Uroporphyrinogen-III synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uroporphyrinogen-III synthase HemD, putative

Species:

Leishmania mexicana

UniProt:

E9AJV1_LEIMU

TriTrypDb:

LmxM.03.0680

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV1

Function

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Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006778	porphyrin-containing compound metabolic process	5	6
GO:0006779	porphyrin-containing compound biosynthetic process	6	6
GO:0006782	protoporphyrinogen IX biosynthetic process	7	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004852	uroporphyrinogen-III synthase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	86	92	PF00089	0.243
CLV_NRD_NRD_1	100	102	PF00675	0.440
CLV_NRD_NRD_1	233	235	PF00675	0.440
CLV_PCSK_KEX2_1	100	102	PF00082	0.527
CLV_PCSK_KEX2_1	16	18	PF00082	0.527
CLV_PCSK_KEX2_1	233	235	PF00082	0.440
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.527
CLV_PCSK_SKI1_1	100	104	PF00082	0.436
CLV_PCSK_SKI1_1	111	115	PF00082	0.419
CLV_PCSK_SKI1_1	47	51	PF00082	0.527

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H553	Leishmania donovani	92%	100%
A4H3M9	Leishmania braziliensis	81%	100%
A4HRV6	Leishmania infantum	92%	100%
E9ACL3	Leishmania major	92%	100%

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