Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania mexicana

UniProt:

E9AJV8_LEIMU

TriTrypDb:

LmxM.03.0750

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	7	1
GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	8	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.373
CLV_C14_Caspase3-7	402	406	PF00656	0.471
CLV_C14_Caspase3-7	519	523	PF00656	0.420
CLV_C14_Caspase3-7	608	612	PF00656	0.702
CLV_C14_Caspase3-7	692	696	PF00656	0.671
CLV_NRD_NRD_1	109	111	PF00675	0.249
CLV_NRD_NRD_1	121	123	PF00675	0.249
CLV_NRD_NRD_1	18	20	PF00675	0.627
CLV_NRD_NRD_1	546	548	PF00675	0.525
CLV_NRD_NRD_1	568	570	PF00675	0.510
CLV_PCSK_FUR_1	564	568	PF00082	0.551
CLV_PCSK_KEX2_1	121	123	PF00082	0.332
CLV_PCSK_KEX2_1	18	20	PF00082	0.699
CLV_PCSK_KEX2_1	35	37	PF00082	0.532
CLV_PCSK_KEX2_1	524	526	PF00082	0.562
CLV_PCSK_KEX2_1	545	547	PF00082	0.575
CLV_PCSK_KEX2_1	563	565	PF00082	0.450
CLV_PCSK_KEX2_1	566	568	PF00082	0.475
CLV_PCSK_KEX2_1	598	600	PF00082	0.502
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.530
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.562
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.459
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.475
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.502
CLV_PCSK_SKI1_1	10	14	PF00082	0.625
CLV_PCSK_SKI1_1	165	169	PF00082	0.246
CLV_PCSK_SKI1_1	260	264	PF00082	0.307
CLV_PCSK_SKI1_1	294	298	PF00082	0.271
CLV_PCSK_SKI1_1	571	575	PF00082	0.569
DEG_SPOP_SBC_1	190	194	PF00917	0.418
DEG_SPOP_SBC_1	304	308	PF00917	0.373
DEG_SPOP_SBC_1	412	416	PF00917	0.406
DOC_CKS1_1	441	446	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	393	396	PF00134	0.532
DOC_MAPK_MEF2A_6	267	276	PF00069	0.467
DOC_PP1_RVXF_1	171	178	PF00149	0.532
DOC_PP2B_LxvP_1	393	396	PF13499	0.532
DOC_PP4_MxPP_1	473	476	PF00568	0.373
DOC_USP7_MATH_1	191	195	PF00917	0.464
DOC_USP7_MATH_1	304	308	PF00917	0.418
DOC_USP7_MATH_1	315	319	PF00917	0.582
DOC_USP7_MATH_1	412	416	PF00917	0.418
DOC_USP7_MATH_1	591	595	PF00917	0.767
DOC_USP7_MATH_1	688	692	PF00917	0.564
DOC_USP7_UBL2_3	566	570	PF12436	0.485
DOC_WW_Pin1_4	193	198	PF00397	0.578
DOC_WW_Pin1_4	43	48	PF00397	0.482
DOC_WW_Pin1_4	440	445	PF00397	0.456
DOC_WW_Pin1_4	684	689	PF00397	0.567
DOC_WW_Pin1_4	95	100	PF00397	0.495
LIG_14-3-3_CanoR_1	141	145	PF00244	0.595
LIG_eIF4E_1	256	262	PF01652	0.532
LIG_FHA_1	128	134	PF00498	0.373
LIG_FHA_1	287	293	PF00498	0.507
LIG_FHA_2	166	172	PF00498	0.435
LIG_FHA_2	306	312	PF00498	0.405
LIG_FHA_2	32	38	PF00498	0.647
LIG_FHA_2	466	472	PF00498	0.533
LIG_FHA_2	483	489	PF00498	0.518
LIG_FHA_2	517	523	PF00498	0.434
LIG_LIR_Apic_2	37	41	PF02991	0.579
LIG_LIR_Gen_1	468	478	PF02991	0.494
LIG_LIR_Gen_1	579	589	PF02991	0.583
LIG_LIR_Nem_3	579	584	PF02991	0.576
LIG_LYPXL_SIV_4	99	107	PF13949	0.317
LIG_NRBOX	298	304	PF00104	0.507
LIG_NRBOX	429	435	PF00104	0.467
LIG_NRBOX	526	532	PF00104	0.501
LIG_Pex14_2	262	266	PF04695	0.549
LIG_PTAP_UEV_1	347	352	PF05743	0.373
LIG_PTB_Apo_2	583	590	PF02174	0.589
LIG_SH2_CRK	205	209	PF00017	0.467
LIG_SH2_CRK	38	42	PF00017	0.573
LIG_SH2_CRK	462	466	PF00017	0.467
LIG_SH2_NCK_1	38	42	PF00017	0.641
LIG_SH2_PTP2	357	360	PF00017	0.373
LIG_SH2_SRC	100	103	PF00017	0.317
LIG_SH2_SRC	462	465	PF00017	0.518
LIG_SH2_STAP1	462	466	PF00017	0.532
LIG_SH2_STAT3	464	467	PF00017	0.507
LIG_SH2_STAT5	100	103	PF00017	0.317
LIG_SH2_STAT5	357	360	PF00017	0.451
LIG_SH2_STAT5	38	41	PF00017	0.572
LIG_SH2_STAT5	451	454	PF00017	0.465
LIG_SH2_STAT5	464	467	PF00017	0.430
LIG_SH3_1	21	27	PF00018	0.608
LIG_SH3_1	44	50	PF00018	0.424
LIG_SH3_3	21	27	PF00018	0.608
LIG_SH3_3	269	275	PF00018	0.525
LIG_SH3_3	345	351	PF00018	0.484
LIG_SH3_3	44	50	PF00018	0.400
LIG_SH3_3	453	459	PF00018	0.467
LIG_TRAF2_1	123	126	PF00917	0.492
LIG_TRAF2_1	594	597	PF00917	0.677
LIG_TYR_ITIM	203	208	PF00017	0.518
LIG_WW_3	394	398	PF00397	0.525
MOD_CDC14_SPxK_1	196	199	PF00782	0.409
MOD_CDK_SPK_2	440	445	PF00069	0.373
MOD_CDK_SPK_2	684	689	PF00069	0.504
MOD_CDK_SPxK_1	193	199	PF00069	0.409
MOD_CK1_1	383	389	PF00069	0.524
MOD_CK1_1	415	421	PF00069	0.551
MOD_CK1_1	579	585	PF00069	0.554
MOD_CK1_1	602	608	PF00069	0.747
MOD_CK2_1	284	290	PF00069	0.507
MOD_CK2_1	31	37	PF00069	0.453
MOD_CK2_1	562	568	PF00069	0.639
MOD_CK2_1	591	597	PF00069	0.661
MOD_CK2_1	611	617	PF00069	0.531
MOD_GlcNHglycan	165	168	PF01048	0.327
MOD_GlcNHglycan	317	320	PF01048	0.316
MOD_GlcNHglycan	382	385	PF01048	0.347
MOD_GlcNHglycan	405	408	PF01048	0.344
MOD_GlcNHglycan	418	421	PF01048	0.376
MOD_GlcNHglycan	488	492	PF01048	0.382
MOD_GlcNHglycan	602	605	PF01048	0.703
MOD_GlcNHglycan	613	616	PF01048	0.658
MOD_GlcNHglycan	655	658	PF01048	0.796
MOD_GlcNHglycan	666	669	PF01048	0.752
MOD_GlcNHglycan	675	678	PF01048	0.550
MOD_GlcNHglycan	76	79	PF01048	0.399
MOD_GSK3_1	13	20	PF00069	0.588
MOD_GSK3_1	140	147	PF00069	0.474
MOD_GSK3_1	185	192	PF00069	0.558
MOD_GSK3_1	284	291	PF00069	0.532
MOD_GSK3_1	36	43	PF00069	0.544
MOD_GSK3_1	399	406	PF00069	0.525
MOD_GSK3_1	407	414	PF00069	0.549
MOD_GSK3_1	600	607	PF00069	0.675
MOD_GSK3_1	684	691	PF00069	0.677
MOD_N-GLC_1	246	251	PF02516	0.332
MOD_N-GLC_1	30	35	PF02516	0.649
MOD_N-GLC_1	576	581	PF02516	0.547
MOD_N-GLC_1	684	689	PF02516	0.617
MOD_NEK2_1	144	149	PF00069	0.533
MOD_NEK2_1	17	22	PF00069	0.590
MOD_NEK2_1	288	293	PF00069	0.532
MOD_NEK2_1	303	308	PF00069	0.532
MOD_NEK2_1	329	334	PF00069	0.478
MOD_NEK2_1	434	439	PF00069	0.492
MOD_NEK2_1	658	663	PF00069	0.646
MOD_NEK2_1	71	76	PF00069	0.676
MOD_PIKK_1	428	434	PF00454	0.467
MOD_PIKK_1	639	645	PF00454	0.513
MOD_PKA_2	140	146	PF00069	0.600
MOD_PKA_2	156	162	PF00069	0.385
MOD_PKA_2	17	23	PF00069	0.599
MOD_PKA_2	591	597	PF00069	0.677
MOD_PKA_2	688	694	PF00069	0.749
MOD_Plk_1	482	488	PF00069	0.498
MOD_Plk_1	579	585	PF00069	0.554
MOD_Plk_2-3	284	290	PF00069	0.494
MOD_Plk_4	140	146	PF00069	0.578
MOD_Plk_4	465	471	PF00069	0.506
MOD_ProDKin_1	193	199	PF00069	0.578
MOD_ProDKin_1	43	49	PF00069	0.475
MOD_ProDKin_1	440	446	PF00069	0.456
MOD_ProDKin_1	684	690	PF00069	0.567
MOD_ProDKin_1	95	101	PF00069	0.486
MOD_SUMO_for_1	368	371	PF00179	0.471
MOD_SUMO_rev_2	125	130	PF00179	0.543
MOD_SUMO_rev_2	371	378	PF00179	0.421
MOD_SUMO_rev_2	5	15	PF00179	0.584
TRG_DiLeu_BaEn_1	140	145	PF01217	0.507
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.558
TRG_ENDOCYTIC_2	205	208	PF00928	0.467
TRG_ENDOCYTIC_2	357	360	PF00928	0.409
TRG_ENDOCYTIC_2	462	465	PF00928	0.449
TRG_ENDOCYTIC_2	470	473	PF00928	0.449
TRG_ER_diArg_1	120	122	PF00400	0.532
TRG_ER_diArg_1	17	19	PF00400	0.707
TRG_ER_diArg_1	545	547	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E3	Leptomonas seymouri	55%	87%
A0A0S4JQM7	Bodo saltans	27%	100%
A0A1X0P9U8	Trypanosomatidae	31%	88%
A0A451EJS4	Leishmania donovani	84%	98%
A4H3N6	Leishmania braziliensis	64%	100%
A4HRW3	Leishmania infantum	84%	98%
C9ZKG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
E9ACM0	Leishmania major	76%	100%