Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJU6_LEIMU

TriTrypDb:

LmxM.03.0630

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU6

PDB structure(s): 7ane_ak

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.802
CLV_C14_Caspase3-7	307	311	PF00656	0.681
CLV_NRD_NRD_1	135	137	PF00675	0.572
CLV_NRD_NRD_1	188	190	PF00675	0.647
CLV_NRD_NRD_1	266	268	PF00675	0.488
CLV_NRD_NRD_1	271	273	PF00675	0.479
CLV_NRD_NRD_1	285	287	PF00675	0.348
CLV_PCSK_FUR_1	186	190	PF00082	0.635
CLV_PCSK_KEX2_1	135	137	PF00082	0.602
CLV_PCSK_KEX2_1	188	190	PF00082	0.660
CLV_PCSK_KEX2_1	271	273	PF00082	0.531
CLV_PCSK_KEX2_1	285	287	PF00082	0.395
CLV_PCSK_KEX2_1	298	300	PF00082	0.417
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.495
CLV_PCSK_PC7_1	267	273	PF00082	0.571
CLV_PCSK_SKI1_1	123	127	PF00082	0.448
CLV_PCSK_SKI1_1	16	20	PF00082	0.405
DEG_APCC_DBOX_1	285	293	PF00400	0.574
DEG_SPOP_SBC_1	90	94	PF00917	0.709
DOC_PP2B_LxvP_1	235	238	PF13499	0.476
DOC_PP4_FxxP_1	179	182	PF00568	0.543
DOC_SPAK_OSR1_1	178	182	PF12202	0.572
DOC_USP7_MATH_1	228	232	PF00917	0.414
DOC_USP7_MATH_1	44	48	PF00917	0.484
DOC_USP7_MATH_1	90	94	PF00917	0.707
DOC_USP7_UBL2_3	294	298	PF12436	0.528
DOC_WW_Pin1_4	80	85	PF00397	0.695
LIG_14-3-3_CanoR_1	28	32	PF00244	0.500
LIG_14-3-3_CanoR_1	285	293	PF00244	0.538
LIG_14-3-3_CterR_2	319	322	PF00244	0.592
LIG_Actin_WH2_2	305	321	PF00022	0.710
LIG_APCC_ABBAyCdc20_2	14	20	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_Clathr_ClatBox_1	240	244	PF01394	0.439
LIG_CtBP_PxDLS_1	101	106	PF00389	0.571
LIG_deltaCOP1_diTrp_1	172	179	PF00928	0.572
LIG_FHA_1	211	217	PF00498	0.566
LIG_FHA_1	4	10	PF00498	0.428
LIG_FHA_2	305	311	PF00498	0.651
LIG_FHA_2	67	73	PF00498	0.568
LIG_FHA_2	98	104	PF00498	0.611
LIG_GBD_Chelix_1	9	17	PF00786	0.445
LIG_LIR_Gen_1	115	124	PF02991	0.529
LIG_LIR_Gen_1	275	284	PF02991	0.518
LIG_LIR_Nem_3	115	119	PF02991	0.519
LIG_LIR_Nem_3	275	281	PF02991	0.477
LIG_LIR_Nem_3	30	34	PF02991	0.494
LIG_LIR_Nem_3	43	48	PF02991	0.383
LIG_Pex14_1	59	63	PF04695	0.451
LIG_SH2_CRK	45	49	PF00017	0.409
LIG_SH2_GRB2like	5	8	PF00017	0.434
LIG_SH2_STAP1	150	154	PF00017	0.451
LIG_SH2_STAP1	301	305	PF00017	0.551
LIG_SH2_STAP1	5	9	PF00017	0.430
LIG_SH2_STAT5	5	8	PF00017	0.434
LIG_SH3_3	178	184	PF00018	0.558
LIG_SH3_3	55	61	PF00018	0.558
LIG_SH3_3	81	87	PF00018	0.709
LIG_SUMO_SIM_anti_2	100	106	PF11976	0.577
LIG_SUMO_SIM_anti_2	212	221	PF11976	0.595
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.452
LIG_TRAF2_1	125	128	PF00917	0.477
LIG_TYR_ITSM	41	48	PF00017	0.518
LIG_UBA3_1	260	268	PF00899	0.474
MOD_CDC14_SPxK_1	83	86	PF00782	0.728
MOD_CDK_SPxK_1	80	86	PF00069	0.732
MOD_CK1_1	85	91	PF00069	0.747
MOD_CK1_1	92	98	PF00069	0.661
MOD_CK2_1	66	72	PF00069	0.479
MOD_GlcNHglycan	107	110	PF01048	0.433
MOD_GlcNHglycan	88	91	PF01048	0.696
MOD_GlcNHglycan	96	99	PF01048	0.651
MOD_GSK3_1	248	255	PF00069	0.602
MOD_GSK3_1	284	291	PF00069	0.575
MOD_GSK3_1	40	47	PF00069	0.369
MOD_GSK3_1	82	89	PF00069	0.747
MOD_GSK3_1	90	97	PF00069	0.687
MOD_NEK2_1	107	112	PF00069	0.402
MOD_NEK2_1	3	8	PF00069	0.435
MOD_NEK2_1	304	309	PF00069	0.686
MOD_NEK2_1	9	14	PF00069	0.396
MOD_NEK2_2	228	233	PF00069	0.435
MOD_OFUCOSY	35	42	PF10250	0.451
MOD_PIKK_1	284	290	PF00454	0.564
MOD_PKA_2	27	33	PF00069	0.438
MOD_PKA_2	284	290	PF00069	0.564
MOD_PKA_2	3	9	PF00069	0.435
MOD_PKA_2	85	91	PF00069	0.750
MOD_Plk_4	210	216	PF00069	0.458
MOD_Plk_4	44	50	PF00069	0.402
MOD_ProDKin_1	80	86	PF00069	0.696
MOD_SUMO_for_1	125	128	PF00179	0.477
MOD_SUMO_rev_2	202	210	PF00179	0.710
MOD_SUMO_rev_2	310	316	PF00179	0.623
TRG_DiLeu_BaEn_1	279	284	PF01217	0.453
TRG_DiLeu_BaEn_4	313	319	PF01217	0.620
TRG_ENDOCYTIC_2	301	304	PF00928	0.659
TRG_ENDOCYTIC_2	45	48	PF00928	0.396
TRG_ER_diArg_1	134	136	PF00400	0.609
TRG_ER_diArg_1	187	189	PF00400	0.645
TRG_ER_diArg_1	270	272	PF00400	0.557
TRG_ER_diArg_1	284	286	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B1	Leptomonas seymouri	65%	100%
A0A0S4JDA3	Bodo saltans	31%	100%
A0A1X0P8U5	Trypanosomatidae	46%	100%
A0A3S5H551	Leishmania donovani	90%	99%
A0A422NMF2	Trypanosoma rangeli	46%	100%
D0A266	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9ACK8	Leishmania major	90%	100%
E9AG52	Leishmania infantum	90%	98%
V5BCA0	Trypanosoma cruzi	45%	100%