Carn_acyltransf domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJU7_LEIMU

TriTrypDb:

LmxM.03.0640

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.455
CLV_C14_Caspase3-7	384	388	PF00656	0.626
CLV_C14_Caspase3-7	428	432	PF00656	0.575
CLV_NRD_NRD_1	321	323	PF00675	0.467
CLV_NRD_NRD_1	394	396	PF00675	0.637
CLV_NRD_NRD_1	473	475	PF00675	0.435
CLV_NRD_NRD_1	493	495	PF00675	0.251
CLV_PCSK_KEX2_1	144	146	PF00082	0.559
CLV_PCSK_KEX2_1	321	323	PF00082	0.512
CLV_PCSK_KEX2_1	472	474	PF00082	0.466
CLV_PCSK_KEX2_1	573	575	PF00082	0.506
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.559
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.635
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.526
CLV_PCSK_SKI1_1	150	154	PF00082	0.458
CLV_PCSK_SKI1_1	229	233	PF00082	0.677
CLV_PCSK_SKI1_1	264	268	PF00082	0.586
CLV_PCSK_SKI1_1	291	295	PF00082	0.398
CLV_PCSK_SKI1_1	323	327	PF00082	0.653
CLV_PCSK_SKI1_1	438	442	PF00082	0.434
CLV_PCSK_SKI1_1	481	485	PF00082	0.413
CLV_PCSK_SKI1_1	528	532	PF00082	0.537
CLV_PCSK_SKI1_1	93	97	PF00082	0.483
CLV_Separin_Metazoa	261	265	PF03568	0.513
DEG_APCC_DBOX_1	283	291	PF00400	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.295
DEG_SPOP_SBC_1	218	222	PF00917	0.791
DEG_SPOP_SBC_1	50	54	PF00917	0.605
DOC_CKS1_1	449	454	PF01111	0.389
DOC_CYCLIN_RxL_1	286	295	PF00134	0.450
DOC_CYCLIN_RxL_1	320	328	PF00134	0.595
DOC_CYCLIN_RxL_1	435	442	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.504
DOC_MAPK_FxFP_2	9	12	PF00069	0.510
DOC_MAPK_gen_1	281	290	PF00069	0.434
DOC_MAPK_gen_1	321	327	PF00069	0.585
DOC_MAPK_JIP1_4	284	290	PF00069	0.459
DOC_MAPK_MEF2A_6	246	254	PF00069	0.369
DOC_MAPK_MEF2A_6	281	289	PF00069	0.385
DOC_MAPK_MEF2A_6	291	298	PF00069	0.385
DOC_MAPK_MEF2A_6	333	341	PF00069	0.424
DOC_MAPK_MEF2A_6	461	470	PF00069	0.488
DOC_PP2B_LxvP_1	294	297	PF13499	0.419
DOC_PP2B_LxvP_1	419	422	PF13499	0.373
DOC_PP4_FxxP_1	9	12	PF00568	0.510
DOC_USP7_MATH_1	207	211	PF00917	0.750
DOC_USP7_MATH_1	218	222	PF00917	0.759
DOC_USP7_MATH_1	390	394	PF00917	0.635
DOC_USP7_MATH_1	450	454	PF00917	0.549
DOC_USP7_MATH_1	48	52	PF00917	0.782
DOC_USP7_UBL2_3	89	93	PF12436	0.507
DOC_WW_Pin1_4	110	115	PF00397	0.501
DOC_WW_Pin1_4	223	228	PF00397	0.753
DOC_WW_Pin1_4	429	434	PF00397	0.508
DOC_WW_Pin1_4	448	453	PF00397	0.425
LIG_14-3-3_CanoR_1	423	433	PF00244	0.469
LIG_14-3-3_CanoR_1	461	470	PF00244	0.544
LIG_14-3-3_CanoR_1	67	73	PF00244	0.593
LIG_Actin_RPEL_3	326	345	PF02755	0.567
LIG_Actin_WH2_2	248	266	PF00022	0.495
LIG_APCC_ABBA_1	368	373	PF00400	0.560
LIG_BIR_III_2	576	580	PF00653	0.582
LIG_BIR_III_4	30	34	PF00653	0.595
LIG_BIR_III_4	373	377	PF00653	0.528
LIG_BRCT_BRCA1_1	431	435	PF00533	0.564
LIG_BRCT_BRCA1_1	453	457	PF00533	0.638
LIG_Clathr_ClatBox_1	95	99	PF01394	0.521
LIG_CtBP_PxDLS_1	4	8	PF00389	0.567
LIG_EH1_1	565	573	PF00400	0.480
LIG_FHA_1	173	179	PF00498	0.388
LIG_FHA_1	249	255	PF00498	0.486
LIG_FHA_1	293	299	PF00498	0.393
LIG_FHA_1	406	412	PF00498	0.388
LIG_FHA_1	67	73	PF00498	0.640
LIG_FHA_2	274	280	PF00498	0.557
LIG_FHA_2	382	388	PF00498	0.577
LIG_FHA_2	426	432	PF00498	0.588
LIG_FHA_2	535	541	PF00498	0.495
LIG_LIR_Apic_2	279	285	PF02991	0.444
LIG_LIR_Apic_2	6	12	PF02991	0.500
LIG_LIR_Gen_1	413	422	PF02991	0.466
LIG_LIR_Gen_1	454	463	PF02991	0.542
LIG_LIR_Nem_3	413	417	PF02991	0.382
LIG_LIR_Nem_3	454	460	PF02991	0.550
LIG_LYPXL_S_1	489	493	PF13949	0.538
LIG_NRBOX	289	295	PF00104	0.497
LIG_NRBOX	340	346	PF00104	0.483
LIG_PCNA_yPIPBox_3	256	264	PF02747	0.549
LIG_PDZ_Class_2	575	580	PF00595	0.572
LIG_Pex14_2	183	187	PF04695	0.384
LIG_SH2_CRK	342	346	PF00017	0.519
LIG_SH2_NCK_1	378	382	PF00017	0.560
LIG_SH2_SRC	315	318	PF00017	0.575
LIG_SH2_SRC	378	381	PF00017	0.596
LIG_SH2_SRC	516	519	PF00017	0.401
LIG_SH2_STAP1	124	128	PF00017	0.439
LIG_SH2_STAP1	142	146	PF00017	0.505
LIG_SH2_STAP1	407	411	PF00017	0.364
LIG_SH2_STAP1	414	418	PF00017	0.358
LIG_SH2_STAP1	549	553	PF00017	0.404
LIG_SH2_STAT5	10	13	PF00017	0.489
LIG_SH2_STAT5	315	318	PF00017	0.520
LIG_SH2_STAT5	407	410	PF00017	0.384
LIG_SH2_STAT5	516	519	PF00017	0.401
LIG_SH3_3	108	114	PF00018	0.583
LIG_SH3_3	191	197	PF00018	0.617
LIG_SH3_3	446	452	PF00018	0.466
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.508
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.519
LIG_SUMO_SIM_par_1	445	451	PF11976	0.499
LIG_SUMO_SIM_par_1	94	99	PF11976	0.519
LIG_TRAF2_1	557	560	PF00917	0.463
LIG_TRFH_1	441	445	PF08558	0.540
LIG_TYR_ITIM	547	552	PF00017	0.390
LIG_UBA3_1	287	291	PF00899	0.387
LIG_UBA3_1	326	331	PF00899	0.575
MOD_CDC14_SPxK_1	226	229	PF00782	0.648
MOD_CDK_SPxK_1	223	229	PF00069	0.659
MOD_CK1_1	209	215	PF00069	0.781
MOD_CK1_1	219	225	PF00069	0.772
MOD_CK1_1	39	45	PF00069	0.759
MOD_CK1_1	46	52	PF00069	0.709
MOD_CK1_1	57	63	PF00069	0.728
MOD_CK2_1	273	279	PF00069	0.532
MOD_CK2_1	39	45	PF00069	0.711
MOD_CK2_1	50	56	PF00069	0.771
MOD_CK2_1	534	540	PF00069	0.473
MOD_CK2_1	554	560	PF00069	0.260
MOD_CK2_1	80	86	PF00069	0.533
MOD_GlcNHglycan	203	206	PF01048	0.721
MOD_GlcNHglycan	48	51	PF01048	0.796
MOD_GlcNHglycan	524	527	PF01048	0.398
MOD_GlcNHglycan	56	59	PF01048	0.752
MOD_GlcNHglycan	72	75	PF01048	0.504
MOD_GSK3_1	161	168	PF00069	0.379
MOD_GSK3_1	201	208	PF00069	0.742
MOD_GSK3_1	209	216	PF00069	0.759
MOD_GSK3_1	217	224	PF00069	0.715
MOD_GSK3_1	292	299	PF00069	0.382
MOD_GSK3_1	39	46	PF00069	0.752
MOD_GSK3_1	425	432	PF00069	0.584
MOD_GSK3_1	451	458	PF00069	0.514
MOD_GSK3_1	50	57	PF00069	0.549
MOD_GSK3_1	63	70	PF00069	0.587
MOD_GSK3_1	72	79	PF00069	0.655
MOD_N-GLC_1	131	136	PF02516	0.589
MOD_N-GLC_1	382	387	PF02516	0.647
MOD_N-GLC_1	461	466	PF02516	0.519
MOD_NEK2_1	173	178	PF00069	0.420
MOD_NEK2_1	250	255	PF00069	0.460
MOD_NEK2_1	517	522	PF00069	0.395
MOD_NEK2_1	534	539	PF00069	0.388
MOD_PIKK_1	207	213	PF00454	0.729
MOD_PKA_1	472	478	PF00069	0.431
MOD_PKA_2	36	42	PF00069	0.663
MOD_PKA_2	472	478	PF00069	0.501
MOD_PKA_2	66	72	PF00069	0.599
MOD_Plk_1	173	179	PF00069	0.440
MOD_Plk_1	382	388	PF00069	0.679
MOD_Plk_1	535	541	PF00069	0.392
MOD_Plk_1	80	86	PF00069	0.605
MOD_Plk_4	250	256	PF00069	0.452
MOD_Plk_4	451	457	PF00069	0.602
MOD_Plk_4	499	505	PF00069	0.403
MOD_Plk_4	91	97	PF00069	0.535
MOD_ProDKin_1	110	116	PF00069	0.495
MOD_ProDKin_1	223	229	PF00069	0.752
MOD_ProDKin_1	429	435	PF00069	0.495
MOD_ProDKin_1	448	454	PF00069	0.437
MOD_SUMO_rev_2	230	240	PF00179	0.361
MOD_SUMO_rev_2	243	248	PF00179	0.353
MOD_SUMO_rev_2	389	398	PF00179	0.624
MOD_SUMO_rev_2	557	564	PF00179	0.437
TRG_DiLeu_BaEn_1	567	572	PF01217	0.449
TRG_DiLeu_BaEn_4	260	266	PF01217	0.516
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.477
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.516
TRG_ENDOCYTIC_2	342	345	PF00928	0.518
TRG_ENDOCYTIC_2	414	417	PF00928	0.382
TRG_ENDOCYTIC_2	490	493	PF00928	0.543
TRG_ENDOCYTIC_2	549	552	PF00928	0.403
TRG_ER_diArg_1	472	474	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q3	Leptomonas seymouri	64%	94%
A0A0S4JDH1	Bodo saltans	30%	100%
A0A1X0P9P0	Trypanosomatidae	48%	100%
A0A422NMG4	Trypanosoma rangeli	49%	100%
A0A451EJR4	Leishmania donovani	92%	96%
A4H3M5	Leishmania braziliensis	86%	100%
D0A267	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	92%
E9ACK9	Leishmania major	91%	100%
E9AG53	Leishmania infantum	91%	95%
V5BSR7	Trypanosoma cruzi	48%	100%