Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJW2_LEIMU

TriTrypDb:

LmxM.03.0790

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.474
CLV_C14_Caspase3-7	274	278	PF00656	0.655
CLV_C14_Caspase3-7	411	415	PF00656	0.447
CLV_NRD_NRD_1	13	15	PF00675	0.571
CLV_NRD_NRD_1	233	235	PF00675	0.417
CLV_NRD_NRD_1	242	244	PF00675	0.495
CLV_PCSK_FUR_1	11	15	PF00082	0.567
CLV_PCSK_KEX2_1	11	13	PF00082	0.570
CLV_PCSK_KEX2_1	233	235	PF00082	0.431
CLV_PCSK_KEX2_1	241	243	PF00082	0.538
CLV_PCSK_PC7_1	238	244	PF00082	0.359
CLV_PCSK_SKI1_1	384	388	PF00082	0.555
DEG_SCF_FBW7_1	340	345	PF00400	0.488
DEG_SPOP_SBC_1	276	280	PF00917	0.507
DEG_SPOP_SBC_1	299	303	PF00917	0.577
DEG_SPOP_SBC_1	88	92	PF00917	0.464
DOC_CKS1_1	332	337	PF01111	0.638
DOC_CYCLIN_RxL_1	381	391	PF00134	0.561
DOC_MAPK_gen_1	238	246	PF00069	0.365
DOC_PP2B_LxvP_1	244	247	PF13499	0.587
DOC_USP7_MATH_1	104	108	PF00917	0.388
DOC_USP7_MATH_1	125	129	PF00917	0.584
DOC_USP7_MATH_1	179	183	PF00917	0.620
DOC_USP7_MATH_1	309	313	PF00917	0.779
DOC_USP7_MATH_1	362	366	PF00917	0.653
DOC_USP7_MATH_1	382	386	PF00917	0.378
DOC_USP7_MATH_1	54	58	PF00917	0.592
DOC_USP7_MATH_1	88	92	PF00917	0.580
DOC_USP7_MATH_1	95	99	PF00917	0.463
DOC_WW_Pin1_4	102	107	PF00397	0.547
DOC_WW_Pin1_4	133	138	PF00397	0.459
DOC_WW_Pin1_4	253	258	PF00397	0.709
DOC_WW_Pin1_4	292	297	PF00397	0.599
DOC_WW_Pin1_4	331	336	PF00397	0.645
DOC_WW_Pin1_4	338	343	PF00397	0.558
DOC_WW_Pin1_4	366	371	PF00397	0.733
LIG_14-3-3_CanoR_1	143	152	PF00244	0.556
LIG_14-3-3_CanoR_1	285	289	PF00244	0.643
LIG_14-3-3_CanoR_1	384	393	PF00244	0.534
LIG_14-3-3_CanoR_1	63	68	PF00244	0.633
LIG_Clathr_ClatBox_1	265	269	PF01394	0.494
LIG_CSL_BTD_1	244	247	PF09270	0.502
LIG_CSL_BTD_1	343	346	PF09270	0.496
LIG_FHA_1	144	150	PF00498	0.411
LIG_FHA_1	278	284	PF00498	0.597
LIG_FHA_1	332	338	PF00498	0.790
LIG_FHA_1	46	52	PF00498	0.477
LIG_FHA_1	84	90	PF00498	0.601
LIG_FHA_1	97	103	PF00498	0.542
LIG_FHA_2	146	152	PF00498	0.531
LIG_FHA_2	301	307	PF00498	0.619
LIG_FHA_2	315	321	PF00498	0.671
LIG_LIR_Gen_1	156	163	PF02991	0.655
LIG_LIR_Gen_1	190	201	PF02991	0.461
LIG_LIR_Gen_1	215	223	PF02991	0.446
LIG_LIR_LC3C_4	108	113	PF02991	0.569
LIG_LIR_Nem_3	156	162	PF02991	0.652
LIG_LIR_Nem_3	190	196	PF02991	0.437
LIG_LIR_Nem_3	215	220	PF02991	0.491
LIG_LIR_Nem_3	405	410	PF02991	0.410
LIG_LIR_Nem_3	5	10	PF02991	0.526
LIG_NRBOX	110	116	PF00104	0.572
LIG_NRP_CendR_1	445	446	PF00754	0.488
LIG_PCNA_yPIPBox_3	3	17	PF02747	0.512
LIG_SH2_CRK	159	163	PF00017	0.668
LIG_SH2_CRK	193	197	PF00017	0.429
LIG_SH2_CRK	7	11	PF00017	0.511
LIG_SH2_STAP1	193	197	PF00017	0.427
LIG_SH2_STAT3	373	376	PF00017	0.621
LIG_SH2_STAT5	123	126	PF00017	0.464
LIG_SH3_2	255	260	PF14604	0.503
LIG_SH3_3	149	155	PF00018	0.472
LIG_SH3_3	248	254	PF00018	0.754
LIG_SH3_3	290	296	PF00018	0.497
LIG_SH3_3	329	335	PF00018	0.578
LIG_SH3_3	394	400	PF00018	0.406
LIG_Sin3_3	47	54	PF02671	0.473
LIG_SUMO_SIM_par_1	110	117	PF11976	0.480
LIG_SUMO_SIM_par_1	85	92	PF11976	0.441
LIG_TRFH_1	25	29	PF08558	0.599
MOD_CDK_SPxxK_3	253	260	PF00069	0.497
MOD_CDK_SPxxK_3	342	349	PF00069	0.502
MOD_CK1_1	105	111	PF00069	0.459
MOD_CK1_1	369	375	PF00069	0.691
MOD_CK1_1	385	391	PF00069	0.369
MOD_CK1_1	59	65	PF00069	0.631
MOD_CK1_1	66	72	PF00069	0.726
MOD_CK1_1	98	104	PF00069	0.479
MOD_CK2_1	267	273	PF00069	0.541
MOD_CK2_1	275	281	PF00069	0.494
MOD_CK2_1	385	391	PF00069	0.524
MOD_Cter_Amidation	443	446	PF01082	0.461
MOD_GlcNHglycan	133	136	PF01048	0.600
MOD_GlcNHglycan	168	171	PF01048	0.716
MOD_GlcNHglycan	175	178	PF01048	0.601
MOD_GlcNHglycan	262	265	PF01048	0.697
MOD_GlcNHglycan	311	314	PF01048	0.784
MOD_GlcNHglycan	355	358	PF01048	0.668
MOD_GlcNHglycan	52	55	PF01048	0.590
MOD_GlcNHglycan	56	59	PF01048	0.593
MOD_GlcNHglycan	76	79	PF01048	0.786
MOD_GlcNHglycan	91	94	PF01048	0.592
MOD_GSK3_1	162	169	PF00069	0.672
MOD_GSK3_1	175	182	PF00069	0.591
MOD_GSK3_1	183	190	PF00069	0.475
MOD_GSK3_1	327	334	PF00069	0.759
MOD_GSK3_1	338	345	PF00069	0.559
MOD_GSK3_1	362	369	PF00069	0.740
MOD_GSK3_1	50	57	PF00069	0.603
MOD_GSK3_1	59	66	PF00069	0.602
MOD_GSK3_1	83	90	PF00069	0.587
MOD_GSK3_1	98	105	PF00069	0.621
MOD_N-GLC_1	125	130	PF02516	0.591
MOD_N-GLC_1	260	265	PF02516	0.649
MOD_N-GLC_1	327	332	PF02516	0.705
MOD_NEK2_1	131	136	PF00069	0.590
MOD_NEK2_1	188	193	PF00069	0.579
MOD_NEK2_1	31	36	PF00069	0.586
MOD_NEK2_1	68	73	PF00069	0.640
MOD_PIKK_1	301	307	PF00454	0.576
MOD_PK_1	267	273	PF00069	0.541
MOD_PK_1	63	69	PF00069	0.632
MOD_PKA_2	284	290	PF00069	0.705
MOD_PKA_2	309	315	PF00069	0.712
MOD_PKB_1	143	151	PF00069	0.420
MOD_Plk_1	116	122	PF00069	0.449
MOD_Plk_1	125	131	PF00069	0.508
MOD_Plk_1	327	333	PF00069	0.651
MOD_Plk_4	116	122	PF00069	0.449
MOD_Plk_4	126	132	PF00069	0.522
MOD_Plk_4	154	160	PF00069	0.547
MOD_Plk_4	179	185	PF00069	0.524
MOD_Plk_4	63	69	PF00069	0.656
MOD_Plk_4	98	104	PF00069	0.498
MOD_ProDKin_1	102	108	PF00069	0.538
MOD_ProDKin_1	133	139	PF00069	0.458
MOD_ProDKin_1	253	259	PF00069	0.712
MOD_ProDKin_1	292	298	PF00069	0.604
MOD_ProDKin_1	331	337	PF00069	0.643
MOD_ProDKin_1	338	344	PF00069	0.559
MOD_ProDKin_1	366	372	PF00069	0.724
MOD_SUMO_for_1	266	269	PF00179	0.687
TRG_DiLeu_BaEn_1	391	396	PF01217	0.489
TRG_DiLeu_BaEn_1	5	10	PF01217	0.526
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.605
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.410
TRG_ENDOCYTIC_2	159	162	PF00928	0.666
TRG_ENDOCYTIC_2	193	196	PF00928	0.435
TRG_ENDOCYTIC_2	407	410	PF00928	0.420
TRG_ENDOCYTIC_2	7	10	PF00928	0.510
TRG_ER_diArg_1	10	13	PF00400	0.568
TRG_ER_diArg_1	232	234	PF00400	0.416
TRG_ER_diArg_1	240	243	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J3	Leptomonas seymouri	47%	98%
A0A3S5H559	Leishmania donovani	82%	100%
A4H3P0	Leishmania braziliensis	69%	99%
A4HRW7	Leishmania infantum	82%	100%
E9ACM4	Leishmania major	81%	98%