DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJW7_LEIMU

TriTrypDb:

LmxM.03.0830

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.633
CLV_NRD_NRD_1	25	27	PF00675	0.575
CLV_NRD_NRD_1	72	74	PF00675	0.443
CLV_NRD_NRD_1	87	89	PF00675	0.451
CLV_PCSK_KEX2_1	111	113	PF00082	0.611
CLV_PCSK_KEX2_1	239	241	PF00082	0.614
CLV_PCSK_KEX2_1	25	27	PF00082	0.575
CLV_PCSK_KEX2_1	87	89	PF00082	0.589
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.646
CLV_PCSK_SKI1_1	111	115	PF00082	0.629
CLV_PCSK_SKI1_1	14	18	PF00082	0.548
CLV_PCSK_SKI1_1	190	194	PF00082	0.526
CLV_PCSK_SKI1_1	197	201	PF00082	0.480
CLV_PCSK_SKI1_1	25	29	PF00082	0.638
CLV_PCSK_SKI1_1	336	340	PF00082	0.609
CLV_PCSK_SKI1_1	41	45	PF00082	0.415
CLV_PCSK_SKI1_1	62	66	PF00082	0.450
CLV_PCSK_SKI1_1	73	77	PF00082	0.439
DEG_APCC_DBOX_1	24	32	PF00400	0.625
DEG_APCC_DBOX_1	72	80	PF00400	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SPOP_SBC_1	130	134	PF00917	0.494
DOC_CYCLIN_RxL_1	107	117	PF00134	0.633
DOC_CYCLIN_RxL_1	187	198	PF00134	0.599
DOC_CYCLIN_RxL_1	38	46	PF00134	0.431
DOC_CYCLIN_RxL_1	71	80	PF00134	0.487
DOC_MAPK_gen_1	73	81	PF00069	0.560
DOC_MAPK_MEF2A_6	152	160	PF00069	0.497
DOC_MAPK_MEF2A_6	269	276	PF00069	0.599
DOC_MAPK_MEF2A_6	73	81	PF00069	0.390
DOC_MAPK_NFAT4_5	74	82	PF00069	0.405
DOC_USP7_MATH_1	120	124	PF00917	0.555
DOC_USP7_MATH_1	130	134	PF00917	0.554
DOC_USP7_MATH_1	35	39	PF00917	0.511
DOC_WW_Pin1_4	131	136	PF00397	0.563
DOC_WW_Pin1_4	223	228	PF00397	0.582
LIG_14-3-3_CanoR_1	119	129	PF00244	0.598
LIG_14-3-3_CanoR_1	2	9	PF00244	0.727
LIG_Actin_WH2_2	106	121	PF00022	0.443
LIG_APCC_ABBA_1	293	298	PF00400	0.625
LIG_APCC_ABBA_1	75	80	PF00400	0.510
LIG_APCC_ABBAyCdc20_2	74	80	PF00400	0.507
LIG_BIR_III_4	198	202	PF00653	0.530
LIG_Clathr_ClatBox_1	192	196	PF01394	0.580
LIG_Clathr_ClatBox_1	76	80	PF01394	0.506
LIG_FAT_LD_1	185	193	PF03623	0.612
LIG_FHA_1	151	157	PF00498	0.432
LIG_FHA_1	281	287	PF00498	0.508
LIG_FHA_2	306	312	PF00498	0.455
LIG_FHA_2	330	336	PF00498	0.561
LIG_GBD_Chelix_1	184	192	PF00786	0.620
LIG_Integrin_RGD_1	208	210	PF01839	0.547
LIG_LIR_Gen_1	100	110	PF02991	0.561
LIG_LIR_Gen_1	123	131	PF02991	0.583
LIG_LIR_Gen_1	229	238	PF02991	0.547
LIG_LIR_Gen_1	46	56	PF02991	0.494
LIG_LIR_Nem_3	100	105	PF02991	0.507
LIG_LIR_Nem_3	198	203	PF02991	0.539
LIG_LIR_Nem_3	332	337	PF02991	0.589
LIG_PCNA_PIPBox_1	58	67	PF02747	0.487
LIG_Pex14_1	334	338	PF04695	0.543
LIG_PTB_Apo_2	327	334	PF02174	0.598
LIG_SH2_SRC	136	139	PF00017	0.592
LIG_SH2_SRC	297	300	PF00017	0.620
LIG_SH2_STAP1	125	129	PF00017	0.507
LIG_SH2_STAT5	12	15	PF00017	0.628
LIG_SH2_STAT5	136	139	PF00017	0.591
LIG_SH2_STAT5	244	247	PF00017	0.513
LIG_SH2_STAT5	337	340	PF00017	0.620
LIG_SH3_1	269	275	PF00018	0.640
LIG_SH3_3	132	138	PF00018	0.622
LIG_SH3_3	269	275	PF00018	0.652
LIG_SH3_3	31	37	PF00018	0.423
LIG_SUMO_SIM_anti_2	191	196	PF11976	0.585
LIG_SUMO_SIM_par_1	191	196	PF11976	0.537
LIG_UBA3_1	233	239	PF00899	0.528
LIG_UBA3_1	75	83	PF00899	0.532
MOD_CK1_1	309	315	PF00069	0.432
MOD_CK2_1	305	311	PF00069	0.607
MOD_CK2_1	329	335	PF00069	0.540
MOD_GlcNHglycan	5	8	PF01048	0.673
MOD_GSK3_1	142	149	PF00069	0.586
MOD_GSK3_1	276	283	PF00069	0.550
MOD_GSK3_1	3	10	PF00069	0.695
MOD_GSK3_1	305	312	PF00069	0.546
MOD_N-GLC_1	329	334	PF02516	0.633
MOD_N-GLC_2	243	245	PF02516	0.568
MOD_NEK2_1	129	134	PF00069	0.536
MOD_NEK2_1	214	219	PF00069	0.748
MOD_NEK2_1	276	281	PF00069	0.553
MOD_NEK2_1	326	331	PF00069	0.674
MOD_PKA_2	309	315	PF00069	0.432
MOD_Plk_1	329	335	PF00069	0.594
MOD_Plk_4	276	282	PF00069	0.668
MOD_Plk_4	8	14	PF00069	0.569
MOD_ProDKin_1	131	137	PF00069	0.560
MOD_ProDKin_1	223	229	PF00069	0.580
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.526
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.659
TRG_ENDOCYTIC_2	125	128	PF00928	0.489
TRG_ER_diArg_1	110	112	PF00400	0.644
TRG_ER_diArg_1	24	26	PF00400	0.564
TRG_ER_diArg_1	87	89	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	66%	88%
A0A0S4IVU1	Bodo saltans	38%	100%
A0A1X0P922	Trypanosomatidae	49%	88%
A0A451EJT2	Leishmania donovani	95%	86%
A4H3P5	Leishmania braziliensis	84%	99%
C9ZKH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E8NHC8	Leishmania infantum	95%	86%
E9ACM8	Leishmania major	94%	100%
V5DTZ7	Trypanosoma cruzi	49%	85%