Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJV9_LEIMU

TriTrypDb:

LmxM.03.0760

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.748
CLV_NRD_NRD_1	284	286	PF00675	0.752
CLV_NRD_NRD_1	51	53	PF00675	0.685
CLV_NRD_NRD_1	87	89	PF00675	0.448
CLV_PCSK_KEX2_1	284	286	PF00082	0.752
CLV_PCSK_KEX2_1	51	53	PF00082	0.684
CLV_PCSK_KEX2_1	86	88	PF00082	0.460
CLV_PCSK_PC7_1	280	286	PF00082	0.606
CLV_PCSK_SKI1_1	292	296	PF00082	0.676
CLV_PCSK_SKI1_1	7	11	PF00082	0.597
DEG_APCC_DBOX_1	85	93	PF00400	0.439
DEG_SPOP_SBC_1	150	154	PF00917	0.695
DEG_SPOP_SBC_1	192	196	PF00917	0.721
DEG_SPOP_SBC_1	43	47	PF00917	0.752
DOC_CDC14_PxL_1	180	188	PF14671	0.435
DOC_MAPK_gen_1	86	93	PF00069	0.428
DOC_MAPK_MEF2A_6	216	225	PF00069	0.425
DOC_MAPK_MEF2A_6	86	93	PF00069	0.428
DOC_PP2B_LxvP_1	188	191	PF13499	0.599
DOC_USP7_MATH_1	12	16	PF00917	0.671
DOC_USP7_MATH_1	150	154	PF00917	0.633
DOC_USP7_MATH_1	172	176	PF00917	0.688
DOC_USP7_MATH_1	193	197	PF00917	0.665
DOC_USP7_MATH_1	42	46	PF00917	0.706
DOC_WW_Pin1_4	168	173	PF00397	0.765
LIG_14-3-3_CanoR_1	113	121	PF00244	0.530
LIG_14-3-3_CanoR_1	51	56	PF00244	0.750
LIG_BRCT_BRCA1_1	114	118	PF00533	0.515
LIG_CtBP_PxDLS_1	179	183	PF00389	0.514
LIG_eIF4E_1	112	118	PF01652	0.556
LIG_EVH1_1	75	79	PF00568	0.693
LIG_FHA_1	112	118	PF00498	0.568
LIG_FHA_1	238	244	PF00498	0.568
LIG_FHA_1	265	271	PF00498	0.664
LIG_FHA_2	104	110	PF00498	0.573
LIG_FHA_2	169	175	PF00498	0.737
LIG_LIR_Gen_1	115	126	PF02991	0.513
LIG_LIR_Nem_3	115	121	PF02991	0.515
LIG_LIR_Nem_3	213	217	PF02991	0.382
LIG_LIR_Nem_3	218	223	PF02991	0.417
LIG_LIR_Nem_3	73	78	PF02991	0.605
LIG_MYND_1	98	102	PF01753	0.581
LIG_NRBOX	271	277	PF00104	0.656
LIG_SH2_PTP2	258	261	PF00017	0.547
LIG_SH2_STAT5	214	217	PF00017	0.504
LIG_SH2_STAT5	248	251	PF00017	0.508
LIG_SH2_STAT5	258	261	PF00017	0.547
LIG_SH2_STAT5	302	305	PF00017	0.466
LIG_SH3_3	125	131	PF00018	0.414
LIG_SH3_3	141	147	PF00018	0.237
LIG_SH3_3	181	187	PF00018	0.674
LIG_SH3_3	250	256	PF00018	0.309
LIG_SH3_3	73	79	PF00018	0.672
LIG_SxIP_EBH_1	16	26	PF03271	0.596
LIG_TRAF2_1	288	291	PF00917	0.753
LIG_WW_3	55	59	PF00397	0.775
MOD_CK1_1	152	158	PF00069	0.631
MOD_CK1_1	194	200	PF00069	0.718
MOD_CK2_1	257	263	PF00069	0.621
MOD_Cter_Amidation	282	285	PF01082	0.737
MOD_GlcNHglycan	114	117	PF01048	0.518
MOD_GlcNHglycan	157	160	PF01048	0.682
MOD_GlcNHglycan	163	166	PF01048	0.730
MOD_GlcNHglycan	174	177	PF01048	0.616
MOD_GlcNHglycan	30	33	PF01048	0.569
MOD_GlcNHglycan	35	39	PF01048	0.511
MOD_GlcNHglycan	53	56	PF01048	0.735
MOD_GSK3_1	112	119	PF00069	0.527
MOD_GSK3_1	149	156	PF00069	0.615
MOD_GSK3_1	157	164	PF00069	0.624
MOD_GSK3_1	168	175	PF00069	0.643
MOD_GSK3_1	191	198	PF00069	0.664
MOD_N-GLC_1	18	23	PF02516	0.698
MOD_NEK2_1	117	122	PF00069	0.370
MOD_NEK2_1	149	154	PF00069	0.692
MOD_NEK2_1	237	242	PF00069	0.589
MOD_NEK2_1	257	262	PF00069	0.572
MOD_NEK2_1	314	319	PF00069	0.719
MOD_PIKK_1	157	163	PF00454	0.616
MOD_PK_1	266	272	PF00069	0.675
MOD_PKA_1	51	57	PF00069	0.750
MOD_PKA_2	112	118	PF00069	0.488
MOD_PKA_2	237	243	PF00069	0.557
MOD_PKA_2	50	56	PF00069	0.692
MOD_Plk_1	18	24	PF00069	0.725
MOD_Plk_4	117	123	PF00069	0.372
MOD_Plk_4	18	24	PF00069	0.698
MOD_ProDKin_1	168	174	PF00069	0.757
TRG_DiLeu_BaEn_1	271	276	PF01217	0.687
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.576
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.429
TRG_ENDOCYTIC_2	214	217	PF00928	0.483
TRG_ENDOCYTIC_2	258	261	PF00928	0.547
TRG_ER_diArg_1	50	52	PF00400	0.680
TRG_ER_diArg_1	85	88	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN8	Leptomonas seymouri	57%	97%
A0A1X0PA92	Trypanosomatidae	40%	100%
A0A3R7KEM6	Trypanosoma rangeli	40%	100%
A0A3S5H557	Leishmania donovani	85%	100%
A4HRW4	Leishmania infantum	86%	100%
C9ZKG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACM1	Leishmania major	83%	97%
V5BC94	Trypanosoma cruzi	40%	100%