Kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase-like protein

Gene product:

kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9AJU4_LEIMU

TriTrypDb:

LmxM.03.0610

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.261
CLV_NRD_NRD_1	194	196	PF00675	0.294
CLV_NRD_NRD_1	258	260	PF00675	0.291
CLV_NRD_NRD_1	279	281	PF00675	0.463
CLV_NRD_NRD_1	5	7	PF00675	0.448
CLV_PCSK_KEX2_1	194	196	PF00082	0.384
CLV_PCSK_KEX2_1	215	217	PF00082	0.200
CLV_PCSK_KEX2_1	258	260	PF00082	0.291
CLV_PCSK_KEX2_1	279	281	PF00082	0.463
CLV_PCSK_KEX2_1	328	330	PF00082	0.519
CLV_PCSK_KEX2_1	5	7	PF00082	0.448
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.162
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.519
CLV_PCSK_SKI1_1	10	14	PF00082	0.257
CLV_PCSK_SKI1_1	154	158	PF00082	0.261
CLV_PCSK_SKI1_1	44	48	PF00082	0.346
CLV_PCSK_SKI1_1	5	9	PF00082	0.378
DEG_COP1_1	227	237	PF00400	0.326
DEG_Nend_UBRbox_1	1	4	PF02207	0.342
DOC_CYCLIN_yCln2_LP_2	163	166	PF00134	0.261
DOC_MAPK_gen_1	176	182	PF00069	0.261
DOC_MAPK_gen_1	69	79	PF00069	0.320
DOC_MAPK_MEF2A_6	154	163	PF00069	0.261
DOC_MAPK_MEF2A_6	69	76	PF00069	0.366
DOC_PP2B_LxvP_1	162	165	PF13499	0.261
DOC_PP2B_PxIxI_1	221	227	PF00149	0.297
DOC_PP4_FxxP_1	219	222	PF00568	0.320
DOC_USP7_MATH_1	110	114	PF00917	0.261
DOC_USP7_MATH_1	15	19	PF00917	0.345
DOC_USP7_MATH_1	20	24	PF00917	0.295
DOC_WW_Pin1_4	108	113	PF00397	0.261
DOC_WW_Pin1_4	296	301	PF00397	0.449
DOC_WW_Pin1_4	47	52	PF00397	0.261
LIG_14-3-3_CanoR_1	258	267	PF00244	0.366
LIG_14-3-3_CanoR_1	279	285	PF00244	0.280
LIG_APCC_ABBAyCdc20_2	208	214	PF00400	0.320
LIG_deltaCOP1_diTrp_1	236	245	PF00928	0.263
LIG_eIF4E_1	269	275	PF01652	0.261
LIG_FHA_1	141	147	PF00498	0.283
LIG_FHA_2	11	17	PF00498	0.261
LIG_FHA_2	187	193	PF00498	0.261
LIG_FHA_2	245	251	PF00498	0.403
LIG_FHA_2	297	303	PF00498	0.403
LIG_FHA_2	309	315	PF00498	0.453
LIG_FHA_2	93	99	PF00498	0.261
LIG_LIR_Apic_2	106	110	PF02991	0.329
LIG_LIR_Gen_1	122	133	PF02991	0.406
LIG_LIR_Gen_1	236	244	PF02991	0.320
LIG_LIR_Nem_3	122	128	PF02991	0.406
LIG_LIR_Nem_3	263	269	PF02991	0.357
LIG_NRBOX	25	31	PF00104	0.326
LIG_PCNA_PIPBox_1	97	106	PF02747	0.282
LIG_Pex14_2	136	140	PF04695	0.320
LIG_Pex14_2	266	270	PF04695	0.261
LIG_SH2_PTP2	107	110	PF00017	0.320
LIG_SH2_STAP1	206	210	PF00017	0.368
LIG_SH2_STAT5	107	110	PF00017	0.320
LIG_SH2_STAT5	212	215	PF00017	0.314
LIG_SH2_STAT5	269	272	PF00017	0.303
LIG_SH2_STAT5	65	68	PF00017	0.297
LIG_SH3_4	196	203	PF00018	0.282
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.445
LIG_SUMO_SIM_par_1	126	132	PF11976	0.368
LIG_SUMO_SIM_par_1	178	184	PF11976	0.261
LIG_SUMO_SIM_par_1	222	227	PF11976	0.261
LIG_SUMO_SIM_par_1	75	80	PF11976	0.261
LIG_TRAF2_1	227	230	PF00917	0.326
MOD_CDK_SPK_2	296	301	PF00069	0.449
MOD_CK1_1	50	56	PF00069	0.282
MOD_CK1_1	83	89	PF00069	0.261
MOD_CK2_1	10	16	PF00069	0.261
MOD_CK2_1	165	171	PF00069	0.261
MOD_CK2_1	224	230	PF00069	0.413
MOD_CK2_1	244	250	PF00069	0.140
MOD_CK2_1	296	302	PF00069	0.417
MOD_CK2_1	308	314	PF00069	0.453
MOD_CK2_1	92	98	PF00069	0.261
MOD_Cter_Amidation	192	195	PF01082	0.282
MOD_GlcNHglycan	112	115	PF01048	0.320
MOD_GlcNHglycan	167	170	PF01048	0.261
MOD_GlcNHglycan	203	206	PF01048	0.326
MOD_GlcNHglycan	226	229	PF01048	0.320
MOD_GlcNHglycan	250	253	PF01048	0.271
MOD_GlcNHglycan	47	50	PF01048	0.261
MOD_GlcNHglycan	52	55	PF01048	0.261
MOD_GSK3_1	10	17	PF00069	0.261
MOD_GSK3_1	20	27	PF00069	0.261
MOD_GSK3_1	244	251	PF00069	0.330
MOD_GSK3_1	50	57	PF00069	0.301
MOD_GSK3_1	79	86	PF00069	0.261
MOD_GSK3_1	99	106	PF00069	0.140
MOD_NEK2_1	14	19	PF00069	0.320
MOD_NEK2_1	140	145	PF00069	0.285
MOD_NEK2_1	244	249	PF00069	0.367
MOD_NEK2_1	45	50	PF00069	0.320
MOD_NEK2_1	58	63	PF00069	0.320
MOD_PIKK_1	148	154	PF00454	0.320
MOD_Plk_1	21	27	PF00069	0.246
MOD_Plk_1	92	98	PF00069	0.281
MOD_Plk_4	103	109	PF00069	0.261
MOD_Plk_4	25	31	PF00069	0.162
MOD_Plk_4	54	60	PF00069	0.355
MOD_Plk_4	86	92	PF00069	0.261
MOD_ProDKin_1	108	114	PF00069	0.261
MOD_ProDKin_1	296	302	PF00069	0.447
MOD_ProDKin_1	47	53	PF00069	0.261
TRG_ENDOCYTIC_2	267	270	PF00928	0.366
TRG_ER_diArg_1	257	259	PF00400	0.291
TRG_ER_diArg_1	279	281	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P9	Leptomonas seymouri	80%	94%
A0A0S4JDW1	Bodo saltans	53%	81%
A0A451EJR1	Leishmania donovani	94%	95%
A4H3M2	Leishmania braziliensis	87%	100%
A8XGZ9	Caenorhabditis briggsae	40%	80%
E9ACK6	Leishmania major	92%	100%
E9AG50	Leishmania infantum	94%	95%
O28980	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	32%	95%
O58012	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	100%
P27254	Escherichia coli (strain K12)	40%	100%
P37895	Caulobacter vibrioides (strain ATCC 19089 / CB15)	44%	100%
P63578	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	98%
P9WPZ0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	98%
P9WPZ1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	98%
Q22111	Caenorhabditis elegans	39%	83%
Q8C7H1	Mus musculus	39%	80%
Q8IVH4	Homo sapiens	39%	79%
Q9V225	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%