Putative arginine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AJU3_LEIMU

TriTrypDb:

LmxM.03.0600

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	120	124	PF00082	0.417
CLV_PCSK_SKI1_1	158	162	PF00082	0.489
CLV_PCSK_SKI1_1	19	23	PF00082	0.606
CLV_PCSK_SKI1_1	300	304	PF00082	0.512
CLV_PCSK_SKI1_1	33	37	PF00082	0.438
CLV_PCSK_SKI1_1	74	78	PF00082	0.351
CLV_Separin_Metazoa	215	219	PF03568	0.530
DEG_APCC_DBOX_1	180	188	PF00400	0.408
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DOC_CDC14_PxL_1	231	239	PF14671	0.445
DOC_CKS1_1	362	367	PF01111	0.552
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.409
DOC_MAPK_gen_1	368	377	PF00069	0.460
DOC_MAPK_gen_1	60	68	PF00069	0.446
DOC_MAPK_gen_1	69	79	PF00069	0.298
DOC_MAPK_HePTP_8	89	101	PF00069	0.398
DOC_MAPK_MEF2A_6	92	101	PF00069	0.365
DOC_PP1_RVXF_1	118	125	PF00149	0.447
DOC_USP7_MATH_1	264	268	PF00917	0.495
DOC_USP7_MATH_1	314	318	PF00917	0.513
DOC_WW_Pin1_4	361	366	PF00397	0.540
LIG_14-3-3_CanoR_1	158	165	PF00244	0.480
LIG_14-3-3_CanoR_1	181	185	PF00244	0.425
LIG_14-3-3_CanoR_1	300	305	PF00244	0.504
LIG_14-3-3_CanoR_1	47	55	PF00244	0.492
LIG_14-3-3_CanoR_1	72	77	PF00244	0.480
LIG_deltaCOP1_diTrp_1	199	208	PF00928	0.382
LIG_eIF4E_1	165	171	PF01652	0.406
LIG_FHA_1	159	165	PF00498	0.422
LIG_FHA_1	21	27	PF00498	0.677
LIG_FHA_1	293	299	PF00498	0.464
LIG_FHA_1	306	312	PF00498	0.285
LIG_FHA_1	357	363	PF00498	0.507
LIG_FHA_2	248	254	PF00498	0.562
LIG_FHA_2	27	33	PF00498	0.500
LIG_FHA_2	362	368	PF00498	0.488
LIG_FHA_2	371	377	PF00498	0.380
LIG_FHA_2	52	58	PF00498	0.363
LIG_LIR_Apic_2	148	152	PF02991	0.398
LIG_LIR_Gen_1	199	210	PF02991	0.419
LIG_LIR_Gen_1	303	314	PF02991	0.335
LIG_LIR_Gen_1	334	344	PF02991	0.530
LIG_LIR_Nem_3	199	205	PF02991	0.399
LIG_LIR_Nem_3	303	309	PF02991	0.331
LIG_LIR_Nem_3	334	340	PF02991	0.568
LIG_LIR_Nem_3	393	399	PF02991	0.422
LIG_LIR_Nem_3	65	71	PF02991	0.508
LIG_Pex14_1	202	206	PF04695	0.378
LIG_PTB_Apo_2	118	125	PF02174	0.305
LIG_SH2_CRK	86	90	PF00017	0.447
LIG_SH2_NCK_1	290	294	PF00017	0.461
LIG_SH2_NCK_1	64	68	PF00017	0.499
LIG_SH2_SRC	310	313	PF00017	0.436
LIG_SH2_STAP1	192	196	PF00017	0.372
LIG_SH2_STAP1	257	261	PF00017	0.513
LIG_SH2_STAP1	290	294	PF00017	0.477
LIG_SH2_STAP1	64	68	PF00017	0.460
LIG_SH2_STAP1	86	90	PF00017	0.447
LIG_SH2_STAT3	206	209	PF00017	0.556
LIG_SH2_STAT3	257	260	PF00017	0.515
LIG_SH2_STAT3	394	397	PF00017	0.379
LIG_SH2_STAT5	144	147	PF00017	0.447
LIG_SH2_STAT5	306	309	PF00017	0.392
LIG_SH2_STAT5	310	313	PF00017	0.379
LIG_SH2_STAT5	86	89	PF00017	0.430
LIG_SH3_3	229	235	PF00018	0.505
LIG_SUMO_SIM_par_1	151	157	PF11976	0.447
LIG_SUMO_SIM_par_1	185	191	PF11976	0.410
LIG_SUMO_SIM_par_1	294	299	PF11976	0.397
LIG_SUMO_SIM_par_1	373	378	PF11976	0.469
LIG_TRAF2_1	250	253	PF00917	0.581
LIG_WRC_WIRS_1	306	311	PF05994	0.347
MOD_CDK_SPxxK_3	361	368	PF00069	0.559
MOD_CK2_1	247	253	PF00069	0.567
MOD_CK2_1	26	32	PF00069	0.504
MOD_CK2_1	370	376	PF00069	0.445
MOD_GlcNHglycan	102	106	PF01048	0.335
MOD_GlcNHglycan	13	16	PF01048	0.614
MOD_GlcNHglycan	173	176	PF01048	0.473
MOD_GlcNHglycan	232	235	PF01048	0.514
MOD_GlcNHglycan	389	393	PF01048	0.426
MOD_GSK3_1	22	29	PF00069	0.547
MOD_GSK3_1	226	233	PF00069	0.452
MOD_GSK3_1	247	254	PF00069	0.513
MOD_GSK3_1	292	299	PF00069	0.383
MOD_GSK3_1	46	53	PF00069	0.475
MOD_N-GLC_1	300	305	PF02516	0.432
MOD_N-GLC_1	33	38	PF02516	0.551
MOD_N-GLC_1	335	340	PF02516	0.541
MOD_N-GLC_1	50	55	PF02516	0.481
MOD_N-GLC_2	16	18	PF02516	0.532
MOD_NEK2_1	171	176	PF00069	0.503
MOD_NEK2_1	22	27	PF00069	0.657
MOD_NEK2_1	237	242	PF00069	0.381
MOD_NEK2_1	294	299	PF00069	0.509
MOD_PIKK_1	4	10	PF00454	0.645
MOD_PKA_2	180	186	PF00069	0.423
MOD_PKA_2	46	52	PF00069	0.450
MOD_Plk_1	101	107	PF00069	0.305
MOD_Plk_1	300	306	PF00069	0.369
MOD_Plk_1	338	344	PF00069	0.390
MOD_Plk_1	50	56	PF00069	0.549
MOD_Plk_2-3	253	259	PF00069	0.517
MOD_Plk_4	22	28	PF00069	0.538
MOD_Plk_4	305	311	PF00069	0.331
MOD_Plk_4	36	42	PF00069	0.479
MOD_Plk_4	390	396	PF00069	0.484
MOD_Plk_4	72	78	PF00069	0.380
MOD_Plk_4	84	90	PF00069	0.287
MOD_ProDKin_1	361	367	PF00069	0.552
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.362
TRG_ENDOCYTIC_2	306	309	PF00928	0.362
TRG_ENDOCYTIC_2	64	67	PF00928	0.375
TRG_ENDOCYTIC_2	86	89	PF00928	0.447
TRG_ER_diArg_1	125	128	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	82%	100%
A0A0N0P7Z0	Leptomonas seymouri	22%	100%
A0A0S4JDH7	Bodo saltans	42%	100%
A0A0S4JWH9	Bodo saltans	26%	100%
A0A1X0NMC6	Trypanosomatidae	28%	100%
A0A1X0PA69	Trypanosomatidae	52%	96%
A0A3R7NHM3	Trypanosoma rangeli	51%	100%
A0A3S5H6M7	Leishmania donovani	25%	100%
A0A451EJR0	Leishmania donovani	96%	99%
A2Y953	Oryza sativa subsp. indica	26%	100%
A2YPT7	Oryza sativa subsp. indica	25%	76%
A2Z0C0	Oryza sativa subsp. indica	26%	100%
A2Z8S0	Oryza sativa subsp. indica	27%	100%
A3KPF2	Arabidopsis thaliana	24%	76%
A4H8A2	Leishmania braziliensis	91%	100%
A4H8D0	Leishmania braziliensis	22%	100%
A8IEF3	Chlamydomonas reinhardtii	25%	100%
B0JYW5	Xenopus tropicalis	24%	100%
B0W3L6	Culex quinquefasciatus	25%	67%
B3DLB3	Xenopus tropicalis	26%	92%
B3M1E1	Drosophila ananassae	23%	75%
B3P4N5	Drosophila erecta	23%	75%
B4GZ20	Drosophila persimilis	23%	75%
B4HJC0	Drosophila sechellia	23%	75%
B4JXV2	Drosophila grimshawi	23%	73%
B4NKI9	Drosophila willistoni	23%	75%
B4PVH6	Drosophila yakuba	24%	75%
B4QVW6	Drosophila simulans	23%	75%
C9ZI39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A264	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D9IVE5	Xenopus laevis	24%	92%
E9ACK5	Leishmania major	94%	100%
E9AG49	Leishmania infantum	96%	99%
E9AGI9	Leishmania infantum	24%	100%
E9AIN9	Leishmania braziliensis	24%	100%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O13648	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	73%
O60678	Homo sapiens	29%	75%
O70467	Rattus norvegicus	27%	76%
O82210	Arabidopsis thaliana	25%	100%
P55345	Homo sapiens	25%	92%
Q0J2C6	Oryza sativa subsp. japonica	26%	100%
Q0WVD6	Arabidopsis thaliana	24%	66%
Q174R2	Aedes aegypti	25%	67%
Q28F07	Xenopus tropicalis	26%	100%
Q29B63	Drosophila pseudoobscura pseudoobscura	23%	75%
Q4QF17	Leishmania major	22%	100%
Q4QGG2	Leishmania major	25%	100%
Q54EF2	Dictyostelium discoideum	26%	100%
Q5E9L5	Bos taurus	26%	100%
Q5RGQ2	Danio rerio	26%	95%
Q5XK84	Xenopus laevis	23%	66%
Q63009	Rattus norvegicus	25%	100%
Q6DC04	Danio rerio	25%	68%
Q6NZB1	Mus musculus	27%	100%
Q6PAK3	Mus musculus	27%	100%
Q6VRB0	Xenopus laevis	26%	100%
Q75G68	Oryza sativa subsp. japonica	27%	100%
Q7XI75	Oryza sativa subsp. japonica	25%	76%
Q7XKC0	Oryza sativa subsp. japonica	22%	100%
Q84W92	Arabidopsis thaliana	24%	75%
Q8AV13	Xenopus laevis	26%	100%
Q922H1	Mus musculus	27%	76%
Q96LA8	Homo sapiens	27%	100%
Q99873	Homo sapiens	26%	100%
Q9JIF0	Mus musculus	25%	100%
Q9NR22	Homo sapiens	27%	100%
Q9R144	Mus musculus	26%	89%
Q9SNQ2	Oryza sativa subsp. japonica	26%	100%
Q9SU94	Arabidopsis thaliana	25%	100%
Q9U2X0	Caenorhabditis elegans	25%	100%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9VH48	Drosophila melanogaster	23%	75%
V5BXE6	Trypanosoma cruzi	50%	100%