Putative MP99

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative MP99

Gene product:

mitochondrial protein 99, putative

Species:

Leishmania mexicana

UniProt:

E9AJU5_LEIMU

TriTrypDb:

LmxM.03.0620

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016605	PML body	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AJU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU5

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.511
CLV_NRD_NRD_1	112	114	PF00675	0.474
CLV_NRD_NRD_1	118	120	PF00675	0.418
CLV_NRD_NRD_1	268	270	PF00675	0.510
CLV_NRD_NRD_1	532	534	PF00675	0.561
CLV_NRD_NRD_1	88	90	PF00675	0.444
CLV_NRD_NRD_1	92	94	PF00675	0.441
CLV_PCSK_KEX2_1	112	114	PF00082	0.521
CLV_PCSK_KEX2_1	118	120	PF00082	0.525
CLV_PCSK_KEX2_1	268	270	PF00082	0.455

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUJ3	Leptomonas seymouri	56%	98%
A0A0S4J9X6	Bodo saltans	33%	81%
A0A1X0NSS8	Trypanosomatidae	26%	67%
A0A1X0P940	Trypanosomatidae	43%	73%
A0A3R7NI16	Trypanosoma rangeli	27%	71%
A0A3S5H550	Leishmania donovani	91%	97%
A0A422NMS5	Trypanosoma rangeli	41%	72%
A4H3M3	Leishmania braziliensis	78%	100%
C9ZRZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
D0A265	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	71%

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