LeishMANIAdb
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DUF3533 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3533 domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9AJU8_LEIMU
TriTrypDb:
LmxM.03.0650
Length:
892

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9AJU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 352 356 PF00656 0.414
CLV_C14_Caspase3-7 582 586 PF00656 0.604
CLV_C14_Caspase3-7 605 609 PF00656 0.685
CLV_C14_Caspase3-7 879 883 PF00656 0.701
CLV_NRD_NRD_1 109 111 PF00675 0.504
CLV_NRD_NRD_1 294 296 PF00675 0.352
CLV_NRD_NRD_1 394 396 PF00675 0.321
CLV_NRD_NRD_1 533 535 PF00675 0.484
CLV_NRD_NRD_1 72 74 PF00675 0.523
CLV_NRD_NRD_1 862 864 PF00675 0.482
CLV_NRD_NRD_1 866 868 PF00675 0.472
CLV_PCSK_FUR_1 69 73 PF00082 0.427
CLV_PCSK_FUR_1 860 864 PF00082 0.485
CLV_PCSK_KEX2_1 109 111 PF00082 0.504
CLV_PCSK_KEX2_1 294 296 PF00082 0.367
CLV_PCSK_KEX2_1 394 396 PF00082 0.321
CLV_PCSK_KEX2_1 533 535 PF00082 0.484
CLV_PCSK_KEX2_1 71 73 PF00082 0.524
CLV_PCSK_KEX2_1 862 864 PF00082 0.482
CLV_PCSK_KEX2_1 866 868 PF00082 0.472
CLV_PCSK_PC7_1 862 868 PF00082 0.471
CLV_PCSK_SKI1_1 408 412 PF00082 0.389
CLV_PCSK_SKI1_1 452 456 PF00082 0.400
CLV_PCSK_SKI1_1 511 515 PF00082 0.583
DEG_APCC_DBOX_1 143 151 PF00400 0.713
DEG_SCF_FBW7_1 153 159 PF00400 0.659
DEG_SCF_FBW7_1 339 345 PF00400 0.353
DEG_SCF_FBW7_1 46 52 PF00400 0.702
DEG_SPOP_SBC_1 342 346 PF00917 0.467
DEG_SPOP_SBC_1 348 352 PF00917 0.482
DOC_CKS1_1 153 158 PF01111 0.666
DOC_CKS1_1 170 175 PF01111 0.658
DOC_CKS1_1 339 344 PF01111 0.352
DOC_CKS1_1 46 51 PF01111 0.702
DOC_CYCLIN_RxL_1 449 457 PF00134 0.323
DOC_CYCLIN_yCln2_LP_2 31 37 PF00134 0.663
DOC_CYCLIN_yCln2_LP_2 336 342 PF00134 0.347
DOC_CYCLIN_yCln2_LP_2 750 756 PF00134 0.304
DOC_MAPK_gen_1 109 117 PF00069 0.618
DOC_MAPK_gen_1 394 400 PF00069 0.514
DOC_MAPK_gen_1 533 541 PF00069 0.261
DOC_MAPK_gen_1 866 876 PF00069 0.611
DOC_MAPK_JIP1_4 120 126 PF00069 0.600
DOC_MAPK_MEF2A_6 109 117 PF00069 0.627
DOC_MAPK_MEF2A_6 459 468 PF00069 0.575
DOC_PP1_RVXF_1 406 412 PF00149 0.484
DOC_PP1_RVXF_1 509 516 PF00149 0.297
DOC_PP2B_LxvP_1 542 545 PF13499 0.369
DOC_USP7_MATH_1 264 268 PF00917 0.610
DOC_USP7_MATH_1 342 346 PF00917 0.463
DOC_USP7_MATH_1 348 352 PF00917 0.486
DOC_USP7_MATH_1 353 357 PF00917 0.474
DOC_USP7_MATH_1 364 368 PF00917 0.351
DOC_USP7_MATH_1 418 422 PF00917 0.369
DOC_USP7_MATH_1 478 482 PF00917 0.304
DOC_USP7_MATH_1 602 606 PF00917 0.630
DOC_USP7_MATH_1 631 635 PF00917 0.642
DOC_USP7_MATH_1 87 91 PF00917 0.696
DOC_USP7_UBL2_3 452 456 PF12436 0.370
DOC_WW_Pin1_4 152 157 PF00397 0.760
DOC_WW_Pin1_4 169 174 PF00397 0.648
DOC_WW_Pin1_4 233 238 PF00397 0.674
DOC_WW_Pin1_4 258 263 PF00397 0.676
DOC_WW_Pin1_4 265 270 PF00397 0.676
DOC_WW_Pin1_4 277 282 PF00397 0.632
DOC_WW_Pin1_4 335 340 PF00397 0.340
DOC_WW_Pin1_4 35 40 PF00397 0.679
DOC_WW_Pin1_4 428 433 PF00397 0.316
DOC_WW_Pin1_4 45 50 PF00397 0.679
DOC_WW_Pin1_4 524 529 PF00397 0.522
DOC_WW_Pin1_4 59 64 PF00397 0.722
DOC_WW_Pin1_4 769 774 PF00397 0.388
DOC_WW_Pin1_4 79 84 PF00397 0.604
DOC_WW_Pin1_4 91 96 PF00397 0.649
LIG_14-3-3_CanoR_1 109 117 PF00244 0.742
LIG_14-3-3_CanoR_1 120 125 PF00244 0.673
LIG_14-3-3_CanoR_1 144 153 PF00244 0.689
LIG_14-3-3_CanoR_1 560 568 PF00244 0.547
LIG_14-3-3_CanoR_1 71 79 PF00244 0.713
LIG_14-3-3_CanoR_1 738 744 PF00244 0.495
LIG_Actin_WH2_2 385 401 PF00022 0.345
LIG_APCC_ABBA_1 790 795 PF00400 0.341
LIG_BIR_II_1 1 5 PF00653 0.705
LIG_BIR_III_2 684 688 PF00653 0.430
LIG_BIR_III_2 770 774 PF00653 0.338
LIG_BRCT_BRCA1_1 446 450 PF00533 0.304
LIG_BRCT_BRCA1_1 722 726 PF00533 0.304
LIG_BRCT_BRCA1_2 446 452 PF00533 0.304
LIG_Clathr_ClatBox_1 680 684 PF01394 0.284
LIG_deltaCOP1_diTrp_1 403 411 PF00928 0.520
LIG_EVH1_2 284 288 PF00568 0.594
LIG_FHA_1 157 163 PF00498 0.724
LIG_FHA_1 297 303 PF00498 0.542
LIG_FHA_1 368 374 PF00498 0.269
LIG_FHA_1 387 393 PF00498 0.313
LIG_FHA_1 429 435 PF00498 0.318
LIG_FHA_1 449 455 PF00498 0.346
LIG_FHA_1 594 600 PF00498 0.690
LIG_FHA_1 722 728 PF00498 0.369
LIG_FHA_1 753 759 PF00498 0.304
LIG_FHA_2 132 138 PF00498 0.678
LIG_FHA_2 153 159 PF00498 0.691
LIG_FHA_2 173 179 PF00498 0.641
LIG_FHA_2 234 240 PF00498 0.712
LIG_FHA_2 285 291 PF00498 0.573
LIG_FHA_2 560 566 PF00498 0.518
LIG_FHA_2 796 802 PF00498 0.522
LIG_GBD_Chelix_1 384 392 PF00786 0.369
LIG_IBAR_NPY_1 463 465 PF08397 0.563
LIG_LIR_Apic_2 167 173 PF02991 0.711
LIG_LIR_Apic_2 460 464 PF02991 0.562
LIG_LIR_Gen_1 158 168 PF02991 0.690
LIG_LIR_Gen_1 210 218 PF02991 0.630
LIG_LIR_Gen_1 287 296 PF02991 0.620
LIG_LIR_Gen_1 367 377 PF02991 0.272
LIG_LIR_Gen_1 469 478 PF02991 0.292
LIG_LIR_Gen_1 481 487 PF02991 0.400
LIG_LIR_Gen_1 723 734 PF02991 0.304
LIG_LIR_Gen_1 772 783 PF02991 0.286
LIG_LIR_Gen_1 871 880 PF02991 0.673
LIG_LIR_Nem_3 202 206 PF02991 0.667
LIG_LIR_Nem_3 210 214 PF02991 0.629
LIG_LIR_Nem_3 287 291 PF02991 0.629
LIG_LIR_Nem_3 367 372 PF02991 0.311
LIG_LIR_Nem_3 469 473 PF02991 0.304
LIG_LIR_Nem_3 481 486 PF02991 0.374
LIG_LIR_Nem_3 512 518 PF02991 0.388
LIG_LIR_Nem_3 723 729 PF02991 0.304
LIG_LIR_Nem_3 772 778 PF02991 0.286
LIG_LIR_Nem_3 859 864 PF02991 0.675
LIG_LIR_Nem_3 871 875 PF02991 0.661
LIG_LYPXL_SIV_4 464 472 PF13949 0.469
LIG_PCNA_yPIPBox_3 560 571 PF02747 0.500
LIG_Pex14_1 328 332 PF04695 0.316
LIG_Pex14_1 407 411 PF04695 0.484
LIG_Pex14_1 536 540 PF04695 0.304
LIG_Pex14_1 553 557 PF04695 0.497
LIG_Pex14_2 320 324 PF04695 0.496
LIG_Pex14_2 379 383 PF04695 0.304
LIG_Pex14_2 400 404 PF04695 0.528
LIG_RPA_C_Fungi 290 302 PF08784 0.477
LIG_SH2_CRK 170 174 PF00017 0.640
LIG_SH2_CRK 461 465 PF00017 0.431
LIG_SH2_CRK 718 722 PF00017 0.304
LIG_SH2_CRK 872 876 PF00017 0.604
LIG_SH2_GRB2like 461 464 PF00017 0.365
LIG_SH2_GRB2like 735 738 PF00017 0.336
LIG_SH2_NCK_1 170 174 PF00017 0.520
LIG_SH2_NCK_1 426 430 PF00017 0.419
LIG_SH2_NCK_1 461 465 PF00017 0.366
LIG_SH2_PTP2 465 468 PF00017 0.304
LIG_SH2_PTP2 775 778 PF00017 0.304
LIG_SH2_SRC 206 209 PF00017 0.556
LIG_SH2_SRC 461 464 PF00017 0.401
LIG_SH2_STAP1 100 104 PF00017 0.697
LIG_SH2_STAP1 199 203 PF00017 0.613
LIG_SH2_STAP1 369 373 PF00017 0.304
LIG_SH2_STAP1 446 450 PF00017 0.304
LIG_SH2_STAP1 739 743 PF00017 0.336
LIG_SH2_STAP1 872 876 PF00017 0.604
LIG_SH2_STAT5 369 372 PF00017 0.332
LIG_SH2_STAT5 465 468 PF00017 0.338
LIG_SH2_STAT5 485 488 PF00017 0.406
LIG_SH2_STAT5 561 564 PF00017 0.351
LIG_SH2_STAT5 570 573 PF00017 0.452
LIG_SH2_STAT5 718 721 PF00017 0.304
LIG_SH2_STAT5 730 733 PF00017 0.304
LIG_SH2_STAT5 735 738 PF00017 0.336
LIG_SH2_STAT5 775 778 PF00017 0.304
LIG_SH2_STAT5 791 794 PF00017 0.340
LIG_SH3_3 150 156 PF00018 0.579
LIG_SH3_3 174 180 PF00018 0.513
LIG_SH3_3 234 240 PF00018 0.637
LIG_SH3_3 256 262 PF00018 0.757
LIG_SH3_3 263 269 PF00018 0.721
LIG_SH3_3 278 284 PF00018 0.509
LIG_SH3_3 336 342 PF00018 0.489
LIG_SH3_3 34 40 PF00018 0.630
LIG_SH3_3 374 380 PF00018 0.445
LIG_SH3_3 43 49 PF00018 0.731
LIG_SH3_3 607 613 PF00018 0.518
LIG_SH3_3 622 628 PF00018 0.593
LIG_SH3_3 847 853 PF00018 0.613
LIG_SUMO_SIM_anti_2 287 293 PF11976 0.424
LIG_SUMO_SIM_anti_2 755 761 PF11976 0.304
LIG_SUMO_SIM_par_1 148 155 PF11976 0.684
LIG_SUMO_SIM_par_1 522 532 PF11976 0.407
LIG_SUMO_SIM_par_1 662 671 PF11976 0.406
LIG_SUMO_SIM_par_1 780 785 PF11976 0.243
LIG_TRAF2_1 236 239 PF00917 0.648
LIG_TRAF2_1 798 801 PF00917 0.385
LIG_WRC_WIRS_1 369 374 PF05994 0.304
LIG_WRC_WIRS_1 467 472 PF05994 0.369
MOD_CDK_SPxxK_3 169 176 PF00069 0.640
MOD_CK1_1 131 137 PF00069 0.607
MOD_CK1_1 143 149 PF00069 0.568
MOD_CK1_1 277 283 PF00069 0.543
MOD_CK1_1 338 344 PF00069 0.531
MOD_CK1_1 346 352 PF00069 0.615
MOD_CK1_1 367 373 PF00069 0.372
MOD_CK1_1 38 44 PF00069 0.633
MOD_CK1_1 496 502 PF00069 0.597
MOD_CK1_1 519 525 PF00069 0.515
MOD_CK1_1 629 635 PF00069 0.554
MOD_CK1_1 668 674 PF00069 0.270
MOD_CK1_1 7 13 PF00069 0.540
MOD_CK1_1 745 751 PF00069 0.304
MOD_CK1_1 75 81 PF00069 0.807
MOD_CK1_1 785 791 PF00069 0.369
MOD_CK1_1 841 847 PF00069 0.617
MOD_CK1_1 86 92 PF00069 0.700
MOD_CK1_1 881 887 PF00069 0.641
MOD_CK2_1 172 178 PF00069 0.610
MOD_CK2_1 233 239 PF00069 0.687
MOD_CK2_1 284 290 PF00069 0.458
MOD_CK2_1 691 697 PF00069 0.393
MOD_CK2_1 795 801 PF00069 0.377
MOD_CMANNOS 404 407 PF00535 0.378
MOD_DYRK1A_RPxSP_1 258 262 PF00069 0.559
MOD_GlcNHglycan 147 150 PF01048 0.697
MOD_GlcNHglycan 221 224 PF01048 0.551
MOD_GlcNHglycan 27 30 PF01048 0.577
MOD_GlcNHglycan 276 279 PF01048 0.572
MOD_GlcNHglycan 346 349 PF01048 0.623
MOD_GlcNHglycan 351 354 PF01048 0.647
MOD_GlcNHglycan 355 358 PF01048 0.660
MOD_GlcNHglycan 374 377 PF01048 0.425
MOD_GlcNHglycan 420 423 PF01048 0.304
MOD_GlcNHglycan 446 449 PF01048 0.304
MOD_GlcNHglycan 496 499 PF01048 0.582
MOD_GlcNHglycan 518 521 PF01048 0.455
MOD_GlcNHglycan 628 631 PF01048 0.611
MOD_GlcNHglycan 732 735 PF01048 0.363
MOD_GlcNHglycan 750 753 PF01048 0.200
MOD_GlcNHglycan 824 827 PF01048 0.581
MOD_GlcNHglycan 847 850 PF01048 0.593
MOD_GlcNHglycan 89 92 PF01048 0.627
MOD_GSK3_1 136 143 PF00069 0.602
MOD_GSK3_1 152 159 PF00069 0.551
MOD_GSK3_1 164 171 PF00069 0.578
MOD_GSK3_1 331 338 PF00069 0.481
MOD_GSK3_1 342 349 PF00069 0.577
MOD_GSK3_1 351 358 PF00069 0.612
MOD_GSK3_1 364 371 PF00069 0.364
MOD_GSK3_1 4 11 PF00069 0.649
MOD_GSK3_1 444 451 PF00069 0.343
MOD_GSK3_1 45 52 PF00069 0.709
MOD_GSK3_1 490 497 PF00069 0.546
MOD_GSK3_1 516 523 PF00069 0.504
MOD_GSK3_1 540 547 PF00069 0.503
MOD_GSK3_1 59 66 PF00069 0.565
MOD_GSK3_1 664 671 PF00069 0.304
MOD_GSK3_1 748 755 PF00069 0.304
MOD_GSK3_1 75 82 PF00069 0.748
MOD_GSK3_1 761 768 PF00069 0.386
MOD_GSK3_1 83 90 PF00069 0.602
MOD_GSK3_1 838 845 PF00069 0.601
MOD_N-GLC_1 156 161 PF02516 0.606
MOD_N-GLC_1 765 770 PF02516 0.391
MOD_N-GLC_1 838 843 PF02516 0.586
MOD_N-GLC_2 22 24 PF02516 0.627
MOD_NEK2_1 12 17 PF00069 0.610
MOD_NEK2_1 162 167 PF00069 0.616
MOD_NEK2_1 20 25 PF00069 0.592
MOD_NEK2_1 274 279 PF00069 0.592
MOD_NEK2_1 296 301 PF00069 0.387
MOD_NEK2_1 365 370 PF00069 0.380
MOD_NEK2_1 372 377 PF00069 0.304
MOD_NEK2_1 4 9 PF00069 0.601
MOD_NEK2_1 438 443 PF00069 0.304
MOD_NEK2_1 472 477 PF00069 0.369
MOD_NEK2_1 540 545 PF00069 0.304
MOD_NEK2_1 689 694 PF00069 0.448
MOD_NEK2_1 721 726 PF00069 0.308
MOD_NEK2_1 782 787 PF00069 0.369
MOD_NEK2_1 843 848 PF00069 0.581
MOD_NEK2_2 125 130 PF00069 0.619
MOD_NEK2_2 478 483 PF00069 0.304
MOD_NEK2_2 774 779 PF00069 0.304
MOD_PIKK_1 162 168 PF00454 0.689
MOD_PIKK_1 63 69 PF00454 0.523
MOD_PIKK_1 745 751 PF00454 0.304
MOD_PKA_1 72 78 PF00069 0.639
MOD_PKA_2 108 114 PF00069 0.712
MOD_PKA_2 119 125 PF00069 0.591
MOD_PKA_2 143 149 PF00069 0.611
MOD_PKA_2 398 404 PF00069 0.389
MOD_PKA_2 559 565 PF00069 0.367
MOD_PKA_2 602 608 PF00069 0.617
MOD_PKA_2 72 78 PF00069 0.648
MOD_PKA_2 737 743 PF00069 0.339
MOD_PKA_2 856 862 PF00069 0.537
MOD_PKB_1 71 79 PF00069 0.641
MOD_Plk_1 156 162 PF00069 0.550
MOD_Plk_1 296 302 PF00069 0.397
MOD_Plk_1 4 10 PF00069 0.643
MOD_Plk_1 657 663 PF00069 0.373
MOD_Plk_1 668 674 PF00069 0.314
MOD_Plk_1 795 801 PF00069 0.441
MOD_Plk_1 881 887 PF00069 0.521
MOD_Plk_2-3 795 801 PF00069 0.381
MOD_Plk_4 113 119 PF00069 0.786
MOD_Plk_4 284 290 PF00069 0.438
MOD_Plk_4 297 303 PF00069 0.392
MOD_Plk_4 368 374 PF00069 0.304
MOD_Plk_4 438 444 PF00069 0.304
MOD_Plk_4 466 472 PF00069 0.369
MOD_Plk_4 478 484 PF00069 0.304
MOD_Plk_4 544 550 PF00069 0.335
MOD_Plk_4 552 558 PF00069 0.408
MOD_Plk_4 742 748 PF00069 0.304
MOD_Plk_4 774 780 PF00069 0.369
MOD_Plk_4 785 791 PF00069 0.266
MOD_ProDKin_1 152 158 PF00069 0.710
MOD_ProDKin_1 169 175 PF00069 0.556
MOD_ProDKin_1 233 239 PF00069 0.593
MOD_ProDKin_1 258 264 PF00069 0.593
MOD_ProDKin_1 265 271 PF00069 0.590
MOD_ProDKin_1 277 283 PF00069 0.518
MOD_ProDKin_1 335 341 PF00069 0.403
MOD_ProDKin_1 35 41 PF00069 0.600
MOD_ProDKin_1 428 434 PF00069 0.368
MOD_ProDKin_1 45 51 PF00069 0.602
MOD_ProDKin_1 524 530 PF00069 0.649
MOD_ProDKin_1 59 65 PF00069 0.651
MOD_ProDKin_1 769 775 PF00069 0.467
MOD_ProDKin_1 79 85 PF00069 0.494
MOD_ProDKin_1 91 97 PF00069 0.555
MOD_SUMO_rev_2 795 804 PF00179 0.444
TRG_DiLeu_BaEn_1 297 302 PF01217 0.361
TRG_DiLeu_BaLyEn_6 405 410 PF01217 0.365
TRG_ENDOCYTIC_2 369 372 PF00928 0.342
TRG_ENDOCYTIC_2 465 468 PF00928 0.304
TRG_ENDOCYTIC_2 718 721 PF00928 0.304
TRG_ENDOCYTIC_2 775 778 PF00928 0.304
TRG_ENDOCYTIC_2 831 834 PF00928 0.607
TRG_ENDOCYTIC_2 872 875 PF00928 0.581
TRG_ER_diArg_1 293 295 PF00400 0.426
TRG_ER_diArg_1 393 395 PF00400 0.399
TRG_ER_diArg_1 533 535 PF00400 0.325
TRG_ER_diArg_1 71 73 PF00400 0.660
TRG_ER_diArg_1 861 863 PF00400 0.607
TRG_ER_diArg_1 866 869 PF00400 0.591
TRG_NES_CRM1_1 673 684 PF08389 0.304
TRG_Pf-PMV_PEXEL_1 866 871 PF00026 0.452

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I037 Leptomonas seymouri 57% 91%
A0A451EJR5 Leishmania donovani 85% 100%
A4H3M6 Leishmania braziliensis 67% 96%
E9ACL0 Leishmania major 82% 99%
E9AG54 Leishmania infantum 84% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS