Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJW0_LEIMU

TriTrypDb:

LmxM.03.0770

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AJW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJW0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043014	alpha-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.384
CLV_C14_Caspase3-7	365	369	PF00656	0.371
CLV_C14_Caspase3-7	8	12	PF00656	0.392
CLV_PCSK_SKI1_1	119	123	PF00082	0.422
CLV_PCSK_SKI1_1	149	153	PF00082	0.359
CLV_PCSK_SKI1_1	294	298	PF00082	0.457
CLV_PCSK_SKI1_1	322	326	PF00082	0.456
CLV_PCSK_SKI1_1	37	41	PF00082	0.438
CLV_PCSK_SKI1_1	376	380	PF00082	0.521
DEG_APCC_DBOX_1	54	62	PF00400	0.496
DEG_SPOP_SBC_1	141	145	PF00917	0.562
DEG_SPOP_SBC_1	456	460	PF00917	0.679
DOC_CDC14_PxL_1	114	122	PF14671	0.487
DOC_CDC14_PxL_1	125	133	PF14671	0.519
DOC_CDC14_PxL_1	166	174	PF14671	0.436
DOC_CKS1_1	510	515	PF01111	0.532
DOC_CYCLIN_RxL_1	170	179	PF00134	0.526
DOC_MAPK_gen_1	291	301	PF00069	0.411
DOC_MAPK_gen_1	36	43	PF00069	0.609
DOC_MAPK_gen_1	415	423	PF00069	0.425
DOC_MAPK_gen_1	49	58	PF00069	0.394
DOC_MAPK_MEF2A_6	181	189	PF00069	0.581
DOC_MAPK_MEF2A_6	36	43	PF00069	0.426
DOC_MAPK_MEF2A_6	405	413	PF00069	0.432
DOC_MAPK_MEF2A_6	417	425	PF00069	0.493
DOC_MAPK_MEF2A_6	52	60	PF00069	0.511
DOC_MAPK_MEF2A_6	62	70	PF00069	0.370
DOC_PP2B_LxvP_1	261	264	PF13499	0.498
DOC_PP4_MxPP_1	1	4	PF00568	0.418
DOC_PP4_MxPP_1	134	137	PF00568	0.554
DOC_USP7_MATH_1	141	145	PF00917	0.536
DOC_USP7_MATH_1	204	208	PF00917	0.737
DOC_USP7_MATH_1	457	461	PF00917	0.681
DOC_USP7_MATH_1	5	9	PF00917	0.468
DOC_USP7_UBL2_3	415	419	PF12436	0.469
DOC_WW_Pin1_4	192	197	PF00397	0.665
DOC_WW_Pin1_4	460	465	PF00397	0.532
DOC_WW_Pin1_4	509	514	PF00397	0.515
LIG_14-3-3_CanoR_1	119	124	PF00244	0.476
LIG_14-3-3_CanoR_1	294	299	PF00244	0.452
LIG_14-3-3_CanoR_1	327	337	PF00244	0.371
LIG_14-3-3_CanoR_1	497	501	PF00244	0.488
LIG_14-3-3_CanoR_1	55	59	PF00244	0.500
LIG_deltaCOP1_diTrp_1	35	40	PF00928	0.651
LIG_eIF4E_1	373	379	PF01652	0.504
LIG_FHA_1	120	126	PF00498	0.425
LIG_FHA_1	137	143	PF00498	0.537
LIG_FHA_1	221	227	PF00498	0.359
LIG_FHA_1	276	282	PF00498	0.540
LIG_FHA_1	308	314	PF00498	0.442
LIG_FHA_1	323	329	PF00498	0.240
LIG_FHA_1	350	356	PF00498	0.465
LIG_FHA_1	467	473	PF00498	0.515
LIG_FHA_1	55	61	PF00498	0.421
LIG_FHA_2	181	187	PF00498	0.527
LIG_FHA_2	334	340	PF00498	0.514
LIG_FHA_2	510	516	PF00498	0.466
LIG_LIR_Gen_1	329	335	PF02991	0.386
LIG_LIR_Gen_1	35	43	PF02991	0.577
LIG_LIR_Gen_1	438	446	PF02991	0.493
LIG_LIR_LC3C_4	57	60	PF02991	0.494
LIG_LIR_Nem_3	155	160	PF02991	0.481
LIG_LIR_Nem_3	215	221	PF02991	0.433
LIG_LIR_Nem_3	232	237	PF02991	0.341
LIG_LIR_Nem_3	329	333	PF02991	0.386
LIG_LIR_Nem_3	35	41	PF02991	0.592
LIG_LIR_Nem_3	438	442	PF02991	0.526
LIG_LIR_Nem_3	443	449	PF02991	0.406
LIG_LIR_Nem_3	520	526	PF02991	0.466
LIG_LYPXL_yS_3	408	411	PF13949	0.396
LIG_PTB_Apo_2	151	158	PF02174	0.459
LIG_SH2_CRK	290	294	PF00017	0.408
LIG_SH2_CRK	330	334	PF00017	0.420
LIG_SH2_NCK_1	452	456	PF00017	0.642
LIG_SH2_PTP2	439	442	PF00017	0.535
LIG_SH2_STAP1	330	334	PF00017	0.379
LIG_SH2_STAP1	452	456	PF00017	0.671
LIG_SH2_STAT5	116	119	PF00017	0.490
LIG_SH2_STAT5	252	255	PF00017	0.471
LIG_SH2_STAT5	292	295	PF00017	0.364
LIG_SH2_STAT5	345	348	PF00017	0.344
LIG_SH2_STAT5	373	376	PF00017	0.370
LIG_SH2_STAT5	439	442	PF00017	0.535
LIG_SH2_STAT5	533	536	PF00017	0.527
LIG_SH3_1	112	118	PF00018	0.502
LIG_SH3_3	112	118	PF00018	0.502
LIG_SH3_3	164	170	PF00018	0.433
LIG_SH3_3	185	191	PF00018	0.606
LIG_SH3_3	213	219	PF00018	0.585
LIG_SH3_3	283	289	PF00018	0.526
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.571
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.465
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.511
LIG_SUMO_SIM_par_1	440	445	PF11976	0.500
LIG_SUMO_SIM_par_1	504	512	PF11976	0.504
LIG_TRAF2_1	69	72	PF00917	0.289
LIG_TYR_ITIM	328	333	PF00017	0.415
LIG_TYR_ITIM	406	411	PF00017	0.429
LIG_TYR_ITIM	521	526	PF00017	0.392
LIG_UBA3_1	298	302	PF00899	0.483
LIG_WRC_WIRS_1	323	328	PF05994	0.335
MOD_CK1_1	100	106	PF00069	0.543
MOD_CK1_1	145	151	PF00069	0.451
MOD_CK1_1	460	466	PF00069	0.398
MOD_CK1_1	474	480	PF00069	0.239
MOD_CK1_1	499	505	PF00069	0.307
MOD_CK1_1	527	533	PF00069	0.376
MOD_CK1_1	74	80	PF00069	0.645
MOD_CK2_1	103	109	PF00069	0.449
MOD_CK2_1	333	339	PF00069	0.509
MOD_GlcNHglycan	18	21	PF01048	0.605
MOD_GlcNHglycan	206	209	PF01048	0.727
MOD_GlcNHglycan	396	399	PF01048	0.652
MOD_GlcNHglycan	501	504	PF01048	0.309
MOD_GlcNHglycan	72	76	PF01048	0.697
MOD_GSK3_1	136	143	PF00069	0.557
MOD_GSK3_1	152	159	PF00069	0.400
MOD_GSK3_1	176	183	PF00069	0.492
MOD_GSK3_1	303	310	PF00069	0.457
MOD_GSK3_1	322	329	PF00069	0.185
MOD_GSK3_1	392	399	PF00069	0.669
MOD_GSK3_1	428	435	PF00069	0.630
MOD_GSK3_1	455	462	PF00069	0.649
MOD_GSK3_1	463	470	PF00069	0.300
MOD_N-GLC_1	152	157	PF02516	0.453
MOD_N-GLC_1	204	209	PF02516	0.637
MOD_N-GLC_1	303	308	PF02516	0.418
MOD_NEK2_1	142	147	PF00069	0.438
MOD_NEK2_1	152	157	PF00069	0.406
MOD_NEK2_1	307	312	PF00069	0.515
MOD_NEK2_1	326	331	PF00069	0.186
MOD_PIKK_1	246	252	PF00454	0.473
MOD_PKA_2	326	332	PF00069	0.354
MOD_PKA_2	357	363	PF00069	0.527
MOD_PKA_2	496	502	PF00069	0.356
MOD_PKA_2	54	60	PF00069	0.499
MOD_PKB_1	14	22	PF00069	0.322
MOD_Plk_1	100	106	PF00069	0.437
MOD_Plk_1	303	309	PF00069	0.432
MOD_Plk_2-3	21	27	PF00069	0.634
MOD_Plk_4	263	269	PF00069	0.470
MOD_Plk_4	294	300	PF00069	0.412
MOD_Plk_4	329	335	PF00069	0.452
MOD_Plk_4	435	441	PF00069	0.614
MOD_Plk_4	5	11	PF00069	0.439
MOD_Plk_4	527	533	PF00069	0.389
MOD_Plk_4	54	60	PF00069	0.499
MOD_ProDKin_1	192	198	PF00069	0.668
MOD_ProDKin_1	460	466	PF00069	0.415
MOD_ProDKin_1	509	515	PF00069	0.392
MOD_SUMO_rev_2	30	39	PF00179	0.415
TRG_DiLeu_BaEn_1	109	114	PF01217	0.496
TRG_ENDOCYTIC_2	290	293	PF00928	0.364
TRG_ENDOCYTIC_2	330	333	PF00928	0.368
TRG_ENDOCYTIC_2	408	411	PF00928	0.396
TRG_ENDOCYTIC_2	439	442	PF00928	0.535
TRG_ENDOCYTIC_2	523	526	PF00928	0.392
TRG_ER_diArg_1	13	16	PF00400	0.312
TRG_NES_CRM1_1	168	178	PF08389	0.352
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTC4	Leptomonas seymouri	62%	99%
A0A0S4JLX2	Bodo saltans	39%	100%
A0A1X0P967	Trypanosomatidae	42%	100%
A0A3S5H558	Leishmania donovani	93%	98%
A0A422NHN6	Trypanosoma rangeli	44%	100%
A4H3N8	Leishmania braziliensis	81%	100%
A4HRW5	Leishmania infantum	93%	99%
C9ZKH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACM2	Leishmania major	91%	100%
Q15813	Homo sapiens	22%	100%
Q32KS0	Bos taurus	22%	100%
Q5RBD9	Pongo abelii	23%	100%
Q5U508	Xenopus laevis	21%	100%
Q8GRL7	Arabidopsis thaliana	26%	100%
V5C274	Trypanosoma cruzi	43%	100%