	PF01394	0.443
LIG_deltaCOP1_diTrp_1	239	244	PF00928	0.351
LIG_FHA_1	187	193	PF00498	0.373
LIG_FHA_1	232	238	PF00498	0.362
LIG_FHA_1	259	265	PF00498	0.376
LIG_FHA_1	365	371	PF00498	0.360
LIG_FHA_1	373	379	PF00498	0.290
LIG_FHA_1	4	10	PF00498	0.338
LIG_FHA_1	426	432	PF00498	0.278
LIG_FHA_2	222	228	PF00498	0.413
LIG_FHA_2	542	548	PF00498	0.700
LIG_LIR_Apic_2	172	176	PF02991	0.451
LIG_LIR_Gen_1	208	216	PF02991	0.367
LIG_LIR_Gen_1	239	247	PF02991	0.325
LIG_LIR_Gen_1	300	309	PF02991	0.384
LIG_LIR_Gen_1	499	510	PF02991	0.335
LIG_LIR_Nem_3	239	244	PF02991	0.333
LIG_LIR_Nem_3	300	306	PF02991	0.377
LIG_LIR_Nem_3	311	316	PF02991	0.341
LIG_LIR_Nem_3	346	352	PF02991	0.244
LIG_LIR_Nem_3	361	366	PF02991	0.298
LIG_LIR_Nem_3	466	470	PF02991	0.285
LIG_LIR_Nem_3	499	505	PF02991	0.335
LIG_NRBOX	504	510	PF00104	0.257
LIG_PCNA_PIPBox_1	128	137	PF02747	0.393
LIG_PCNA_yPIPBox_3	128	142	PF02747	0.422
LIG_Pex14_2	491	495	PF04695	0.558
LIG_PTB_Apo_2	42	49	PF02174	0.362
LIG_SH2_CRK	173	177	PF00017	0.338
LIG_SH2_CRK	502	506	PF00017	0.402
LIG_SH2_GRB2like	210	213	PF00017	0.398
LIG_SH2_STAP1	502	506	PF00017	0.285
LIG_SH2_STAT5	210	213	PF00017	0.398
LIG_SH2_STAT5	243	246	PF00017	0.302
LIG_SH2_STAT5	276	279	PF00017	0.359
LIG_SH2_STAT5	303	306	PF00017	0.330
LIG_SH2_STAT5	330	333	PF00017	0.371
LIG_SH2_STAT5	351	354	PF00017	0.261
LIG_SH2_STAT5	445	448	PF00017	0.321
LIG_SH2_STAT5	467	470	PF00017	0.282
LIG_SH2_STAT5	520	523	PF00017	0.709
LIG_SH3_3	115	121	PF00018	0.473
LIG_SH3_3	157	163	PF00018	0.464
LIG_SH3_3	287	293	PF00018	0.441
LIG_SH3_3	466	472	PF00018	0.356
LIG_SH3_3	54	60	PF00018	0.364
LIG_Sin3_3	506	513	PF02671	0.320
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.177
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.440
LIG_SUMO_SIM_anti_2	251	259	PF11976	0.360
LIG_SUMO_SIM_par_1	233	239	PF11976	0.428
LIG_SUMO_SIM_par_1	251	259	PF11976	0.268
LIG_SUMO_SIM_par_1	506	512	PF11976	0.188
LIG_TYR_ITAM	310	332	PF00017	0.479
LIG_TYR_ITSM	309	316	PF00017	0.467
LIG_UBA3_1	274	282	PF00899	0.421
LIG_WRC_WIRS_1	399	404	PF05994	0.313
MOD_CDK_SPxK_1	56	62	PF00069	0.271
MOD_CDK_SPxxK_3	468	475	PF00069	0.395
MOD_CDK_SPxxK_3	541	548	PF00069	0.680
MOD_CK1_1	471	477	PF00069	0.411
MOD_CK2_1	541	547	PF00069	0.697
MOD_Cter_Amidation	285	288	PF01082	0.545
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.177
MOD_GlcNHglycan	421	424	PF01048	0.509
MOD_GlcNHglycan	492	495	PF01048	0.608
MOD_GlcNHglycan	511	514	PF01048	0.494
MOD_GlcNHglycan	528	531	PF01048	0.538
MOD_GSK3_1	258	265	PF00069	0.408
MOD_GSK3_1	337	344	PF00069	0.309
MOD_GSK3_1	496	503	PF00069	0.462
MOD_GSK3_1	537	544	PF00069	0.732
MOD_N-GLC_1	137	142	PF02516	0.616
MOD_N-GLC_1	211	216	PF02516	0.511
MOD_N-GLC_1	29	34	PF02516	0.521
MOD_N-GLC_1	297	302	PF02516	0.464
MOD_N-GLC_1	342	347	PF02516	0.508
MOD_N-GLC_1	41	46	PF02516	0.435
MOD_N-GLC_1	411	416	PF02516	0.482
MOD_NEK2_1	137	142	PF00069	0.307
MOD_NEK2_1	221	226	PF00069	0.350
MOD_NEK2_1	242	247	PF00069	0.315
MOD_NEK2_1	28	33	PF00069	0.354
MOD_NEK2_1	341	346	PF00069	0.313
MOD_NEK2_1	425	430	PF00069	0.334
MOD_NEK2_1	463	468	PF00069	0.282
MOD_NEK2_1	509	514	PF00069	0.362
MOD_NEK2_2	205	210	PF00069	0.312
MOD_NEK2_2	34	39	PF00069	0.338
MOD_NEK2_2	434	439	PF00069	0.386
MOD_PIKK_1	124	130	PF00454	0.407
MOD_PIKK_1	316	322	PF00454	0.354
MOD_PIKK_1	483	489	PF00454	0.441
MOD_PKA_2	186	192	PF00069	0.426
MOD_PKA_2	231	237	PF00069	0.361
MOD_PKA_2	248	254	PF00069	0.270
MOD_PKA_2	425	431	PF00069	0.282
MOD_PKA_2	526	532	PF00069	0.730
MOD_Plk_1	15	21	PF00069	0.276
MOD_Plk_1	211	217	PF00069	0.330
MOD_Plk_1	314	320	PF00069	0.365
MOD_Plk_1	411	417	PF00069	0.283
MOD_Plk_2-3	531	537	PF00069	0.718
MOD_Plk_4	15	21	PF00069	0.280
MOD_Plk_4	154	160	PF00069	0.459
MOD_Plk_4	299	305	PF00069	0.373
MOD_Plk_4	308	314	PF00069	0.419
MOD_Plk_4	441	447	PF00069	0.286
MOD_Plk_4	463	469	PF00069	0.282
MOD_Plk_4	500	506	PF00069	0.438
MOD_Plk_4	531	537	PF00069	0.588
MOD_Plk_4	66	72	PF00069	0.386
MOD_ProDKin_1	114	120	PF00069	0.469
MOD_ProDKin_1	297	303	PF00069	0.447
MOD_ProDKin_1	468	474	PF00069	0.384
MOD_ProDKin_1	541	547	PF00069	0.713
MOD_ProDKin_1	56	62	PF00069	0.230
MOD_SUMO_rev_2	167	176	PF00179	0.342
MOD_SUMO_rev_2	471	480	PF00179	0.411
TRG_DiLeu_LyEn_5	547	552	PF01217	0.719
TRG_ENDOCYTIC_2	210	213	PF00928	0.392
TRG_ENDOCYTIC_2	303	306	PF00928	0.388
TRG_ENDOCYTIC_2	313	316	PF00928	0.386
TRG_ENDOCYTIC_2	329	332	PF00928	0.277
TRG_ENDOCYTIC_2	349	352	PF00928	0.150
TRG_ENDOCYTIC_2	363	366	PF00928	0.282
TRG_ENDOCYTIC_2	502	505	PF00928	0.476
TRG_ENDOCYTIC_2	96	99	PF00928	0.296
TRG_ER_diArg_1	231	233	PF00400	0.361
TRG_ER_diArg_1	521	524	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX0	Leptomonas seymouri	62%	87%
A0A1X0P996	Trypanosomatidae	51%	86%
A0A3R7JTK5	Trypanosoma rangeli	53%	87%
A0A3S5H569	Leishmania donovani	91%	88%
A4H3Q7	Leishmania braziliensis	78%	100%
A4HRY1	Leishmania infantum	91%	88%
C9ZKJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	86%
E9ACP0	Leishmania major	90%	100%
V5BXB2	Trypanosoma cruzi	51%	88%