Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-Repressible Phosphate Permease-like protein

Species:

Leishmania mexicana

UniProt:

E9AJT3_LEIMU

TriTrypDb:

LmxM.03.0500

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

E9AJT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJT3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.532
CLV_NRD_NRD_1	205	207	PF00675	0.214
CLV_NRD_NRD_1	247	249	PF00675	0.235
CLV_NRD_NRD_1	260	262	PF00675	0.194
CLV_NRD_NRD_1	263	265	PF00675	0.186
CLV_NRD_NRD_1	489	491	PF00675	0.220
CLV_NRD_NRD_1	96	98	PF00675	0.493
CLV_PCSK_KEX2_1	204	206	PF00082	0.256
CLV_PCSK_KEX2_1	247	249	PF00082	0.205
CLV_PCSK_KEX2_1	260	262	PF00082	0.194
CLV_PCSK_KEX2_1	489	491	PF00082	0.283
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.322
CLV_PCSK_SKI1_1	133	137	PF00082	0.303
CLV_PCSK_SKI1_1	287	291	PF00082	0.334
CLV_PCSK_SKI1_1	492	496	PF00082	0.222
DEG_Nend_Nbox_1	1	3	PF02207	0.354
DEG_ODPH_VHL_1	145	157	PF01847	0.408
DEG_SPOP_SBC_1	467	471	PF00917	0.271
DOC_CKS1_1	148	153	PF01111	0.157
DOC_CKS1_1	441	446	PF01111	0.555
DOC_CYCLIN_RxL_1	130	140	PF00134	0.233
DOC_CYCLIN_RxL_1	287	296	PF00134	0.397
DOC_MAPK_DCC_7	144	154	PF00069	0.408
DOC_MAPK_gen_1	204	212	PF00069	0.505
DOC_MAPK_gen_1	489	497	PF00069	0.428
DOC_MAPK_MEF2A_6	490	499	PF00069	0.555
DOC_MAPK_NFAT4_5	492	500	PF00069	0.550
DOC_MAPK_RevD_3	190	206	PF00069	0.303
DOC_MAPK_RevD_3	477	490	PF00069	0.337
DOC_PP1_RVXF_1	171	177	PF00149	0.280
DOC_PP1_RVXF_1	487	494	PF00149	0.261
DOC_PP4_FxxP_1	115	118	PF00568	0.305
DOC_PP4_FxxP_1	427	430	PF00568	0.233
DOC_USP7_MATH_1	102	106	PF00917	0.283
DOC_USP7_MATH_1	372	376	PF00917	0.320
DOC_USP7_MATH_1	377	381	PF00917	0.328
DOC_USP7_MATH_1	467	471	PF00917	0.271
DOC_USP7_MATH_1	527	531	PF00917	0.528
DOC_USP7_MATH_1	68	72	PF00917	0.305
DOC_USP7_MATH_2	275	281	PF00917	0.397
DOC_USP7_UBL2_3	258	262	PF12436	0.408
DOC_WW_Pin1_4	114	119	PF00397	0.305
DOC_WW_Pin1_4	147	152	PF00397	0.354
DOC_WW_Pin1_4	310	315	PF00397	0.509
DOC_WW_Pin1_4	440	445	PF00397	0.471
LIG_14-3-3_CanoR_1	173	183	PF00244	0.298
LIG_14-3-3_CanoR_1	264	271	PF00244	0.580
LIG_BRCT_BRCA1_1	513	517	PF00533	0.362
LIG_CaM_NSCaTE_8	411	418	PF13499	0.336
LIG_DCNL_PONY_1	1	4	PF03556	0.354
LIG_EH1_1	362	370	PF00400	0.354
LIG_FHA_1	138	144	PF00498	0.499
LIG_FHA_1	397	403	PF00498	0.301
LIG_FHA_1	424	430	PF00498	0.294
LIG_FHA_1	452	458	PF00498	0.309
LIG_FHA_1	461	467	PF00498	0.322
LIG_FHA_1	469	475	PF00498	0.332
LIG_FHA_1	504	510	PF00498	0.319
LIG_FHA_1	521	527	PF00498	0.356
LIG_FHA_2	244	250	PF00498	0.364
LIG_FHA_2	334	340	PF00498	0.513
LIG_FHA_2	34	40	PF00498	0.197
LIG_GBD_Chelix_1	452	460	PF00786	0.233
LIG_LIR_Apic_2	113	118	PF02991	0.305
LIG_LIR_Apic_2	426	430	PF02991	0.233
LIG_LIR_Apic_2	462	467	PF02991	0.321
LIG_LIR_Gen_1	156	167	PF02991	0.299
LIG_LIR_Gen_1	182	190	PF02991	0.157
LIG_LIR_Gen_1	39	49	PF02991	0.232
LIG_LIR_Gen_1	55	65	PF02991	0.365
LIG_LIR_LC3C_4	454	458	PF02991	0.335
LIG_LIR_LC3C_4	506	509	PF02991	0.264
LIG_LIR_Nem_3	100	104	PF02991	0.258
LIG_LIR_Nem_3	105	110	PF02991	0.266
LIG_LIR_Nem_3	156	162	PF02991	0.299
LIG_LIR_Nem_3	182	186	PF02991	0.349
LIG_LIR_Nem_3	360	366	PF02991	0.460
LIG_LIR_Nem_3	39	45	PF02991	0.253
LIG_LIR_Nem_3	485	491	PF02991	0.295
LIG_LIR_Nem_3	55	61	PF02991	0.352
LIG_MYND_1	147	151	PF01753	0.408
LIG_NRP_CendR_1	528	531	PF00754	0.567
LIG_Pex14_2	155	159	PF04695	0.306
LIG_Pex14_2	162	166	PF04695	0.307
LIG_SH2_CRK	300	304	PF00017	0.397
LIG_SH2_CRK	390	394	PF00017	0.208
LIG_SH2_CRK	46	50	PF00017	0.341
LIG_SH2_CRK	464	468	PF00017	0.365
LIG_SH2_NCK_1	390	394	PF00017	0.208
LIG_SH2_PTP2	42	45	PF00017	0.157
LIG_SH2_SRC	347	350	PF00017	0.408
LIG_SH2_STAP1	390	394	PF00017	0.267
LIG_SH2_STAT5	103	106	PF00017	0.253
LIG_SH2_STAT5	129	132	PF00017	0.468
LIG_SH2_STAT5	148	151	PF00017	0.420
LIG_SH2_STAT5	253	256	PF00017	0.481
LIG_SH2_STAT5	344	347	PF00017	0.526
LIG_SH2_STAT5	42	45	PF00017	0.306
LIG_SH3_3	438	444	PF00018	0.555
LIG_SH3_3	96	102	PF00018	0.154
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.555
LIG_SUMO_SIM_par_1	108	113	PF11976	0.296
LIG_SUMO_SIM_par_1	150	156	PF11976	0.336
LIG_SUMO_SIM_par_1	456	463	PF11976	0.295
LIG_SUMO_SIM_par_1	477	482	PF11976	0.321
LIG_SUMO_SIM_par_1	505	510	PF11976	0.332
LIG_TRAF2_1	275	278	PF00917	0.408
LIG_TYR_ITIM	298	303	PF00017	0.397
LIG_TYR_ITIM	44	49	PF00017	0.295
LIG_UBA3_1	199	204	PF00899	0.295
LIG_UBA3_1	431	438	PF00899	0.496
LIG_ULM_U2AF65_1	489	494	PF00076	0.396
LIG_WRC_WIRS_1	241	246	PF05994	0.408
LIG_WRC_WIRS_1	34	39	PF05994	0.197
LIG_WRC_WIRS_1	424	429	PF05994	0.366
MOD_CDK_SPxK_1	440	446	PF00069	0.471
MOD_CK1_1	240	246	PF00069	0.486
MOD_CK1_1	459	465	PF00069	0.324
MOD_CK2_1	243	249	PF00069	0.440
MOD_Cter_Amidation	95	98	PF01082	0.408
MOD_GlcNHglycan	104	107	PF01048	0.590
MOD_GlcNHglycan	12	16	PF01048	0.379
MOD_GlcNHglycan	176	179	PF01048	0.581
MOD_GlcNHglycan	212	215	PF01048	0.317
MOD_GlcNHglycan	266	269	PF01048	0.182
MOD_GlcNHglycan	28	31	PF01048	0.453
MOD_GlcNHglycan	348	352	PF01048	0.370
MOD_GlcNHglycan	403	406	PF01048	0.519
MOD_GlcNHglycan	513	516	PF01048	0.318
MOD_GSK3_1	110	117	PF00069	0.316
MOD_GSK3_1	168	175	PF00069	0.177
MOD_GSK3_1	18	25	PF00069	0.321
MOD_GSK3_1	206	213	PF00069	0.513
MOD_GSK3_1	306	313	PF00069	0.464
MOD_GSK3_1	367	374	PF00069	0.248
MOD_GSK3_1	377	384	PF00069	0.325
MOD_GSK3_1	456	463	PF00069	0.371
MOD_GSK3_1	468	475	PF00069	0.304
MOD_GSK3_1	48	55	PF00069	0.340
MOD_GSK3_1	503	510	PF00069	0.337
MOD_N-GLC_2	320	322	PF02516	0.202
MOD_NEK2_1	137	142	PF00069	0.516
MOD_NEK2_1	174	179	PF00069	0.305
MOD_NEK2_1	231	236	PF00069	0.448
MOD_NEK2_1	456	461	PF00069	0.322
MOD_NEK2_1	479	484	PF00069	0.233
MOD_NEK2_1	48	53	PF00069	0.280
MOD_NEK2_1	507	512	PF00069	0.357
MOD_NEK2_1	60	65	PF00069	0.201
MOD_PK_1	206	212	PF00069	0.397
MOD_PK_1	237	243	PF00069	0.397
MOD_PKA_1	264	270	PF00069	0.354
MOD_PKA_1	97	103	PF00069	0.227
MOD_PKA_2	172	178	PF00069	0.197
MOD_PKA_2	210	216	PF00069	0.567
MOD_PKA_2	263	269	PF00069	0.375
MOD_Plk_1	137	143	PF00069	0.408
MOD_Plk_2-3	306	312	PF00069	0.516
MOD_Plk_4	110	116	PF00069	0.292
MOD_Plk_4	179	185	PF00069	0.168
MOD_Plk_4	52	58	PF00069	0.324
MOD_ProDKin_1	114	120	PF00069	0.305
MOD_ProDKin_1	147	153	PF00069	0.354
MOD_ProDKin_1	310	316	PF00069	0.509
MOD_ProDKin_1	440	446	PF00069	0.471
MOD_SUMO_for_1	271	274	PF00179	0.397
MOD_SUMO_rev_2	257	267	PF00179	0.354
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.295
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.442
TRG_ENDOCYTIC_2	300	303	PF00928	0.397
TRG_ENDOCYTIC_2	390	393	PF00928	0.208
TRG_ENDOCYTIC_2	42	45	PF00928	0.308
TRG_ENDOCYTIC_2	46	49	PF00928	0.302
TRG_ER_diArg_1	205	207	PF00400	0.417
TRG_ER_diArg_1	488	490	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.208
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.230

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	48%	100%
A0A0S4JEW4	Bodo saltans	24%	84%
A0A1X0NXY5	Trypanosomatidae	47%	100%
A0A1X0P0T2	Trypanosomatidae	24%	80%
A0A3Q8I8Y3	Leishmania donovani	46%	100%
A0A3Q8IBK1	Leishmania donovani	44%	98%
A0A3R7K4N2	Trypanosoma rangeli	40%	100%
A0A3R7L5P3	Trypanosoma rangeli	24%	88%
A0A3S5H545	Leishmania donovani	90%	93%
A4H5Y5	Leishmania braziliensis	46%	94%
A4H6C2	Leishmania braziliensis	46%	94%
A4HBH2	Leishmania braziliensis	43%	100%
A4HH06	Leishmania braziliensis	76%	100%
A4HUP5	Leishmania infantum	46%	100%
A4HYJ6	Leishmania infantum	44%	98%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ACJ5	Leishmania major	89%	100%
E9AG39	Leishmania infantum	91%	93%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	93%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	90%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	93%
Q4QH82	Leishmania major	46%	94%
Q4QHL7	Leishmania major	46%	94%
Q63488	Rattus norvegicus	27%	81%
Q80UP8	Mus musculus	27%	81%
Q95L97	Felis catus	27%	81%
V5DS90	Trypanosoma cruzi	45%	100%