Putative MP99

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative MP99

Gene product:

mitochondrial protein 99, putative

Species:

Leishmania mexicana

UniProt:

E9AJU5_LEIMU

TriTrypDb:

LmxM.03.0620

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016605	PML body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.511
CLV_NRD_NRD_1	112	114	PF00675	0.474
CLV_NRD_NRD_1	118	120	PF00675	0.418
CLV_NRD_NRD_1	268	270	PF00675	0.510
CLV_NRD_NRD_1	532	534	PF00675	0.561
CLV_NRD_NRD_1	88	90	PF00675	0.444
CLV_NRD_NRD_1	92	94	PF00675	0.441
CLV_PCSK_KEX2_1	112	114	PF00082	0.521
CLV_PCSK_KEX2_1	118	120	PF00082	0.525
CLV_PCSK_KEX2_1	268	270	PF00082	0.455
CLV_PCSK_KEX2_1	88	90	PF00082	0.430
CLV_PCSK_SKI1_1	112	116	PF00082	0.541
CLV_PCSK_SKI1_1	219	223	PF00082	0.510
CLV_PCSK_SKI1_1	330	334	PF00082	0.544
CLV_PCSK_SKI1_1	541	545	PF00082	0.390
DEG_APCC_DBOX_1	273	281	PF00400	0.486
DOC_CKS1_1	147	152	PF01111	0.531
DOC_CKS1_1	159	164	PF01111	0.406
DOC_CKS1_1	296	301	PF01111	0.514
DOC_CYCLIN_RxL_1	88	101	PF00134	0.403
DOC_MAPK_gen_1	434	444	PF00069	0.556
DOC_MAPK_MEF2A_6	274	282	PF00069	0.340
DOC_MAPK_MEF2A_6	343	351	PF00069	0.562
DOC_PP1_RVXF_1	328	335	PF00149	0.553
DOC_PP1_RVXF_1	92	99	PF00149	0.432
DOC_PP2B_LxvP_1	181	184	PF13499	0.592
DOC_USP7_MATH_1	19	23	PF00917	0.354
DOC_USP7_MATH_1	338	342	PF00917	0.517
DOC_USP7_MATH_1	415	419	PF00917	0.704
DOC_USP7_MATH_1	551	555	PF00917	0.677
DOC_USP7_MATH_1	564	568	PF00917	0.506
DOC_USP7_MATH_1	639	643	PF00917	0.719
DOC_USP7_MATH_1	92	96	PF00917	0.402
DOC_WW_Pin1_4	127	132	PF00397	0.377
DOC_WW_Pin1_4	146	151	PF00397	0.486
DOC_WW_Pin1_4	158	163	PF00397	0.411
DOC_WW_Pin1_4	213	218	PF00397	0.385
DOC_WW_Pin1_4	295	300	PF00397	0.482
DOC_WW_Pin1_4	378	383	PF00397	0.566
DOC_WW_Pin1_4	406	411	PF00397	0.496
DOC_WW_Pin1_4	473	478	PF00397	0.570
LIG_14-3-3_CanoR_1	123	133	PF00244	0.482
LIG_14-3-3_CanoR_1	17	27	PF00244	0.524
LIG_14-3-3_CanoR_1	219	225	PF00244	0.452
LIG_14-3-3_CanoR_1	328	333	PF00244	0.542
LIG_14-3-3_CanoR_1	352	357	PF00244	0.459
LIG_14-3-3_CanoR_1	437	444	PF00244	0.527
LIG_14-3-3_CanoR_1	510	515	PF00244	0.583
LIG_14-3-3_CanoR_1	533	539	PF00244	0.493
LIG_14-3-3_CanoR_1	611	615	PF00244	0.506
LIG_14-3-3_CanoR_1	650	654	PF00244	0.577
LIG_14-3-3_CanoR_1	80	86	PF00244	0.502
LIG_14-3-3_CanoR_1	93	97	PF00244	0.302
LIG_Actin_WH2_2	236	252	PF00022	0.552
LIG_Actin_WH2_2	607	625	PF00022	0.364
LIG_APCC_ABBAyCdc20_2	330	336	PF00400	0.543
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	330	334	PF00533	0.516
LIG_BRCT_BRCA1_1	577	581	PF00533	0.492
LIG_BRCT_BRCA1_1	94	98	PF00533	0.422
LIG_CSL_BTD_1	407	410	PF09270	0.613
LIG_DLG_GKlike_1	352	359	PF00625	0.443
LIG_eIF4E_1	60	66	PF01652	0.577
LIG_FHA_1	159	165	PF00498	0.520
LIG_FHA_1	176	182	PF00498	0.346
LIG_FHA_1	197	203	PF00498	0.450
LIG_FHA_1	273	279	PF00498	0.334
LIG_FHA_1	287	293	PF00498	0.392
LIG_FHA_1	392	398	PF00498	0.494
LIG_FHA_1	421	427	PF00498	0.663
LIG_FHA_1	446	452	PF00498	0.486
LIG_FHA_1	470	476	PF00498	0.337
LIG_FHA_1	488	494	PF00498	0.452
LIG_FHA_1	523	529	PF00498	0.498
LIG_FHA_1	533	539	PF00498	0.486
LIG_FHA_1	556	562	PF00498	0.648
LIG_FHA_1	60	66	PF00498	0.483
LIG_FHA_1	617	623	PF00498	0.529
LIG_FHA_1	82	88	PF00498	0.509
LIG_FHA_2	193	199	PF00498	0.525
LIG_FHA_2	384	390	PF00498	0.552
LIG_FHA_2	484	490	PF00498	0.385
LIG_FHA_2	494	500	PF00498	0.406
LIG_FHA_2	511	517	PF00498	0.478
LIG_Integrin_RGD_1	633	635	PF01839	0.482
LIG_LIR_Apic_2	472	477	PF02991	0.580
LIG_LIR_Gen_1	207	218	PF02991	0.390
LIG_LIR_Gen_1	239	249	PF02991	0.405
LIG_LIR_Gen_1	298	308	PF02991	0.422
LIG_LIR_Nem_3	185	189	PF02991	0.655
LIG_LIR_Nem_3	207	213	PF02991	0.392
LIG_LIR_Nem_3	215	221	PF02991	0.417
LIG_LIR_Nem_3	239	245	PF02991	0.426
LIG_LIR_Nem_3	298	303	PF02991	0.409
LIG_LIR_Nem_3	31	36	PF02991	0.434
LIG_LIR_Nem_3	433	438	PF02991	0.570
LIG_LIR_Nem_3	595	599	PF02991	0.441
LIG_MAD2	179	187	PF02301	0.565
LIG_NRBOX	244	250	PF00104	0.568
LIG_NRBOX	278	284	PF00104	0.485
LIG_NRBOX	355	361	PF00104	0.494
LIG_PCNA_yPIPBox_3	533	543	PF02747	0.561
LIG_SH2_STAP1	120	124	PF00017	0.548
LIG_SH2_STAP1	612	616	PF00017	0.388
LIG_SH2_STAT5	134	137	PF00017	0.434
LIG_SH2_STAT5	172	175	PF00017	0.494
LIG_SH2_STAT5	281	284	PF00017	0.375
LIG_SH2_STAT5	307	310	PF00017	0.439
LIG_SH2_STAT5	449	452	PF00017	0.497
LIG_SH2_STAT5	474	477	PF00017	0.552
LIG_SH2_STAT5	60	63	PF00017	0.511
LIG_SH3_3	156	162	PF00018	0.478
LIG_SH3_3	181	187	PF00018	0.580
LIG_SH3_3	200	206	PF00018	0.491
LIG_SH3_3	317	323	PF00018	0.700
LIG_SH3_3	341	347	PF00018	0.654
LIG_SH3_3	369	375	PF00018	0.630
LIG_SH3_3	411	417	PF00018	0.438
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.426
LIG_SUMO_SIM_par_1	172	178	PF11976	0.425
LIG_SUMO_SIM_par_1	428	433	PF11976	0.597
LIG_SUMO_SIM_par_1	47	52	PF11976	0.486
LIG_SUMO_SIM_par_1	489	494	PF11976	0.461
LIG_TRAF2_1	235	238	PF00917	0.465
LIG_TRAF2_1	546	549	PF00917	0.604
LIG_UBA3_1	86	94	PF00899	0.416
MOD_CDC14_SPxK_1	476	479	PF00782	0.534
MOD_CDK_SPxK_1	213	219	PF00069	0.443
MOD_CDK_SPxK_1	473	479	PF00069	0.583
MOD_CK1_1	127	133	PF00069	0.397
MOD_CK1_1	22	28	PF00069	0.405
MOD_CK1_1	418	424	PF00069	0.698
MOD_CK1_1	648	654	PF00069	0.787
MOD_CK2_1	232	238	PF00069	0.450
MOD_CK2_1	383	389	PF00069	0.588
MOD_CK2_1	483	489	PF00069	0.408
MOD_CK2_1	493	499	PF00069	0.402
MOD_Cter_Amidation	116	119	PF01082	0.517
MOD_GlcNHglycan	11	14	PF01048	0.782
MOD_GlcNHglycan	156	159	PF01048	0.426
MOD_GlcNHglycan	169	172	PF01048	0.339
MOD_GlcNHglycan	315	318	PF01048	0.581
MOD_GlcNHglycan	340	343	PF01048	0.606
MOD_GlcNHglycan	367	370	PF01048	0.555
MOD_GlcNHglycan	418	421	PF01048	0.739
MOD_GlcNHglycan	438	441	PF01048	0.443
MOD_GlcNHglycan	461	464	PF01048	0.667
MOD_GlcNHglycan	468	472	PF01048	0.468
MOD_GlcNHglycan	493	496	PF01048	0.448
MOD_GlcNHglycan	553	556	PF01048	0.692
MOD_GlcNHglycan	566	569	PF01048	0.666
MOD_GSK3_1	154	161	PF00069	0.515
MOD_GSK3_1	18	25	PF00069	0.363
MOD_GSK3_1	192	199	PF00069	0.552
MOD_GSK3_1	2	9	PF00069	0.751
MOD_GSK3_1	232	239	PF00069	0.456
MOD_GSK3_1	402	409	PF00069	0.537
MOD_GSK3_1	415	422	PF00069	0.620
MOD_GSK3_1	445	452	PF00069	0.486
MOD_GSK3_1	469	476	PF00069	0.621
MOD_GSK3_1	483	490	PF00069	0.454
MOD_GSK3_1	549	556	PF00069	0.633
MOD_GSK3_1	571	578	PF00069	0.468
MOD_GSK3_1	610	617	PF00069	0.456
MOD_GSK3_1	645	652	PF00069	0.642
MOD_N-GLC_1	219	224	PF02516	0.401
MOD_N-GLC_1	426	431	PF02516	0.652
MOD_N-GLC_1	614	619	PF02516	0.554
MOD_NEK2_1	388	393	PF00069	0.419
MOD_NEK2_1	426	431	PF00069	0.621
MOD_NEK2_1	483	488	PF00069	0.440
MOD_NEK2_1	491	496	PF00069	0.359
MOD_NEK2_1	532	537	PF00069	0.373
MOD_NEK2_1	54	59	PF00069	0.496
MOD_NEK2_1	581	586	PF00069	0.555
MOD_NEK2_2	469	474	PF00069	0.635
MOD_PIKK_1	402	408	PF00454	0.606
MOD_PIKK_1	493	499	PF00454	0.562
MOD_PIKK_1	520	526	PF00454	0.590
MOD_PIKK_1	532	538	PF00454	0.518
MOD_PIKK_1	544	550	PF00454	0.614
MOD_PK_1	328	334	PF00069	0.575
MOD_PKA_2	23	29	PF00069	0.442
MOD_PKA_2	436	442	PF00069	0.552
MOD_PKA_2	532	538	PF00069	0.574
MOD_PKA_2	610	616	PF00069	0.509
MOD_PKA_2	649	655	PF00069	0.749
MOD_PKA_2	69	75	PF00069	0.417
MOD_PKA_2	92	98	PF00069	0.496
MOD_Plk_1	219	225	PF00069	0.400
MOD_Plk_1	388	394	PF00069	0.513
MOD_Plk_1	49	55	PF00069	0.415
MOD_Plk_4	383	389	PF00069	0.545
MOD_Plk_4	426	432	PF00069	0.606
MOD_Plk_4	445	451	PF00069	0.442
MOD_Plk_4	469	475	PF00069	0.625
MOD_Plk_4	487	493	PF00069	0.400
MOD_Plk_4	81	87	PF00069	0.481
MOD_ProDKin_1	127	133	PF00069	0.375
MOD_ProDKin_1	146	152	PF00069	0.479
MOD_ProDKin_1	158	164	PF00069	0.407
MOD_ProDKin_1	213	219	PF00069	0.391
MOD_ProDKin_1	295	301	PF00069	0.480
MOD_ProDKin_1	378	384	PF00069	0.555
MOD_ProDKin_1	406	412	PF00069	0.504
MOD_ProDKin_1	473	479	PF00069	0.574
MOD_SUMO_for_1	603	606	PF00179	0.545
TRG_DiLeu_BaLyEn_6	620	625	PF01217	0.447
TRG_ENDOCYTIC_2	307	310	PF00928	0.456
TRG_ENDOCYTIC_2	596	599	PF00928	0.467
TRG_ER_diArg_1	112	114	PF00400	0.512
TRG_ER_diArg_1	118	120	PF00400	0.566
TRG_ER_diArg_1	268	270	PF00400	0.528
TRG_ER_diArg_1	327	330	PF00400	0.599
TRG_ER_diArg_1	87	89	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUJ3	Leptomonas seymouri	56%	98%
A0A0S4J9X6	Bodo saltans	33%	81%
A0A1X0NSS8	Trypanosomatidae	26%	67%
A0A1X0P940	Trypanosomatidae	43%	73%
A0A3R7NI16	Trypanosoma rangeli	27%	71%
A0A3S5H550	Leishmania donovani	91%	97%
A0A422NMS5	Trypanosoma rangeli	41%	72%
A4H3M3	Leishmania braziliensis	78%	100%
C9ZRZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
D0A265	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	71%
E9AG51	Leishmania infantum	91%	97%
Q6T444	Leishmania major	91%	100%
V5BPW5	Trypanosoma cruzi	26%	71%