Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family, putative

Species:

Leishmania mexicana

UniProt:

E9AJX6_LEIMU

TriTrypDb:

LmxM.03.0920

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

E9AJX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJX6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	22
GO:0008104	protein localization	4	22
GO:0009987	cellular process	1	22
GO:0015031	protein transport	4	22
GO:0016192	vesicle-mediated transport	4	22
GO:0033036	macromolecule localization	2	22
GO:0045184	establishment of protein localization	3	22
GO:0051179	localization	1	22
GO:0051234	establishment of localization	2	22
GO:0051641	cellular localization	2	22
GO:0070727	cellular macromolecule localization	3	22
GO:0071702	organic substance transport	4	22
GO:0071705	nitrogen compound transport	4	22

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	125	129	PF00082	0.266
CLV_PCSK_SKI1_1	182	186	PF00082	0.516
DOC_CYCLIN_RxL_1	28	39	PF00134	0.582
DOC_MAPK_MEF2A_6	182	189	PF00069	0.695
LIG_Actin_WH2_2	171	188	PF00022	0.518
LIG_BRCT_BRCA1_1	112	116	PF00533	0.282
LIG_BRCT_BRCA1_1	192	196	PF00533	0.514
LIG_eIF4E_1	30	36	PF01652	0.580
LIG_FHA_1	112	118	PF00498	0.350
LIG_FHA_1	42	48	PF00498	0.781
LIG_FHA_1	67	73	PF00498	0.681
LIG_FHA_2	124	130	PF00498	0.414
LIG_GBD_Chelix_1	143	151	PF00786	0.233
LIG_GBD_Chelix_1	167	175	PF00786	0.260
LIG_LIR_Gen_1	190	199	PF02991	0.500
LIG_LIR_Gen_1	73	84	PF02991	0.344
LIG_LIR_Nem_3	176	180	PF02991	0.341
LIG_LIR_Nem_3	193	199	PF02991	0.353
LIG_NRBOX	83	89	PF00104	0.260
LIG_PCNA_yPIPBox_3	205	215	PF02747	0.177
LIG_SH2_CRK	30	34	PF00017	0.641
LIG_SH2_SRC	139	142	PF00017	0.260
LIG_SH2_STAP1	173	177	PF00017	0.288
LIG_SH2_STAP1	180	184	PF00017	0.579
LIG_SH2_STAP1	191	195	PF00017	0.463
LIG_SH2_STAP1	68	72	PF00017	0.622
LIG_SH2_STAT3	180	183	PF00017	0.662
LIG_SH2_STAT3	24	27	PF00017	0.669
LIG_SH2_STAT5	139	142	PF00017	0.390
LIG_SH2_STAT5	68	71	PF00017	0.683
LIG_Sin3_3	161	168	PF02671	0.210
LIG_SUMO_SIM_par_1	142	149	PF11976	0.203
LIG_SxIP_EBH_1	171	182	PF03271	0.387
LIG_UBA3_1	147	156	PF00899	0.373
MOD_CK1_1	190	196	PF00069	0.435
MOD_CK1_1	34	40	PF00069	0.684
MOD_CK1_1	61	67	PF00069	0.632
MOD_CK2_1	123	129	PF00069	0.433
MOD_GlcNHglycan	148	151	PF01048	0.387
MOD_GlcNHglycan	3	6	PF01048	0.509
MOD_GSK3_1	139	146	PF00069	0.342
MOD_GSK3_1	41	48	PF00069	0.622
MOD_GSK3_1	66	73	PF00069	0.662
MOD_GSK3_1	97	104	PF00069	0.269
MOD_N-GLC_2	208	210	PF02516	0.210
MOD_NEK2_1	1	6	PF00069	0.678
MOD_NEK2_1	101	106	PF00069	0.339
MOD_NEK2_1	111	116	PF00069	0.357
MOD_NEK2_1	66	71	PF00069	0.637
MOD_PIKK_1	23	29	PF00454	0.679
MOD_PIKK_1	66	72	PF00454	0.677
MOD_PKA_1	97	103	PF00069	0.329
MOD_PKA_2	70	76	PF00069	0.529
MOD_Plk_1	64	70	PF00069	0.631
MOD_Plk_4	111	117	PF00069	0.327
MOD_Plk_4	143	149	PF00069	0.315
MOD_Plk_4	173	179	PF00069	0.410
MOD_Plk_4	190	196	PF00069	0.526
MOD_Plk_4	31	37	PF00069	0.621
MOD_SUMO_rev_2	15	21	PF00179	0.587
TRG_ENDOCYTIC_2	191	194	PF00928	0.630
TRG_ENDOCYTIC_2	30	33	PF00928	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I1	Leptomonas seymouri	71%	98%
A0A0N1I3M5	Leptomonas seymouri	32%	100%
A0A1X0P315	Trypanosomatidae	33%	100%
A0A1X0P7F6	Trypanosomatidae	30%	100%
A0A1X0P987	Trypanosomatidae	44%	100%
A0A3Q8IBK0	Leishmania donovani	36%	100%
A0A3S5H567	Leishmania donovani	94%	99%
A0A3S5H5K3	Leishmania donovani	37%	100%
A0A422N175	Trypanosoma rangeli	46%	100%
A4H3Q4	Leishmania braziliensis	87%	100%
A4HDV3	Leishmania braziliensis	38%	100%
A4HRX8	Leishmania infantum	94%	99%
A4HSK3	Leishmania infantum	37%	100%
A4I148	Leishmania infantum	36%	100%
C9ZKI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	78%
E9ACN7	Leishmania major	93%	100%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QA90	Leishmania major	38%	100%
Q4QJC1	Leishmania major	37%	100%