Putative aminoalcohol phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AJW6_LEIMU

TriTrypDb:

LmxM.03.0821

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AJW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJW6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.407
CLV_C14_Caspase3-7	265	269	PF00656	0.661
CLV_NRD_NRD_1	126	128	PF00675	0.260
CLV_NRD_NRD_1	305	307	PF00675	0.344
CLV_NRD_NRD_1	368	370	PF00675	0.547
CLV_NRD_NRD_1	381	383	PF00675	0.505
CLV_NRD_NRD_1	419	421	PF00675	0.325
CLV_NRD_NRD_1	454	456	PF00675	0.508
CLV_NRD_NRD_1	595	597	PF00675	0.392
CLV_PCSK_KEX2_1	126	128	PF00082	0.251
CLV_PCSK_KEX2_1	305	307	PF00082	0.344
CLV_PCSK_KEX2_1	368	370	PF00082	0.556
CLV_PCSK_KEX2_1	381	383	PF00082	0.583
CLV_PCSK_KEX2_1	419	421	PF00082	0.325
CLV_PCSK_KEX2_1	454	456	PF00082	0.508
CLV_PCSK_SKI1_1	12	16	PF00082	0.305
CLV_PCSK_SKI1_1	187	191	PF00082	0.482
CLV_PCSK_SKI1_1	294	298	PF00082	0.362
CLV_PCSK_SKI1_1	580	584	PF00082	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DEG_ODPH_VHL_1	457	469	PF01847	0.259
DEG_ODPH_VHL_1	46	58	PF01847	0.282
DEG_SCF_FBW7_2	367	374	PF00400	0.361
DOC_CYCLIN_RxL_1	291	300	PF00134	0.493
DOC_MAPK_gen_1	10	17	PF00069	0.491
DOC_MAPK_gen_1	381	387	PF00069	0.306
DOC_MAPK_MEF2A_6	10	17	PF00069	0.491
DOC_MAPK_MEF2A_6	187	194	PF00069	0.284
DOC_MAPK_MEF2A_6	339	347	PF00069	0.419
DOC_MAPK_MEF2A_6	395	404	PF00069	0.230
DOC_MAPK_MEF2A_6	435	442	PF00069	0.230
DOC_MAPK_MEF2A_6	454	463	PF00069	0.205
DOC_MAPK_NFAT4_5	10	18	PF00069	0.492
DOC_MAPK_NFAT4_5	187	195	PF00069	0.288
DOC_MAPK_NFAT4_5	435	443	PF00069	0.230
DOC_MAPK_RevD_3	440	455	PF00069	0.319
DOC_PP2B_LxvP_1	190	193	PF13499	0.240
DOC_PP2B_LxvP_1	557	560	PF13499	0.485
DOC_PP4_FxxP_1	562	565	PF00568	0.476
DOC_SPAK_OSR1_1	382	386	PF12202	0.303
DOC_USP7_MATH_1	156	160	PF00917	0.440
DOC_USP7_MATH_1	267	271	PF00917	0.568
DOC_USP7_MATH_1	334	338	PF00917	0.435
DOC_USP7_MATH_1	353	357	PF00917	0.259
DOC_USP7_MATH_1	590	594	PF00917	0.521
DOC_WW_Pin1_4	129	134	PF00397	0.429
DOC_WW_Pin1_4	367	372	PF00397	0.397
DOC_WW_Pin1_4	86	91	PF00397	0.510
LIG_14-3-3_CanoR_1	127	133	PF00244	0.478
LIG_14-3-3_CanoR_1	327	336	PF00244	0.506
LIG_14-3-3_CanoR_1	339	344	PF00244	0.476
LIG_14-3-3_CanoR_1	454	458	PF00244	0.257
LIG_14-3-3_CanoR_1	580	588	PF00244	0.518
LIG_14-3-3_CanoR_1	83	93	PF00244	0.388
LIG_14-3-3_CterR_2	596	599	PF00244	0.547
LIG_Actin_WH2_2	557	575	PF00022	0.494
LIG_BRCT_BRCA1_1	383	387	PF00533	0.358
LIG_BRCT_BRCA1_1	446	450	PF00533	0.323
LIG_Clathr_ClatBox_1	276	280	PF01394	0.476
LIG_eIF4E_1	185	191	PF01652	0.205
LIG_EVH1_2	273	277	PF00568	0.493
LIG_EVH1_2	98	102	PF00568	0.247
LIG_FHA_1	164	170	PF00498	0.416
LIG_FHA_1	210	216	PF00498	0.317
LIG_FHA_1	291	297	PF00498	0.568
LIG_FHA_1	340	346	PF00498	0.405
LIG_FHA_1	426	432	PF00498	0.230
LIG_FHA_1	541	547	PF00498	0.442
LIG_FHA_1	551	557	PF00498	0.560
LIG_FHA_1	583	589	PF00498	0.543
LIG_FHA_1	60	66	PF00498	0.307
LIG_FHA_1	86	92	PF00498	0.520
LIG_FHA_2	179	185	PF00498	0.310
LIG_FHA_2	259	265	PF00498	0.667
LIG_GBD_Chelix_1	109	117	PF00786	0.259
LIG_LIR_Gen_1	166	175	PF02991	0.230
LIG_LIR_Gen_1	24	34	PF02991	0.467
LIG_LIR_Gen_1	337	348	PF02991	0.479
LIG_LIR_Gen_1	499	507	PF02991	0.683
LIG_LIR_Gen_1	541	550	PF02991	0.475
LIG_LIR_Nem_3	166	170	PF02991	0.232
LIG_LIR_Nem_3	181	185	PF02991	0.301
LIG_LIR_Nem_3	337	343	PF02991	0.504
LIG_LIR_Nem_3	384	390	PF02991	0.442
LIG_LIR_Nem_3	40	44	PF02991	0.476
LIG_LIR_Nem_3	447	453	PF02991	0.278
LIG_LIR_Nem_3	499	503	PF02991	0.683
LIG_LIR_Nem_3	541	545	PF02991	0.519
LIG_LIR_Nem_3	57	61	PF02991	0.267
LIG_NRBOX	112	118	PF00104	0.342
LIG_PCNA_PIPBox_1	322	331	PF02747	0.553
LIG_PCNA_yPIPBox_3	322	333	PF02747	0.507
LIG_Pex14_1	182	186	PF04695	0.205
LIG_Pex14_2	178	182	PF04695	0.250
LIG_Pex14_2	383	387	PF04695	0.295
LIG_SH2_CRK	186	190	PF00017	0.226
LIG_SH2_CRK	340	344	PF00017	0.419
LIG_SH2_CRK	364	368	PF00017	0.255
LIG_SH2_CRK	433	437	PF00017	0.282
LIG_SH2_GRB2like	222	225	PF00017	0.482
LIG_SH2_SRC	222	225	PF00017	0.482
LIG_SH2_SRC	4	7	PF00017	0.541
LIG_SH2_SRC	41	44	PF00017	0.481
LIG_SH2_STAP1	433	437	PF00017	0.342
LIG_SH2_STAP1	518	522	PF00017	0.653
LIG_SH2_STAP1	532	536	PF00017	0.473
LIG_SH2_STAT5	16	19	PF00017	0.475
LIG_SH2_STAT5	209	212	PF00017	0.261
LIG_SH2_STAT5	25	28	PF00017	0.463
LIG_SH2_STAT5	259	262	PF00017	0.561
LIG_SH2_STAT5	4	7	PF00017	0.461
LIG_SH2_STAT5	41	44	PF00017	0.481
LIG_SH2_STAT5	433	436	PF00017	0.250
LIG_SH2_STAT5	471	474	PF00017	0.385
LIG_SH2_STAT5	505	508	PF00017	0.620
LIG_SH3_1	286	292	PF00018	0.504
LIG_SH3_2	289	294	PF14604	0.566
LIG_SH3_3	212	218	PF00018	0.328
LIG_SH3_3	223	229	PF00018	0.507
LIG_SH3_3	286	292	PF00018	0.530
LIG_SH3_3	91	97	PF00018	0.454
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.259
LIG_SUMO_SIM_par_1	166	173	PF11976	0.282
LIG_SUMO_SIM_par_1	397	403	PF11976	0.284
LIG_TRAF2_1	181	184	PF00917	0.250
LIG_TRAF2_1	261	264	PF00917	0.511
LIG_TYR_ITIM	112	117	PF00017	0.181
LIG_TYR_ITIM	338	343	PF00017	0.468
LIG_TYR_ITIM	39	44	PF00017	0.553
LIG_TYR_ITIM	431	436	PF00017	0.282
LIG_UBA3_1	1	10	PF00899	0.500
LIG_WRC_WIRS_1	174	179	PF05994	0.259
LIG_WRC_WIRS_1	401	406	PF05994	0.259
MOD_CK1_1	163	169	PF00069	0.551
MOD_CK1_1	316	322	PF00069	0.496
MOD_CK1_1	510	516	PF00069	0.573
MOD_CK1_1	538	544	PF00069	0.512
MOD_CK2_1	178	184	PF00069	0.310
MOD_CK2_1	258	264	PF00069	0.653
MOD_CMANNOS	164	167	PF00535	0.219
MOD_CMANNOS	211	214	PF00535	0.342
MOD_Cter_Amidation	379	382	PF01082	0.520
MOD_GlcNHglycan	158	161	PF01048	0.306
MOD_GlcNHglycan	268	272	PF01048	0.483
MOD_GlcNHglycan	315	318	PF01048	0.320
MOD_GlcNHglycan	322	325	PF01048	0.419
MOD_GlcNHglycan	355	358	PF01048	0.342
MOD_GlcNHglycan	406	409	PF01048	0.267
MOD_GlcNHglycan	446	449	PF01048	0.572
MOD_GlcNHglycan	485	488	PF01048	0.488
MOD_GlcNHglycan	518	521	PF01048	0.510
MOD_GlcNHglycan	537	540	PF01048	0.211
MOD_GlcNHglycan	75	78	PF01048	0.602
MOD_GSK3_1	125	132	PF00069	0.440
MOD_GSK3_1	156	163	PF00069	0.460
MOD_GSK3_1	17	24	PF00069	0.484
MOD_GSK3_1	316	323	PF00069	0.484
MOD_GSK3_1	400	407	PF00069	0.373
MOD_GSK3_1	503	510	PF00069	0.619
MOD_GSK3_1	79	86	PF00069	0.571
MOD_N-GLC_1	473	478	PF02516	0.335
MOD_N-GLC_1	83	88	PF02516	0.630
MOD_NEK2_1	279	284	PF00069	0.615
MOD_NEK2_1	404	409	PF00069	0.295
MOD_NEK2_1	410	415	PF00069	0.386
MOD_NEK2_1	425	430	PF00069	0.230
MOD_NEK2_1	431	436	PF00069	0.230
MOD_NEK2_1	453	458	PF00069	0.309
MOD_NEK2_1	535	540	PF00069	0.517
MOD_NEK2_1	545	550	PF00069	0.516
MOD_NEK2_2	334	339	PF00069	0.491
MOD_PK_1	381	387	PF00069	0.306
MOD_PKA_1	381	387	PF00069	0.306
MOD_PKA_2	125	131	PF00069	0.460
MOD_PKA_2	381	387	PF00069	0.374
MOD_PKA_2	453	459	PF00069	0.257
MOD_PKA_2	513	519	PF00069	0.560
MOD_PKA_2	550	556	PF00069	0.491
MOD_Plk_1	21	27	PF00069	0.446
MOD_Plk_1	473	479	PF00069	0.647
MOD_Plk_4	163	169	PF00069	0.452
MOD_Plk_4	170	176	PF00069	0.314
MOD_Plk_4	316	322	PF00069	0.520
MOD_Plk_4	467	473	PF00069	0.282
MOD_Plk_4	54	60	PF00069	0.181
MOD_ProDKin_1	129	135	PF00069	0.429
MOD_ProDKin_1	367	373	PF00069	0.401
MOD_ProDKin_1	86	92	PF00069	0.509
TRG_DiLeu_BaEn_1	552	557	PF01217	0.463
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.542
TRG_ENDOCYTIC_2	114	117	PF00928	0.230
TRG_ENDOCYTIC_2	186	189	PF00928	0.285
TRG_ENDOCYTIC_2	27	30	PF00928	0.452
TRG_ENDOCYTIC_2	340	343	PF00928	0.447
TRG_ENDOCYTIC_2	364	367	PF00928	0.248
TRG_ENDOCYTIC_2	41	44	PF00928	0.481
TRG_ENDOCYTIC_2	433	436	PF00928	0.282
TRG_ENDOCYTIC_2	532	535	PF00928	0.532
TRG_ER_diArg_1	367	369	PF00400	0.348
TRG_ER_diArg_1	381	383	PF00400	0.383
TRG_ER_diArg_1	418	420	PF00400	0.513
TRG_ER_diArg_1	453	455	PF00400	0.314
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y1	Leptomonas seymouri	63%	100%
A0A0S4J7L0	Bodo saltans	46%	100%
A0A1X0P8W0	Trypanosomatidae	45%	100%
A0A3S5H562	Leishmania donovani	84%	97%
E8NHC2	Leishmania infantum	84%	97%
V5BXC7	Trypanosoma cruzi	44%	100%