LeishMANIAdb
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DUF1989 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1989 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AJU1_LEIMU
TriTrypDb:
LmxM.03.0580
Length:
178

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AJU1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJU1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 168 170 PF00675 0.701
CLV_NRD_NRD_1 172 174 PF00675 0.697
CLV_PCSK_FUR_1 146 150 PF00082 0.575
CLV_PCSK_KEX2_1 148 150 PF00082 0.501
CLV_PCSK_PC1ET2_1 148 150 PF00082 0.499
CLV_PCSK_SKI1_1 124 128 PF00082 0.517
CLV_PCSK_SKI1_1 2 6 PF00082 0.379
CLV_PCSK_SKI1_1 92 96 PF00082 0.554
DEG_Nend_UBRbox_1 1 4 PF02207 0.414
DOC_PP1_RVXF_1 22 28 PF00149 0.535
DOC_PP2B_LxvP_1 73 76 PF13499 0.459
DOC_USP7_MATH_1 126 130 PF00917 0.625
DOC_USP7_MATH_1 37 41 PF00917 0.487
DOC_USP7_MATH_1 83 87 PF00917 0.615
DOC_USP7_UBL2_3 124 128 PF12436 0.539
DOC_USP7_UBL2_3 170 174 PF12436 0.638
DOC_WW_Pin1_4 44 49 PF00397 0.568
LIG_14-3-3_CanoR_1 116 120 PF00244 0.601
LIG_14-3-3_CanoR_1 92 99 PF00244 0.608
LIG_BRCT_BRCA1_1 85 89 PF00533 0.606
LIG_CSL_BTD_1 25 28 PF09270 0.452
LIG_FHA_1 67 73 PF00498 0.556
LIG_FHA_2 12 18 PF00498 0.561
LIG_FHA_2 93 99 PF00498 0.531
LIG_LIR_Nem_3 52 58 PF02991 0.436
LIG_SH3_3 162 168 PF00018 0.607
LIG_SUMO_SIM_par_1 69 78 PF11976 0.445
LIG_WW_3 89 93 PF00397 0.428
MOD_CK1_1 129 135 PF00069 0.652
MOD_CK1_1 47 53 PF00069 0.587
MOD_CK1_1 85 91 PF00069 0.602
MOD_CK2_1 161 167 PF00069 0.754
MOD_GlcNHglycan 128 131 PF01048 0.642
MOD_GlcNHglycan 51 54 PF01048 0.576
MOD_GlcNHglycan 85 88 PF01048 0.605
MOD_GSK3_1 115 122 PF00069 0.552
MOD_N-GLC_1 160 165 PF02516 0.471
MOD_PKA_2 115 121 PF00069 0.545
MOD_PKA_2 29 35 PF00069 0.668
MOD_Plk_1 160 166 PF00069 0.589
MOD_ProDKin_1 44 50 PF00069 0.572
MOD_SUMO_for_1 147 150 PF00179 0.544
MOD_SUMO_rev_2 167 176 PF00179 0.662
TRG_ENDOCYTIC_2 55 58 PF00928 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ04 Leptomonas seymouri 67% 98%
A0A0S4INX7 Bodo saltans 41% 90%
A0A1X0P8U1 Trypanosomatidae 38% 91%
A0A3S5H549 Leishmania donovani 94% 100%
A0A422NMF6 Trypanosoma rangeli 40% 95%
A4H3M0 Leishmania braziliensis 87% 100%
D0A262 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 79%
E9ACK3 Leishmania major 93% 100%
E9AG47 Leishmania infantum 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS