Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inorganic pyrophosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AJX5_LEIMU

TriTrypDb:

LmxM.03.0910

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9AJX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJX5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004427	inorganic diphosphate phosphatase activity	6	11
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	107	111	PF00082	0.163
CLV_PCSK_SKI1_1	228	232	PF00082	0.272
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_CKS1_1	149	154	PF01111	0.444
DOC_CYCLIN_RxL_1	1	11	PF00134	0.427
DOC_MAPK_gen_1	76	84	PF00069	0.417
DOC_USP7_MATH_1	30	34	PF00917	0.399
DOC_USP7_MATH_1	47	51	PF00917	0.447
DOC_WW_Pin1_4	148	153	PF00397	0.463
LIG_APCC_ABBAyCdc20_2	107	113	PF00400	0.342
LIG_FHA_1	133	139	PF00498	0.491
LIG_FHA_1	43	49	PF00498	0.474
LIG_FHA_2	122	128	PF00498	0.450
LIG_FHA_2	185	191	PF00498	0.546
LIG_FHA_2	203	209	PF00498	0.472
LIG_FHA_2	23	29	PF00498	0.422
LIG_LIR_Apic_2	124	128	PF02991	0.417
LIG_LIR_Apic_2	211	216	PF02991	0.510
LIG_LIR_Gen_1	245	251	PF02991	0.539
LIG_LIR_Gen_1	50	58	PF02991	0.281
LIG_LIR_Nem_3	157	161	PF02991	0.523
LIG_LIR_Nem_3	174	180	PF02991	0.350
LIG_LIR_Nem_3	190	195	PF02991	0.466
LIG_LIR_Nem_3	208	213	PF02991	0.528
LIG_LIR_Nem_3	245	250	PF02991	0.499
LIG_LIR_Nem_3	33	39	PF02991	0.276
LIG_LIR_Nem_3	50	55	PF02991	0.297
LIG_PCNA_yPIPBox_3	197	210	PF02747	0.510
LIG_Pex14_1	209	213	PF04695	0.417
LIG_Pex14_1	36	40	PF04695	0.282
LIG_Pex14_2	116	120	PF04695	0.417
LIG_PTB_Apo_2	254	261	PF02174	0.358
LIG_PTB_Phospho_1	254	260	PF10480	0.362
LIG_SH2_CRK	118	122	PF00017	0.510
LIG_SH2_CRK	158	162	PF00017	0.500
LIG_SH2_CRK	192	196	PF00017	0.430
LIG_SH2_CRK	247	251	PF00017	0.378
LIG_SH2_STAT5	108	111	PF00017	0.476
LIG_SH2_STAT5	58	61	PF00017	0.271
LIG_SH3_1	86	92	PF00018	0.463
LIG_SH3_2	89	94	PF14604	0.526
LIG_SH3_3	15	21	PF00018	0.400
LIG_SH3_3	86	92	PF00018	0.469
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.417
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.437
LIG_SUMO_SIM_par_1	64	69	PF11976	0.309
LIG_SxIP_EBH_1	67	81	PF03271	0.292
LIG_TRAF2_1	25	28	PF00917	0.396
LIG_TRAF2_1	85	88	PF00917	0.472
MOD_CDK_SPxK_1	148	154	PF00069	0.444
MOD_CK1_1	10	16	PF00069	0.585
MOD_CK1_1	183	189	PF00069	0.342
MOD_CK2_1	184	190	PF00069	0.546
MOD_CK2_1	22	28	PF00069	0.377
MOD_CK2_1	82	88	PF00069	0.472
MOD_Cter_Amidation	217	220	PF01082	0.248
MOD_GlcNHglycan	12	15	PF01048	0.559
MOD_GlcNHglycan	49	52	PF01048	0.296
MOD_GlcNHglycan	61	64	PF01048	0.475
MOD_GSK3_1	180	187	PF00069	0.471
MOD_N-GLC_1	23	28	PF02516	0.327
MOD_NEK2_1	202	207	PF00069	0.460
MOD_NEK2_1	66	71	PF00069	0.417
MOD_NEK2_1	8	13	PF00069	0.449
MOD_PIKK_1	242	248	PF00454	0.507
MOD_Plk_4	13	19	PF00069	0.434
MOD_Plk_4	202	208	PF00069	0.448
MOD_Plk_4	235	241	PF00069	0.435
MOD_ProDKin_1	148	154	PF00069	0.463
MOD_SUMO_for_1	80	83	PF00179	0.417
MOD_SUMO_rev_2	171	180	PF00179	0.417
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.426
TRG_ENDOCYTIC_2	111	114	PF00928	0.417
TRG_ENDOCYTIC_2	118	121	PF00928	0.417
TRG_ENDOCYTIC_2	158	161	PF00928	0.510
TRG_ENDOCYTIC_2	192	195	PF00928	0.421
TRG_ENDOCYTIC_2	247	250	PF00928	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXJ8	Leptomonas seymouri	59%	96%
A0A1X0NCY3	Trypanosomatidae	38%	100%
A0A1X0PAB0	Trypanosomatidae	50%	94%
A0A422N180	Trypanosoma rangeli	51%	97%
A0A451EJT9	Leishmania donovani	92%	100%
A2X8Q3	Oryza sativa subsp. indica	29%	100%
A4H3Q3	Leishmania braziliensis	84%	100%
A4HRX7	Leishmania infantum	91%	100%
C9ZKI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ACN6	Leishmania major	92%	100%
O13505	Komagataella pastoris	41%	92%
O23979	Hordeum vulgare subsp. vulgare	31%	100%
O26363	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O48556	Zea mays	32%	100%
O77392	Plasmodium falciparum (isolate 3D7)	33%	69%
O77460	Drosophila melanogaster	40%	78%
O82597	Arabidopsis thaliana	28%	100%
P00817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	92%
P13998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	92%
P19117	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	91%
P21216	Arabidopsis thaliana	31%	100%
P28239	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	85%
P37980	Bos taurus	41%	91%
P37981	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
P83777	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	91%
P87118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	92%
Q0DYB1	Oryza sativa subsp. japonica	29%	100%
Q15181	Homo sapiens	42%	91%
Q4R543	Macaca fascicularis	42%	91%
Q54PV8	Dictyostelium discoideum	38%	94%
Q5B912	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	92%
Q5R8T6	Pongo abelii	41%	91%
Q6BWA5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	92%
Q6C1T4	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	92%
Q6FRB7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	92%
Q6MVH7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	45%	91%
Q72MG4	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	28%	100%
Q757J8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	92%
Q8EZ21	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	28%	100%
Q8SR69	Encephalitozoon cuniculi (strain GB-M1)	37%	95%
Q91VM9	Mus musculus	39%	80%
Q93V56	Arabidopsis thaliana	28%	100%
Q93Y52	Chlamydomonas reinhardtii	38%	94%
Q949J1	Chlamydomonas reinhardtii	28%	100%
Q9AC20	Caulobacter vibrioides (strain ATCC 19089 / CB15)	28%	100%
Q9C0T9	Zygosaccharomyces bailii	40%	92%
Q9D819	Mus musculus	41%	91%
Q9H2U2	Homo sapiens	39%	79%
Q9JVG3	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	27%	100%
Q9K0G4	Neisseria meningitidis serogroup B (strain MC58)	29%	100%
Q9LFF9	Arabidopsis thaliana	33%	100%
Q9LXC9	Arabidopsis thaliana	38%	88%
V5BSV4	Trypanosoma cruzi	50%	97%