Putative peter pan protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peter pan protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJX4_LEIMU

TriTrypDb:

LmxM.03.0900

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AJX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJX4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.414
CLV_NRD_NRD_1	111	113	PF00675	0.214
CLV_NRD_NRD_1	207	209	PF00675	0.241
CLV_NRD_NRD_1	300	302	PF00675	0.486
CLV_NRD_NRD_1	308	310	PF00675	0.454
CLV_NRD_NRD_1	317	319	PF00675	0.437
CLV_NRD_NRD_1	328	330	PF00675	0.311
CLV_NRD_NRD_1	333	335	PF00675	0.451
CLV_PCSK_FUR_1	320	324	PF00082	0.495
CLV_PCSK_KEX2_1	111	113	PF00082	0.214
CLV_PCSK_KEX2_1	12	14	PF00082	0.432
CLV_PCSK_KEX2_1	207	209	PF00082	0.216
CLV_PCSK_KEX2_1	307	309	PF00082	0.484
CLV_PCSK_KEX2_1	319	321	PF00082	0.515
CLV_PCSK_KEX2_1	322	324	PF00082	0.468
CLV_PCSK_KEX2_1	333	335	PF00082	0.457
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.432
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.438
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.455
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.429
CLV_PCSK_PC7_1	318	324	PF00082	0.472
CLV_PCSK_PC7_1	329	335	PF00082	0.420
CLV_PCSK_SKI1_1	151	155	PF00082	0.233
CLV_PCSK_SKI1_1	198	202	PF00082	0.238
CLV_PCSK_SKI1_1	308	312	PF00082	0.603
CLV_PCSK_SKI1_1	37	41	PF00082	0.214
CLV_PCSK_SKI1_1	53	57	PF00082	0.214
DEG_APCC_DBOX_1	251	259	PF00400	0.414
DOC_CYCLIN_RxL_1	148	156	PF00134	0.508
DOC_CYCLIN_RxL_1	198	205	PF00134	0.414
DOC_MAPK_DCC_7	118	128	PF00069	0.508
DOC_MAPK_gen_1	109	116	PF00069	0.514
DOC_MAPK_gen_1	12	20	PF00069	0.422
DOC_MAPK_gen_1	245	255	PF00069	0.414
DOC_MAPK_gen_1	285	293	PF00069	0.507
DOC_MAPK_gen_1	53	61	PF00069	0.445
DOC_MAPK_MEF2A_6	151	159	PF00069	0.419
DOC_MAPK_MEF2A_6	22	29	PF00069	0.421
DOC_MAPK_MEF2A_6	86	95	PF00069	0.414
DOC_PP1_RVXF_1	94	101	PF00149	0.414
DOC_PP4_FxxP_1	132	135	PF00568	0.414
DOC_PP4_FxxP_1	73	76	PF00568	0.427
DOC_PP4_FxxP_1	88	91	PF00568	0.468
DOC_USP7_MATH_1	42	46	PF00917	0.414
DOC_USP7_UBL2_3	12	16	PF12436	0.376
DOC_USP7_UBL2_3	198	202	PF12436	0.414
DOC_USP7_UBL2_3	322	326	PF12436	0.513
DOC_USP7_UBL2_3	47	51	PF12436	0.508
DOC_WW_Pin1_4	11	16	PF00397	0.381
LIG_14-3-3_CanoR_1	261	265	PF00244	0.414
LIG_14-3-3_CanoR_1	96	101	PF00244	0.414
LIG_APCC_ABBA_1	100	105	PF00400	0.508
LIG_deltaCOP1_diTrp_1	35	43	PF00928	0.440
LIG_EH_1	343	347	PF12763	0.584
LIG_FHA_1	191	197	PF00498	0.508
LIG_FHA_1	261	267	PF00498	0.414
LIG_FHA_2	131	137	PF00498	0.437
LIG_FHA_2	229	235	PF00498	0.414
LIG_FHA_2	285	291	PF00498	0.511
LIG_FHA_2	6	12	PF00498	0.484
LIG_HP1_1	125	129	PF01393	0.414
LIG_Integrin_RGD_1	22	24	PF01839	0.449
LIG_LIR_Gen_1	57	65	PF02991	0.414
LIG_LIR_Nem_3	147	153	PF02991	0.524
LIG_LIR_Nem_3	35	39	PF02991	0.414
LIG_LIR_Nem_3	57	61	PF02991	0.414
LIG_LIR_Nem_3	92	98	PF02991	0.414
LIG_PCNA_yPIPBox_3	46	59	PF02747	0.414
LIG_Pex14_1	36	40	PF04695	0.442
LIG_Pex14_2	150	154	PF04695	0.414
LIG_SH2_GRB2like	188	191	PF00017	0.508
LIG_SH2_NCK_1	175	179	PF00017	0.414
LIG_SH2_SRC	175	178	PF00017	0.414
LIG_SH2_SRC	188	191	PF00017	0.414
LIG_SH2_STAT5	188	191	PF00017	0.416
LIG_SH3_3	36	42	PF00018	0.436
LIG_SUMO_SIM_par_1	112	117	PF11976	0.477
LIG_WRC_WIRS_1	97	102	PF05994	0.414
MOD_CDK_SPK_2	11	16	PF00069	0.381
MOD_CK1_1	77	83	PF00069	0.557
MOD_CK2_1	214	220	PF00069	0.470
MOD_CK2_1	228	234	PF00069	0.414
MOD_CK2_1	264	270	PF00069	0.434
MOD_CK2_1	284	290	PF00069	0.371
MOD_GlcNHglycan	65	68	PF01048	0.336
MOD_GSK3_1	158	165	PF00069	0.494
MOD_GSK3_1	190	197	PF00069	0.489
MOD_GSK3_1	207	214	PF00069	0.352
MOD_GSK3_1	260	267	PF00069	0.494
MOD_GSK3_1	280	287	PF00069	0.412
MOD_GSK3_1	61	68	PF00069	0.417
MOD_GSK3_1	74	81	PF00069	0.414
MOD_LATS_1	49	55	PF00433	0.427
MOD_N-GLC_1	130	135	PF02516	0.227
MOD_N-GLC_1	293	298	PF02516	0.481
MOD_N-GLC_1	51	56	PF02516	0.225
MOD_NEK2_1	146	151	PF00069	0.441
MOD_NEK2_1	264	269	PF00069	0.434
MOD_NEK2_1	65	70	PF00069	0.414
MOD_NEK2_1	98	103	PF00069	0.427
MOD_NEK2_2	91	96	PF00069	0.445
MOD_PIKK_1	74	80	PF00454	0.468
MOD_PKA_1	207	213	PF00069	0.508
MOD_PKA_2	207	213	PF00069	0.511
MOD_PKA_2	260	266	PF00069	0.414
MOD_PKA_2	300	306	PF00069	0.527
MOD_Plk_1	51	57	PF00069	0.414
MOD_Plk_2-3	226	232	PF00069	0.414
MOD_Plk_2-3	284	290	PF00069	0.511
MOD_Plk_4	14	20	PF00069	0.356
MOD_ProDKin_1	11	17	PF00069	0.371
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.427
TRG_ENDOCYTIC_2	175	178	PF00928	0.414
TRG_ER_diArg_1	111	113	PF00400	0.414
TRG_ER_diArg_1	207	209	PF00400	0.508
TRG_ER_diArg_1	298	301	PF00400	0.510
TRG_ER_diArg_1	308	310	PF00400	0.499
TRG_NLS_Bipartite_1	301	323	PF00514	0.477
TRG_NLS_MonoExtC_3	317	322	PF00514	0.445
TRG_NLS_MonoExtN_4	305	311	PF00514	0.531
TRG_NLS_MonoExtN_4	318	323	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P540	Leptomonas seymouri	88%	98%
A0A1X0P9W9	Trypanosomatidae	72%	99%
A0A3R7N9Q4	Trypanosoma rangeli	71%	99%
A0A3S5H566	Leishmania donovani	98%	95%
A4H3Q2	Leishmania braziliensis	94%	100%
A4HRX6	Leishmania infantum	96%	95%
C9ZKI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	99%
E9ACN5	Leishmania major	98%	100%
O14206	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
Q54N44	Dictyostelium discoideum	32%	85%
Q5REM3	Pongo abelii	33%	77%
Q91YU8	Mus musculus	35%	77%
Q9ASU7	Arabidopsis thaliana	30%	100%
Q9NQ55	Homo sapiens	33%	77%
Q9VDE5	Drosophila melanogaster	32%	79%
V5DTY6	Trypanosoma cruzi	71%	99%