tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJV4_LEIMU

TriTrypDb:

LmxM.03.0710

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0052689	carboxylic ester hydrolase activity	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.210
CLV_PCSK_KEX2_1	132	134	PF00082	0.290
CLV_PCSK_KEX2_1	165	167	PF00082	0.271
CLV_PCSK_KEX2_1	235	237	PF00082	0.462
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.309
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.462
CLV_PCSK_SKI1_1	69	73	PF00082	0.383
DEG_Nend_UBRbox_2	1	3	PF02207	0.483
DEG_SPOP_SBC_1	92	96	PF00917	0.507
DOC_MAPK_MEF2A_6	157	164	PF00069	0.480
DOC_MAPK_RevD_3	104	119	PF00069	0.555
DOC_PP1_RVXF_1	44	51	PF00149	0.366
DOC_USP7_MATH_1	113	117	PF00917	0.555
DOC_USP7_MATH_1	214	218	PF00917	0.620
DOC_USP7_UBL2_3	114	118	PF12436	0.489
DOC_USP7_UBL2_3	119	123	PF12436	0.453
DOC_USP7_UBL2_3	54	58	PF12436	0.593
DOC_USP7_UBL2_3	62	66	PF12436	0.614
DOC_WW_Pin1_4	88	93	PF00397	0.751
LIG_14-3-3_CanoR_1	182	186	PF00244	0.551
LIG_14-3-3_CanoR_1	220	227	PF00244	0.472
LIG_APCC_ABBA_1	156	161	PF00400	0.465
LIG_BRCT_BRCA1_1	46	50	PF00533	0.369
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.393
LIG_FHA_1	221	227	PF00498	0.549
LIG_FHA_1	27	33	PF00498	0.393
LIG_FHA_2	182	188	PF00498	0.555
LIG_FHA_2	95	101	PF00498	0.589
LIG_GBD_Chelix_1	44	52	PF00786	0.381
LIG_LIR_Gen_1	197	203	PF02991	0.384
LIG_LIR_Nem_3	137	142	PF02991	0.555
LIG_LIR_Nem_3	197	201	PF02991	0.411
LIG_NRBOX	47	53	PF00104	0.449
LIG_PCNA_yPIPBox_3	58	72	PF02747	0.376
LIG_PDZ_Class_3	243	248	PF00595	0.470
LIG_SH2_PTP2	169	172	PF00017	0.555
LIG_SH2_SRC	159	162	PF00017	0.536
LIG_SH2_SRC	169	172	PF00017	0.536
LIG_SH2_STAP1	191	195	PF00017	0.471
LIG_SH2_STAT5	139	142	PF00017	0.555
LIG_SH2_STAT5	159	162	PF00017	0.362
LIG_SH2_STAT5	169	172	PF00017	0.536
LIG_SH3_4	54	61	PF00018	0.552
MOD_CK1_1	218	224	PF00069	0.661
MOD_CK1_1	26	32	PF00069	0.394
MOD_CK1_1	91	97	PF00069	0.705
MOD_CK2_1	181	187	PF00069	0.509
MOD_CK2_1	239	245	PF00069	0.464
MOD_CK2_1	54	60	PF00069	0.573
MOD_GlcNHglycan	115	118	PF01048	0.339
MOD_GlcNHglycan	25	29	PF01048	0.407
MOD_GlcNHglycan	78	82	PF01048	0.737
MOD_GlcNHglycan	88	91	PF01048	0.706
MOD_GSK3_1	214	221	PF00069	0.622
MOD_GSK3_1	86	93	PF00069	0.739
MOD_NEK2_1	160	165	PF00069	0.474
MOD_NEK2_1	23	28	PF00069	0.459
MOD_PKA_2	181	187	PF00069	0.436
MOD_PKA_2	219	225	PF00069	0.474
MOD_PKA_2	86	92	PF00069	0.691
MOD_Plk_1	160	166	PF00069	0.471
MOD_Plk_4	46	52	PF00069	0.432
MOD_ProDKin_1	88	94	PF00069	0.752
MOD_SUMO_rev_2	57	63	PF00179	0.572
TRG_ENDOCYTIC_2	139	142	PF00928	0.555
TRG_ENDOCYTIC_2	159	162	PF00928	0.362
TRG_ER_diArg_1	131	133	PF00400	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U1	Leptomonas seymouri	61%	100%
A0A1X0P8W1	Trypanosomatidae	42%	100%
A0A3R7N573	Trypanosoma rangeli	40%	100%
A0A3S5H554	Leishmania donovani	79%	100%
A4H3N2	Leishmania braziliensis	65%	100%
A4HRV9	Leishmania infantum	79%	100%
E9ACL6	Leishmania major	81%	100%