Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJV0_LEIMU

TriTrypDb:

LmxM.03.0670

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.593
CLV_NRD_NRD_1	170	172	PF00675	0.645
CLV_NRD_NRD_1	276	278	PF00675	0.433
CLV_NRD_NRD_1	322	324	PF00675	0.470
CLV_PCSK_KEX2_1	14	16	PF00082	0.604
CLV_PCSK_KEX2_1	170	172	PF00082	0.645
CLV_PCSK_KEX2_1	276	278	PF00082	0.480
CLV_PCSK_KEX2_1	322	324	PF00082	0.470
CLV_PCSK_KEX2_1	464	466	PF00082	0.508
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.508
CLV_PCSK_PC7_1	10	16	PF00082	0.417
CLV_PCSK_SKI1_1	268	272	PF00082	0.488
CLV_PCSK_SKI1_1	322	326	PF00082	0.590
CLV_PCSK_SKI1_1	380	384	PF00082	0.516
DEG_SCF_TRCP1_1	302	308	PF00400	0.281
DEG_SPOP_SBC_1	17	21	PF00917	0.505
DOC_CKS1_1	1	6	PF01111	0.507
DOC_MAPK_gen_1	170	176	PF00069	0.686
DOC_MAPK_gen_1	276	285	PF00069	0.360
DOC_MAPK_MEF2A_6	178	185	PF00069	0.651
DOC_PP2B_LxvP_1	9	12	PF13499	0.514
DOC_USP7_MATH_1	17	21	PF00917	0.457
DOC_USP7_MATH_1	210	214	PF00917	0.657
DOC_USP7_MATH_1	222	226	PF00917	0.666
DOC_USP7_MATH_1	275	279	PF00917	0.425
DOC_USP7_MATH_1	34	38	PF00917	0.409
DOC_WW_Pin1_4	134	139	PF00397	0.609
DOC_WW_Pin1_4	183	188	PF00397	0.481
DOC_WW_Pin1_4	297	302	PF00397	0.582
DOC_WW_Pin1_4	331	336	PF00397	0.546
DOC_WW_Pin1_4	406	411	PF00397	0.628
DOC_WW_Pin1_4	438	443	PF00397	0.534
DOC_WW_Pin1_4	55	60	PF00397	0.640
DOC_WW_Pin1_4	63	68	PF00397	0.765
LIG_14-3-3_CanoR_1	15	25	PF00244	0.574
LIG_14-3-3_CanoR_1	154	161	PF00244	0.589
LIG_14-3-3_CanoR_1	170	176	PF00244	0.681
LIG_14-3-3_CanoR_1	277	285	PF00244	0.381
LIG_14-3-3_CanoR_1	306	314	PF00244	0.542
LIG_14-3-3_CanoR_1	331	335	PF00244	0.564
LIG_14-3-3_CanoR_1	384	391	PF00244	0.495
LIG_14-3-3_CanoR_1	503	508	PF00244	0.576
LIG_AP2alpha_2	49	51	PF02296	0.392
LIG_APCC_ABBAyCdc20_2	197	203	PF00400	0.538
LIG_BIR_III_2	56	60	PF00653	0.426
LIG_BRCT_BRCA1_1	520	524	PF00533	0.369
LIG_CtBP_PxDLS_1	182	186	PF00389	0.509
LIG_deltaCOP1_diTrp_1	196	201	PF00928	0.560
LIG_DLG_GKlike_1	503	511	PF00625	0.384
LIG_EH1_1	528	536	PF00400	0.224
LIG_eIF4E_1	189	195	PF01652	0.469
LIG_FHA_1	104	110	PF00498	0.522
LIG_FHA_1	118	124	PF00498	0.503
LIG_FHA_1	161	167	PF00498	0.593
LIG_FHA_1	280	286	PF00498	0.348
LIG_FHA_1	345	351	PF00498	0.535
LIG_FHA_1	384	390	PF00498	0.542
LIG_FHA_1	394	400	PF00498	0.351
LIG_FHA_1	526	532	PF00498	0.421
LIG_FHA_1	6	12	PF00498	0.436
LIG_FHA_1	71	77	PF00498	0.602
LIG_FHA_2	306	312	PF00498	0.473
LIG_FHA_2	412	418	PF00498	0.434
LIG_FHA_2	477	483	PF00498	0.500
LIG_GBD_Chelix_1	526	534	PF00786	0.535
LIG_LIR_Apic_2	479	484	PF02991	0.505
LIG_LIR_Gen_1	196	206	PF02991	0.517
LIG_LIR_Gen_1	96	105	PF02991	0.713
LIG_LIR_Nem_3	196	201	PF02991	0.417
LIG_LIR_Nem_3	249	254	PF02991	0.439
LIG_LIR_Nem_3	414	419	PF02991	0.443
LIG_LIR_Nem_3	47	51	PF02991	0.360
LIG_LIR_Nem_3	96	100	PF02991	0.719
LIG_PCNA_yPIPBox_3	140	151	PF02747	0.517
LIG_PDZ_Class_1	534	539	PF00595	0.291
LIG_Pex14_1	44	48	PF04695	0.472
LIG_Rb_LxCxE_1	511	533	PF01857	0.414
LIG_SH2_CRK	481	485	PF00017	0.502
LIG_SH2_NCK_1	481	485	PF00017	0.502
LIG_SH2_PTP2	97	100	PF00017	0.531
LIG_SH2_SRC	115	118	PF00017	0.635
LIG_SH2_STAP1	189	193	PF00017	0.494
LIG_SH2_STAT5	105	108	PF00017	0.523
LIG_SH2_STAT5	135	138	PF00017	0.597
LIG_SH2_STAT5	405	408	PF00017	0.402
LIG_SH2_STAT5	97	100	PF00017	0.541
LIG_SH3_3	123	129	PF00018	0.675
LIG_SH3_3	20	26	PF00018	0.542
LIG_SH3_3	204	210	PF00018	0.486
LIG_SH3_3	269	275	PF00018	0.422
LIG_SH3_3	364	370	PF00018	0.476
LIG_SH3_3	82	88	PF00018	0.496
LIG_Sin3_3	204	211	PF02671	0.446
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.437
LIG_SUMO_SIM_par_1	181	186	PF11976	0.662
LIG_SUMO_SIM_par_1	417	423	PF11976	0.411
LIG_SUMO_SIM_par_1	426	431	PF11976	0.453
LIG_SUMO_SIM_par_1	530	537	PF11976	0.230
MOD_CDC14_SPxK_1	137	140	PF00782	0.605
MOD_CDC14_SPxK_1	58	61	PF00782	0.453
MOD_CDK_SPxK_1	134	140	PF00069	0.609
MOD_CDK_SPxK_1	440	446	PF00069	0.545
MOD_CDK_SPxK_1	55	61	PF00069	0.418
MOD_CK1_1	21	27	PF00069	0.542
MOD_CK1_1	215	221	PF00069	0.603
MOD_CK1_1	278	284	PF00069	0.353
MOD_CK1_1	300	306	PF00069	0.581
MOD_CK1_1	409	415	PF00069	0.687
MOD_CK1_1	533	539	PF00069	0.417
MOD_CK2_1	305	311	PF00069	0.519
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.386
MOD_GlcNHglycan	191	194	PF01048	0.644
MOD_GlcNHglycan	214	217	PF01048	0.648
MOD_GlcNHglycan	263	266	PF01048	0.416
MOD_GlcNHglycan	277	280	PF01048	0.372
MOD_GlcNHglycan	288	291	PF01048	0.508
MOD_GlcNHglycan	297	300	PF01048	0.525
MOD_GlcNHglycan	302	305	PF01048	0.572
MOD_GlcNHglycan	328	331	PF01048	0.452
MOD_GlcNHglycan	37	40	PF01048	0.574
MOD_GSK3_1	156	163	PF00069	0.595
MOD_GSK3_1	17	24	PF00069	0.634
MOD_GSK3_1	211	218	PF00069	0.543
MOD_GSK3_1	259	266	PF00069	0.483
MOD_GSK3_1	275	282	PF00069	0.287
MOD_GSK3_1	326	333	PF00069	0.538
MOD_GSK3_1	401	408	PF00069	0.609
MOD_GSK3_1	436	443	PF00069	0.495
MOD_GSK3_1	530	537	PF00069	0.243
MOD_GSK3_1	55	62	PF00069	0.614
MOD_GSK3_1	63	70	PF00069	0.676
MOD_N-GLC_1	35	40	PF02516	0.439
MOD_NEK2_1	166	171	PF00069	0.565
MOD_NEK2_1	261	266	PF00069	0.444
MOD_NEK2_1	313	318	PF00069	0.357
MOD_NEK2_1	338	343	PF00069	0.434
MOD_NEK2_1	393	398	PF00069	0.538
MOD_NEK2_1	401	406	PF00069	0.563
MOD_NEK2_1	437	442	PF00069	0.521
MOD_NEK2_1	476	481	PF00069	0.460
MOD_NEK2_1	5	10	PF00069	0.551
MOD_NEK2_1	530	535	PF00069	0.391
MOD_NEK2_1	76	81	PF00069	0.445
MOD_PIKK_1	222	228	PF00454	0.625
MOD_PIKK_1	411	417	PF00454	0.613
MOD_PKA_2	153	159	PF00069	0.571
MOD_PKA_2	169	175	PF00069	0.670
MOD_PKA_2	222	228	PF00069	0.512
MOD_PKA_2	275	281	PF00069	0.392
MOD_PKA_2	305	311	PF00069	0.549
MOD_PKA_2	330	336	PF00069	0.557
MOD_PKA_2	383	389	PF00069	0.525
MOD_Plk_1	35	41	PF00069	0.457
MOD_Plk_1	401	407	PF00069	0.527
MOD_Plk_4	162	168	PF00069	0.663
MOD_Plk_4	333	339	PF00069	0.505
MOD_Plk_4	530	536	PF00069	0.459
MOD_ProDKin_1	134	140	PF00069	0.609
MOD_ProDKin_1	183	189	PF00069	0.481
MOD_ProDKin_1	297	303	PF00069	0.577
MOD_ProDKin_1	331	337	PF00069	0.538
MOD_ProDKin_1	406	412	PF00069	0.626
MOD_ProDKin_1	438	444	PF00069	0.535
MOD_ProDKin_1	55	61	PF00069	0.649
MOD_ProDKin_1	63	69	PF00069	0.762
TRG_DiLeu_BaEn_2	367	373	PF01217	0.467
TRG_DiLeu_BaEn_2	46	52	PF01217	0.438
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.561
TRG_ENDOCYTIC_2	251	254	PF00928	0.403
TRG_ENDOCYTIC_2	48	51	PF00928	0.352
TRG_ENDOCYTIC_2	97	100	PF00928	0.601
TRG_ER_diArg_1	13	15	PF00400	0.490
TRG_ER_diArg_1	275	277	PF00400	0.495
TRG_ER_diArg_1	321	323	PF00400	0.572
TRG_ER_diArg_1	397	400	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSY5	Leptomonas seymouri	53%	93%
A0A0S4J7P5	Bodo saltans	25%	100%
A0A1X0P955	Trypanosomatidae	30%	100%
A0A3S5H552	Leishmania donovani	89%	95%
A0A422NMI0	Trypanosoma rangeli	33%	100%
A4H3M8	Leishmania braziliensis	84%	100%
D0A270	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ACL2	Leishmania major	89%	100%
E9AG56	Leishmania infantum	89%	95%
V5BXE2	Trypanosoma cruzi	32%	100%