FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AJX3_LEIMU

TriTrypDb:

LmxM.03.0890

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJX3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.638
CLV_C14_Caspase3-7	344	348	PF00656	0.547
CLV_C14_Caspase3-7	530	534	PF00656	0.521
CLV_C14_Caspase3-7	565	569	PF00656	0.642
CLV_MEL_PAP_1	189	195	PF00089	0.599
CLV_NRD_NRD_1	328	330	PF00675	0.624
CLV_NRD_NRD_1	526	528	PF00675	0.724
CLV_NRD_NRD_1	64	66	PF00675	0.495
CLV_PCSK_KEX2_1	191	193	PF00082	0.579
CLV_PCSK_KEX2_1	525	527	PF00082	0.723
CLV_PCSK_KEX2_1	64	66	PF00082	0.495
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.647
CLV_PCSK_PC7_1	521	527	PF00082	0.688
CLV_PCSK_SKI1_1	275	279	PF00082	0.363
CLV_PCSK_SKI1_1	309	313	PF00082	0.281
CLV_PCSK_SKI1_1	325	329	PF00082	0.425
CLV_PCSK_SKI1_1	477	481	PF00082	0.334
CLV_PCSK_SKI1_1	564	568	PF00082	0.645
CLV_PCSK_SKI1_1	634	638	PF00082	0.496
CLV_PCSK_SKI1_1	64	68	PF00082	0.576
DEG_APCC_DBOX_1	324	332	PF00400	0.478
DEG_SPOP_SBC_1	240	244	PF00917	0.354
DOC_CYCLIN_yCln2_LP_2	86	89	PF00134	0.550
DOC_MAPK_DCC_7	477	487	PF00069	0.295
DOC_MAPK_gen_1	225	233	PF00069	0.317
DOC_MAPK_gen_1	477	487	PF00069	0.336
DOC_MAPK_MEF2A_6	225	233	PF00069	0.319
DOC_MAPK_MEF2A_6	480	489	PF00069	0.295
DOC_PP1_RVXF_1	194	201	PF00149	0.529
DOC_PP1_RVXF_1	62	69	PF00149	0.595
DOC_PP1_SILK_1	634	639	PF00149	0.560
DOC_PP2B_LxvP_1	479	482	PF13499	0.295
DOC_PP2B_LxvP_1	504	507	PF13499	0.331
DOC_PP2B_LxvP_1	628	631	PF13499	0.481
DOC_PP2B_LxvP_1	85	88	PF13499	0.609
DOC_PP4_MxPP_1	516	519	PF00568	0.630
DOC_USP7_MATH_1	113	117	PF00917	0.591
DOC_USP7_MATH_1	258	262	PF00917	0.303
DOC_USP7_MATH_1	31	35	PF00917	0.623
DOC_USP7_MATH_1	341	345	PF00917	0.663
DOC_USP7_MATH_1	354	358	PF00917	0.606
DOC_USP7_MATH_1	374	378	PF00917	0.557
DOC_USP7_MATH_1	42	46	PF00917	0.615
DOC_USP7_MATH_1	546	550	PF00917	0.656
DOC_USP7_MATH_1	80	84	PF00917	0.602
DOC_USP7_UBL2_3	470	474	PF12436	0.354
LIG_14-3-3_CanoR_1	133	142	PF00244	0.552
LIG_14-3-3_CanoR_1	183	189	PF00244	0.619
LIG_14-3-3_CanoR_1	192	200	PF00244	0.605
LIG_14-3-3_CanoR_1	275	285	PF00244	0.354
LIG_14-3-3_CanoR_1	350	354	PF00244	0.707
LIG_Actin_WH2_2	623	640	PF00022	0.467
LIG_BIR_III_4	556	560	PF00653	0.678
LIG_Clathr_ClatBox_1	486	490	PF01394	0.354
LIG_deltaCOP1_diTrp_1	124	131	PF00928	0.667
LIG_FHA_1	501	507	PF00498	0.275
LIG_FHA_2	250	256	PF00498	0.295
LIG_FHA_2	391	397	PF00498	0.685
LIG_FHA_2	444	450	PF00498	0.726
LIG_FHA_2	558	564	PF00498	0.690
LIG_FHA_2	591	597	PF00498	0.652
LIG_FHA_2	607	613	PF00498	0.721
LIG_GBD_Chelix_1	229	237	PF00786	0.354
LIG_LIR_Gen_1	252	260	PF02991	0.301
LIG_LIR_Gen_1	270	281	PF02991	0.397
LIG_LIR_Gen_1	432	443	PF02991	0.485
LIG_LIR_LC3C_4	625	630	PF02991	0.437
LIG_LIR_Nem_3	187	193	PF02991	0.560
LIG_LIR_Nem_3	252	256	PF02991	0.311
LIG_LIR_Nem_3	270	276	PF02991	0.445
LIG_LIR_Nem_3	432	438	PF02991	0.486
LIG_LIR_Nem_3	5	9	PF02991	0.735
LIG_NRBOX	616	622	PF00104	0.539
LIG_NRBOX	623	629	PF00104	0.433
LIG_PAM2_1	276	288	PF00658	0.354
LIG_Pex14_1	127	131	PF04695	0.668
LIG_Pex14_1	269	273	PF04695	0.354
LIG_SH2_CRK	190	194	PF00017	0.599
LIG_SH2_CRK	273	277	PF00017	0.354
LIG_SH2_CRK	435	439	PF00017	0.485
LIG_SH2_CRK	6	10	PF00017	0.792
LIG_SH2_SRC	509	512	PF00017	0.509
LIG_SH2_STAP1	273	277	PF00017	0.354
LIG_SH2_STAP1	297	301	PF00017	0.295
LIG_SH2_STAT3	315	318	PF00017	0.354
LIG_SH2_STAT5	509	512	PF00017	0.529
LIG_SH3_3	103	109	PF00018	0.529
LIG_SH3_3	122	128	PF00018	0.604
LIG_SH3_3	502	508	PF00018	0.325
LIG_SH3_3	86	92	PF00018	0.647
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.295
LIG_SUMO_SIM_anti_2	625	632	PF11976	0.454
LIG_SUMO_SIM_par_1	227	232	PF11976	0.318
LIG_SUMO_SIM_par_1	484	490	PF11976	0.369
LIG_SUMO_SIM_par_1	611	622	PF11976	0.616
LIG_SUMO_SIM_par_1	625	632	PF11976	0.436
LIG_TRAF2_1	560	563	PF00917	0.578
LIG_TYR_ITIM	188	193	PF00017	0.602
MOD_CK1_1	135	141	PF00069	0.482
MOD_CK1_1	158	164	PF00069	0.706
MOD_CK1_1	241	247	PF00069	0.354
MOD_CK1_1	377	383	PF00069	0.624
MOD_CK1_1	389	395	PF00069	0.598
MOD_CK1_1	428	434	PF00069	0.787
MOD_CK1_1	594	600	PF00069	0.754
MOD_CK2_1	249	255	PF00069	0.295
MOD_CK2_1	258	264	PF00069	0.295
MOD_CK2_1	51	57	PF00069	0.510
MOD_CK2_1	557	563	PF00069	0.722
MOD_CK2_1	619	625	PF00069	0.491
MOD_CK2_1	7	13	PF00069	0.634
MOD_Cter_Amidation	68	71	PF01082	0.604
MOD_GlcNHglycan	137	140	PF01048	0.593
MOD_GlcNHglycan	174	177	PF01048	0.550
MOD_GlcNHglycan	260	263	PF01048	0.295
MOD_GlcNHglycan	291	294	PF01048	0.334
MOD_GlcNHglycan	33	36	PF01048	0.597
MOD_GlcNHglycan	343	346	PF01048	0.695
MOD_GlcNHglycan	362	365	PF01048	0.726
MOD_GlcNHglycan	367	370	PF01048	0.779
MOD_GlcNHglycan	379	382	PF01048	0.638
MOD_GlcNHglycan	388	391	PF01048	0.602
MOD_GlcNHglycan	401	404	PF01048	0.803
MOD_GlcNHglycan	427	430	PF01048	0.691
MOD_GlcNHglycan	44	47	PF01048	0.650
MOD_GlcNHglycan	529	532	PF01048	0.600
MOD_GlcNHglycan	536	539	PF01048	0.651
MOD_GlcNHglycan	78	81	PF01048	0.597
MOD_GSK3_1	113	120	PF00069	0.601
MOD_GSK3_1	131	138	PF00069	0.581
MOD_GSK3_1	150	157	PF00069	0.547
MOD_GSK3_1	217	224	PF00069	0.501
MOD_GSK3_1	36	43	PF00069	0.655
MOD_GSK3_1	376	383	PF00069	0.661
MOD_GSK3_1	386	393	PF00069	0.753
MOD_GSK3_1	425	432	PF00069	0.712
MOD_GSK3_1	434	441	PF00069	0.766
MOD_GSK3_1	489	496	PF00069	0.363
MOD_GSK3_1	546	553	PF00069	0.737
MOD_GSK3_1	564	571	PF00069	0.644
MOD_GSK3_1	590	597	PF00069	0.668
MOD_GSK3_1	76	83	PF00069	0.647
MOD_LATS_1	405	411	PF00433	0.504
MOD_N-GLC_1	155	160	PF02516	0.691
MOD_N-GLC_1	172	177	PF02516	0.521
MOD_N-GLC_1	399	404	PF02516	0.777
MOD_NEK2_1	131	136	PF00069	0.663
MOD_NEK2_1	198	203	PF00069	0.537
MOD_NEK2_1	209	214	PF00069	0.464
MOD_NEK2_1	233	238	PF00069	0.295
MOD_NEK2_1	276	281	PF00069	0.297
MOD_NEK2_1	289	294	PF00069	0.289
MOD_NEK2_1	29	34	PF00069	0.529
MOD_NEK2_1	425	430	PF00069	0.665
MOD_NEK2_1	438	443	PF00069	0.529
MOD_NEK2_1	93	98	PF00069	0.589
MOD_NEK2_2	546	551	PF00069	0.629
MOD_PKA_1	191	197	PF00069	0.572
MOD_PKA_1	526	532	PF00069	0.695
MOD_PKA_2	132	138	PF00069	0.603
MOD_PKA_2	191	197	PF00069	0.569
MOD_PKA_2	349	355	PF00069	0.664
MOD_PKA_2	386	392	PF00069	0.672
MOD_PKA_2	406	412	PF00069	0.677
MOD_PKA_2	520	526	PF00069	0.695
MOD_PKA_2	7	13	PF00069	0.675
MOD_PKB_1	181	189	PF00069	0.653
MOD_PKB_1	525	533	PF00069	0.525
MOD_Plk_1	159	165	PF00069	0.660
MOD_Plk_1	233	239	PF00069	0.295
MOD_Plk_1	29	35	PF00069	0.627
MOD_Plk_1	493	499	PF00069	0.340
MOD_Plk_1	500	506	PF00069	0.341
MOD_Plk_1	594	600	PF00069	0.619
MOD_Plk_2-3	150	156	PF00069	0.658
MOD_Plk_2-3	16	22	PF00069	0.665
MOD_Plk_2-3	51	57	PF00069	0.484
MOD_Plk_2-3	595	601	PF00069	0.570
MOD_Plk_4	101	107	PF00069	0.510
MOD_Plk_4	143	149	PF00069	0.625
MOD_Plk_4	184	190	PF00069	0.550
MOD_Plk_4	297	303	PF00069	0.295
MOD_Plk_4	439	445	PF00069	0.515
MOD_Plk_4	493	499	PF00069	0.313
MOD_Plk_4	500	506	PF00069	0.341
MOD_Plk_4	619	625	PF00069	0.528
MOD_SUMO_rev_2	16	26	PF00179	0.628
MOD_SUMO_rev_2	418	424	PF00179	0.652
TRG_DiLeu_BaEn_1	493	498	PF01217	0.354
TRG_DiLeu_BaEn_1	613	618	PF01217	0.560
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.280
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.550
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.363
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.561
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.608
TRG_DiLeu_LyEn_5	57	62	PF01217	0.428
TRG_ENDOCYTIC_2	190	193	PF00928	0.604
TRG_ENDOCYTIC_2	273	276	PF00928	0.354
TRG_ENDOCYTIC_2	435	438	PF00928	0.486
TRG_ENDOCYTIC_2	6	9	PF00928	0.806
TRG_ER_diArg_1	168	171	PF00400	0.668
TRG_ER_diArg_1	525	527	PF00400	0.724
TRG_ER_diArg_1	64	66	PF00400	0.534
TRG_ER_diArg_1	81	84	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT8	Leptomonas seymouri	58%	91%
A0A3S5H565	Leishmania donovani	89%	87%
A4H3Q1	Leishmania braziliensis	78%	100%
A4HRX5	Leishmania infantum	89%	87%
E9ACN4	Leishmania major	85%	100%
V5BXB7	Trypanosoma cruzi	41%	100%