RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJT5_LEIMU

TriTrypDb:

LmxM.03.0520

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0089701	U2AF complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AJT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJT5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003727	single-stranded RNA binding	5	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0030628	pre-mRNA 3'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.486
CLV_C14_Caspase3-7	470	474	PF00656	0.509
CLV_C14_Caspase3-7	8	12	PF00656	0.748
CLV_MEL_PAP_1	330	336	PF00089	0.442
CLV_NRD_NRD_1	203	205	PF00675	0.535
CLV_NRD_NRD_1	285	287	PF00675	0.453
CLV_NRD_NRD_1	291	293	PF00675	0.393
CLV_NRD_NRD_1	319	321	PF00675	0.384
CLV_NRD_NRD_1	40	42	PF00675	0.625
CLV_NRD_NRD_1	414	416	PF00675	0.412
CLV_NRD_NRD_1	662	664	PF00675	0.491
CLV_NRD_NRD_1	73	75	PF00675	0.842
CLV_PCSK_FUR_1	38	42	PF00082	0.716
CLV_PCSK_FUR_1	654	658	PF00082	0.434
CLV_PCSK_KEX2_1	285	287	PF00082	0.453
CLV_PCSK_KEX2_1	291	293	PF00082	0.393
CLV_PCSK_KEX2_1	319	321	PF00082	0.384
CLV_PCSK_KEX2_1	40	42	PF00082	0.610
CLV_PCSK_KEX2_1	414	416	PF00082	0.412
CLV_PCSK_KEX2_1	656	658	PF00082	0.456
CLV_PCSK_KEX2_1	662	664	PF00082	0.471
CLV_PCSK_KEX2_1	73	75	PF00082	0.735
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.432
CLV_PCSK_PC7_1	36	42	PF00082	0.651
CLV_PCSK_SKI1_1	361	365	PF00082	0.278
CLV_PCSK_SKI1_1	397	401	PF00082	0.476
CLV_PCSK_SKI1_1	429	433	PF00082	0.375
CLV_PCSK_SKI1_1	445	449	PF00082	0.212
CLV_PCSK_SKI1_1	453	457	PF00082	0.279
CLV_PCSK_SKI1_1	472	476	PF00082	0.180
CLV_PCSK_SKI1_1	501	505	PF00082	0.396
CLV_PCSK_SKI1_1	581	585	PF00082	0.509
DEG_SPOP_SBC_1	253	257	PF00917	0.675
DEG_SPOP_SBC_1	815	819	PF00917	0.720
DOC_CKS1_1	616	621	PF01111	0.472
DOC_CYCLIN_RxL_1	394	403	PF00134	0.490
DOC_CYCLIN_RxL_1	450	458	PF00134	0.509
DOC_CYCLIN_RxL_1	578	587	PF00134	0.570
DOC_MAPK_FxFP_2	754	757	PF00069	0.515
DOC_MAPK_gen_1	369	378	PF00069	0.376
DOC_MAPK_gen_1	651	660	PF00069	0.401
DOC_MAPK_MEF2A_6	231	238	PF00069	0.650
DOC_MAPK_MEF2A_6	371	380	PF00069	0.381
DOC_MAPK_MEF2A_6	506	513	PF00069	0.473
DOC_MAPK_NFAT4_5	231	239	PF00069	0.655
DOC_PP1_RVXF_1	451	458	PF00149	0.509
DOC_PP2B_LxvP_1	274	277	PF13499	0.580
DOC_PP2B_LxvP_1	313	316	PF13499	0.454
DOC_PP2B_LxvP_1	658	661	PF13499	0.382
DOC_PP4_FxxP_1	133	136	PF00568	0.811
DOC_PP4_FxxP_1	52	55	PF00568	0.706
DOC_PP4_FxxP_1	588	591	PF00568	0.555
DOC_PP4_FxxP_1	754	757	PF00568	0.515
DOC_USP7_MATH_1	136	140	PF00917	0.710
DOC_USP7_MATH_1	165	169	PF00917	0.679
DOC_USP7_MATH_1	252	256	PF00917	0.728
DOC_USP7_MATH_1	293	297	PF00917	0.481
DOC_USP7_MATH_1	440	444	PF00917	0.543
DOC_USP7_MATH_1	533	537	PF00917	0.733
DOC_USP7_MATH_1	557	561	PF00917	0.724
DOC_USP7_MATH_1	697	701	PF00917	0.357
DOC_USP7_MATH_1	816	820	PF00917	0.726
DOC_USP7_MATH_1	825	829	PF00917	0.769
DOC_USP7_MATH_1	98	102	PF00917	0.623
DOC_USP7_UBL2_3	522	526	PF12436	0.539
DOC_WW_Pin1_4	152	157	PF00397	0.738
DOC_WW_Pin1_4	185	190	PF00397	0.717
DOC_WW_Pin1_4	615	620	PF00397	0.494
DOC_WW_Pin1_4	836	841	PF00397	0.743
LIG_14-3-3_CanoR_1	319	327	PF00244	0.483
LIG_14-3-3_CanoR_1	369	374	PF00244	0.478
LIG_14-3-3_CanoR_1	711	715	PF00244	0.536
LIG_14-3-3_CanoR_1	748	757	PF00244	0.410
LIG_AP2alpha_2	50	52	PF02296	0.687
LIG_APCC_ABBA_1	624	629	PF00400	0.426
LIG_BIR_III_2	418	422	PF00653	0.518
LIG_BIR_III_4	775	779	PF00653	0.566
LIG_BRCT_BRCA1_1	371	375	PF00533	0.375
LIG_BRCT_BRCA1_1	752	756	PF00533	0.444
LIG_Clathr_ClatBox_1	271	275	PF01394	0.661
LIG_Clathr_ClatBox_1	454	458	PF01394	0.479
LIG_eIF4E_1	616	622	PF01652	0.385
LIG_FHA_1	214	220	PF00498	0.706
LIG_FHA_1	349	355	PF00498	0.514
LIG_FHA_1	406	412	PF00498	0.565
LIG_FHA_1	533	539	PF00498	0.661
LIG_FHA_1	585	591	PF00498	0.455
LIG_FHA_1	616	622	PF00498	0.383
LIG_FHA_1	711	717	PF00498	0.501
LIG_FHA_1	750	756	PF00498	0.440
LIG_FHA_1	837	843	PF00498	0.802
LIG_FHA_2	300	306	PF00498	0.456
LIG_FHA_2	421	427	PF00498	0.507
LIG_FHA_2	510	516	PF00498	0.475
LIG_FHA_2	587	593	PF00498	0.552
LIG_Integrin_RGD_1	201	203	PF01839	0.667
LIG_LIR_Apic_2	50	55	PF02991	0.695
LIG_LIR_Apic_2	585	591	PF02991	0.563
LIG_LIR_Apic_2	614	619	PF02991	0.499
LIG_LIR_Apic_2	752	757	PF02991	0.507
LIG_LIR_Apic_2	84	90	PF02991	0.630
LIG_LIR_Gen_1	308	318	PF02991	0.422
LIG_LIR_Gen_1	372	383	PF02991	0.355
LIG_LIR_Gen_1	467	474	PF02991	0.479
LIG_LIR_Gen_1	635	645	PF02991	0.414
LIG_LIR_Gen_1	726	734	PF02991	0.403
LIG_LIR_Nem_3	223	228	PF02991	0.646
LIG_LIR_Nem_3	308	314	PF02991	0.391
LIG_LIR_Nem_3	372	378	PF02991	0.360
LIG_LIR_Nem_3	449	454	PF02991	0.476
LIG_LIR_Nem_3	467	471	PF02991	0.394
LIG_LIR_Nem_3	635	641	PF02991	0.425
LIG_LIR_Nem_3	650	655	PF02991	0.405
LIG_LIR_Nem_3	726	730	PF02991	0.399
LIG_LIR_Nem_3	753	759	PF02991	0.437
LIG_LYPXL_S_1	600	604	PF13949	0.529
LIG_LYPXL_yS_3	409	412	PF13949	0.470
LIG_LYPXL_yS_3	601	604	PF13949	0.547
LIG_MAD2	429	437	PF02301	0.443
LIG_MYND_1	190	194	PF01753	0.515
LIG_MYND_1	602	606	PF01753	0.470
LIG_NRBOX	172	178	PF00104	0.598
LIG_NRBOX	499	505	PF00104	0.421
LIG_PCNA_TLS_4	304	311	PF02747	0.478
LIG_Pex14_2	133	137	PF04695	0.691
LIG_Rb_pABgroove_1	621	629	PF01858	0.408
LIG_SH2_CRK	451	455	PF00017	0.509
LIG_SH2_CRK	616	620	PF00017	0.414
LIG_SH2_CRK	638	642	PF00017	0.433
LIG_SH2_CRK	652	656	PF00017	0.365
LIG_SH2_CRK	720	724	PF00017	0.498
LIG_SH2_GRB2like	608	611	PF00017	0.579
LIG_SH2_GRB2like	708	711	PF00017	0.532
LIG_SH2_NCK_1	679	683	PF00017	0.451
LIG_SH2_NCK_1	727	731	PF00017	0.416
LIG_SH2_SRC	463	466	PF00017	0.521
LIG_SH2_SRC	608	611	PF00017	0.561
LIG_SH2_SRC	679	682	PF00017	0.459
LIG_SH2_STAP1	634	638	PF00017	0.452
LIG_SH2_STAT3	99	102	PF00017	0.633
LIG_SH2_STAT5	310	313	PF00017	0.394
LIG_SH2_STAT5	523	526	PF00017	0.572
LIG_SH3_2	190	195	PF14604	0.520
LIG_SH3_3	187	193	PF00018	0.705
LIG_SH3_3	224	230	PF00018	0.594
LIG_SH3_3	430	436	PF00018	0.433
LIG_SH3_3	664	670	PF00018	0.527
LIG_SH3_5	675	679	PF00018	0.597
LIG_SUMO_SIM_anti_2	426	434	PF11976	0.423
LIG_SUMO_SIM_anti_2	618	624	PF11976	0.349
LIG_SUMO_SIM_par_1	270	275	PF11976	0.686
LIG_SUMO_SIM_par_1	562	571	PF11976	0.679
LIG_TRAF2_1	221	224	PF00917	0.615
LIG_TRAF2_1	303	306	PF00917	0.503
LIG_TRAF2_1	789	792	PF00917	0.739
LIG_TYR_ITIM	725	730	PF00017	0.392
LIG_UBA3_1	755	761	PF00899	0.470
LIG_WRC_WIRS_1	751	756	PF05994	0.413
LIG_WW_2	190	193	PF00397	0.522
LIG_WW_3	192	196	PF00397	0.702
LIG_WW_3	54	58	PF00397	0.689
MOD_CK1_1	21	27	PF00069	0.698
MOD_CK1_1	255	261	PF00069	0.756
MOD_CK1_1	560	566	PF00069	0.610
MOD_CK1_1	611	617	PF00069	0.552
MOD_CK1_1	636	642	PF00069	0.494
MOD_CK1_1	841	847	PF00069	0.657
MOD_CK2_1	218	224	PF00069	0.658
MOD_CK2_1	299	305	PF00069	0.459
MOD_CK2_1	371	377	PF00069	0.338
MOD_CK2_1	435	441	PF00069	0.544
MOD_GlcNHglycan	138	141	PF01048	0.773
MOD_GlcNHglycan	150	153	PF01048	0.586
MOD_GlcNHglycan	161	164	PF01048	0.646
MOD_GlcNHglycan	210	213	PF01048	0.668
MOD_GlcNHglycan	267	270	PF01048	0.626
MOD_GlcNHglycan	27	30	PF01048	0.632
MOD_GlcNHglycan	295	298	PF01048	0.515
MOD_GlcNHglycan	365	368	PF01048	0.475
MOD_GlcNHglycan	390	393	PF01048	0.465
MOD_GlcNHglycan	519	522	PF01048	0.454
MOD_GlcNHglycan	559	562	PF01048	0.768
MOD_GlcNHglycan	64	67	PF01048	0.734
MOD_GlcNHglycan	826	830	PF01048	0.751
MOD_GSK3_1	148	155	PF00069	0.575
MOD_GSK3_1	204	211	PF00069	0.678
MOD_GSK3_1	21	28	PF00069	0.585
MOD_GSK3_1	359	366	PF00069	0.529
MOD_GSK3_1	5	12	PF00069	0.809
MOD_GSK3_1	611	618	PF00069	0.539
MOD_GSK3_1	746	753	PF00069	0.462
MOD_N-GLC_1	400	405	PF02516	0.479
MOD_N-GLC_1	636	641	PF02516	0.497
MOD_NEK2_1	148	153	PF00069	0.520
MOD_NEK2_1	363	368	PF00069	0.456
MOD_NEK2_1	399	404	PF00069	0.472
MOD_NEK2_1	584	589	PF00069	0.534
MOD_NEK2_2	440	445	PF00069	0.531
MOD_PIKK_1	255	261	PF00454	0.669
MOD_PIKK_1	386	392	PF00454	0.451
MOD_PIKK_1	5	11	PF00454	0.562
MOD_PIKK_1	608	614	PF00454	0.586
MOD_PIKK_1	636	642	PF00454	0.494
MOD_PIKK_1	816	822	PF00454	0.693
MOD_PIKK_1	98	104	PF00454	0.626
MOD_PK_1	838	844	PF00069	0.572
MOD_PKA_1	204	210	PF00069	0.528
MOD_PKA_2	3	9	PF00069	0.744
MOD_PKA_2	710	716	PF00069	0.532
MOD_Plk_1	400	406	PF00069	0.480
MOD_Plk_1	440	446	PF00069	0.509
MOD_Plk_1	509	515	PF00069	0.502
MOD_Plk_1	533	539	PF00069	0.658
MOD_Plk_1	584	590	PF00069	0.519
MOD_Plk_1	636	642	PF00069	0.462
MOD_Plk_1	746	752	PF00069	0.498
MOD_Plk_4	229	235	PF00069	0.555
MOD_Plk_4	533	539	PF00069	0.458
MOD_Plk_4	611	617	PF00069	0.530
MOD_Plk_4	750	756	PF00069	0.406
MOD_ProDKin_1	152	158	PF00069	0.740
MOD_ProDKin_1	185	191	PF00069	0.717
MOD_ProDKin_1	615	621	PF00069	0.484
MOD_ProDKin_1	836	842	PF00069	0.742
MOD_SUMO_for_1	455	458	PF00179	0.509
MOD_SUMO_rev_2	199	207	PF00179	0.533
MOD_SUMO_rev_2	358	363	PF00179	0.480
MOD_SUMO_rev_2	426	431	PF00179	0.466
MOD_SUMO_rev_2	695	700	PF00179	0.334
MOD_SUMO_rev_2	775	784	PF00179	0.706
TRG_DiLeu_BaEn_1	332	337	PF01217	0.520
TRG_ENDOCYTIC_2	112	115	PF00928	0.709
TRG_ENDOCYTIC_2	310	313	PF00928	0.429
TRG_ENDOCYTIC_2	409	412	PF00928	0.537
TRG_ENDOCYTIC_2	451	454	PF00928	0.527
TRG_ENDOCYTIC_2	465	468	PF00928	0.399
TRG_ENDOCYTIC_2	497	500	PF00928	0.332
TRG_ENDOCYTIC_2	601	604	PF00928	0.547
TRG_ENDOCYTIC_2	638	641	PF00928	0.414
TRG_ENDOCYTIC_2	652	655	PF00928	0.399
TRG_ENDOCYTIC_2	720	723	PF00928	0.437
TRG_ENDOCYTIC_2	727	730	PF00928	0.381
TRG_ER_diArg_1	285	288	PF00400	0.483
TRG_ER_diArg_1	318	320	PF00400	0.367
TRG_ER_diArg_1	36	39	PF00400	0.714
TRG_ER_diArg_1	413	415	PF00400	0.397
TRG_ER_diArg_1	661	663	PF00400	0.437
TRG_ER_diArg_1	73	76	PF00400	0.686
TRG_NES_CRM1_1	326	340	PF08389	0.450
TRG_NES_CRM1_1	578	592	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWG2	Leptomonas seymouri	57%	100%
A0A0S4IUY1	Bodo saltans	32%	100%
A0A3R7MIS4	Trypanosoma rangeli	39%	96%
A0A3S5H546	Leishmania donovani	89%	100%
A4H3L4	Leishmania braziliensis	81%	98%
E9ACJ7	Leishmania major	89%	99%
E9AG41	Leishmania infantum	88%	99%