Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJV5_LEIMU

TriTrypDb:

LmxM.03.0720

Length:

911

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.659
CLV_C14_Caspase3-7	242	246	PF00656	0.537
CLV_C14_Caspase3-7	270	274	PF00656	0.482
CLV_C14_Caspase3-7	341	345	PF00656	0.665
CLV_C14_Caspase3-7	347	351	PF00656	0.653
CLV_NRD_NRD_1	103	105	PF00675	0.522
CLV_NRD_NRD_1	133	135	PF00675	0.710
CLV_NRD_NRD_1	22	24	PF00675	0.818
CLV_NRD_NRD_1	377	379	PF00675	0.683
CLV_NRD_NRD_1	486	488	PF00675	0.459
CLV_NRD_NRD_1	511	513	PF00675	0.498
CLV_NRD_NRD_1	571	573	PF00675	0.808
CLV_NRD_NRD_1	642	644	PF00675	0.398
CLV_NRD_NRD_1	705	707	PF00675	0.741
CLV_NRD_NRD_1	770	772	PF00675	0.487
CLV_NRD_NRD_1	869	871	PF00675	0.775
CLV_NRD_NRD_1	886	888	PF00675	0.701
CLV_PCSK_FUR_1	128	132	PF00082	0.716
CLV_PCSK_KEX2_1	103	105	PF00082	0.522
CLV_PCSK_KEX2_1	130	132	PF00082	0.719
CLV_PCSK_KEX2_1	133	135	PF00082	0.660
CLV_PCSK_KEX2_1	169	171	PF00082	0.531
CLV_PCSK_KEX2_1	22	24	PF00082	0.818
CLV_PCSK_KEX2_1	376	378	PF00082	0.679
CLV_PCSK_KEX2_1	486	488	PF00082	0.459
CLV_PCSK_KEX2_1	510	512	PF00082	0.450
CLV_PCSK_KEX2_1	571	573	PF00082	0.808
CLV_PCSK_KEX2_1	705	707	PF00082	0.686
CLV_PCSK_KEX2_1	770	772	PF00082	0.487
CLV_PCSK_KEX2_1	833	835	PF00082	0.523
CLV_PCSK_KEX2_1	868	870	PF00082	0.765
CLV_PCSK_KEX2_1	886	888	PF00082	0.683
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.719
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.531
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.569
CLV_PCSK_PC7_1	128	134	PF00082	0.639
CLV_PCSK_PC7_1	829	835	PF00082	0.557
CLV_PCSK_SKI1_1	159	163	PF00082	0.551
CLV_PCSK_SKI1_1	231	235	PF00082	0.581
CLV_PCSK_SKI1_1	297	301	PF00082	0.538
CLV_PCSK_SKI1_1	325	329	PF00082	0.486
CLV_PCSK_SKI1_1	377	381	PF00082	0.672
CLV_PCSK_SKI1_1	516	520	PF00082	0.632
CLV_PCSK_SKI1_1	646	650	PF00082	0.537
CLV_PCSK_SKI1_1	658	662	PF00082	0.506
CLV_PCSK_SKI1_1	677	681	PF00082	0.507
CLV_PCSK_SKI1_1	69	73	PF00082	0.479
CLV_PCSK_SKI1_1	762	766	PF00082	0.449
CLV_Separin_Metazoa	100	104	PF03568	0.604
DEG_APCC_DBOX_1	169	177	PF00400	0.656
DEG_APCC_DBOX_1	230	238	PF00400	0.592
DEG_APCC_DBOX_1	511	519	PF00400	0.349
DEG_APCC_DBOX_1	645	653	PF00400	0.565
DEG_APCC_DBOX_1	676	684	PF00400	0.545
DEG_COP1_1	142	150	PF00400	0.452
DEG_ODPH_VHL_1	670	682	PF01847	0.431
DEG_SCF_FBW7_1	107	112	PF00400	0.692
DEG_SPOP_SBC_1	419	423	PF00917	0.480
DEG_SPOP_SBC_1	584	588	PF00917	0.474
DEG_SPOP_SBC_1	873	877	PF00917	0.717
DOC_ANK_TNKS_1	345	352	PF00023	0.489
DOC_CYCLIN_RxL_1	674	684	PF00134	0.464
DOC_MAPK_gen_1	169	175	PF00069	0.566
DOC_MAPK_gen_1	486	496	PF00069	0.588
DOC_MAPK_gen_1	643	653	PF00069	0.564
DOC_MAPK_HePTP_8	641	653	PF00069	0.469
DOC_MAPK_MEF2A_6	243	252	PF00069	0.281
DOC_MAPK_MEF2A_6	644	653	PF00069	0.554
DOC_MAPK_NFAT4_5	646	654	PF00069	0.570
DOC_MAPK_RevD_3	495	511	PF00069	0.510
DOC_MAPK_RevD_3	821	834	PF00069	0.534
DOC_MIT_MIM_1	81	89	PF04212	0.497
DOC_PP1_RVXF_1	448	454	PF00149	0.412
DOC_PP2B_LxvP_1	412	415	PF13499	0.602
DOC_PP2B_LxvP_1	462	465	PF13499	0.563
DOC_SPAK_OSR1_1	610	614	PF12202	0.349
DOC_USP7_MATH_1	109	113	PF00917	0.711
DOC_USP7_MATH_1	190	194	PF00917	0.715
DOC_USP7_MATH_1	246	250	PF00917	0.390
DOC_USP7_MATH_1	419	423	PF00917	0.730
DOC_USP7_MATH_1	427	431	PF00917	0.607
DOC_USP7_MATH_1	55	59	PF00917	0.657
DOC_USP7_MATH_1	579	583	PF00917	0.663
DOC_USP7_MATH_1	630	634	PF00917	0.731
DOC_USP7_MATH_1	699	703	PF00917	0.670
DOC_USP7_MATH_1	793	797	PF00917	0.641
DOC_USP7_MATH_1	873	877	PF00917	0.791
DOC_WW_Pin1_4	103	108	PF00397	0.678
DOC_WW_Pin1_4	220	225	PF00397	0.663
DOC_WW_Pin1_4	32	37	PF00397	0.736
DOC_WW_Pin1_4	563	568	PF00397	0.757
DOC_WW_Pin1_4	60	65	PF00397	0.551
DOC_WW_Pin1_4	743	748	PF00397	0.449
DOC_WW_Pin1_4	877	882	PF00397	0.775
LIG_14-3-3_CanoR_1	159	168	PF00244	0.533
LIG_14-3-3_CanoR_1	297	302	PF00244	0.467
LIG_14-3-3_CanoR_1	320	324	PF00244	0.583
LIG_14-3-3_CanoR_1	325	335	PF00244	0.614
LIG_14-3-3_CanoR_1	39	43	PF00244	0.804
LIG_14-3-3_CanoR_1	435	444	PF00244	0.540
LIG_14-3-3_CanoR_1	510	516	PF00244	0.477
LIG_14-3-3_CanoR_1	556	562	PF00244	0.754
LIG_14-3-3_CanoR_1	57	63	PF00244	0.655
LIG_14-3-3_CanoR_1	658	664	PF00244	0.541
LIG_14-3-3_CanoR_1	677	683	PF00244	0.502
LIG_14-3-3_CanoR_1	69	74	PF00244	0.476
LIG_14-3-3_CanoR_1	762	772	PF00244	0.331
LIG_14-3-3_CanoR_1	786	794	PF00244	0.508
LIG_14-3-3_CanoR_1	895	903	PF00244	0.445
LIG_Actin_WH2_2	304	322	PF00022	0.558
LIG_Actin_WH2_2	772	788	PF00022	0.274
LIG_APCC_ABBA_1	275	280	PF00400	0.577
LIG_BRCT_BRCA1_1	304	308	PF00533	0.541
LIG_BRCT_BRCA1_1	439	443	PF00533	0.488
LIG_CaM_NSCaTE_8	454	461	PF13499	0.525
LIG_Clathr_ClatBox_1	261	265	PF01394	0.630
LIG_FHA_1	109	115	PF00498	0.759
LIG_FHA_1	160	166	PF00498	0.502
LIG_FHA_1	197	203	PF00498	0.607
LIG_FHA_1	245	251	PF00498	0.551
LIG_FHA_1	419	425	PF00498	0.687
LIG_FHA_1	437	443	PF00498	0.372
LIG_FHA_1	465	471	PF00498	0.521
LIG_FHA_1	504	510	PF00498	0.491
LIG_FHA_1	613	619	PF00498	0.430
LIG_FHA_1	684	690	PF00498	0.600
LIG_FHA_1	729	735	PF00498	0.247
LIG_FHA_1	894	900	PF00498	0.495
LIG_FHA_1	902	908	PF00498	0.474
LIG_FHA_2	268	274	PF00498	0.428
LIG_FHA_2	298	304	PF00498	0.546
LIG_FHA_2	326	332	PF00498	0.398
LIG_FHA_2	592	598	PF00498	0.625
LIG_FHA_2	630	636	PF00498	0.728
LIG_FHA_2	659	665	PF00498	0.568
LIG_FHA_2	679	685	PF00498	0.215
LIG_FHA_2	70	76	PF00498	0.523
LIG_GBD_Chelix_1	271	279	PF00786	0.524
LIG_GBD_Chelix_1	396	404	PF00786	0.525
LIG_GSK3_LRP6_1	743	749	PF00069	0.455
LIG_Integrin_isoDGR_2	389	391	PF01839	0.608
LIG_LIR_Apic_2	38	43	PF02991	0.578
LIG_LIR_Gen_1	302	312	PF02991	0.418
LIG_LIR_Gen_1	439	448	PF02991	0.436
LIG_LIR_Gen_1	90	98	PF02991	0.537
LIG_LIR_LC3C_4	475	480	PF02991	0.574
LIG_LIR_Nem_3	302	307	PF02991	0.431
LIG_LIR_Nem_3	439	444	PF02991	0.444
LIG_LIR_Nem_3	766	772	PF02991	0.322
LIG_LIR_Nem_3	897	903	PF02991	0.450
LIG_NRBOX	503	509	PF00104	0.436
LIG_NRBOX	678	684	PF00104	0.463
LIG_PCNA_yPIPBox_3	152	165	PF02747	0.536
LIG_PCNA_yPIPBox_3	501	512	PF02747	0.555
LIG_Pex14_2	304	308	PF04695	0.237
LIG_SH2_CRK	40	44	PF00017	0.575
LIG_SH2_CRK	760	764	PF00017	0.603
LIG_SH2_NCK_1	40	44	PF00017	0.575
LIG_SH2_NCK_1	857	861	PF00017	0.662
LIG_SH2_STAP1	66	70	PF00017	0.438
LIG_SH2_STAP1	709	713	PF00017	0.703
LIG_SH2_STAP1	728	732	PF00017	0.276
LIG_SH2_STAP1	857	861	PF00017	0.689
LIG_SH2_STAP1	903	907	PF00017	0.525
LIG_SH2_STAP1	91	95	PF00017	0.518
LIG_SH2_STAT3	323	326	PF00017	0.662
LIG_SH2_STAT5	323	326	PF00017	0.662
LIG_SH2_STAT5	40	43	PF00017	0.577
LIG_SH2_STAT5	469	472	PF00017	0.487
LIG_SH2_STAT5	903	906	PF00017	0.572
LIG_SH3_1	738	744	PF00018	0.632
LIG_SH3_3	177	183	PF00018	0.454
LIG_SH3_3	331	337	PF00018	0.455
LIG_SH3_3	615	621	PF00018	0.599
LIG_SH3_3	715	721	PF00018	0.618
LIG_SH3_3	737	743	PF00018	0.605
LIG_SH3_4	207	214	PF00018	0.724
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.521
LIG_SUMO_SIM_anti_2	475	482	PF11976	0.578
LIG_SUMO_SIM_anti_2	493	498	PF11976	0.397
LIG_SUMO_SIM_anti_2	502	509	PF11976	0.469
LIG_SUMO_SIM_anti_2	592	597	PF11976	0.531
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.323
LIG_SUMO_SIM_par_1	58	63	PF11976	0.477
LIG_SUMO_SIM_par_1	678	684	PF11976	0.462
LIG_SUMO_SIM_par_1	720	725	PF11976	0.390
LIG_SUMO_SIM_par_1	771	777	PF11976	0.303
LIG_TRAF2_1	300	303	PF00917	0.575
LIG_TRAF2_1	328	331	PF00917	0.623
LIG_TYR_ITIM	758	763	PF00017	0.542
LIG_Vh1_VBS_1	160	178	PF01044	0.540
LIG_WW_3	620	624	PF00397	0.637
LIG_WW_3	739	743	PF00397	0.634
MOD_CDK_SPxxK_3	32	39	PF00069	0.513
MOD_CK1_1	24	30	PF00069	0.766
MOD_CK1_1	32	38	PF00069	0.530
MOD_CK1_1	503	509	PF00069	0.530
MOD_CK1_1	560	566	PF00069	0.680
MOD_CK1_1	58	64	PF00069	0.623
MOD_CK1_1	582	588	PF00069	0.603
MOD_CK1_1	589	595	PF00069	0.692
MOD_CK1_1	662	668	PF00069	0.330
MOD_CK1_1	746	752	PF00069	0.494
MOD_CK1_1	872	878	PF00069	0.793
MOD_CK2_1	216	222	PF00069	0.753
MOD_CK2_1	297	303	PF00069	0.566
MOD_CK2_1	325	331	PF00069	0.537
MOD_CK2_1	335	341	PF00069	0.766
MOD_CK2_1	629	635	PF00069	0.744
MOD_CK2_1	678	684	PF00069	0.481
MOD_CK2_1	69	75	PF00069	0.447
MOD_Cter_Amidation	484	487	PF01082	0.438
MOD_GlcNHglycan	111	114	PF01048	0.733
MOD_GlcNHglycan	148	151	PF01048	0.731
MOD_GlcNHglycan	192	195	PF01048	0.753
MOD_GlcNHglycan	225	228	PF01048	0.442
MOD_GlcNHglycan	26	29	PF01048	0.765
MOD_GlcNHglycan	31	34	PF01048	0.712
MOD_GlcNHglycan	337	340	PF01048	0.750
MOD_GlcNHglycan	369	372	PF01048	0.668
MOD_GlcNHglycan	428	432	PF01048	0.628
MOD_GlcNHglycan	475	478	PF01048	0.524
MOD_GlcNHglycan	490	493	PF01048	0.580
MOD_GlcNHglycan	559	562	PF01048	0.653
MOD_GlcNHglycan	575	579	PF01048	0.695
MOD_GlcNHglycan	588	591	PF01048	0.708
MOD_GlcNHglycan	632	635	PF01048	0.713
MOD_GlcNHglycan	765	768	PF01048	0.587
MOD_GlcNHglycan	858	861	PF01048	0.638
MOD_GlcNHglycan	864	867	PF01048	0.690
MOD_GlcNHglycan	871	874	PF01048	0.751
MOD_GSK3_1	103	110	PF00069	0.616
MOD_GSK3_1	146	153	PF00069	0.702
MOD_GSK3_1	159	166	PF00069	0.477
MOD_GSK3_1	17	24	PF00069	0.694
MOD_GSK3_1	216	223	PF00069	0.786
MOD_GSK3_1	235	242	PF00069	0.397
MOD_GSK3_1	267	274	PF00069	0.515
MOD_GSK3_1	28	35	PF00069	0.728
MOD_GSK3_1	282	289	PF00069	0.478
MOD_GSK3_1	325	332	PF00069	0.459
MOD_GSK3_1	51	58	PF00069	0.509
MOD_GSK3_1	556	563	PF00069	0.713
MOD_GSK3_1	566	573	PF00069	0.672
MOD_GSK3_1	579	586	PF00069	0.608
MOD_GSK3_1	654	661	PF00069	0.528
MOD_GSK3_1	662	669	PF00069	0.489
MOD_GSK3_1	708	715	PF00069	0.767
MOD_GSK3_1	746	753	PF00069	0.650
MOD_GSK3_1	852	859	PF00069	0.636
MOD_GSK3_1	869	876	PF00069	0.742
MOD_GSK3_1	901	908	PF00069	0.482
MOD_N-GLC_1	185	190	PF02516	0.721
MOD_N-GLC_1	436	441	PF02516	0.587
MOD_N-GLC_1	488	493	PF02516	0.592
MOD_NEK2_1	1	6	PF00069	0.487
MOD_NEK2_1	244	249	PF00069	0.567
MOD_NEK2_1	271	276	PF00069	0.559
MOD_NEK2_1	307	312	PF00069	0.467
MOD_NEK2_1	319	324	PF00069	0.438
MOD_NEK2_1	380	385	PF00069	0.608
MOD_NEK2_1	400	405	PF00069	0.430
MOD_NEK2_1	436	441	PF00069	0.493
MOD_NEK2_1	500	505	PF00069	0.384
MOD_NEK2_1	518	523	PF00069	0.590
MOD_NEK2_1	557	562	PF00069	0.679
MOD_NEK2_1	653	658	PF00069	0.441
MOD_NEK2_1	683	688	PF00069	0.548
MOD_NEK2_1	785	790	PF00069	0.595
MOD_NEK2_1	89	94	PF00069	0.595
MOD_PIKK_1	154	160	PF00454	0.362
MOD_PIKK_1	17	23	PF00454	0.783
MOD_PIKK_1	326	332	PF00454	0.620
MOD_PIKK_1	351	357	PF00454	0.492
MOD_PKA_1	510	516	PF00069	0.488
MOD_PKA_1	869	875	PF00069	0.704
MOD_PKA_2	21	27	PF00069	0.520
MOD_PKA_2	216	222	PF00069	0.710
MOD_PKA_2	227	233	PF00069	0.472
MOD_PKA_2	319	325	PF00069	0.631
MOD_PKA_2	38	44	PF00069	0.479
MOD_PKA_2	510	516	PF00069	0.484
MOD_PKA_2	570	576	PF00069	0.807
MOD_PKA_2	785	791	PF00069	0.582
MOD_PKA_2	862	868	PF00069	0.711
MOD_PKA_2	869	875	PF00069	0.785
MOD_PKA_2	885	891	PF00069	0.569
MOD_PKA_2	894	900	PF00069	0.483
MOD_PKB_1	572	580	PF00069	0.512
MOD_Plk_1	239	245	PF00069	0.533
MOD_Plk_1	302	308	PF00069	0.501
MOD_Plk_1	436	442	PF00069	0.585
MOD_Plk_1	699	705	PF00069	0.555
MOD_Plk_1	89	95	PF00069	0.550
MOD_Plk_2-3	216	222	PF00069	0.720
MOD_Plk_2-3	344	350	PF00069	0.699
MOD_Plk_4	163	169	PF00069	0.467
MOD_Plk_4	267	273	PF00069	0.519
MOD_Plk_4	319	325	PF00069	0.622
MOD_Plk_4	400	406	PF00069	0.507
MOD_Plk_4	437	443	PF00069	0.438
MOD_Plk_4	500	506	PF00069	0.389
MOD_Plk_4	591	597	PF00069	0.508
MOD_Plk_4	678	684	PF00069	0.550
MOD_Plk_4	699	705	PF00069	0.629
MOD_Plk_4	90	96	PF00069	0.558
MOD_ProDKin_1	103	109	PF00069	0.691
MOD_ProDKin_1	220	226	PF00069	0.649
MOD_ProDKin_1	32	38	PF00069	0.736
MOD_ProDKin_1	563	569	PF00069	0.757
MOD_ProDKin_1	60	66	PF00069	0.539
MOD_ProDKin_1	743	749	PF00069	0.455
MOD_ProDKin_1	877	883	PF00069	0.777
MOD_SUMO_rev_2	546	553	PF00179	0.510
TRG_DiLeu_BaEn_1	302	307	PF01217	0.506
TRG_DiLeu_BaEn_1	647	652	PF01217	0.564
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.515
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.526
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.563
TRG_DiLeu_BaLyEn_6	906	911	PF01217	0.543
TRG_ENDOCYTIC_2	760	763	PF00928	0.609
TRG_ENDOCYTIC_2	91	94	PF00928	0.555
TRG_ER_diArg_1	102	104	PF00400	0.510
TRG_ER_diArg_1	131	134	PF00400	0.719
TRG_ER_diArg_1	375	378	PF00400	0.706
TRG_ER_diArg_1	509	512	PF00400	0.494
TRG_ER_diArg_1	571	574	PF00400	0.712
TRG_ER_diArg_1	637	640	PF00400	0.608
TRG_ER_diArg_1	704	706	PF00400	0.681
TRG_ER_diArg_1	735	738	PF00400	0.545
TRG_ER_diArg_1	769	771	PF00400	0.532
TRG_ER_diArg_1	802	805	PF00400	0.662
TRG_ER_diArg_1	868	870	PF00400	0.761
TRG_NLS_MonoCore_2	129	134	PF00514	0.639
TRG_NLS_MonoExtC_3	129	134	PF00514	0.717
TRG_NLS_MonoExtN_4	128	134	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG87	Leptomonas seymouri	34%	84%
A0A3S5H555	Leishmania donovani	80%	100%
A0A422MU26	Trypanosoma rangeli	23%	100%
A4H3N3	Leishmania braziliensis	65%	86%
A4HRW0	Leishmania infantum	80%	82%
C9ZKG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ACL7	Leishmania major	77%	99%
V5BXD7	Trypanosoma cruzi	22%	100%