Putative cytochrome c oxidase copper chaperone

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase copper chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9AJV7_LEIMU

TriTrypDb:

LmxM.03.0740

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	9
GO:0031970	organelle envelope lumen	5	9
GO:0031974	membrane-enclosed lumen	2	9
GO:0043233	organelle lumen	3	9
GO:0070013	intracellular organelle lumen	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AJV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005507	copper ion binding	6	9
GO:0016530	metallochaperone activity	2	9
GO:0016531	copper chaperone activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0140104	molecular carrier activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	38	40	PF00675	0.462
CLV_NRD_NRD_1	65	67	PF00675	0.503
CLV_PCSK_KEX2_1	38	40	PF00082	0.462
CLV_PCSK_KEX2_1	65	67	PF00082	0.472
CLV_PCSK_KEX2_1	78	80	PF00082	0.545
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.545
DOC_USP7_UBL2_3	78	82	PF12436	0.545
DOC_WW_Pin1_4	22	27	PF00397	0.581
LIG_14-3-3_CanoR_1	20	26	PF00244	0.537
LIG_14-3-3_CterR_2	79	84	PF00244	0.528
LIG_SH2_CRK	61	65	PF00017	0.237
LIG_SH3_3	8	14	PF00018	0.675
LIG_TRAF2_1	70	73	PF00917	0.458
LIG_TRAF2_2	13	18	PF00917	0.594
MOD_CDK_SPxxK_3	22	29	PF00069	0.542
MOD_CK1_1	22	28	PF00069	0.555
MOD_CK1_1	4	10	PF00069	0.649
MOD_CK2_1	67	73	PF00069	0.225
MOD_GlcNHglycan	3	6	PF01048	0.569
MOD_GlcNHglycan	69	72	PF01048	0.572
MOD_GSK3_1	20	27	PF00069	0.566
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NMyristoyl	1	7	PF02799	0.629
MOD_PKA_1	78	84	PF00069	0.567
MOD_PKA_2	19	25	PF00069	0.598
MOD_PKA_2	78	84	PF00069	0.494
MOD_Plk_1	42	48	PF00069	0.262
MOD_Plk_4	42	48	PF00069	0.262
MOD_ProDKin_1	22	28	PF00069	0.574
TRG_DiLeu_BaEn_4	72	78	PF01217	0.450
TRG_ENDOCYTIC_2	61	64	PF00928	0.237
TRG_ER_diArg_1	38	41	PF00400	0.262
TRG_ER_diArg_1	64	66	PF00400	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM2	Leptomonas seymouri	67%	100%
A0A3S5H556	Leishmania donovani	93%	100%
A0A422MU41	Trypanosoma rangeli	56%	82%
A4H3N5	Leishmania braziliensis	74%	95%
A4HRW2	Leishmania infantum	93%	100%
C9ZKG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ACL9	Leishmania major	93%	100%
Q9LJQ9	Arabidopsis thaliana	33%	100%